David C Glahn

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Psychol Med 36:1085-95. 2006
  2. ncbi request reprint Reduced educational attainment in bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Affect Disord 92:309-12. 2006
  3. ncbi request reprint Declarative memory impairment in pediatric bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:546-54. 2005
  4. doi request reprint Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 64:774-81. 2008
  5. ncbi request reprint Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:60-9. 2005
  6. ncbi request reprint Adjudicating neurocognitive endophenotypes for schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007
  7. ncbi request reprint Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
    David C Glahn
    Division of Schizophrenia and Related Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Bipolar Disord 8:117-23. 2006
  8. ncbi request reprint The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Bipolar Disord 6:171-82. 2004
  9. ncbi request reprint Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function
    David C Glahn
    Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    Hum Brain Mapp 28:488-501. 2007
  10. pmc A multimodal assessment of the genetic control over working memory
    Katherine H Karlsgodt
    Department of Psychiatry, Cognitive Neuroscience Center, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:8197-202. 2010

Research Grants

  1. Genetics of Brain Structure and Function
    David Glahn; Fiscal Year: 2007

Detail Information

Publications65

  1. ncbi request reprint Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Psychol Med 36:1085-95. 2006
    ..Clarifying the nature and degree of overlap in memory deficits between the two illnesses could help to distinguish brain systems disrupted in these illnesses, and indicate cognitive remediation strategies to improve patient outcomes...
  2. ncbi request reprint Reduced educational attainment in bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229, USA
    J Affect Disord 92:309-12. 2006
    ..To document educational attainment in relation to IQ in patients with bipolar disorder, in order to establish guidelines for matching patients with appropriate comparison subjects...
  3. ncbi request reprint Declarative memory impairment in pediatric bipolar disorder
    David C Glahn
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:546-54. 2005
    ..However, similar impairments in juvenile-onset bipolar disorder have not been yet documented. Here, we assessed declarative memory in a large sample of clinically well-characterized children with bipolar disorder...
  4. doi request reprint Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 64:774-81. 2008
    ..In this study, we performed a voxelwise, coordinate-based meta-analysis to better conceptualize the neuroanatomic correlates of schizophrenia...
  5. ncbi request reprint Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:60-9. 2005
    ....
  6. ncbi request reprint Adjudicating neurocognitive endophenotypes for schizophrenia
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Med Genet B Neuropsychiatr Genet 144:242-9. 2007
    ..We present a practical model for adjudicating endophenotypes and determining which measures are best suited for use in linkage analyses...
  7. ncbi request reprint Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis
    David C Glahn
    Division of Schizophrenia and Related Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Bipolar Disord 8:117-23. 2006
    ..Although working memory dysfunction has been proposed to be central to the pathophysiology of schizophrenia, it has received less attention in studies of bipolar disorder...
  8. ncbi request reprint The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Bipolar Disord 6:171-82. 2004
    ..We reviewed the literature to determine if neuropsychological measures could be used as effective endophenotypes to aid molecular genetic studies searching for genes predisposing to BPD...
  9. ncbi request reprint Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function
    David C Glahn
    Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    Hum Brain Mapp 28:488-501. 2007
    ..In addition, we review genetic approaches that capitalize on the use of quantitative traits, including those derived from brain images...
  10. pmc A multimodal assessment of the genetic control over working memory
    Katherine H Karlsgodt
    Department of Psychiatry, Cognitive Neuroscience Center, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:8197-202. 2010
    ....
  11. ncbi request reprint The neurocognitive signature of psychotic bipolar disorder
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 62:910-6. 2007
    ..We sought to ascertain the profile of cognitive impairment in patients with bipolar disorder and to determine whether a distinct profile of cognitive deficits characterizes bipolar patients with a history of psychosis...
  12. doi request reprint Fronto-temporal dysregulation in remitted bipolar patients: an fMRI delayed-non-match-to-sample (DNMS) study
    Jennifer L Robinson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Bipolar Disord 11:351-60. 2009
    ..Bipolar disorder is associated with working memory (WM) impairments that persist during periods of symptomatic remission. However, the neural underpinnings of these deficits are not well understood...
  13. doi request reprint Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse
    M Kathleen Holmes
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Bipolar Disord 11:33-40. 2009
    ..Here we examine multiple dimensions of impulsivity and risk taking, using cognitive tasks and self-report measures, in BD patients with and without a history of alcohol abuse...
  14. pmc Comparing the efficacy of interventions that use environmental supports to improve outcomes in patients with schizophrenia
    Dawn I Velligan
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
    Schizophr Res 102:312-9. 2008
