Research Topics
Genomes and Genes
| Christopher GlassSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gammaGabriel Pascual
Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nature 437:759-63. 2005..This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis...
Inflammation and lipid signaling in the etiology of insulin resistanceChristopher K Glass
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0673, USA
Cell Metab 15:635-45. 2012..Here, we review recent findings related to this interconnected network from the perspective of immunity and metabolic disease...- Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolismShakti Gupta
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
BMC Syst Biol 5:26. 2011.... - Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoterKate Liddiard
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
BMC Mol Biol 7:45. 2006..Delineating the molecular mechanisms responsible for the IL-4 induction of TARC expression will be important for a better understanding of the role of Th2 cytokines in allergic disease... - Mechanisms underlying inflammation in neurodegenerationChristopher K Glass
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
Cell 140:918-34. 2010..A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease... - Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cellsChristopher K Glass
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, GPL Room 217A, La Jolla, California 92093 0651, USA
Nat Rev Immunol 10:365-76. 2010..These nuclear receptor-dependent transrepression pathways are proposed to have roles in controlling the initiation, magnitude and duration of pro-inflammatory gene expression and are amenable to pharmacological manipulation... 
Combinatorial roles of nuclear receptors in inflammation and immunityChristopher K Glass
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Rev Immunol 6:44-55. 2006..We suggest that by using receptor-specific mechanisms, PPARs and LXRs function in a combinatorial manner with the glucocorticoid receptor to integrate local and systemic responses to inflammation...- Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expressionBrandee L Wagner
X Ceptor Therapeutics, San Diego, California 92121, USA
Mol Cell Biol 23:5780-9. 2003.... - A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factorsValentina Perissi
Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
Cell 116:511-26. 2004..The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors... - Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinedionesAndrea L Hevener
Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
J Clin Invest 117:1658-69. 2007..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs... - Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentChrissa Kioussi
Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 111:673-85. 2002.... - Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathwaysSerena Ghisletti
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
Genes Dev 23:681-93. 2009..These findings reveal a combinatorial, corepressor-based strategy for integration of inflammatory and anti-inflammatory signals that play essential roles in immunity and homeostasis... - PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiationDominique Sawka-Verhelle
Departments of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
J Biol Chem 279:17772-84. 2004..Inhibition of CREB function also results in reduced expression of CD54 and impaired cell adhesion. Taken together, these findings reveal new roles of CREB-1/CREM-1 as regulators of macrophage differentiation... - Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgammaSerena Ghisletti
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell 25:57-70. 2007..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis... - Molecular determinants of crosstalk between nuclear receptors and toll-like receptorsSumito Ogawa
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Cell 122:707-21. 2005..These findings reveal combinatorial control of homeostasis and immune responses by nuclear receptors and suggest new approaches for treatment of inflammatory diseases... - Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpointWendy Huang
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
Mol Cell 35:48-57. 2009..These findings reveal mechanisms for integration of TLR, calcium, and nuclear receptor signaling pathways that underlie pathogen-specific responses and disease-specific programs of inflammation... - PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophagesJohn S Welch
Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093 0651, USA
Proc Natl Acad Sci U S A 100:6712-7. 2003..These findings support a physiological role of PPARgamma in regulating both native and acquired immune responses... - Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisionsPeter J Cook
Howard Hughes Medical Institute School of Medicine, University of California, San Diego, California 92037, USA
Nature 458:591-6. 2009.... - Anti-inflammatory and antidiabetic roles of PPARgammaGabriel Pascual
Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Novartis Found Symp 286:183-96; discussion 196-203. 2007.... - Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosisMercedes Ricote
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, Calif 92093-0651, USA
Arterioscler Thromb Vasc Biol 24:230-9. 2004..This review summarizes recent efforts to decode the differential and overlapping roles of PPARs and LXRs in the context of macrophage lipid homeostasis and the control of inflammation... - Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanismsDaniel S Straus
Biomedical Sciences Division, University of California, Riverside, Riverside, CA 92521 0121, USA
Trends Immunol 28:551-8. 2007..The anti-inflammatory activity of PPAR ligands in mouse models suggests their possible use for treating human inflammatory and autoimmune diseases... - Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathwayBong Gun Ju
Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
Cell 119:815-29. 2004..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms... - Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesisVictoria V Lunyak
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
