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Genomes and GenesSpecies | Charles GlabeSummaryAffiliation: University of California Country: USA Publications
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Publications
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Science 300:486-9. 2003..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...- Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesisCharles G Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Neurology 66:S74-8. 2006.... 
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomersVolker Luibl
Beckman Macular Research Center, Doheny Eye Institute and Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
J Clin Invest 116:378-85. 2006..These results suggest that amyloid oligomers may be involved in drusen biogenesis and that similar protein misfolding processes may occur in AMD and amyloid diseases...- Common mechanisms of amyloid oligomer pathogenesis in degenerative diseaseCharles G Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Neurobiol Aging 27:570-5. 2006..Although, these upstream events may be unique to a particular disease related protein, their effects can be rationalized as having a primary effect of increasing the amount of mis-folded, potentially amyloidogenic proteins... - Conformation-dependent anti-amyloid oligomer antibodiesRakez Kayed
UC Irvine, Department of Molecular Biology and Biochemistry, Irvine, CA, USA
Methods Enzymol 413:326-44. 2006..The purpose of this chapter is to review the methods for the production, characterization, and application of this antibody to understanding the contribution of amyloid oligomers to the disease process... - Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 miceSUHAIL RASOOL
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Mol Neurodegener 7:37. 2012..However, autoimmune side effects have halted the development of vaccines based on full length human Aβ. Further development of an effective vaccine depends on overcoming these side effects while maintaining an effective immune response... - Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectinThuzar M Shin
Zilhka Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
Mol Neurodegener 3:16. 2008..The investigation of vitronectin aggregation is significant since the formation of oligomeric and fibrillar structures are common features of amyloid proteins... - Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloidKathryn E Nichol
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
J Neuroinflammation 5:13. 2008..Our objective was to determine if exercise could induce a shift from the immune profile in aged (17-19 months) Tg2576 mice to a response that reduces Abeta pathology... - Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's diseaseC Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
J Mol Neurosci 17:137-45. 2001.... - Conformation-dependent antibodies target diseases of protein misfoldingCharles G Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
Trends Biochem Sci 29:542-7. 2004..The common structures and mechanisms hold promise for the development of broad-spectrum drugs and vaccines that will be effective for the treatment of many of these diseases... - Structural classification of toxic amyloid oligomersCharles G Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 283:29639-43. 2008..Classification of amyloid oligomers according to their underlying structures may be a more useful and rational approach than relying on differences in size and morphology... - Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomersRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
Mol Neurodegener 5:57. 2010..Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates... - Biomedicine. Avoiding collateral damage in Alzheimer's disease treatmentCharles Glabe
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Science 314:602-3. 2006 - Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomersRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Mol Neurodegener 2:18. 2007..Conformation dependent antibodies have been reported that specifically recognize distinct assembly states of amyloids, including prefibrillar oligomers and fibrils... - Annular protofibrils are a structurally and functionally distinct type of amyloid oligomerRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 284:4230-7. 2009..The annular anti-protofibril antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the antibody recognizes an epitope that is specific for a beta barrel structural motif... - A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brainFloyd Sarsoza
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697, USA
Acta Neuropathol 118:505-17. 2009.... - Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease modelsEmily Mitchell Sontag
Department of Biological Chemistry, Psychiatry and Human Behavior, University of California, Irvine, California 92697, USA
J Neurosci 32:11109-19. 2012..Furthermore, MB treatment also promoted an increase in levels of BDNF RNA and protein in vivo. Thus, MB, which is well tolerated and used in humans, has therapeutic potential for HD... - Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsEmiley Pham
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
FEBS J 277:3051-67. 2010..In conclusion, this study suggests that the presence of a subpopulation of amyloid-beta oligomers in the brains of patients with Alzheimer's disease might be related to alterations in selected synaptic proteins and cognitive impairment... - Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathologySalvatore Oddo
Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4545, USA
J Biol Chem 281:1599-604. 2006..Therefore, Abeta oligomers may play a role in the induction of tau pathology, making the interference of Abeta oligomerization a valid therapeutic target... - Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formationJessica W Wu
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 285:6071-9. 2010.... - Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseasesRakez Kayed
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA
J Biol Chem 279:46363-6. 2004.... - The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic propertiesBrian Soreghan
Department of Molecular Biology and Bichemistry, University of California, Irvine, CA 92697 3900, USA
Neuromolecular Med 1:81-94. 2002..These results indicate that although beta-sheet conformation may be required for toxic activity, it is not sufficient and 6-10 nm fibril morphology is not an obligate requirement for neuronal toxicity... - The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS proteinNoriko Kamei
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, USA
Genes Dev 17:2502-7. 2003..Thus,the species-specific domains of egg bindin receptor 1 (EBR1) from both species function as the egg surface receptor to mediate species-specific sperm adhesion... 
