Research Topics
Species | Gerald GleichSummaryAffiliation: University of Utah Country: USA Publications
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Detail Information
Publications
Eosinophil major basic protein: first identified natural heparanase-inhibiting proteinVladislav Temkin
Department of Pharmacology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Allergy Clin Immunol 113:703-9. 2004..CONCLUSIONS: MBP is the first identified natural heparanase-inhibiting protein. Its presence in the eosinophil granules might indicate a protective function of these cells in diseases associated with inflammation and cancer progression...- The hypereosinophilic syndromes: still more heterogeneityGerald J Gleich
Department of Dermatology, University of Utah Health Sciences Center, 4B454 School of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
Curr Opin Immunol 17:679-84. 2005..This new information critically modifies our view of HES and indicates that several cell lines are altered and likely to contribute to HES pathophysiology... - Anaphylaxis: implications of monoclonal antibody use in oncologyGerald J Gleich
Department of Dermatology, University of Utah, Health Sciences Center, Salt Lake City, Utah, USA
Oncology (Williston Park) 23:7-13. 2009..Increased awareness of the mechanisms, symptoms, and treatment of anaphylaxis can aid caregivers to make informed decisions when new agents, such as monoclonal antibodies, are introduced into the clinic... - Treatment of hypereosinophilic syndrome with imatinib mesilateGerald J Gleich
Department of Immunology, Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN, USA
Lancet 359:1577-8. 2002..All patients who responded stopped other treatments and reduced imatinib mesilate to 200 mg per week. This drug effectively controls eosinophilia in patients with hypereosinophilic syndrome and normal interleukin-5 concentrations... 
The hypereosinophilic syndromes: current concepts and treatmentsGerald J Gleich
Departments of Dermatology and Medicine, The Health Sciences Center, School of Medicine, University of Utah, Salt Lake City, UT 84103, USA
Br J Haematol 145:271-85. 2009..These advances augur well for continued progress in the understanding and treatment of HES...- Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathwayNeeta G Shenoy
Department of Immunology Microbiology, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
J Immunol 171:3734-41. 2003.... - Differential extraction of eosinophil granule proteinsLyo E Ohnuki
Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
J Immunol Methods 307:54-61. 2005..These results indicate that repetitive extraction of eosinophil granules yields an increased amount of all granule proteins, and that MBP2 can now be recovered in good quantities and in a relatively pure form... - Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungiSeung-Heon Shin
Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Allergy Clin Immunol 114:1369-75. 2004..The anomalous immune and inflammatory responses to ubiquitous fungi may explain the chronicity of airway inflammation in CRS... - Major basic protein homolog (MBP2): a specific human eosinophil markerDouglas A Plager
Allergic Diseases Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Immunol 177:7340-5. 2006..These results indicate that MBP2 is present only in eosinophils and that it may be a useful biomarker for eosinophil-associated diseases... - Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groupsLori A Wagner
Department of Dermatology, School of Medicine, University of Utah, Room 4RI22 SOM 30 North 1900 East, Salt Lake City, Utah, 84132, USA
Protein J 26:13-8. 2007..MBP2, similar to MBP1, has conserved motifs in common with C-type lectins. The disulfide bond locations are conserved among human MBP1, MBP2 and C-type lectins... - Hypereosinophilic syndrome: case presentation and updateKristin M Leiferman
Department of Dermatology, University of Utah, Salt Lake City, Utah 84132-2409, USA
J Allergy Clin Immunol 113:50-8. 2004..We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES... - Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilizationMark D P Davis
Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
J Allergy Clin Immunol 112:988-94. 2003.... 
EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expressionLori A Wagner
School of Medicine, Department of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA
Blood 109:5191-8. 2007..Therefore, EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression...- Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammationAdrian M Piliponsky
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University-Hadassah Medical School, P.O. Box 12065, 91120, Jerusalem, Israel
Mol Immunol 38:1369. 2002.... - Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factorAdrian M Piliponsky
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
Blood 101:1898-904. 2003..Mast cell responsiveness to eosinophil mediators is a potentially novel evidence for an alternative pathway of allergen-independent activation able to contribute to the perpetuation of allergy... - The effect of cationic charge on release of eosinophil mediatorsDarryl J Adamko
Department of Pediatrics, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada
J Allergy Clin Immunol 122:383-90, 390.e1-4. 2008..Although the role of cytokines in cell activation is well established, the presence of cationic-charged tissue can also be an important factor in inflammatory cell function... - Treatment of patients with the hypereosinophilic syndrome with mepolizumabMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
N Engl J Med 358:1215-28. 2008..Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity... - Dermatologic manifestations of the hypereosinophilic syndromesKristin M Leiferman
Department of Dermatology, 4B454 School of Medicine, University of Utah Health Sciences Center, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132 2409, USA
Immunol Allergy Clin North Am 27:415-41. 2007..Recognition of dermatologic manifestations is important in approaching diagnosis and treatment of HES. This article reviews cutaneous involvement in HES and other eosinophil-associated skin diseases... - Sensitization of isolated rat vagal pulmonary sensory neurons by eosinophil-derived cationic proteinsQihai Gu
Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
Am J Physiol Lung Cell Mol Physiol 294:L544-52. 2008.... - Approaches to the treatment of hypereosinophilic syndromes: a workshop summary reportAmy D Klion
Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 117:1292-302. 2006..Furthermore, the need for newer therapeutic strategies and novel drugs, as well as multicenter trials to assess all treatment modalities, was emphasized... - Identification of basophils by a mAb directed against pro-major basic protein 1Douglas A Plager
Department of Dermatology, Mayo Clinic Rochester, MN, and Department of Internal Medicine, Virginia Commonwealth University, USA
J Allergy Clin Immunol 117:626-34. 2006..A mAb (J175-7D4) generated against the recombinant pro-form of human eosinophil granule major basic protein 1 (rproMBP1) appeared to stain only basophils in tissue specimens... - Eosinophil-granule major basic protein, a C-type lectin, binds heparinG Jawahar Swaminathan
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
Biochemistry 44:14152-8. 2005..We propose that the sugars recognized by EMBP are likely to be proteoglycans such as heparin, leading to new interpretations for EMBP function... - Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defenseShida Yousefi
Institute of Pharmacology, University of Bern, Friedbuhlstrasse 49, CH 3010 Bern, Switzerland
Nat Med 14:949-53. 2008.... - Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitisJens U Ponikau
Department of Otorhinolaryngology Head and Neck Surgery, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Allergy Clin Immunol 116:362-9. 2005..The mechanisms by which eosinophilic inflammation damages the epithelium and contributes to recurrent acute exacerbations in chronic rhinosinusitis (CRS) have not been fully elucidated... - Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuliHitoshi Kobayashi
Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Blood 99:2214-20. 2002..Alternatively, eosinophils may play important roles in maintenance and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF... - Evidence for pathogenic involvementof eosinophils and neutrophilsin Churg-Strauss syndromeLisa A Drage
Department of Dermatology, Mayo Clinic/Mayo Foundation, Rochester, USA
J Am Acad Dermatol 47:209-16. 2002..Blister fluid contained more NE than normal serum. CONCLUSIONS: Both eosinophils and neutrophils likely participate in skin lesion development in CSS... - A modular on-line three-dimensional liquid chromatography-tandem mass spectrometry approach to characterization of organelle proteomesKenneth L Johnson
