Christopher Glass

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
  2. pmc Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
    Michael T Y Lam
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 498:511-5. 2013
  3. pmc Mechanisms establishing TLR4-responsive activation states of inflammatory response genes
    Laure Escoubet-Lozach
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 7:e1002401. 2011
  4. pmc Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nature 470:414-8. 2011
  5. pmc Vespucci: a system for building annotated databases of nascent transcripts
    Karmel A Allison
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA, Department of Bioinformatics and Systems Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA, San Diego Center for Systems Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA, A I Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, P O Box 1627, 70120 Kuopio, Finland, Institute for Genomic Medicine and Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Nucleic Acids Res 42:2433-47. 2014
  6. pmc Inflammation and lipid signaling in the etiology of insulin resistance
    Christopher K Glass
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0673, USA
    Cell Metab 15:635-45. 2012
  7. pmc Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism
    Shakti Gupta
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    BMC Syst Biol 5:26. 2011
  8. pmc Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter
    Kate Liddiard
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    BMC Mol Biol 7:45. 2006
  9. pmc Mechanisms underlying inflammation in neurodegeneration
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
    Cell 140:918-34. 2010
  10. ncbi request reprint Combinatorial roles of nuclear receptors in inflammation and immunity
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Immunol 6:44-55. 2006

Detail Information

Publications89

  1. pmc A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 437:759-63. 2005
    ..This mechanism provides an explanation for how an agonist-bound nuclear receptor can be converted from an activator of transcription to a promoter-specific repressor of NF-kappaB target genes that regulate immunity and homeostasis...
  2. pmc Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
    Michael T Y Lam
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 498:511-5. 2013
    ..These studies provide evidence for a direct role of eRNAs in contributing to enhancer functions and suggest that Rev-Erbs act to suppress gene expression at a distance by repressing eRNA transcription...
  3. pmc Mechanisms establishing TLR4-responsive activation states of inflammatory response genes
    Laure Escoubet-Lozach
    Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 7:e1002401. 2011
    ..Collectively, these findings reveal broadly utilized mechanisms underlying temporally distinct patterns of TLR4-dependent gene activation required for homeostasis and effective immune responses...
  4. pmc Coronin 2A mediates actin-dependent de-repression of inflammatory response genes
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0651, USA
    Nature 470:414-8. 2011
    ....
  5. pmc Vespucci: a system for building annotated databases of nascent transcripts
    Karmel A Allison
    Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA, Department of Bioinformatics and Systems Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA, San Diego Center for Systems Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0375, USA, A I Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, P O Box 1627, 70120 Kuopio, Finland, Institute for Genomic Medicine and Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Nucleic Acids Res 42:2433-47. 2014
    ..Vespucci thereby provides a robust system for defining, storing and analyzing diverse classes of primary RNA transcripts that are of increasing biological interest. ..
  6. pmc Inflammation and lipid signaling in the etiology of insulin resistance
    Christopher K Glass
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0673, USA
    Cell Metab 15:635-45. 2012
    ..Here, we review recent findings related to this interconnected network from the perspective of immunity and metabolic disease...
  7. pmc Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism
    Shakti Gupta
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    BMC Syst Biol 5:26. 2011
    ....
  8. pmc Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter
    Kate Liddiard
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    BMC Mol Biol 7:45. 2006
    ..Delineating the molecular mechanisms responsible for the IL-4 induction of TARC expression will be important for a better understanding of the role of Th2 cytokines in allergic disease...
  9. pmc Mechanisms underlying inflammation in neurodegeneration
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, 92093, USA
    Cell 140:918-34. 2010
    ..A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease...
  10. ncbi request reprint Combinatorial roles of nuclear receptors in inflammation and immunity
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Rev Immunol 6:44-55. 2006
    ..We suggest that by using receptor-specific mechanisms, PPARs and LXRs function in a combinatorial manner with the glucocorticoid receptor to integrate local and systemic responses to inflammation...
  11. doi request reprint Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, GPL Room 217A, La Jolla, California 92093 0651, USA
    Nat Rev Immunol 10:365-76. 2010
    ..These nuclear receptor-dependent transrepression pathways are proposed to have roles in controlling the initiation, magnitude and duration of pro-inflammatory gene expression and are amenable to pharmacological manipulation...
