Gerald Gleich

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Eosinophil major basic protein: first identified natural heparanase-inhibiting protein
    Vladislav Temkin
    Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Allergy Clin Immunol 113:703-9. 2004
  2. ncbi request reprint The hypereosinophilic syndromes: still more heterogeneity
    Gerald J Gleich
    Department of Dermatology, University of Utah Health Sciences Center, 4B454 School of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
    Curr Opin Immunol 17:679-84. 2005
  3. doi request reprint The consequences of not having eosinophils
    G J Gleich
    University of Utah Health Sciences Center, Salt Lake City, UT 84132 2409, USA
    Allergy 68:829-35. 2013
  4. doi request reprint The hypereosinophilic syndromes: current concepts and treatments
    Gerald J Gleich
    Departments of Dermatology and Medicine, The Health Sciences Center, School of Medicine, University of Utah, Salt Lake City, UT 84103, USA
    Br J Haematol 145:271-85. 2009
  5. ncbi request reprint Anaphylaxis: implications of monoclonal antibody use in oncology
    Gerald J Gleich
    Department of Dermatology, University of Utah, Health Sciences Center, Salt Lake City, Utah, USA
    Oncology (Williston Park) 23:7-13. 2009
  6. ncbi request reprint Treatment of hypereosinophilic syndrome with imatinib mesilate
    Gerald J Gleich
    Department of Immunology, Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN, USA
    Lancet 359:1577-8. 2002
  7. ncbi request reprint A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica
    Claudia F Lucchinetti
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Brain 125:1450-61. 2002
  8. ncbi request reprint Major basic protein homolog (MBP2): a specific human eosinophil marker
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 177:7340-5. 2006
  9. ncbi request reprint Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi
    Seung Heon Shin
    Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:1369-75. 2004
  10. ncbi request reprint Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005