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain AbetaElizabeth Head
Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
J Neurosci 28:3555-66. 2008..Alternatively, clearing preexisting Abeta from the brain in a treatment study may be more efficacious for cognition if combined with a second intervention that restores neuron health...- Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neuronsAtul Deshpande
Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
J Neurosci 26:6011-8. 2006..Thus various Abeta species may play relevant roles in AD, causing neurotoxicity by distinct non-overlapping mechanisms affecting neuronal function and viability over multiple time courses... - Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitroQiu-Lan Ma
Department of Medicine, University of California, Los Angeles, California 91343, USA
J Neurosci Res 83:374-84. 2006..These data suggest that antibodies that are highly specific for toxic oligomer subspecies may reduce toxicity via reduction of GSK-3beta, which could be an important strategy for Alzheimer's disease (AD) therapeutics... - Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomersHiromi Arai
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Biochim Biophys Acta 1820:1908-14. 2012..The detailed structure of these amyloid oligomers is not known nor is the mechanism for the recognition of the generic epitope by conformation-dependent monoclonal antibodies... - Soluble amyloid oligomers increase bilayer conductance by altering dielectric structureYuri Sokolov
Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697, USA
J Gen Physiol 128:637-47. 2006.... - Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42Yun-Ru Chen
Department of Molecular Biology and Biochemistry, The University of California, Irvine, California 92697, USA
J Biol Chem 281:24414-22. 2006..The distinct initial folding properties of Abeta40 and Abeta42 may play an important role in the higher aggregation potential and pathological significance of Abeta42... - A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapsesAtul Deshpande
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
J Neurosci 29:4004-15. 2009..In AD brains, oligomers of different size colocalized with synaptic markers in hippocampus and cortex, where oligomer synaptic accumulation correlated with synaptic loss... - Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomersAngelo Demuro
Department of Neurobiology and Behavior and Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 280:17294-300. 2005.... - Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathwayTatyana Gurlo
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
Am J Pathol 176:861-9. 2010..Toxic oligomer-induced secretory pathway and mitochondrial membrane disruption is a novel mechanism to account for cellular dysfunction and apoptosis in T2DM... - Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillizationMihaela Necula
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
Biochemistry 46:8850-60. 2007..If Abeta oligomers represent the primary pathogenic species, then inhibition of this highly toxic species via promotion of formation of less toxic aggregates may be therapeutically useful... - Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinctMihaela Necula
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 282:10311-24. 2007..In addition, these data suggest that small molecule inhibitors are useful for clarifying the mechanisms underlying protein aggregation and may represent potential therapeutic agents that target fundamental disease mechanisms... - Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivoEmanuela Colla
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 32:3301-5. 2012..These results indicate that αS oligomers with toxic conformation accumulate in ER, and αS oligomer-dependent ER stress is pathologically relevant for PD... - Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunctionJennifer L Tomic
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
Neurobiol Dis 35:352-8. 2009..These results indicate that fibrillar oligomers may play a key role in the pathology of AD and may be a new target for diagnostic and therapeutic development... - Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structureJoshua C Yoburn
Department of Chemistry, University of California, Irvine, California 92697, USA
Chem Res Toxicol 16:531-5. 2003..Thus, the fibrillar structure of Abeta enhances formation of dityrosine cross-links, but dityrosine cross-links do not seem to enhance local secondary structure... - Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitroErene W Mina