  12. pmc Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression
    Brandee L Wagner
    X Ceptor Therapeutics, San Diego, California 92121, USA
    Mol Cell Biol 23:5780-9. 2003
    ....
  13. ncbi request reprint A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
    Valentina Perissi
    Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Cell 116:511-26. 2004
    ..The role of TBLR1 and TBL1 in cofactor exchange appears to also operate for c-Jun and NFkappaB and is therefore likely to be prototypic of similar mechanisms for other signal-dependent transcription factors...
  14. pmc Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    Andrea L Hevener
    Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
    J Clin Invest 117:1658-69. 2007
    ..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs...
  15. ncbi request reprint Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002
    ....
  16. pmc Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 23:681-93. 2009
    ..These findings reveal a combinatorial, corepressor-based strategy for integration of inflammatory and anti-inflammatory signals that play essential roles in immunity and homeostasis...
  17. ncbi request reprint PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation
    Dominique Sawka-Verhelle
    Departments of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 279:17772-84. 2004
    ..Inhibition of CREB function also results in reduced expression of CD54 and impaired cell adhesion. Taken together, these findings reveal new roles of CREB-1/CREM-1 as regulators of macrophage differentiation...
  18. pmc Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Cell 122:707-21. 2005
    ..These findings reveal combinatorial control of homeostasis and immune responses by nuclear receptors and suggest new approaches for treatment of inflammatory diseases...
  19. pmc Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
    Peter J Cook
    Howard Hughes Medical Institute School of Medicine, University of California, San Diego, California 92037, USA
    Nature 458:591-6. 2009
    ....
  20. pmc PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    John S Welch
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093 0651, USA
    Proc Natl Acad Sci U S A 100:6712-7. 2003
    ..These findings support a physiological role of PPARgamma in regulating both native and acquired immune responses...
  21. pmc Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma
    Serena Ghisletti
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 25:57-70. 2007
    ..These studies define parallel but functionally distinct pathways that are utilized by PPARgamma and LXRs to differentially regulate complex programs of gene expression that control immunity and homeostasis...
  22. pmc Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
    Wendy Huang
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Mol Cell 35:48-57. 2009
    ..These findings reveal mechanisms for integration of TLR, calcium, and nuclear receptor signaling pathways that underlie pathogen-specific responses and disease-specific programs of inflammation...
  23. ncbi request reprint Nuclear receptors versus inflammation: mechanisms of transrepression
    Gabriel Pascual
    Department of Cellular and Molecular Medicine, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Trends Endocrinol Metab 17:321-7. 2006
    ....
  24. ncbi request reprint Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
    Daniel S Straus
    Biomedical Sciences Division, University of California, Riverside, Riverside, CA 92521 0121, USA
    Trends Immunol 28:551-8. 2007
    ..The anti-inflammatory activity of PPAR ligands in mouse models suggests their possible use for treating human inflammatory and autoimmune diseases...
  25. ncbi request reprint Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis
    Victoria V Lunyak
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 317:248-51. 2007
    ..These data suggest that transcription of interspersed repetitive sequences may represent a developmental strategy for the establishment of functionally distinct domains within the mammalian genome to control gene activation...
  26. ncbi request reprint Anti-inflammatory and antidiabetic roles of PPARgamma
    Gabriel Pascual
    Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Novartis Found Symp 286:183-96; discussion 196-203. 2007
    ....
  27. ncbi request reprint Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    Bong Gun Ju
    Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
    Cell 119:815-29. 2004
    ..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
  28. ncbi request reprint Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis
    Mercedes Ricote
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, Calif 92093 0651, USA
    Arterioscler Thromb Vasc Biol 24:230-9. 2004
    ..This review summarizes recent efforts to decode the differential and overlapping roles of PPARs and LXRs in the context of macrophage lipid homeostasis and the control of inflammation...
  29. pmc TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
    Valentina Perissi
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:755-66. 2008
    ..Thus, our data reveal a strategy of dual-factor repression checkpoints, in which dedicated exchange factors serve as sensors for signal-specific dismissal of distinct corepressors, with specificity imposed by upstream signaling pathways...
