N Glaser

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Subclinical cerebral edema in children with diabetic ketoacidosis randomized to 2 different rehydration protocols
    Nicole S Glaser
    Department of Pediatrics, School of Medicine, University of California Davis, Davis, California, USA
    Pediatrics 131:e73-80. 2013
  2. pmc Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism
    Nicole Glaser
    Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, California, USA
    Diabetes 61:1831-7. 2012
  3. pmc Cognitive dysfunction associated with diabetic ketoacidosis in rats
    Nicole Glaser
    Department of Pediatrics, University of California Davis, School of Medicine, Sacramento, CA 95817, USA
    Neurosci Lett 510:110-4. 2012
  4. pmc Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, California, USA
    Diabetes 59:702-9. 2010
  5. doi request reprint Correlation of clinical and biochemical findings with diabetic ketoacidosis-related cerebral edema in children using magnetic resonance diffusion-weighted imaging
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    J Pediatr 153:541-6. 2008
  6. doi request reprint Predicting the likelihood of remission in children with Graves' disease: a prospective, multicenter study
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, 2516 Stockton Blvd, Sacramento, CA 95817, USA
    Pediatrics 121:e481-8. 2008
  7. ncbi request reprint New perspectives on the pathogenesis of cerebral edema complicating diabetic ketoacidosis in children
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, Sacramento, 95817, USA
    Pediatr Endocrinol Rev 3:379-86. 2006
  8. ncbi request reprint Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis
    Nicole S Glaser
    Department of Pediatrics, University of California Davis School of Medicine, Sacramento 95817, USA
    Pediatr Diabetes 7:75-80. 2006
  9. ncbi request reprint Pediatric diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Nicole Glaser
    Department of Pediatrics, School of Medicine, University of California Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
    Pediatr Clin North Am 52:1611-35. 2005
  10. ncbi request reprint Benefits of an insulin dosage calculation device for adolescents with type 1 diabetes mellitus
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    J Pediatr Endocrinol Metab 17:1641-51. 2004

