Thomas Glover

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Breaking news on fragile sites in cancer
    Thomas W Glover
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 23:137-9. 2013
  2. ncbi request reprint Mechanisms of common fragile site instability
    Thomas W Glover
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Mol Genet 14:R197-205. 2005
  3. ncbi request reprint Common fragile sites
    Thomas W Glover
    Department of Human Genetics, 4909 Buhl, Box 0618, 1241 E Catherine Street, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Cancer Lett 232:4-12. 2006
  4. ncbi request reprint The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region
    T W Glover
    Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:3409-14. 1998
  5. pmc Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links
    J Kevin Hicks
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Mol Cell Biol 30:1217-30. 2010
  6. ncbi request reprint Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genes Chromosomes Cancer 33:82-92. 2002
  7. ncbi request reprint ATR regulates fragile site stability
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 111:779-89. 2002
  8. pmc Chromosomal instability at common fragile sites in Seckel syndrome
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Am J Hum Genet 75:654-60. 2004
  9. ncbi request reprint The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas
    Lin Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 62:5273-9. 2002
  10. ncbi request reprint Common fragile sites as targets for chromosome rearrangements
    Martin F Arlt
    Department of Human, Genetics University of Michigan, 4909 Buhl Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109, USA
    DNA Repair (Amst) 5:1126-35. 2006

