Britt A Glaunsinger

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Deep sequencing reveals direct targets of gammaherpesvirus-induced mRNA decay and suggests that multiple mechanisms govern cellular transcript escape
    Karen Clyde
    Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e19655. 2011
  2. pmc Dual short upstream open reading frames control translation of a herpesviral polycistronic mRNA
    Lisa M Kronstad
    Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Pathog 9:e1003156. 2013
  3. pmc Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1
    Sergio Covarrubias
    Division of Infectious Diseases and Immunity, School of Public Health, University of California Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002339. 2011
  4. pmc Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency
    Justin M Richner
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002150. 2011
  5. pmc Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation
    Emma Abernathy
    Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California, United States of America
    PLoS Pathog 10:e1003882. 2014
  6. ncbi request reprint How tails define the ending: divergent roles for polyadenylation in RNA stability and gene expression
    Britt A Glaunsinger
    Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA, USA
    RNA Biol 7:13-7. 2010
  7. pmc Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion
    G Renuka Kumar
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    Mol Cell Biol 31:3113-25. 2011
  8. pmc Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm
    Sergio Covarrubias
    University of California, Berkeley, 94720 3102, USA
    J Virol 83:9554-66. 2009
  9. pmc A common strategy for host RNA degradation by divergent viruses
    Marta Maria Gaglia
    Department of Plant and Microbial Biology, School of Public Health, University of California, Berkeley, California, USA
    J Virol 86:9527-30. 2012
  10. pmc Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA
    G Renuka Kumar
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    Mol Cell Biol 30:4996-5008. 2010

Collaborators

Detail Information

Publications17

  1. pmc Deep sequencing reveals direct targets of gammaherpesvirus-induced mRNA decay and suggests that multiple mechanisms govern cellular transcript escape
    Karen Clyde
    Department of Plant and Microbial Biology, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e19655. 2011
    ..Collectively, these studies lay the framework for dissecting the mechanisms underlying the susceptibility of mRNA to destruction during lytic gammaherpesvirus infection...
  2. pmc Dual short upstream open reading frames control translation of a herpesviral polycistronic mRNA
    Lisa M Kronstad
    Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Pathog 9:e1003156. 2013
    ..Positional conservation of uORFs within a number of related viruses suggests that this may be a common γ-herpesviral adaptation of a host translational regulatory mechanism...
  3. pmc Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1
    Sergio Covarrubias
    Division of Infectious Diseases and Immunity, School of Public Health, University of California Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002339. 2011
    ..This is the first example of a viral protein commandeering cellular mRNA turnover pathways to destroy host mRNAs, and suggests that Xrn1 is poised to deplete messages undergoing translation in mammalian cells...
  4. pmc Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency
    Justin M Richner
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Pathog 7:e1002150. 2011
    ..These results highlight for the first time the importance of global mRNA degradation during a gammaherpesvirus infection and link an exclusively lytic phenomenon with downstream latency establishment...
  5. pmc Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation
    Emma Abernathy
    Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, California, United States of America
    PLoS Pathog 10:e1003882. 2014
    ..This is the first example of a virus that fails to broadly discriminate between cellular and viral transcripts during host shutoff and instead uses the targeting of viral messages to fine-tune overall gene expression. ..
  6. ncbi request reprint How tails define the ending: divergent roles for polyadenylation in RNA stability and gene expression
    Britt A Glaunsinger
    Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA, USA
    RNA Biol 7:13-7. 2010
    ..We show herein that short upstream mRNA polyadenylation events occur in cells undergoing enhanced herpesvirus-mediated mRNA turnover, thereby extending the evidence for poly(A)-stimulated RNA decay in mammals...
  7. pmc Importin alpha-mediated nuclear import of cytoplasmic poly(A) binding protein occurs as a direct consequence of cytoplasmic mRNA depletion
    G Renuka Kumar
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 3102, USA
    Mol Cell Biol 31:3113-25. 2011
    ..These findings further suggest that cells must carefully calibrate the ratio of PABPC to mRNA, as events that offset this balance can dramatically influence gene expression...
  8. pmc Host shutoff is a conserved phenotype of gammaherpesvirus infection and is orchestrated exclusively from the cytoplasm
    Sergio Covarrubias
    University of California, Berkeley, 94720 3102, USA
    J Virol 83:9554-66. 2009
    ..These results have important mechanistic implications for how SOX and muSOX target nascent cellular transcripts in the nucleus. Furthermore, our findings establish MHV68 as a new, genetically tractable model to study host shutoff...
  9. pmc A common strategy for host RNA degradation by divergent viruses
    Marta Maria Gaglia
    Department of Plant and Microbial Biology, School of Public Health, University of California, Berkeley, California, USA
    J Virol 86:9527-30. 2012
    ..Thus, multiple host shutoff factors have converged upon a common mRNA degradation pathway...
  10. pmc Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA
    G Renuka Kumar
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 3102, USA
    Mol Cell Biol 30:4996-5008. 2010
    ....
  11. pmc Diverse virus-host interactions influence RNA-based regulation during γ-herpesvirus infection
    Lisa M Kronstad
    Department of Plant and Microbial Biology, 585B Li Ka Shing Center, University of California, Berkeley, CA 94720 3370, USA
    Curr Opin Microbiol 15:506-11. 2012
    ..Further research in this field should help reveal new mechanisms of RNA-based regulation in both infected and uninfected cells...
  12. pmc Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction
    Yeon J Lee
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 7:e1000107. 2009
    ..SOX-induced mRNA turnover therefore represents both a novel mechanism of host shutoff as well as a new model system to probe the regulation of poly(A) tail-stimulated mRNA turnover in mammalian cells...
  13. pmc Reinitiation after translation of two upstream open reading frames (ORF) governs expression of the ORF35-37 Kaposi's sarcoma-associated herpesvirus polycistronic mRNA
    Lisa M Kronstad
    Department of Plant and Microbial Biology, University of California, Berkeley, California, USA
    J Virol 88:6512-8. 2014
    ..Leaky scanning past the uORFs facilitates ORF35 expression, while a reinitiation mechanism after translation of the uORFs enables ORF36 expression. ..
  14. doi request reprint Viruses and the cellular RNA decay machinery
    Marta Maria Gaglia
    Department of Plant and Microbiology, University of California, Berkeley, CA 94720 3102, USA
    Wiley Interdiscip Rev RNA 1:47-59. 2010
    ..Given our incomplete understanding of how many of these pathways are normally regulated, viruses should be powerful tools to help deconstruct the complex networks and events governing eukaryotic RNA stability...
  15. doi request reprint Getting the message direct manipulation of host mRNA accumulation during gammaherpesvirus lytic infection
    Karen Clyde
    Department of Plant and Microbial Biology, University of California, Berkeley, USA
    Adv Virus Res 78:1-42. 2010
    ....
  16. ncbi request reprint Messenger RNA turnover and its regulation in herpesviral infection
    Britt A Glaunsinger
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, 94143, USA
    Adv Virus Res 66:337-94. 2006
    ..Parallels between the viral and cellular degradation systems as well as the known interactions between viral host shutoff factors and the cellular RNA turnover machinery are highlighted...
  17. pmc An RNA element in human interleukin 6 confers escape from degradation by the gammaherpesvirus SOX protein
    Stephanie Hutin
    Department of Plant and Microbial Biology, University of California, Berkeley, California, USA
    J Virol 87:4672-82. 2013
    ..These findings suggest that SOX activity may be directly counteracted by select RNA regulatory complexes and reveal a novel mechanism contributing to the robust expression of IL-6 during KSHV replication...

Research Grants1