Louise E Glover

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Gastroenterology 140:1748-55. 2011
  2. pmc An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
  3. pmc Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014
  4. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
  5. pmc Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, Department of Anesthesiology and Perioperative Medicine, and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 110:19820-5. 2013
  6. pmc IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
  7. pmc HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
    Thomas Weissmüller
    1Mucosal Inflammation Program, University of Colorado, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 28:256-64. 2014
  8. pmc Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
    Stefan F Ehrentraut
    Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:392-400. 2013
  9. pmc Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
  10. pmc Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010

Collaborators

Detail Information

Publications13

  1. pmc Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Gastroenterology 140:1748-55. 2011
    ..Reagents that activate HIF, via inhibition of the prolyl hydroxylase enzymes, might be developed to induce hypoxia-mediated resolution in patients with intestinal mucosal inflammatory disease...
  2. pmc An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Science Center, Aurora, CO 80045, USA
    J Immunol 186:6505-14. 2011
    ..Taken together, these results identify a global change in methylation, which during inflammation, translates to an overall protective role in mucosal epithelia...
  3. pmc Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation
    Eric L Campbell
    Mucosal Inflammation Program, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA Electronic address
    Immunity 40:66-77. 2014
    ..In conclusion, transcriptional imprinting by infiltrating neutrophils modulates the host response to inflammation, via localized O2 depletion, resulting in microenvironmental hypoxia and effective inflammatory resolution. ..
  4. pmc Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    Eric T Clambey
    Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:E2784-93. 2012
    ..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
  5. pmc Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, Department of Anesthesiology and Perioperative Medicine, and Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 110:19820-5. 2013
    ..These findings establish a role for HIF-regulated CK in epithelial homeostasis and reveal a fundamental link between cellular bioenergetics and mucosal barrier. ..
  6. pmc IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
    Louise E Glover
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:1790-8. 2011
    ..These observations are relevant to the pathophysiology of colitis (i.e., that loss of HIF signaling during active inflammation may exacerbate disease pathogenesis)...
  7. pmc HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function
    Thomas Weissmüller
    1Mucosal Inflammation Program, University of Colorado, 12700 E 19th Ave, Aurora, CO 80045, USA
    FASEB J 28:256-64. 2014
    ..E., Fennimore, B., Curtis, V. F., MacManus, C. F., Ehrentraut, S. F., Campbell, E. L., Scully, M., Grove, B. D., Colgan, S. P. HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function. ..
  8. pmc Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
    Stefan F Ehrentraut
    Mucosal Inflammation Program, Department of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 190:392-400. 2013
    ..Moreover, our findings provide feasibility for therapeutic targeting of the Culs during inflammation...
  9. pmc Contributions of neutrophils to resolution of mucosal inflammation
    Sean P Colgan
    Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Immunol Res 55:75-82. 2013
    ..Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa...
  10. pmc Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
    ..Together, these data implicate a previously unappreciated role for ALPI in RvE1-mediated inflammatory resolution...
  11. pmc Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia
    Simon Keely
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Biol Cell 21:538-46. 2010
    ..Together, these findings reveal that some strains of Gram-positive bacteria exploit HIF-regulated PAFr as a means for translocation through intestinal epithelial cells...
  12. pmc Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, CO 80045
    J Immunol 192:1249-56. 2014
    ..Together, these studies implicate HIF in the transcriptional control of pulmonary adenosine signaling during ALI. ..
  13. pmc Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing
    Simon Keely
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    FASEB J 23:1338-46. 2009
    ..80). Taken together, these results demonstrate that hypoxia induces fibroblast ITGB1 expression and function by transcriptional mechanisms dependent on HIF...