Research Topics
| David C GlahnSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Reduced educational attainment in bipolar disorderDavid C Glahn
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
J Affect Disord 92:309-12. 2006..To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects...- Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosisDavid C Glahn
Division of Schizophrenia and Related Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Bipolar Disord 8:117-23. 2006..Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder... - Dissociable mechanisms for memory impairment in bipolar disorder and schizophreniaDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Psychol Med 36:1085-95. 2006..Clarifying the nature and degree of overlap in memory deficits between the two illnesses could help to distinguish brain systems disrupted in these illnesses, and indicate cognitive remediation strategies to improve patient outcomes... - Adjudicating neurocognitive endophenotypes for schizophreniaDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007..We present a practical model for adjudicating endophenotypes and determining which measures are best suited for use in linkage analyses... - Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophreniaDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Hum Brain Mapp 25:60-9. 2005.... - Declarative memory impairment in pediatric bipolar disorderDavid C Glahn
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Bipolar Disord 7:546-54. 2005..However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disorder... - Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and functionDavid C Glahn
Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
Hum Brain Mapp 28:488-501. 2007..In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images... 
Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysisDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Biol Psychiatry 64:774-81. 2008..In this study, we performed a voxelwise, coordinate-based meta-analysis to better conceptualize the neuroanatomic correlates of schizophrenia...- The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorderDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
Bipolar Disord 6:171-82. 2004..We reviewed the literature to determine if neuropsychological measures could be used as effective endophenotypes to aid molecular genetic studies searching for genes predisposing to BPD... 
A multimodal assessment of the genetic control over working memoryKatherine H Karlsgodt
Department of Psychiatry, Cognitive Neuroscience Center, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci 30:8197-202. 2010....- The neurocognitive signature of psychotic bipolar disorderDavid C Glahn
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Biol Psychiatry 62:910-6. 2007..We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis... - Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuseM Kathleen Holmes
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Bipolar Disord 11:33-40. 2009..Here we examine multiple dimensions of impulsivity and risk taking, using cognitive tasks and self-report measures, in BD patients with and without a history of alcohol abuse... - Fronto-temporal dysregulation in remitted bipolar patients: an fMRI delayed-non-match-to-sample (DNMS) studyJennifer L Robinson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Bipolar Disord 11:351-60. 2009..Bipolar disorder is associated with working memory (WM) impairments that persist during periods of symptomatic remission. However, the neural underpinnings of these deficits are not well understood... - Comparing the efficacy of interventions that use environmental supports to improve outcomes in patients with schizophreniaDawn I Velligan
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
Schizophr Res 102:312-9. 2008..The highest intensity treatment produced the best outcomes with respect to functioning. However, some improvements were seen with a relatively inexpensive, clinic-based treatment using a package of generic environmental supports... - Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal studyOlga C Chaves
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Bipolar Disord 13:118-23. 2011..Here, we sought to determine whether specific neurocognitive functions are sensitive to mood changes in individuals with bipolar disorder assessed three months apart without changes in treatment regimen... - Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disordersFabiano G Nery
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
J Psychiatr Res 42:569-77. 2008..These findings suggest that personality, at least to some extent, mediates the comorbidity phenomena in bipolar disorder... - Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivationJennifer L Robinson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Psychiatry Res 164:106-13. 2008.... - Behavioral interpretations of intrinsic connectivity networksAngela R Laird
Research Imaging Institute, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Cogn Neurosci 23:4022-37. 2011..Our results serve as a resource for functional interpretations of brain networks in resting state studies and future investigations into mental operations and the tasks that drive them... - Amygdala hyperactivation in untreated depressed individualsMarco A M Peluso
Department of Psychiatry, University of Texas Health Science Center at San Antonio UTHSCSA, San Antonio, TX, USA
Psychiatry Res 173:158-61. 2009..This study provides in vivo imaging evidence to support the hypothesis of abnormal amygdala functioning in depressed individuals... - The reliability and validity of the Test of Adaptive Behavior in Schizophrenia (TABS)Dawn I Velligan
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Psychiatry Res 151:55-66. 2007..Further studies of the psychometric properties of the TABS including those examining the sensitivity of the TABS to treatments with different pharmacological agents or psychosocial treatments are encouraged... - Relationships among subjective and objective measures of adherence to oral antipsychotic medicationsDawn I Velligan
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Psychiatr Serv 58:1187-92. 2007..This prospective study examined the agreement among measures of adherence to oral antipsychotic medications among 52 outpatients with schizophrenia... - Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health Patterns ProjectAshley Acheson