  30. pmc Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
    Sung Hee Baek
    Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 100:3245-50. 2003
    ....
  31. ncbi request reprint Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS
    Kelly D Hester
    Biomedical Sciences Graduate Program, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Cell Cycle 6:1594-604. 2007
    ....
  32. ncbi request reprint Opposing LSD1 complexes function in developmental gene activation and repression programmes
    Jianxun Wang
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 446:882-7. 2007
    ..These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs...
  33. pmc Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors
    Ivan Garcia-Bassets
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:505-18. 2007
    ..These events link an inhibitory methylation component of the histone code to a broadly used strategy that circumvents pathological constitutive gene induction by physiologically regulated transcription factors...
  34. pmc Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
    Wenlai Zhou
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 29:69-80. 2008
    ..We suggest that distinct H2A ubiquitinases, each recruited based on interactions with different corepressor complexes, contribute to distinct transcriptional repression programs...
  35. pmc A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 11:635-43. 2010
    ..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate...
  36. pmc Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance
    Wendy Huang
    Department of Cellular and Molecular Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Arterioscler Thromb Vasc Biol 30:1542-9. 2010
    ....
  37. doi request reprint Nuclear receptors, inflammation, and neurodegenerative diseases
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Adv Immunol 106:21-59. 2010
    ....
  38. pmc Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice
    Gary Bradshaw
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 102:11029-34. 2005
    ..GdCl(3)-facilated replacement of Kupffer cells may enhance the efficacy of other HSC-based gene therapies...
  39. ncbi request reprint An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation
    Günter W Klappacher
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 109:169-80. 2002
    ....
  40. ncbi request reprint Corepressor-dependent silencing of chromosomal regions encoding neuronal genes
    Victoria V Lunyak
    Howard Hughes Medical Institute HHMI, Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093 0648, USA
    Science 298:1747-52. 2002
    ....
  41. doi request reprint The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements
    Vivien Ya Fan Wang
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell Rep 2:824-39. 2012
    ..Therefore, through sensing of bp differences within κB sites, NF-κB dimers modulate biological programs by activating, repressing, and altering the expression of effector genes...
  42. ncbi request reprint Systems biology of macrophages
    Mano Ram Maurya
    Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093 0412, USA
    Adv Exp Med Biol 598:62-79. 2007
    ..macrophages? (3) How can we combine proteomic and other cellular measurements to characterize the repertoire of upstream signaling networks invoked by macrophages? (4) How do designed knockdowns of proteins influence cellular phenotypes?..
  43. ncbi request reprint Regulatory network of microRNAs in RAW 264.7 macrophage cells
    Lana X Garmire
    Bioengineering Department of UC San Diego, La Jolla, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:6198-201. 2010
    ....
  44. doi request reprint Evidence mandating earlier and more aggressive treatment of hypercholesterolemia
    Daniel Steinberg
    Department of Medicine, BSB 1080, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0682, USA
    Circulation 118:672-7. 2008
  45. ncbi request reprint Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 168:2795-802. 2002
    ....
  46. ncbi request reprint WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 169:6806-12. 2002
    ..WY14,643 in vitro induces apoptosis in lymphocytes and this effect appears to occur in a PPARalpha-independent manner. Thus WY14,643, a fibrate, is a profound immunosuppressive agent...
  47. ncbi request reprint The macrophage foam cell as a target for therapeutic intervention
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 8:1235-42. 2002
  48. pmc Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer
    Chunru Lin
    Howard Hughes Medical Institute, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Cell 139:1069-83. 2009
    ..Our data suggest that the confluence of two parallel pathways initiated by liganded nuclear receptor and genotoxic stress underlies nonrandom tumor translocations, which may function in many types of tumors and pathological processes...
  49. pmc A mouse macrophage lipidome
    Edward A Dennis
    Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:39976-85. 2010
    ..Our studies provide a systems-level view of lipid metabolism and reveal significant connections between lipid and cell signaling and biochemical pathways that contribute to innate immune responses and to pharmacological perturbations...
  50. doi request reprint Macrophages, inflammation, and insulin resistance
    Jerrold M Olefsky
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0651, USA
    Annu Rev Physiol 72:219-46. 2010
    ..Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention...