Research Grants

  1. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009

Detail Information

Publications21

  1. pmc Subclinical cerebral edema in children with diabetic ketoacidosis randomized to 2 different rehydration protocols
    Nicole S Glaser
    Department of Pediatrics, School of Medicine, University of California Davis, Davis, California, USA
    Pediatrics 131:e73-80. 2013
    ..We used magnetic resonance diffusion weighted imaging to quantify subclinical CE in children with DKA randomized to 2 intravenous fluid regimens...
  2. pmc Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism
    Nicole Glaser
    Department of Pediatrics, School of Medicine, University of California, Davis, Sacramento, California, USA
    Diabetes 61:1831-7. 2012
    ..We conclude that both hyperglycemia and ketosis independently cause reductions in cerebral high-energy phosphates, CBF, and cortical ADC values. These effects may play a role in the pathophysiology of DKA-related brain injury...
  3. pmc Cognitive dysfunction associated with diabetic ketoacidosis in rats
    Nicole Glaser
    Department of Pediatrics, University of California Davis, School of Medicine, Sacramento, CA 95817, USA
    Neurosci Lett 510:110-4. 2012
    ..The current investigation was undertaken to determine whether cognitive deficits could be detected after a single episode of DKA in an animal model...
  4. pmc Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, California, USA
    Diabetes 59:702-9. 2010
    ..Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but data describing cerebral metabolic alterations during DKA are lacking...
  5. doi request reprint Correlation of clinical and biochemical findings with diabetic ketoacidosis-related cerebral edema in children using magnetic resonance diffusion-weighted imaging
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    J Pediatr 153:541-6. 2008
    ..To determine clinical and biochemical factors influencing cerebral edema formation during diabetic ketoacidosis (DKA) in children...
  6. doi request reprint Predicting the likelihood of remission in children with Graves' disease: a prospective, multicenter study
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, 2516 Stockton Blvd, Sacramento, CA 95817, USA
    Pediatrics 121:e481-8. 2008
    ..Antithyroid medications are often used initially, but many children eventually require alternative therapies. We evaluated predictors of remission after 2 years of antithyroid medication use...
  7. ncbi request reprint New perspectives on the pathogenesis of cerebral edema complicating diabetic ketoacidosis in children
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, Sacramento, 95817, USA
    Pediatr Endocrinol Rev 3:379-86. 2006
    ..Recent data have provided helpful evidence in favor or against various theories of pathogenesis and these data are the topic of the current review...
  8. ncbi request reprint Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis
    Nicole S Glaser
    Department of Pediatrics, University of California Davis School of Medicine, Sacramento 95817, USA
    Pediatr Diabetes 7:75-80. 2006
    ....
  9. ncbi request reprint Pediatric diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Nicole Glaser
    Department of Pediatrics, School of Medicine, University of California Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
    Pediatr Clin North Am 52:1611-35. 2005
    ..In this article, the author reviews the pathophysiology of diabetic ketoacidosis and its complications and presents an evidence-based approach to the management of this condition...
  10. ncbi request reprint Benefits of an insulin dosage calculation device for adolescents with type 1 diabetes mellitus
    Nicole S Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    J Pediatr Endocrinol Metab 17:1641-51. 2004
    ..We evaluated the impact of an insulin dosage calculation device (IDC) on metabolic control, treatment satisfaction, regimen adherence and quality of life in adolescents using MDI or CSII...
  11. ncbi request reprint Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics
    N Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, USA
    N Engl J Med 344:264-9. 2001
    ..Cerebral edema is an uncommon but devastating complication of diabetic ketoacidosis in children. Risk factors for this complication have not been clearly defined...
  12. ncbi request reprint Cerebral edema in children with diabetic ketoacidosis
    N Glaser
    University of California Davis, School of Medicine, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
    Curr Diab Rep 1:41-6. 2001
    ..This and other information suggests that the pathophysiology of DKA-related cerebral edema may involve cerebral ischemia...
  13. ncbi request reprint Variation in the management of pediatric diabetic ketoacidosis by specialty training
    N S Glaser
    Department of Pediatrics, University of California, Davis, School of Medicine, Sacramento, USA
    Arch Pediatr Adolesc Med 151:1125-32. 1997
    ..To compare management strategies for pediatric diabetic ketoacidosis (DKA) among physicians with different specialty training...
  14. ncbi request reprint The evaluation and management of children with diabetic ketoacidosis in the emergency department
    Nicole Glaser
    Department of Pediatrics, Emergency Medicine and Pediatrics, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA
    Pediatr Emerg Care 20:477-81; quiz 482-4. 2004
  15. ncbi request reprint Mechanism of cerebral edema in children with diabetic ketoacidosis
    Nicole S Glaser
    Department of Pediatrics, Division of Emergency Medicine, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    J Pediatr 145:164-71. 2004
    ..Cerebral edema during diabetic ketoacidosis (DKA) has been attributed to osmotic cellular swelling during treatment. We evaluated cerebral water distribution and cerebral perfusion during DKA treatment in children...
  16. doi request reprint Progressive decrease in N-acetylaspartate/Creatine ratio in a teenager with type 1 diabetes and repeated episodes of ketoacidosis without clinically apparent cerebral edema: Evidence for permanent brain injury
    S L Wootton-Gorges
    Departments of Radiology, University of California, Davis School of Medicine and UC Davis Children s Hospital, Sacramento, USA
    AJNR Am J Neuroradiol 31:780-1. 2010
    ..However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA...
  17. ncbi request reprint Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis
    S L Wootton-Gorges
    Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    AJNR Am J Neuroradiol 28:895-9. 2007
    ..We hypothesized that brain NAA/Cr ratios may be decreased in children in DKA, indicating subtle neuronal injury...
  18. pmc Non-insulin dependent diabetes mellitus in Mexican-American children
    N S Glaser
    Department of Pediatrics, University of California UC, Davis, School of Medicine, Sacramento 95817, USA
    West J Med 168:11-6. 1998
    ..Children with these characteristics should undergo testing of endogenous insulin secretion for appropriate therapeutic intervention...
  19. doi request reprint Prolonged QT interval corrected for heart rate during diabetic ketoacidosis in children
    Nathan Kuppermann
    Department of Emergency Medicine, University of California, Davis, School of Medicine, 2315 Stockton Blvd, PSSB Bldg, Ste 2100, Sacramento, CA 95817, USA
    Arch Pediatr Adolesc Med 162:544-9. 2008
    ..Prolongation of the QTc has been described in a few children receiving ketogenic diets, but cardiac effects of ketosis have not otherwise been investigated...
  20. ncbi request reprint Imaging of the brain in children with type I diabetes mellitus
    Sandra L Wootton-Gorges
    Department of Radiology, UC Davis Children s Hospital, University of California, Davis Medical Center, Sacramento, CA, USA
    Pediatr Radiol 37:863-9. 2007
    ....
  21. ncbi request reprint European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents
    David B Dunger
    European Society for Paediatric Endocrinology, West Smithfield, London, United Kingdom
    Pediatrics 113:e133-40. 2004

Research Grants4

  1. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..