University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, MC 6240, San Antonio, TX 78229, United States
Drug Alcohol Depend 100:17-23. 2009..These findings correspond to models of risk in FH+ persons that postulate biases in brain decision-making systems as underlying elevated risk for alcoholism... - Meta-analysis of 41 functional neuroimaging studies of executive function in schizophreniaMichael J Minzenberg
Department of Psychiatry, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Arch Gen Psychiatry 66:811-22. 2009..Whether these impairments are properly considered reflective of hypofrontality vs hyperfrontality remains unresolved... - Blood pressure and cerebral white matter share common genetic factors in Mexican AmericansPeter Kochunov
University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, TX 78284, USA
Hypertension 57:330-5. 2011..The magnitude of this overlap appears to be influenced by phylogeny of WM development, suggesting a possible role for genotype-by-age interactions... - Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: validation of the Lancaster transformAngela R Laird
Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
Neuroimage 51:677-83. 2010.... - Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studiesAnderson M Winkler
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neuroimage 53:1135-46. 2010..The results suggest that surface area and cortical thickness measurements should be considered separately and preferred over gray matter volumes for imaging genetic studies... - On the genetic architecture of cortical folding and brain volume in primatesJeffrey Rogers
Department of Genetics, Southwest Foundation for Biomedical Research, 7620 N W Loop 410, San Antonio, TX 78227, USA
Neuroimage 53:1103-8. 2010..These results provide initial evidence for the heritability of gyrification, and possibly a new perspective on the evolutionary mechanisms underlying long-term changes in the nonhuman primate and human brain... - A social cognitive approach to emotional intensity judgment deficits in schizophreniaE Serap Monkul
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Schizophr Res 94:245-52. 2007..These results suggest that patients with schizophrenia differ from healthy subjects in both their ability to rate emotional intensity and the influence of contextual adjustment upon such ratings... - Defining and assessing adherence to oral antipsychotics: a review of the literatureDawn I Velligan
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Schizophr Bull 32:724-42. 2006..The suggestions are designed to advance the field with respect to both understanding predictors of adherence and developing interventions to improve adherence to oral antipsychotic medications... - Measuring and comparing brain cortical surface area and other areal quantitiesAnderson M Winkler
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neuroimage 61:1428-43. 2012..We introduce the concept of facewise analysis, discuss its interpretation and potential applications... - The central sulcus: an observer-independent characterization of sulcal landmarks and depth asymmetryMatthew D Cykowski
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA
Cereb Cortex 18:1999-2009. 2008..Age correlations were performed for these asymmetries, and a significant correlation was seen only in the male subgroup... - Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatmentSteven R Pliszka
Department of Psychiatry, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr, MC 7792, San Antonio, TX 78229 3900, USA
Am J Psychiatry 163:1052-60. 2006..Event-related functional magnetic resonance imaging (fMRI) might establish if these regions differ in their activity in ADHD children relative to healthy comparison subjects... - ALE meta-analysis: controlling the false discovery rate and performing statistical contrastsAngela R Laird
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Hum Brain Mapp 25:155-64. 2005..We then give an example of how comparisons of this sort may lead to advanced designs in future meta-analytic research... - Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depressionPeter Kochunov
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland Southwest Foundation for Biomedical Research, San Antonio, Texas Electronic address
Biol Psychiatry 73:482-91. 2013..We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD... - The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filteringJennifer L Robinson
Neuroscience Institute, Scott and White Healthcare, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
Neuroimage 60:117-29. 2012..Our results provide further validation of meta-analytic connectivity modeling, while also highlighting an additional potential, namely the extraction of behavioral domain specific functional connectivity... - A brief cognitive assessment for use with schizophrenia patients in community clinicsDawn I Velligan
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, M S 7792, San Antonio, TX 78229 3900, USA
Schizophr Res 71:273-83. 2004..The data provide preliminary evidence for the reliability and validity of the BCA. Further studies examining the utility of the BCA for tracking changes in cognitive functioning with treatment are encouraged... - Retrospective motion correction protocol for high-resolution anatomical MRIPeter Kochunov
Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas, USA
Hum Brain Mapp 27:957-62. 2006..RMC was tested on 35 subjects who were considered at high risk for head motion. Our results show that RMC provided better contrast-to-noise ratio and boundary detail when compared to nonmotion-corrected averaged images... - Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modelingAngela R Laird
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Neurosci 29:14496-505. 2009.... - Derivative temporal clustering analysis: detecting prolonged neuronal activityXia Zhao
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Magn Reson Imaging 25:183-7. 2007..By removing the limitations in the previous TCA, DTCA has shown its powerful capability in detecting prolonged plateau neuronal activities... - Genetic contributions to the midsagittal area of the corpus callosumKimberley A Phillips
Department of Psychology, Trinity University, San Antonio, TX, USA