    ..The highest intensity treatment produced the best outcomes with respect to functioning. However, some improvements were seen with a relatively inexpensive, clinic-based treatment using a package of generic environmental supports...
  15. pmc Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders
    Fabiano G Nery
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Psychiatr Res 42:569-77. 2008
    ..These findings suggest that personality, at least to some extent, mediates the comorbidity phenomena in bipolar disorder...
  16. doi request reprint Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal study
    Olga C Chaves
    Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Bipolar Disord 13:118-23. 2011
    ..Here, we sought to determine whether specific neurocognitive functions are sensitive to mood changes in individuals with bipolar disorder assessed three months apart without changes in treatment regimen...
  17. doi request reprint Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation
    Jennifer L Robinson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 164:106-13. 2008
    ....
  18. pmc Sulcal depth-position profile is a genetically mediated neuroscientific trait: description and characterization in the central sulcus
    D Reese McKay
    Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas 78229, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, Department of Physics, Florida International University, Miami, Florida 33199, and South Texas Veterans Health System, San Antonio, Texas 78229
    J Neurosci 33:15618-25. 2013
    ..We argue that DPPs are powerful phenotypes that should inform genetic influence of more complex brain regions and contribute to gene discovery efforts. ..
  19. pmc Behavioral interpretations of intrinsic connectivity networks
    Angela R Laird
    Research Imaging Institute, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Cogn Neurosci 23:4022-37. 2011
    ..Our results serve as a resource for functional interpretations of brain networks in resting state studies and future investigations into mental operations and the tasks that drive them...
  20. pmc Amygdala hyperactivation in untreated depressed individuals
    Marco A M Peluso
    Department of Psychiatry, University of Texas Health Science Center at San Antonio UTHSCSA, San Antonio, TX, USA
    Psychiatry Res 173:158-61. 2009
    ..This study provides in vivo imaging evidence to support the hypothesis of abnormal amygdala functioning in depressed individuals...
  21. ncbi request reprint The reliability and validity of the Test of Adaptive Behavior in Schizophrenia (TABS)
    Dawn I Velligan
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychiatry Res 151:55-66. 2007
    ..Further studies of the psychometric properties of the TABS including those examining the sensitivity of the TABS to treatments with different pharmacological agents or psychosocial treatments are encouraged...
  22. ncbi request reprint Relationships among subjective and objective measures of adherence to oral antipsychotic medications
    Dawn I Velligan
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Psychiatr Serv 58:1187-92. 2007
    ..This prospective study examined the agreement among measures of adherence to oral antipsychotic medications among 52 outpatients with schizophrenia...
  23. pmc Differential activation of the anterior cingulate cortex and caudate nucleus during a gambling simulation in persons with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project
    Ashley Acheson
    University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, MC 6240, San Antonio, TX 78229, United States
    Drug Alcohol Depend 100:17-23. 2009
    ..These findings correspond to models of risk in FH+ persons that postulate biases in brain decision-making systems as underlying elevated risk for alcoholism...
  24. pmc Comparison of the disparity between Talairach and MNI coordinates in functional neuroimaging data: validation of the Lancaster transform
    Angela R Laird
    Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Neuroimage 51:677-83. 2010
    ....
  25. pmc Blood pressure and cerebral white matter share common genetic factors in Mexican Americans
    Peter Kochunov
    University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, TX 78284, USA
    Hypertension 57:330-5. 2011
    ..The magnitude of this overlap appears to be influenced by phylogeny of WM development, suggesting a possible role for genotype-by-age interactions...
  26. pmc Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia
    Michael J Minzenberg
    Department of Psychiatry, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Arch Gen Psychiatry 66:811-22. 2009
    ..Whether these impairments are properly considered reflective of hypofrontality vs hyperfrontality remains unresolved...
  27. pmc Identification of pleiotropic genetic effects on obesity and brain anatomy
    Joanne E Curran
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Tex, USA
    Hum Hered 75:136-43. 2013
    ..In this study, we sought genetic components that influence both brain anatomy and body mass index (BMI) to provide further insight into the role of the brain in energy homeostasis and obesity...
  28. pmc Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression
    Peter Kochunov
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 73:482-91. 2013
    ..We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD...
  29. pmc Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies
    Anderson M Winkler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuroimage 53:1135-46. 2010
    ..The results suggest that surface area and cortical thickness measurements should be considered separately and preferred over gray matter volumes for imaging genetic studies...
  30. ncbi request reprint A social cognitive approach to emotional intensity judgment deficits in schizophrenia
    E Serap Monkul
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Schizophr Res 94:245-52. 2007
    ..These results suggest that patients with schizophrenia differ from healthy subjects in both their ability to rate emotional intensity and the influence of contextual adjustment upon such ratings...