Biomedical Mass Spectrometry and Functional Proteomics Facility and Department of Biochemistry and Molecular Biology, Mayo Clinic/Foundation, Rochester, MN 55905, USA
Biomed Chromatogr 17:106-12. 2003..Details are provided of the analytical approach we have developed and we discuss some of the advantages compared with previously reported analyses, as well as providing some specific examples of novel proteins identified... - Localization and cellular distribution of pregnancy-associated plasma protein-a and major basic protein in human ovary and corpora lutea throughout the menstrual cycleAlice Rhoton-Vlasak
Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida 32610, USA
Fertil Steril 79:1149-53. 2003..To assess the expression and cellular distribution of pregnancy-associated plasma protein-A (PAPP-A) and major basic protein (MBP) in human ovarian tissue during the menstrual cycle... - Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinasePaul J Kingham
Dept of Pharmacology and Therapeutics, Univ of Liverpool, The Sherrington Bldgs, Ashton St, Liverpool L69 3GE, UK
Am J Physiol Lung Cell Mol Physiol 285:L915-24. 2003..These results indicate that eosinophils modify the morphology of nerve cells by distinct mechanisms that involve adhesion and released proteins... - Regulation of eosinophil membrane depolarization during NADPH oxidase activationJennifer L Bankers-Fulbright
Department of Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
J Cell Sci 116:3221-6. 2003..Thus, the membrane depolarization that is associated with NADPH oxidase activation in eosinophils is sufficient to produce marked proton channel activation under physiological conditions... - Effect of eosinophil adhesion on intracellular signaling in cholinergic nerve cellsMarie Therese Walsh
Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland
Am J Respir Cell Mol Biol 30:333-41. 2004.... - Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled studyLoren W Hunt
Department of Internal Medicine, Division of Allergic Diseases, Mayo Clinic and Foundation, Mayo Graduate School of Medicine, Rochester, MN 55905, USA
J Allergy Clin Immunol 113:853-9. 2004..05 for both), and blood eosinophil counts (P < or =.01) and decreases in FEV(1) (P < or =.001). CONCLUSION: Nebulized lidocaine provided effective and safe therapy in subjects with mild-to-moderate asthma... - The induction of eosinophil peroxidase release: improved methods of measurement and stimulationDarryl J Adamko
The Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Immunol Methods 291:101-8. 2004..Finally, using this technique, we have been able to demonstrate secretory IgA (s-IgA)-induced release of EPO. By using OPD, we have developed a more sensitive and specific method to analyze the release of extracellular EPO... - Hypereosinophilia in an islet transplant recipientRaffaella Poggioli
Transplantation 79:853-4. 2005 - Diverse effects of eosinophil cationic granule proteins on IMR-32 nerve cell signaling and survivalRoss K Morgan
Department of Medicine, RCSI, Beaumont Hospital, Dublin 9, Ireland, and Department of Dermatology, University of Utah, Salt Lake City, USA
Am J Respir Cell Mol Biol 33:169-77. 2005..This signaling pathway was not activated by EDN. Thus, MBP1 released from eosinophils at inflammatory sites may regulate peripheral nerve plasticity by inhibiting apoptosis... - The changing role of eosinophils in long-term hyperreactivity following a single ozone exposureBethany L Yost
Dept. of Environmental Sciences, Johns Hospkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Physiol Lung Cell Mol Physiol 289:L627-35. 2005..The site of hyperreactivity, muscle or nerve, changes over 3 days after a single exposure to ozone. Additionally, the role of eosinophils is complex; they mediate hyperreactivity acutely while chronically may be involved in repair... - Biological activities of ecalectin: a novel eosinophil-activating factorRyoji Matsumoto
Department of Immunology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
J Immunol 168:1961-7. 2002..Therefore, we conclude that ecalectin is a novel eosinophil-activating factor. Presumably, these effects allow ecalectin to play a distinctive role in allergic inflammation...
Research Grants
- EOSINOPHIL AND BASOPHIL GRANULE PROTEINSGerald Gleich; Fiscal Year: 2001....
- Eosinophil Granule Proteins and Their FunctionsGerald Gleich; Fiscal Year: 2006..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
- THE FUNCTIONS OF EOSINOPHILSGerald Gleich; Fiscal Year: 1980....
- THE HYPEREOSINOPHILIC SYNDROMES AND MEPOLIZUMABGerald Gleich; Fiscal Year: 2007....