Science 317:248-51. 2007..These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation... - Nuclear receptors versus inflammation: mechanisms of transrepressionGabriel Pascual
Department of Cellular and Molecular Medicine, Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0651, USA
Trends Endocrinol Metab 17:321-7. 2006.... - Nuclear receptors, inflammation, and neurodegenerative diseasesKaoru Saijo
Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
Adv Immunol 106:21-59. 2010.... - Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevanceWendy Huang
Department of Cellular and Molecular Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA
Arterioscler Thromb Vasc Biol 30:1542-9. 2010.... - A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fateYin C Lin
Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
Nat Immunol 11:635-43. 2010..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate... - Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptorsIvan Garcia-Bassets
Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 128:505-18. 2007..These events link an inhibitory methylation component of the histone code to a broadly used strategy that circumvents pathological constitutive gene induction by physiologically regulated transcription factors... - Opposing LSD1 complexes function in developmental gene activation and repression programmesJianxun Wang
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
Nature 446:882-7. 2007..These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs... - TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpointsValentina Perissi
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell 29:755-66. 2008..Thus, our data reveal a strategy of dual-factor repression checkpoints, in which dedicated exchange factors serve as sensors for signal-specific dismissal of distinct corepressors, with specificity imposed by upstream signaling pathways... - Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METSKelly D Hester
Biomedical Sciences Graduate Program, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Cell Cycle 6:1594-604. 2007.... - Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongationWenlai Zhou
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell 29:69-80. 2008..We suggest that distinct H2A ubiquitinases, each recruited based on interactions with different corepressor complexes, contribute to distinct transcriptional repression programs... - Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathwaySung Hee Baek
Howard Hughes Medical Institute, Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0648, USA
Proc Natl Acad Sci U S A 100:3245-50. 2003.... - Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in miceGary Bradshaw
Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
Proc Natl Acad Sci U S A 102:11029-34. 2005..GdCl(3)-facilated replacement of Kupffer cells may enhance the efficacy of other HSC-based gene therapies... - An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiationGünter W Klappacher
Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 109:169-80. 2002.... - Regulatory network of microRNAs in RAW 264.7 macrophage cellsLana X Garmire
Bioengineering Department of UC San Diego, La Jolla, USA
Conf Proc IEEE Eng Med Biol Soc 2010:6198-201. 2010.... - SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuronKristen Jepsen
Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
Nature 450:415-9. 2007.... - A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 282:35279-92. 2007..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance... - A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulationPing Zhu
Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Mol Cell 27:609-21. 2007.... - Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarrayClaudio Napoli
Department of Medicine, University of California San Diego, La Jolla, Calif 92093, USA
Circulation 105:1360-7. 2002..Maternal hypercholesterolemia during pregnancy is associated with markedly enhanced fatty streak formation in human fetal aortas and accelerated progression of atherosclerosis in normocholesterolemic children... - WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivoRobyn Cunard
Research Service, Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, CA 92161, USA
J Immunol 169:6806-12. 2002..WY14,643 in vitro induces apoptosis in lymphocytes and this effect appears to occur in a PPARalpha-independent manner. Thus WY14,643, a fibrate, is a profound immunosuppressive agent... - PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progressionWen Liu
Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nature 466:508-12. 2010..Thus, the identification and characterization of an H4K20me1 demethylase, PHF8, has revealed an intimate link between this enzyme and two distinct events in cell cycle progression... - Evidence mandating earlier and more aggressive treatment of hypercholesterolemiaDaniel Steinberg
Department of Medicine, BSB 1080, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0682, USA
Circulation 118:672-7. 2008 - The macrophage foam cell as a target for therapeutic interventionAndrew C Li
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
Nat Med 8:1235-42. 2002 - Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesSven Heinz
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 38:576-89. 2010.... - TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanismJohn S Welch
Department of Cellular and Molecular Medicine, La Jolla, California 92093 0651, USA
J Biol Chem 277:42821-9. 2002..These studies establish Ym1 as a highly inducible STAT6-dependent transcript in T(H)2-biased inflammation and define Cis-active elements in the Ym1 promoter that are required for this transcriptional response... - A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced deathKaoru Saijo
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California, CA 92093, USA
Cell 137:47-59. 2009..These studies suggest that Nurr1 protects against loss of dopaminergic neurons in Parkinson's disease in part by limiting the production of neurotoxic mediators by microglia and astrocytes... - Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancerChunru Lin
Howard Hughes Medical Institute, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