  31. pmc Defining and assessing adherence to oral antipsychotics: a review of the literature
    Dawn I Velligan
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Schizophr Bull 32:724-42. 2006
    ..The suggestions are designed to advance the field with respect to both understanding predictors of adherence and developing interventions to improve adherence to oral antipsychotic medications...
  32. pmc On the genetic architecture of cortical folding and brain volume in primates
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 N W Loop 410, San Antonio, TX 78227, USA
    Neuroimage 53:1103-8. 2010
    ..These results provide initial evidence for the heritability of gyrification, and possibly a new perspective on the evolutionary mechanisms underlying long-term changes in the nonhuman primate and human brain...
  33. pmc Measuring and comparing brain cortical surface area and other areal quantities
    Anderson M Winkler
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuroimage 61:1428-43. 2012
    ..We introduce the concept of facewise analysis, discuss its interpretation and potential applications...
  34. ncbi request reprint Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment
    Steven R Pliszka
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr, MC 7792, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 163:1052-60. 2006
    ..Event-related functional magnetic resonance imaging (fMRI) might establish if these regions differ in their activity in ADHD children relative to healthy comparison subjects...
  35. ncbi request reprint ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Hum Brain Mapp 25:155-64. 2005
    ..We then give an example of how comparisons of this sort may lead to advanced designs in future meta-analytic research...
  36. pmc The central sulcus: an observer-independent characterization of sulcal landmarks and depth asymmetry
    Matthew D Cykowski
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA
    Cereb Cortex 18:1999-2009. 2008
    ..Age correlations were performed for these asymmetries, and a significant correlation was seen only in the male subgroup...
  37. pmc The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filtering
    Jennifer L Robinson
    Neuroscience Institute, Scott and White Healthcare, Texas A and M Health Science Center, College of Medicine, Temple, TX 76508, USA
    Neuroimage 60:117-29. 2012
    ..Our results provide further validation of meta-analytic connectivity modeling, while also highlighting an additional potential, namely the extraction of behavioral domain specific functional connectivity...
  38. pmc Investigating the functional heterogeneity of the default mode network using coordinate-based meta-analytic modeling
    Angela R Laird
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Neurosci 29:14496-505. 2009
    ....
  39. ncbi request reprint Derivative temporal clustering analysis: detecting prolonged neuronal activity
    Xia Zhao
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Magn Reson Imaging 25:183-7. 2007
    ..By removing the limitations in the previous TCA, DTCA has shown its powerful capability in detecting prolonged plateau neuronal activities...
  40. ncbi request reprint Retrospective motion correction protocol for high-resolution anatomical MRI
    Peter Kochunov
    Research Imaging Center, University of Texas Health Science Center at San Antonio, Texas, USA
    Hum Brain Mapp 27:957-62. 2006
    ..RMC was tested on 35 subjects who were considered at high risk for head motion. Our results show that RMC provided better contrast-to-noise ratio and boundary detail when compared to nonmotion-corrected averaged images...
  41. ncbi request reprint A brief cognitive assessment for use with schizophrenia patients in community clinics
    Dawn I Velligan
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, M S 7792, San Antonio, TX 78229 3900, USA
    Schizophr Res 71:273-83. 2004
    ..The data provide preliminary evidence for the reliability and validity of the BCA. Further studies examining the utility of the BCA for tracking changes in cognitive functioning with treatment are encouraged...
  42. pmc Genetic contributions to the midsagittal area of the corpus callosum
    Kimberley A Phillips
    Department of Psychology, Trinity University, San Antonio, TX, USA
    Twin Res Hum Genet 15:315-23. 2012
    ..Combined with previous research reporting high heritability of other brain structures in baboons, these results reveal a consistent pattern of high heritability for brain morphometric measures in baboons...
  43. ncbi request reprint Neuroimaging studies in bipolar children and adolescents
    Rene L Olvera
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Int Rev Neurobiol 62:121-46. 2004
  44. doi request reprint Heritability of age of onset of psychosis in schizophrenia
    Elizabeth Hare
    South Texas Psychiatric Genetics Research Center, UT Health Science Center, San Antonio, San Antonio, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 153:298-302. 2010
    ..33 (SE = 0.09; P = 0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well...
  45. pmc Reduced amygdala activation in young adults at high risk of alcoholism: studies from the Oklahoma family health patterns project
    David C Glahn
    Neuroimaging Core, Department of Psychiatry, University of Texas Health Science Center at San Antonio, Texas, USA
    Biol Psychiatry 61:1306-9. 2007
    ..Risk of alcoholism is higher in those with a positive family history (FH+) and in those showing behavioral disinhibition, possibly reflecting altered limbic system function...
  46. pmc Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history
    Alan Anticevic
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT 06519, USA
    Biol Psychiatry 73:565-73. 2013
    ..Furthermore, no study has investigated whether such connectivity disruptions differ for bipolar patients with psychosis history, who might exhibit a more severe clinical course...