  51. ncbi request reprint Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray
    Claudio Napoli
    Department of Medicine, University of California San Diego, La Jolla, Calif 92093, USA
    Circulation 105:1360-7. 2002
    ..Maternal hypercholesterolemia during pregnancy is associated with markedly enhanced fatty streak formation in human fetal aortas and accelerated progression of atherosclerosis in normocholesterolemic children...
  52. pmc Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice
    Gregory S Harmon
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Nat Med 16:313-8. 2010
    ..These studies reveal a reversible defect in PPAR-gamma signaling in Cftr-deficient cells that can be pharmacologically corrected to ameliorate the severity of the cystic fibrosis phenotype in mice...
  53. pmc Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells
    Cody J Diehl
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Mol Endocrinol 25:529-45. 2011
    ..This catalog of nuclear receptor expression in B-1 and B-2 cells provides data to be used to better understand the specific roles of nuclear receptors in B cell function, chronic inflammation, and autoimmune disease...
  54. ncbi request reprint TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism
    John S Welch
    Department of Cellular and Molecular Medicine, La Jolla, California 92093 0651, USA
    J Biol Chem 277:42821-9. 2002
    ..These studies establish Ym1 as a highly inducible STAT6-dependent transcript in T(H)2-biased inflammation and define Cis-active elements in the Ym1 promoter that are required for this transcriptional response...
  55. pmc Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    Sven Heinz
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 38:576-89. 2010
    ....
  56. pmc PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
    Wen Liu
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 466:508-12. 2010
    ..Thus, the identification and characterization of an H4K20me1 demethylase, PHF8, has revealed an intimate link between this enzyme and two distinct events in cell cycle progression...
  57. pmc A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    Kaoru Saijo
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, California, CA 92093, USA
    Cell 137:47-59. 2009
    ..These studies suggest that Nurr1 protects against loss of dopaminergic neurons in Parkinson's disease in part by limiting the production of neurotoxic mediators by microglia and astrocytes...
  58. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004
    ..In concert, these findings reveal receptor-specific mechanisms by which PPARs influence macrophage cholesterol homeostasis. In the future, these mechanisms may be exploited pharmacologically to inhibit the development of atherosclerosis...
  59. ncbi request reprint A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription
    Bong Gun Ju
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0648, USA
    Science 312:1798-802. 2006
    ..Our data mechanistically link DNA topoisomerase IIbeta-dependent dsDNA breaks and the components of the DNA damage and repair machinery in regulated gene transcription...
  60. ncbi request reprint Nuclear receptor coregulators: multiple modes of modification
    Ola Hermanson
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, 92093 0648, La Jolla, CA 92093 0648, USA
    Trends Endocrinol Metab 13:55-60. 2002
    ..This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling...
  61. ncbi request reprint Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
    Xue Li
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Nature 426:247-54. 2003
    ....
  62. pmc Going nuclear in metabolic and cardiovascular disease
    Christopher K Glass
    Department of Cellular and Molecular Medicine and Department of Medicine, UCSD, La Jolla, California 92093 0651, USA
    J Clin Invest 116:556-60. 2006
    ....
  63. ncbi request reprint The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology
    Christopher K Glass
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 13:459-67. 2004
    ..Here we highlight recent findings presented at the Symposium that provide new insights into the mechanisms of nuclear receptor action and the diverse roles of members of the nuclear receptor superfamily in development and homeostasis...
  64. ncbi request reprint Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, University of California and Veterans Affairs San Diego Healthcare System 151, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Immunol 172:7530-6. 2004
    ..These studies suggest that many of the observed anti-inflammatory effects of PPARgamma ligands may be related to direct inhibition of IFN-gamma by PPARgamma...
  65. pmc A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
    Sumito Ogawa
    Department of Cellular and Molecular Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:14461-6. 2004
    ....
  66. pmc A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
    Ping Zhu
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cell 27:609-21. 2007
    ....
  67. ncbi request reprint SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
    Kristen Jepsen
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 450:415-9. 2007
    ....