Cell 139:1069-83. 2009..Our data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes... - Macrophages, inflammation, and insulin resistanceJerrold M Olefsky
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
Annu Rev Physiol 72:219-46. 2010..Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention... - A topoisomerase IIbeta-mediated dsDNA break required for regulated transcriptionBong Gun Ju
Howard Hughes Medical Institute, Department of Medicine, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0648, USA
Science 312:1798-802. 2006..Our data mechanistically link DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription... - Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient miceGregory S Harmon
Department of Medicine, University of California San Diego, La Jolla, California, USA
Nat Med 16:313-8. 2010..These studies reveal a reversible defect in PPAR-gamma signaling in Cftr-deficient cells that can be pharmacologically corrected to ameliorate the severity of the cystic fibrosis phenotype in mice... - Going nuclear in metabolic and cardiovascular diseaseChristopher K Glass
Department of Cellular and Molecular Medicine and Department of Medicine, UCSD, La Jolla, California 92093 0651, USA
J Clin Invest 116:556-60. 2006.... - Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional responseMichael G Rosenfeld
Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Genes Dev 20:1405-28. 2006..This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events... - A mouse macrophage lipidomeEdward A Dennis
Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 285:39976-85. 2010..Our studies provide a systems-level view of lipid metabolism and reveal significant connections between lipid and cell signaling and biochemical pathways that contribute to innate immune responses and to pharmacological perturbations... - Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gammaAndrew C Li
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
J Clin Invest 114:1564-76. 2004..In concert, these findings reveal receptor-specific mechanisms by which PPARs influence macrophage cholesterol homeostasis. In the future, these mechanisms may be exploited pharmacologically to inhibit the development of atherosclerosis... - Nuclear receptor coregulators: multiple modes of modificationOla Hermanson
Department of Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, 92093-0648, La Jolla, CA 92093-0648, USA
Trends Endocrinol Metab 13:55-60. 2002..This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling... - PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosisAndrew C Li
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Lipid Res 45:2161-73. 2004..Here, we review recent studies that provide new insights into the mechanisms by which these subclasses of nuclear receptors act to systemically influence lipid and glucose metabolism and regulate gene expression within the artery wall... - A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activationSumito Ogawa
Department of Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 101:14461-6. 2004.... - Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisXue Li
Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
Nature 426:247-54. 2003.... - Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cellsCody J Diehl
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Mol Endocrinol 25:529-45. 2011..This catalog of nuclear receptor expression in B-1 and B-2 cells provides data to be used to better understand the specific roles of nuclear receptors in B cell function, chronic inflammation, and autoimmune disease... - The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biologyChristopher K Glass
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 13:459-67. 2004..Here we highlight recent findings presented at the Symposium that provide new insights into the mechanisms of nuclear receptor action and the diverse roles of members of the nuclear receptor superfamily in development and homeostasis... - Regulation of cytokine expression by ligands of peroxisome proliferator activated receptorsRobyn Cunard
Research Service, Veterans Affairs San Diego Healthcare System, Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92161, USA
J Immunol 168:2795-802. 2002.... - Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gammaRobyn Cunard
Research Service and Division of Nephrology Hypertension, University of California and Veterans Affairs San Diego Healthcare System 151, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Immunol 172:7530-6. 2004..These studies suggest that many of the observed anti-inflammatory effects of PPARgamma ligands may be related to direct inhibition of IFN-gamma by PPARgamma... - The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elementsVivien Ya Fan Wang
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell Rep 2:824-39. 2012..Therefore, through sensing of bp differences within κB sites, NF-κB dimers modulate biological programs by activating, repressing, and altering the expression of effector genes... - Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpressionKazuhito Toyo-oka
Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
Cancer Res 66:5565-73. 2006..These results reveal an important role for Mnt in pregnancy-associated mammary gland development and suggest that mammary gland tumorigenesis in the absence of Mnt is analogous to that caused by Myc deregulation... - Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor proteinSung Hee Baek
Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA
Cell 110:55-67. 2002.... - Systems biology of macrophagesMano Ram Maurya
Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093 0412, USA
Adv Exp Med Biol 598:62-79. 2007..macrophages? (3) How can we combine proteomic and other cellular measurements to characterize the repertoire of upstream signaling networks invoked by macrophages? (4) How do designed knockdowns of proteins influence cellular phenotypes?.. - Corepressor-dependent silencing of chromosomal regions encoding neuronal genesVictoria V Lunyak
Howard Hughes Medical Institute HHMI, Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