Research Grants

  1. EOSINOPHIL AND BASOPHIL GRANULE PROTEINS
    Gerald Gleich; Fiscal Year: 2001
  2. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
  3. THE FUNCTIONS OF EOSINOPHILS
    Gerald Gleich; Fiscal Year: 1980
  4. THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMAB
    Gerald Gleich; Fiscal Year: 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Eosinophil major basic protein: first identified natural heparanase-inhibiting protein
    Vladislav Temkin
    Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Allergy Clin Immunol 113:703-9. 2004
    ..Heparanase and eosinophils are involved in several diseases, including inflammation, cancer, and angiogenesis...
  2. ncbi request reprint The hypereosinophilic syndromes: still more heterogeneity
    Gerald J Gleich
    Department of Dermatology, University of Utah Health Sciences Center, 4B454 School of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
    Curr Opin Immunol 17:679-84. 2005
    ..This new information critically modifies our view of HES and indicates that several cell lines are altered and likely to contribute to HES pathophysiology...
  3. doi request reprint The consequences of not having eosinophils
    G J Gleich
    University of Utah Health Sciences Center, Salt Lake City, UT 84132 2409, USA
    Allergy 68:829-35. 2013
    ....
  4. doi request reprint The hypereosinophilic syndromes: current concepts and treatments
    Gerald J Gleich
    Departments of Dermatology and Medicine, The Health Sciences Center, School of Medicine, University of Utah, Salt Lake City, UT 84103, USA
    Br J Haematol 145:271-85. 2009
    ..These advances augur well for continued progress in the understanding and treatment of HES...
  5. ncbi request reprint Anaphylaxis: implications of monoclonal antibody use in oncology
    Gerald J Gleich
    Department of Dermatology, University of Utah, Health Sciences Center, Salt Lake City, Utah, USA
    Oncology (Williston Park) 23:7-13. 2009
    ..Increased awareness of the mechanisms, symptoms, and treatment of anaphylaxis can aid caregivers to make informed decisions when new agents, such as monoclonal antibodies, are introduced into the clinic...
  6. ncbi request reprint Treatment of hypereosinophilic syndrome with imatinib mesilate
    Gerald J Gleich
    Department of Immunology, Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN, USA
    Lancet 359:1577-8. 2002
    ..All patients who responded stopped other treatments and reduced imatinib mesilate to 200 mg per week. This drug effectively controls eosinophilia in patients with hypereosinophilic syndrome and normal interleukin-5 concentrations...
  7. ncbi request reprint A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica
    Claudia F Lucchinetti
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Brain 125:1450-61. 2002
    ..Based on this study, future therapeutic strategies designed to limit the deleterious effects of complement activation, eosinophil degranulation and neutrophil/macrophage/microglial activation are worthy of further investigation...
  8. ncbi request reprint Major basic protein homolog (MBP2): a specific human eosinophil marker
    Douglas A Plager
    Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol 177:7340-5. 2006
    ..These results indicate that MBP2 is present only in eosinophils and that it may be a useful biomarker for eosinophil-associated diseases...
  9. ncbi request reprint Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi
    Seung Heon Shin
    Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 114:1369-75. 2004
    ..Chronic rhinosinusitis (CRS) is one of the most common long-term illnesses in the United States. The etiology of CRS is unknown, and no effective treatment has been established...
  10. ncbi request reprint Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005
    ..These results indicate that repetitive extraction of eosinophil granules yields an increased amount of all granule proteins, and that MBP2 can now be recovered in good quantities and in a relatively pure form...
  11. pmc EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression
    Lori A Wagner
    School of Medicine, Department of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA
    Blood 109:5191-8. 2007
    ..Therefore, EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression...
  12. ncbi request reprint Hypereosinophilic syndrome: case presentation and update
    Kristin M Leiferman
    Department of Dermatology, University of Utah, Salt Lake City, Utah 84132 2409, USA
    J Allergy Clin Immunol 113:50-8. 2004
    ..We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES...
  13. ncbi request reprint Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups
    Lori A Wagner
    Department of Dermatology, School of Medicine, University of Utah, Room 4RI22 SOM 30 North 1900 East, Salt Lake City, Utah, 84132, USA
    Protein J 26:13-8. 2007
    ..MBP2, similar to MBP1, has conserved motifs in common with C-type lectins. The disulfide bond locations are conserved among human MBP1, MBP2 and C-type lectins...
  14. ncbi request reprint Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization
    Mark D P Davis
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
    J Allergy Clin Immunol 112:988-94. 2003
    ....
  15. ncbi request reprint Dermatologic manifestations of the hypereosinophilic syndromes
    Kristin M Leiferman
    Department of Dermatology, 4B454 School of Medicine, University of Utah Health Sciences Center, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132 2409, USA
    Immunol Allergy Clin North Am 27:415-41. 2007
    ..Recognition of dermatologic manifestations is important in approaching diagnosis and treatment of HES. This article reviews cutaneous involvement in HES and other eosinophil-associated skin diseases...
  16. ncbi request reprint Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation
    Adrian M Piliponsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University Hadassah Medical School, P O Box 12065, 91120, Jerusalem, Israel
    Mol Immunol 38:1369. 2002
    ....
  17. ncbi request reprint Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor
    Adrian M Piliponsky
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Blood 101:1898-904. 2003
    ..Mast cell responsiveness to eosinophil mediators is a potentially novel evidence for an alternative pathway of allergen-independent activation able to contribute to the perpetuation of allergy...
  18. doi request reprint The effect of cationic charge on release of eosinophil mediators
    Darryl J Adamko
    Department of Pediatrics, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:383-90, 390.e1-4. 2008
    ..Although the role of cytokines in cell activation is well established, the presence of cationic-charged tissue can also be an important factor in inflammatory cell function...
  19. doi request reprint Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    N Engl J Med 358:1215-28. 2008
    ..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity...
  20. ncbi request reprint Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway
    Neeta G Shenoy
    Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 171:3734-41. 2003