  68. ncbi request reprint PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Lipid Res 45:2161-73. 2004
    ..Here, we review recent studies that provide new insights into the mechanisms by which these subclasses of nuclear receptors act to systemically influence lipid and glucose metabolism and regulate gene expression within the artery wall...
  69. ncbi request reprint A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    M T Audrey Nguyen
    Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:35279-92. 2007
    ..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance...
  70. ncbi request reprint Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
    Michael G Rosenfeld
    Howard Hughes Medical Institute, Department of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Genes Dev 20:1405-28. 2006
    ..This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events...
  71. ncbi request reprint Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein
    Sung Hee Baek
    Howard Hughes Medical Institute, Department of Molecular Medicine, La Jolla, CA 92093, USA
    Cell 110:55-67. 2002
    ....
  72. ncbi request reprint Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression
    Kazuhito Toyo-oka
    Department of Pediatrics, University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA
    Cancer Res 66:5565-73. 2006
    ..These results reveal an important role for Mnt in pregnancy-associated mammary gland development and suggest that mammary gland tumorigenesis in the absence of Mnt is analogous to that caused by Myc deregulation...
  73. pmc Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages
    Amy L Sullivan
    University of California, San Diego, Department of Cellular and Molecular Medicine, La Jolla, CA 92093 0651, USA
    Mol Cell Biol 31:861-75. 2011
    ....
  74. pmc Gaining weight: the Keystone Symposium on PPAR and LXR
    Michael Lehrke
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:1737-42. 2005
    ..In recognition of this, a recent Keystone Symposium was devoted to these metabolic receptors. Here, we summarize some of the major highlights and future projections discussed at the meeting...
  75. pmc Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    Taro E Akiyama
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:2607-19. 2002
    ..Together, these data indicate that PPAR gamma plays a critical role in the regulation of cholesterol homeostasis by controlling the expression of a network of genes that mediate cholesterol efflux from cells and its transport in plasma...
  76. ncbi request reprint Roles of peroxisome proliferator-activated receptor gamma in lipid homeostasis and inflammatory responses of macrophages
    Günter W Klappacher
    Department of Cardiology, University of Vienna, Austria
    Curr Opin Lipidol 13:305-12. 2002
    ....
  77. pmc Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis
    Annabel F Valledor
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:17813-8. 2004
    ....
  78. ncbi request reprint International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors
    Liliane Michalik
    Center for Integrative Genomics, National Research Centre Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    Pharmacol Rev 58:726-41. 2006
    ..Thus, selective action of PPARs in vivo results from the interplay at a given time point between expression levels of each of the three PPAR and RXR isotypes, affinity for a specific promoter PPRE, and ligand and cofactor availabilities...
  79. pmc Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters
    Young Soo Kwon
    Department of Cellular and Molecular Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093 0651, USA
    Proc Natl Acad Sci U S A 104:4852-7. 2007
    ..This study demonstrates the power of the ChIP-DSL technology in revealing regulatory gene expression programs that have been previously invisible in the human genome...
  80. pmc Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
    Xiangting Wang
    Howard Hughes Medical Institute
    Nature 454:126-30. 2008
    ....
  81. doi request reprint Immunology: Oxysterols hold T cells in check
    Christopher K Glass
    Nature 455:40-1. 2008
  82. doi request reprint Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules
    Esperanza Nunez
    Howard Hughes Medical Institute, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0651, USA
    Cell 132:996-1010. 2008
    ..These findings reveal roles for the modulation of nuclear architecture in orchestrating regulated gene-expression programs in the mammalian nucleus...
  83. pmc Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    Ewan Birney
    Nature 447:799-816. 2007
    ..Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function...
  84. ncbi request reprint Novel eicosanoid activators of PPAR gamma formed by RAW 264.7 macrophage cultures
    Sven Hammarstrom
    Division of Cell Biology, Linkoping University, S 581 85 Linkoping, Sweden
    Adv Exp Med Biol 507:343-9. 2002
  85. pmc PPARs and molecular mechanisms of transrepression
    Mercedes Ricote
    Centro Nacional de Investigaciones Cardiovasculares CNIC, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1771:926-35. 2007
    ..Identification of their mechanism of action should help promote the understanding of the physiologic roles that PPARs play in immunity and contribute to the development of new therapeutic agents...