  47. ncbi request reprint Imaging genomics: mapping the influence of genetics on brain structure and function
    David C Glahn
    Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA
    Hum Brain Mapp 28:461-3. 2007
  48. ncbi request reprint Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
    J Psychiatr Res 40:47-58. 2006
    ..This study seeks to: (i) better characterize the nature of declarative memory impairment in bipolar disorder, and (ii) determine the relationship between clinical variables and memory function in bipolar disorder...
  49. pmc Greater cortical gray matter density in lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 62:7-16. 2007
    ..Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures...
  50. ncbi request reprint Subtle cognitive dysfunction in nonaffected siblings of individuals affected by nonpsychotic disorders
    Mark Weiser
    Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel
    Biol Psychiatry 63:602-8. 2008
    ..We investigated cognitive performance on a large, population-based sample of individuals, affected at the time of testing by nonpsychotic disorders, and their unaffected siblings...
  51. ncbi request reprint Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory
    Junghoon Kim
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 68:173-87. 2004
    ..These results suggest that while both maintenance and central executive aspects of working memory are impaired in schizophrenic patients, the central executive may be more severely affected...
  52. ncbi request reprint Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Arch Gen Psychiatry 62:1071-80. 2005
    ..It remains unclear whether altered regional brain physiological activity in patients with schizophrenia during working memory tasks relates to maintenance-related processes, manipulation-related (ie, executive) processes, or both...
  53. ncbi request reprint Elucidating continuities and discontinuities between schizotypy and schizophrenia in the nervous system
    Tyrone D Cannon
    Department of Psychology, Psychiatry and Biobehavioral Sciences, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Schizophr Res 54:151-6. 2002
    ....
  54. ncbi request reprint Patterns of memory impairment in bipolar disorder and unipolar major depression
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 90095, USA
    Psychiatry Res 142:139-50. 2006
    ..These impairments do not appear to be secondary to clinical state, but rather suggest a similar underlying pathophysiology involving medial temporal dysfunction...
  55. pmc Verbal recall and recognition in twins discordant for schizophrenia
    Theo G M van Erp
    Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095, USA
    Psychiatry Res 159:271-80. 2008
    ....
  56. ncbi request reprint Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Bipolar Disord 9:145-59. 2007
    ..Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD)...
  57. ncbi request reprint The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects
    Katherine H Karlsgodt
    Department of Psychology, UCLA, Los Angeles, CA 90095 1563, USA
    Schizophr Res 89:191-7. 2007
    ..Further, this study offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable...
  58. ncbi request reprint Spatial working memory as an endophenotype for schizophrenia
    David C Glahn
    Department of Psychology, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 53:624-6. 2003
    ....
  59. pmc Mapping cortical thickness in children with 22q11.2 deletions
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 17:1889-98. 2007
    ..These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype...
  60. ncbi request reprint Magnetic resonance findings in bipolar disorder
    Paolo Brambilla
    Section of Psychiatry, Department of Pathology and Experimental and Clinical Medicine, University of Udine, Udine, Italy
    Psychiatr Clin North Am 28:443-67. 2005
    ....
  61. ncbi request reprint Regional brain abnormalities in 22q11.2 deletion syndrome: association with cognitive abilities and behavioral symptoms
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Neurocase 10:198-206. 2004
    ..Although preliminary,these findings suggest a possible underlying pathophysiology of the cognitive deficits seen in this syndrome,and provide insight into complex gene-brain-behavior relationships...
  62. ncbi request reprint Development and Validation of the Design Organization Test (DOT): a rapid screening instrument for assessing visuospatial ability
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital Harvard Medical School, Boston, MA, USA
    J Clin Exp Neuropsychol 27:449-59. 2005
    ..The results suggest that the DOT provides a useful and rapid screening measure of visuospatial ability...
  63. ncbi request reprint Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 33:1229-38. 2008
    ..Moreover, increased hippocampal volume in lithium-treated bipolar patients may reflect postulated neurotrophic effects of this agent, a possibility warranting further study in longitudinal investigations...
  64. pmc Neural phenotypes of common and rare genetic variants
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States
    Biol Psychol 79:43-57. 2008
    ..Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population...
  65. pmc The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis
    Ian Ellison-Wright
    Avon and Wiltshire Mental Health Partnership NHS Trust, Beechlydene Ward, Fountain Way, Wilton Rd, Salisbury SP2 7EP, United Kingdom
    Am J Psychiatry 165:1015-23. 2008
    ..They postulated that the data would show a progression of changes from hippocampal deficits in first-episode schizophrenia to include volume reductions in the amygdala and cortical gray matter in chronic schizophrenia...

Research Grants3

  1. Genetics of Brain Structure and Function
    David Glahn; Fiscal Year: 2007
    ..By identifying genes involved in brain function and structure, we will provide novel biological candidates for the determinants of such diseases and thus improve potential for intervention. ..