Collaborators

Detail Information

Publications30

  1. doi request reprint Breaking news on fragile sites in cancer
    Thomas W Glover
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 23:137-9. 2013
    ....
  2. ncbi request reprint Mechanisms of common fragile site instability
    Thomas W Glover
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Mol Genet 14:R197-205. 2005
    ..However, despite recent advances, many questions remain regarding the normal functional significance of these conserved regions and the basis of their fragility...
  3. ncbi request reprint Common fragile sites
    Thomas W Glover
    Department of Human Genetics, 4909 Buhl, Box 0618, 1241 E Catherine Street, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Cancer Lett 232:4-12. 2006
    ..Some aspects of this review were taken from Glover et al. (T.W. Glover, M.F. Arlt, A.M. Casper, S.G. Durkin, Mechanisms of common fragile site instability, Hum. Molec. Genet. 14 (in press). [1])...
  4. ncbi request reprint The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region
    T W Glover
    Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:3409-14. 1998
    ..Thus, the physical relationship of Fhit to a common fragile site is similar to that observed with the orthologous human FHIT gene and FRA3B...
  5. pmc Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links
    J Kevin Hicks
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Mol Cell Biol 30:1217-30. 2010
    ....
  6. ncbi request reprint Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genes Chromosomes Cancer 33:82-92. 2002
    ..Our results further support the hypothesis that common fragile sites and their associated genes are, in general, unstable in some cancer cells...
  7. ncbi request reprint ATR regulates fragile site stability
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 111:779-89. 2002
    ..These findings have important implications for understanding both the mechanism of fragile site instability and the consequences of stalled replication in mammalian cells...
  8. pmc Chromosomal instability at common fragile sites in Seckel syndrome
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Am J Hum Genet 75:654-60. 2004
    ..This is the first human genetic syndrome associated with increased chromosome instability at fragile sites following replication stress, and these findings may be related to the phenotypic findings in patients with SCKL1...
  9. ncbi request reprint The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas
    Lin Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 62:5273-9. 2002
    ..Amplification of HNF3alpha in esophageal and lung tumors may suggest a potential oncogenic role for this gene in tumorigenesis...
  10. ncbi request reprint Common fragile sites as targets for chromosome rearrangements
    Martin F Arlt
    Department of Human, Genetics University of Michigan, 4909 Buhl Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109, USA
    DNA Repair (Amst) 5:1126-35. 2006
    ..Here we review the relationship of fragile sites to chromosome rearrangements, particularly in tumor cells, and discuss the mechanisms that may be involved...
  11. ncbi request reprint Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    Lin Lin
    Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
    Genes Chromosomes Cancer 45:319-31. 2006
    ..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development...
  12. ncbi request reprint A novel VEGFR3 mutation causes Milroy disease
    Matthew G Butler
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
    Am J Med Genet A 143:1212-7. 2007
    ..This mutant allele segregated with lymphedema among affected individuals with incomplete penetrance. This is the first report of an exon 22 mutation in Milroy disease...
  13. ncbi request reprint Chromosome fragile sites
    Sandra G Durkin
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Annu Rev Genet 41:169-92. 2007
    ..Their study has merged with that of cell cycle checkpoints and DNA repair, and common fragile sites have provided insight into understanding the consequences of replication stress on DNA damage and genome instability in cancer cells...
  14. ncbi request reprint The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability
    Niall G Howlett
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Mol Genet 14:693-701. 2005
    ..Following APH treatment, FANCD2-Ub co-localizes with PCNA (early) and RPA2 (late) in discrete nuclear foci. Our results demonstrate an integral role for the FA pathway in the DNA replication stress response...
  15. ncbi request reprint Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome
    Susan L Dagenais
    Department of Human Genetics, University of Michigan, 4909 Buhl, Box 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Gene Expr Patterns 4:611-9. 2004
    ....
  16. ncbi request reprint Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
    Maria Eriksson
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Nature 423:293-8. 2003
    ..The discovery of the molecular basis of this disease may shed light on the general phenomenon of human ageing...
  17. pmc Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    DNA Repair (Amst) 9:678-89. 2010
    ..These data from cultured human cells demonstrate that topoisomerase I activity is required for DNA common fragile site breaks and suggest that polymerase-helicase uncoupling is a key initial event in this process...
  18. ncbi request reprint Age of onset in hereditary lymphedema
    Kara L Levinson
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Pediatr 142:704-8. 2003
    ..To characterize age of onset patterns and penetrance in hereditary lymphedema, including differences caused by sex and genetic heterogeneity...
  19. ncbi request reprint Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas
    Charles T Miller
    Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:4136-43. 2003
    ..DYRK2 mRNA overexpression occurs more frequently than gene amplification in both esophageal and lung adenocarcinomas. This is the first report of amplification and overexpression of DYRK2 in any tumor type...
  20. ncbi request reprint Mutation of the FOXC2 gene in familial distichiasis
    Brian P Brooks
    Department of Ophthalmology, University of Michigan, Ann Arbor, MI, USA
    J AAPOS 7:354-7. 2003
    ..To examine the FOXC2 gene in a family with hereditary distichiasis...
  21. pmc BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function
    Martin F Arlt
    Department of Human Genetics, 4909 Buhl, Box 0618, 1241 E Catherine Street, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Mol Cell Biol 24:6701-9. 2004
    ..Furthermore, they suggest that mutations in BRCA1 or interacting proteins could lead to rearrangements at fragile sites in cancer cells...
  22. doi request reprint Stably transfected common fragile site sequences exhibit instability at ectopic sites
    Ryan L Ragland
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genes Chromosomes Cancer 47:860-72. 2008
    ..These data support the hypothesis that sequences at CFSs are inherently unstable, and are a major factor in the formation of replication stress induced gaps and breaks at CFSs...
  23. doi request reprint Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response
    Ryan L Ragland
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Mamm Genome 20:375-85. 2009
    ..These mice provide a novel model system for studies of Atr deficiency and replication stress...
  24. ncbi request reprint A Gata2 intronic enhancer confers its pan-endothelia-specific regulation
    Melin Khandekar
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Development 134:1703-12. 2007
    ..Thus, GATA-2 is expressed early in lymphatic, cardiac and blood vascular endothelial cells, and the pan-endothelium-specific expression of Gata2 is controlled by a discrete intronic enhancer...
  25. pmc Replication stress induces tumor-like microdeletions in FHIT/FRA3B
    Sandra G Durkin
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA
    Proc Natl Acad Sci U S A 105:246-51. 2008
    ....
  26. pmc Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Hum Genet 84:339-50. 2009
    ..This is a previously unrecognized consequence of replication stress and suggests that replication fork stalling and subsequent error-prone repair are important mechanisms in the formation of CNVs and pathogenic CNCs in humans...
  27. ncbi request reprint Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
    Michael W Glynn
    Department of Human Genetics, University of Michigan, Ann Arbor, 48109, USA
    Hum Mol Genet 14:2959-69. 2005
    ..These results implicate the abnormal farnesylation of progerin in the cellular phenotype in HGPS cells and suggest that FTIs may represent a therapeutic option for patients with HGPS...
  28. ncbi request reprint Interrupted aortic arch in a child with trisomy 5q31.1q35.1 due to a maternal (20;5) balanced insertion
    Donna M Martin
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109 0688, USA
    Am J Med Genet A 116:268-71. 2003
    ..Here we compare this child's features to other cases of trisomy 5q31.1q35.1, and review other causes of IAA. We conclude that gene dosage in this chromosomal region likely influences aortic arch development...
  29. ncbi request reprint Direct correlation between FRA3B expression and cigarette smoking
    Constance K Stein
    Departments of Pathology and Pediatrics, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Genes Chromosomes Cancer 34:333-40. 2002
    ..The data support the hypothesis that exposure to tobacco carcinogens increases the potential for chromosome breakage at fragile sites...
  30. ncbi request reprint FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome
    Benjamin M Kriederman
    University of Arizona, Department of Surgery, Tucson, Arizona, USA
    Hum Mol Genet 12:1179-85. 2003
    ....

Research Grants29

  1. FRAGILE SITES AND CHROMOSOME BREAKAGE AND CANCER
    Thomas Glover; Fiscal Year: 2002
    ....
  2. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2005
    ..abstract_text> ..
  3. ROLE OF FRAGILE SITES IN CHROMOSOME BREAKAGE AND CANCER
    Thomas Glover; Fiscal Year: 2007
    ....
  4. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..abstract_text> ..
  5. ROLE OF FRAGILE SITES IN CHROMOSOME BREAKAGE AND CANCER
    Thomas Glover; Fiscal Year: 1993
    ....