Twin Res Hum Genet 15:315-23. 2012..Combined with previous research reporting high heritability of other brain structures in baboons, these results reveal a consistent pattern of high heritability for brain morphometric measures in baboons... - Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns projectDavid C Glahn
Neuroimaging Core, Department of Psychiatry, University of Texas Health Science Center at San Antonio, Texas, USA
Biol Psychiatry 61:1306-9. 2007..Risk of alcoholism is higher in those with a positive family history (FH+) and in those showing behavioral disinhibition, possibly reflecting altered limbic system function... - Neuroimaging studies in bipolar children and adolescentsRene L Olvera
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Int Rev Neurobiol 62:121-46. 2004 - Heritability of age of onset of psychosis in schizophreniaElizabeth Hare
South Texas Psychiatric Genetics Research Center, UT Health Science Center, San Antonio, San Antonio, Texas, USA
Am J Med Genet B Neuropsychiatr Genet 153:298-302. 2010..33 (SE = 0.09; P = 0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well... - Imaging genomics: mapping the influence of genetics on brain structure and functionDavid C Glahn
Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA
Hum Brain Mapp 28:461-3. 2007 - Patterns of memory impairment in bipolar disorder and unipolar major depressionCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, USA
Psychiatry Res 142:139-50. 2006..These impairments do not appear to be secondary to clinical state, but rather suggest a similar underlying pathophysiology involving medial temporal dysfunction... - Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous systemTyrone D Cannon
Department of Psychology, Psychiatry and Biobehavioral Sciences, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 54:151-6. 2002.... - Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophreniaTyrone D Cannon
Department of Psychology, University of California, Los Angeles 90095 1563, USA
Arch Gen Psychiatry 62:1071-80. 2005..It remains unclear whether altered regional brain physiological activity in patients with schizophrenia during working memory tasks relates to maintenance-related processes, manipulation-related (ie, executive) processes, or both... - Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical featuresCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
J Psychiatr Res 40:47-58. 2006..This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder... - The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjectsKatherine H Karlsgodt
Department of Psychology, UCLA, Los Angeles, CA 90095 1563, USA
Schizophr Res 89:191-7. 2007..Further, this study offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable... - Spatial working memory as an endophenotype for schizophreniaDavid C Glahn
Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
Biol Psychiatry 53:624-6. 2003..CONCLUSIONS: The findings suggest that deficits in the encoding or storage aspects of short-term spatial mnemonic processing may be an effective endophenotypic marker for schizophrenia... - Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memoryJunghoon Kim
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 68:173-87. 2004..These results suggest that while both maintenance and central executive aspects of working memory are impaired in schizophrenic patients, the central executive may be more severely affected... - Greater cortical gray matter density in lithium-treated patients with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
Biol Psychiatry 62:7-16. 2007..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures... - Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
Bipolar Disord 9:145-59. 2007..Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD)... - Verbal recall and recognition in twins discordant for schizophreniaTheo G M van Erp
Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
Psychiatry Res 159:271-80. 2008.... - Subtle cognitive dysfunction in nonaffected siblings of individuals affected by nonpsychotic disordersMark Weiser
Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel
Biol Psychiatry 63:602-8. 2008..We investigated cognitive performance on a large, population-based sample of individuals, affected at the time of testing by nonpsychotic disorders, and their unaffected siblings... - Magnetic resonance findings in bipolar disorderPaolo Brambilla
Section of Psychiatry, Department of Pathology and Experimental and Clinical Medicine, University of Udine, Udine, Italy
Psychiatr Clin North Am 28:443-67. 2005.... - Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Neuropsychopharmacology 33:1229-38. 2008..Moreover, increased hippocampal volume in lithium-treated bipolar patients may reflect postulated neurotrophic effects of this agent, a possibility warranting further study in longitudinal investigations... - Mapping cortical thickness in children with 22q11.2 deletionsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
Cereb Cortex 17:1889-98. 2007..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype... - The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysisIan Ellison-Wright
Avon and Wiltshire Mental Health Partnership NHS Trust, Beechlydene Ward, Fountain Way, Wilton Rd, Salisbury SP2 7EP, United Kingdom
Am J Psychiatry 165:1015-23. 2008..They postulated that the data would show a progression of changes from hippocampal deficits in first-episode schizophrenia to include volume reductions in the amygdala and cortical gray matter in chronic schizophrenia... - Neural phenotypes of common and rare genetic variantsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
Biol Psychol 79:43-57. 2008..Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population... - Development and Validation of the Design Organization Test (DOT): a rapid screening instrument for assessing visuospatial abilityWilliam D S Killgore
Cognitive Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Boston, MA, USA
J Clin Exp Neuropsychol 27:449-59. 2005..The results suggest that the DOT provides a useful and rapid screening measure of visuospatial ability... - Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptomsCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
Neurocase 10:198-206. 2004..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
Research Grants
- Genetics of Brain Structure and FunctionDavid Glahn; Fiscal Year: 2007..By identifying genes involved in brain function and structure, we will provide novel biological candidates for the determinants of such diseases and thus improve potential for intervention. ..