Averell L Gnatt

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis
    Kyle Hubbard
    Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Cancer 8:133. 2008
  2. ncbi Elongation by RNA polymerase II: structure-function relationship
    Averell Gnatt
    Department of Pharmacology and Experimental Therapeutics and Department of Pathology, University of Maryland Baltimore, 655 West Baltimore St, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1577:175-90. 2002
  3. ncbi A Mediator-responsive form of metazoan RNA polymerase II
    Xiaopeng Hu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:9506-11. 2006
  4. ncbi Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD
    Man Hee Suh
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:17314-9. 2005

Research Grants

  1. Regulation of Transcription:Structure Function Basis
    Averell Gnatt; Fiscal Year: 2006

Collaborators

  • Sohail Malik
  • Ping Ye
  • Kyle Hubbard
  • Jennifer Catalano
  • Xiaopeng Hu
  • Man Hee Suh
  • Raj K Puri
  • Chidambaram Natesa Velalar
  • Costin Catalin Negroiu
  • Robert G Roeder
  • Brian Hampton
  • Dan Grosu
  • Jianhua Fu
  • Mincheng Zhang
  • Man-Hee Suh
  • Stewart Shuman
  • Stephane Hausmann

Detail Information

Publications4

  1. ncbi Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis
    Kyle Hubbard
    Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    BMC Cancer 8:133. 2008
    ..We report on RNA interference of TFIIS, a transcription elongation factor, and its affect on proliferation of cancer cells in culture...
  2. ncbi Elongation by RNA polymerase II: structure-function relationship
    Averell Gnatt
    Department of Pharmacology and Experimental Therapeutics and Department of Pathology, University of Maryland Baltimore, 655 West Baltimore St, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1577:175-90. 2002
    ..Structural studies of RNA polymerases are described below within the context of the process of transcription elongation, its regulation and function...
  3. ncbi A Mediator-responsive form of metazoan RNA polymerase II
    Xiaopeng Hu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:9506-11. 2006
    ..Our results reveal a transcriptional control mechanism in which Mediator-dependent regulation is enforced by means of Gdown1, which likely restricts Pol II function only to be reversed by Mediator...
  4. ncbi Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD
    Man Hee Suh
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:17314-9. 2005
    ..We speculate that Fcp1 interaction with the non-CTD site may mediate its stimulatory effect on transcription elongation reported previously...

Research Grants5

  1. Regulation of Transcription:Structure Function Basis
    Averell Gnatt; Fiscal Year: 2006
    ..Site directed mutagenesis of RNA Polymerase II in yeast will allow for verification and determination of the structure-function relationships of the proteins. ..