Science 298:1747-52. 2002.... - Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophagesAmy L Sullivan
University of California, San Diego, Department of Cellular and Molecular Medicine, La Jolla, CA 92093 0651, USA
Mol Cell Biol 31:861-75. 2011.... - Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol effluxTaro E Akiyama
Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 22:2607-19. 2002..Together, these data indicate that PPAR gamma plays a critical role in the regulation of cholesterol homeostasis by controlling the expression of a network of genes that mediate cholesterol efflux from cells and its transport in plasma... - Gaining weight: the Keystone Symposium on PPAR and LXRMichael Lehrke
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 19:1737-42. 2005..In recognition of this, a recent Keystone Symposium was devoted to these metabolic receptors. Here, we summarize some of the major highlights and future projections discussed at the meeting... - Roles of peroxisome proliferator-activated receptor gamma in lipid homeostasis and inflammatory responses of macrophagesGünter W Klappacher
Department of Cardiology, University of Vienna, Austria
Curr Opin Lipidol 13:305-12. 2002.... - Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosisAnnabel F Valledor
Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 101:17813-8. 2004.... - International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptorsLiliane Michalik
Center for Integrative Genomics, National Research Centre Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
Pharmacol Rev 58:726-41. 2006..Thus, selective action of PPARs in vivo results from the interplay at a given time point between expression levels of each of the three PPAR and RXR isotypes, affinity for a specific promoter PPRE, and ligand and cofactor availabilities... - Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promotersYoung Soo Kwon
Department of Cellular and Molecular Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0651, USA
Proc Natl Acad Sci U S A 104:4852-7. 2007..This study demonstrates the power of the ChIP-DSL technology in revealing regulatory gene expression programs that have been previously invisible in the human genome... - PPARs and molecular mechanisms of transrepressionMercedes Ricote
Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Biochim Biophys Acta 1771:926-35. 2007..Identification of their mechanism of action should help promote the understanding of the physiologic roles that PPARs play in immunity and contribute to the development of new therapeutic agents... - Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectEwan Birney
Nature 447:799-816. 2007..Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function... - Novel eicosanoid activators of PPAR gamma formed by RAW 264.7 macrophage culturesSven Hammarstrom
Division of Cell Biology, Linkoping University, S-581 85 Linkoping, Sweden
Adv Exp Med Biol 507:343-9. 2002 - Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell culturesMats Soderstrom
Department of Biomedicine and Surgery, Linkoping University, S 581 85, Linkoping, Sweden
Biochim Biophys Acta 1631:35-41. 2003..9-hydroxy-11-oxo-, (5Z,9alpha,12E,14Z)-Prosta-5,12,14-trien-1-oic acid (15-deoxy-delta(12,14)-PGD(2)) was identified. The biological significance of these results is currently under investigation... - Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granulesEsperanza Nunez
Howard Hughes Medical Institute, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
Cell 132:996-1010. 2008..These findings reveal roles for the modulation of nuclear architecture in orchestrating regulated gene-expression programs in the mammalian nucleus... - Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionXiangting Wang
Howard Hughes Medical Institute
Nature 454:126-30. 2008.... - Immunology: Oxysterols hold T cells in checkChristopher K Glass
Nature 455:40-1. 2008 - MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBPKenji Deguchi
Division of Hematology and Oncology, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes, of Medicine, 4 Blackfan Circle, Room 420, Boston, MA 02115, USA
Cancer Cell 3:259-71. 2003..These results indicate that nucleosomal targeting by MOZ and recruitment of CBP by TIF2 are critical requirements for MOZ-TIF2 transformation and indicate that MOZ gain of function contributes to leukemogenesis... - Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activityEsther Y Chao
GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
J Med Chem 51:5758-65. 2008.... - The role of transcription factors in allergic inflammationLaure Escoubet-Lozach
Division of Cellular and Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0637, USA
J Allergy Clin Immunol 110:553-64. 2002....
Research Grants
- TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSIONChristopher Glass; Fiscal Year: 2005..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
- INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGESChristopher Glass; Fiscal Year: 2003..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
- INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGESChristopher Glass; Fiscal Year: 2006..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
- INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGESChristopher Glass; Fiscal Year: 2007..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
- Transcriptional Co-Regulators and Macrophage Gene ExpressionChristopher Glass; Fiscal Year: 2007..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..
- HORMONAL REGULATION OF MACROPHAGE DEVELOPMENTChristopher Glass; Fiscal Year: 1993..The proposed studies are likely to provide new insights into the mechanisms by which the retinoic acid and Vitamin D receptors influence the hierarchy of regulatory genes that act to specific cellular phenotype and control cell growth...
- REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORSChristopher Glass; Fiscal Year: 2000..Insights derived from these studies are likely to lead to an improved understanding of the mechanisms by which retinoic acid receptors positively and negatively regulate gene expression. ..
- Transcriptional Co-Regulators and Macrophage Gene ExpressionChristopher K Glass; Fiscal Year: 2010..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..