  86. ncbi request reprint Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures
    Mats Soderstrom
    Department of Biomedicine and Surgery, Linkoping University, S 581 85, Linkoping, Sweden
    Biochim Biophys Acta 1631:35-41. 2003
    ..9-hydroxy-11-oxo-, (5Z,9alpha,12E,14Z)-Prosta-5,12,14-trien-1-oic acid (15-deoxy-delta(12,14)-PGD(2)) was identified. The biological significance of these results is currently under investigation...
  87. ncbi request reprint The role of transcription factors in allergic inflammation
    Laure Escoubet-Lozach
    Division of Cellular and Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0637, USA
    J Allergy Clin Immunol 110:553-64. 2002
    ....
  88. doi request reprint Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity
    Esther Y Chao
    GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 51:5758-65. 2008
    ....
  89. ncbi request reprint MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP
    Kenji Deguchi
    Division of Hematology and Oncology, Brigham and Women s Hospital and Harvard Medical School, Harvard Institutes, of Medicine, 4 Blackfan Circle, Room 420, Boston, MA 02115, USA
    Cancer Cell 3:259-71. 2003
    ..These results indicate that nucleosomal targeting by MOZ and recruitment of CBP by TIF2 are critical requirements for MOZ-TIF2 transformation and indicate that MOZ gain of function contributes to leukemogenesis...

Research Grants29

  1. TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSION
    Christopher Glass; Fiscal Year: 2005
    ..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
  2. INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGES
    Christopher Glass; Fiscal Year: 2003
    ..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
  3. TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSION
    Christopher Glass; Fiscal Year: 2003
    ..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
  4. TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSION
    Christopher Glass; Fiscal Year: 2004
    ..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
  5. INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGES
    Christopher Glass; Fiscal Year: 2006
    ..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
  6. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher Glass; Fiscal Year: 2006
    ..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..
  7. INTEGRATION OF TRANSCRIPTIONAL RESPONSES IN MACROPHAGES
    Christopher Glass; Fiscal Year: 2007
    ..These studies are should provide significant new insights into mechanisms by which permanent exit from the cell cycle is achieved during terminal differentiation of macrophages and other cell types. ..
  8. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher Glass; Fiscal Year: 2007
    ..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..
  9. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher Glass; Fiscal Year: 2009
    ..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..
  10. TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSION
    Christopher Glass; Fiscal Year: 2002
    ..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
  11. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 1999
    ..Insights derived from these studies are likely to lead to an improved understanding of the mechanisms by which retinoic acid receptors positively and negatively regulate gene expression. ..
  12. HORMONAL REGULATION OF MACROPHAGE DEVELOPMENT
    Christopher Glass; Fiscal Year: 1992
    ..The proposed studies are likely to provide new insights into the mechanisms by which the retinoic acid and Vitamin D receptors influence the hierarchy of regulatory genes that act to specific cellular phenotype and control cell growth...
  13. HORMONAL REGULATION OF MACROPHAGE DEVELOPMENT
    Christopher Glass; Fiscal Year: 1993
    ..The proposed studies are likely to provide new insights into the mechanisms by which the retinoic acid and Vitamin D receptors influence the hierarchy of regulatory genes that act to specific cellular phenotype and control cell growth...
  14. REGULATION OF GENE EXPRESSION BY RETINOID RECEPTORS
    Christopher Glass; Fiscal Year: 2000
    ..Insights derived from these studies are likely to lead to an improved understanding of the mechanisms by which retinoic acid receptors positively and negatively regulate gene expression. ..
  15. TRANSCRIPTIONAL COREGULATORS AND MYELOID GENE EXPRESSION
    Christopher Glass; Fiscal Year: 2001
    ..This knowledge may suggest new approaches for the development of nuclear receptor ligands useful in the treatment of a broad spectrum of human diseases. ..
  16. Transcriptional Co-Regulators and Macrophage Gene Expression
    Christopher K Glass; Fiscal Year: 2010
    ..The results of these studies are likely to lead to new insights into the mechanisms underlying transrepression of inflammatory responses that can be exploited for development of novel therapeutic approaches. ..