    ....
  21. doi request reprint Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
    Shida Yousefi
    Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
    Nat Med 14:949-53. 2008
    ....
  22. ncbi request reprint Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report
    Amy D Klion
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 117:1292-302. 2006
    ..Furthermore, the need for newer therapeutic strategies and novel drugs, as well as multicenter trials to assess all treatment modalities, was emphasized...
  23. ncbi request reprint Identification of basophils by a mAb directed against pro-major basic protein 1
    Douglas A Plager
    Department of Dermatology, Mayo Clinic Rochester, MN, and Department of Internal Medicine, Virginia Commonwealth University, USA
    J Allergy Clin Immunol 117:626-34. 2006
    ..A mAb (J175-7D4) generated against the recombinant pro-form of human eosinophil granule major basic protein 1 (rproMBP1) appeared to stain only basophils in tissue specimens...
  24. doi request reprint Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteins
    Qihai Gu
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Lung Cell Mol Physiol 294:L544-52. 2008
    ....
  25. ncbi request reprint Eosinophil-granule major basic protein, a C-type lectin, binds heparin
    G Jawahar Swaminathan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 44:14152-8. 2005
    ..We propose that the sugars recognized by EMBP are likely to be proteoglycans such as heparin, leading to new interpretations for EMBP function...
  26. ncbi request reprint Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis
    Jens U Ponikau
    Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Allergy Clin Immunol 116:362-9. 2005
    ..The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated...
  27. ncbi request reprint Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli
    Hitoshi Kobayashi
    Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 99:2214-20. 2002
    ..Alternatively, eosinophils may play important roles in maintenance and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF...
  28. ncbi request reprint Evidence for pathogenic involvementof eosinophils and neutrophilsin Churg-Strauss syndrome
    Lisa A Drage
    Department of Dermatology, Mayo Clinic Mayo Foundation, Rochester, USA
    J Am Acad Dermatol 47:209-16. 2002
    ..Churg-Strauss syndrome (CSS) is a multi-organ disease with tissue and blood eosinophilia...
  29. ncbi request reprint A modular on-line three-dimensional liquid chromatography-tandem mass spectrometry approach to characterization of organelle proteomes
    Kenneth L Johnson
    Biomedical Mass Spectrometry and Functional Proteomics Facility and Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Biomed Chromatogr 17:106-12. 2003
    ..Details are provided of the analytical approach we have developed and we discuss some of the advantages compared with previously reported analyses, as well as providing some specific examples of novel proteins identified...
  30. ncbi request reprint Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycle
    Alice Rhoton-Vlasak
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
    Fertil Steril 79:1149-53. 2003
    ..To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle...
  31. ncbi request reprint Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinase
    Paul J Kingham
    Dept of Pharmacology and Therapeutics, Univ of Liverpool, The Sherrington Bldgs, Ashton St, Liverpool L69 3GE, UK
    Am J Physiol Lung Cell Mol Physiol 285:L915-24. 2003
    ..These results indicate that eosinophils modify the morphology of nerve cells by distinct mechanisms that involve adhesion and released proteins...
  32. ncbi request reprint Regulation of eosinophil membrane depolarization during NADPH oxidase activation
    Jennifer L Bankers-Fulbright
    Department of Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    J Cell Sci 116:3221-6. 2003
    ..Thus, the membrane depolarization that is associated with NADPH oxidase activation in eosinophils is sufficient to produce marked proton channel activation under physiological conditions...
  33. ncbi request reprint Effect of eosinophil adhesion on intracellular signaling in cholinergic nerve cells
    Marie Therese Walsh
    Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Cell Mol Biol 30:333-41. 2004
    ....
  34. ncbi request reprint Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled study
    Loren W Hunt
    Department of Internal Medicine, Division of Allergic Diseases, Mayo Clinic and Foundation, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
    J Allergy Clin Immunol 113:853-9. 2004
    ..In 2 prior uncontrolled studies, nebulized lidocaine reduced oral glucocorticoid use in patients with severe glucocorticoid-dependent asthma...
  35. ncbi request reprint The induction of eosinophil peroxidase release: improved methods of measurement and stimulation
    Darryl J Adamko
    The Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Immunol Methods 291:101-8. 2004
    ..Finally, using this technique, we have been able to demonstrate secretory IgA (s-IgA)-induced release of EPO. By using OPD, we have developed a more sensitive and specific method to analyze the release of extracellular EPO...
  36. ncbi request reprint Hypereosinophilia in an islet transplant recipient
    Raffaella Poggioli
    Transplantation 79:853-4. 2005
  37. ncbi request reprint Diverse effects of eosinophil cationic granule proteins on IMR-32 nerve cell signaling and survival
    Ross K Morgan
    Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland, and Department of Dermatology, University of Utah, Salt Lake City, USA
    Am J Respir Cell Mol Biol 33:169-77. 2005
    ..This signaling pathway was not activated by EDN. Thus, MBP1 released from eosinophils at inflammatory sites may regulate peripheral nerve plasticity by inhibiting apoptosis...
  38. ncbi request reprint The changing role of eosinophils in long-term hyperreactivity following a single ozone exposure
    Bethany L Yost
    Dept of Environmental Sciences, Johns Hospkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 289:L627-35. 2005
    ..The site of hyperreactivity, muscle or nerve, changes over 3 days after a single exposure to ozone. Additionally, the role of eosinophils is complex; they mediate hyperreactivity acutely while chronically may be involved in repair...
  39. ncbi request reprint Biological activities of ecalectin: a novel eosinophil-activating factor
    Ryoji Matsumoto
    Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Immunol 168:1961-7. 2002
    ..Therefore, we conclude that ecalectin is a novel eosinophil-activating factor. Presumably, these effects allow ecalectin to play a distinctive role in allergic inflammation...

Research Grants24

  1. EOSINOPHIL AND BASOPHIL GRANULE PROTEINS
    Gerald Gleich; Fiscal Year: 2001
    ....
  2. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
  3. THE FUNCTIONS OF EOSINOPHILS
    Gerald Gleich; Fiscal Year: 1980
    ....
  4. THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMAB
    Gerald Gleich; Fiscal Year: 2007
    ....