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
J Mol Biol 391:577-85. 2009.... - Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathyAlina Maloyan
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 104:5995-6000. 2007..The data demonstrate that voluntary exercise slows the progression to HF in the CryAB(R120G) DRM model and that PAO accumulation is mediated, at least in part, by decreased neprilysin activity... - Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloidGeorge S Bloom
Departments of Biology, and Cell Biology, University of Virginia, Charlottesville, VA 22903, USA
Biochim Biophys Acta 1739:116-24. 2005.... - Metabolite-initiated protein misfolding may trigger Alzheimer's diseaseQinghai Zhang
Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:4752-7. 2004.... - Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivoFusheng Yang
Department of Medicine, UCLA, Los Angeles, CA 90095, USA
J Biol Chem 280:5892-901. 2005..These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD... - Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosisAtsushi Sanbe
Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, Children s Hospital Research Foundation, Mail Location Code 7020, 3333 Burnet Avenue, OH 45229 3039, USA
Proc Natl Acad Sci U S A 101:10132-6. 2004..These oligomeric amyloid intermediates are present also in cardiomyocytes derived from many human dilated and hypertrophic cardiomyopathies... - Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labelingMarianna Török
Department of Biochemistry and Molecular Biology, Neurogenetic Institute and Arnold and Mabel Beckman Macular Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Biol Chem 277:40810-5. 2002..Despite their different aggregation properties and roles in disease, the two peptides, Abeta40 and Abeta42, homogeneously co-mix in amyloid fibrils suggesting that they possess the same structural architecture... - Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brainHideko Kokubo
Gunma University School of Health Sciences, 3-39-15 Showa-machi, Maebashi 371-8514, Japan
Brain Res 1031:222-8. 2005..These findings imply that soluble Abeta oligomers might be related to synaptic dysfunction in AD brain... - ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice culturesYoung Hae Chong
Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
J Biol Chem 281:20315-25. 2006.... - Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomersGrigor Mamikonyan
Department of Immunology, The Institute for Molecular Medicine, Huntington Beach, California 92647, USA
J Biol Chem 282:22376-86. 2007.... - Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic miceChia Yu Lin
Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 7345, USA
Diabetes 56:1324-32. 2007.... - A specific amyloid-beta protein assembly in the brain impairs memorySylvain Lesne
Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Nature 440:352-7. 2006..We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive deficits associated with Alzheimer's disease... - Pore-forming proteins share structural and functional homology with amyloid oligomersYuji Yoshiike
Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
Neuromolecular Med 9:270-5. 2007..These results indicate that pore forming proteins (PFP) and amyloid oligomers share structural homology and suggest that PFPs and amyloid oligomers share the same mechanism of membrane permeabilization... - Reversal of amyloid-induced heart disease in desmin-related cardiomyopathyAtsushi Sanbe
Division of Molecular Cardiovascular Biology and Howard Hughes Medical Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Proc Natl Acad Sci U S A 102:13592-7. 2005..Blocking cardiac amyloid oligomer formation, even after cardiac dysfunction presents, may be a therapeutic strategy in DRM as well as in other types of cardiac disease in which significant amyloid accumulation occurs... - NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta productionSylvain Lesne
Unite Mixte de Recherche, Centre National de la Recherche Scientifique 6185, Centre Cyceron, France
J Neurosci 25:9367-77. 2005..These results suggest that even mild deregulation of the glutamatergic neurotransmission may increase Abeta production and represent a causal risk factor for developing AD... - Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brainHideko Kokubo
Gunma University School of Health Sciences, 3-39-15 Showa-machi, Maebashi 371-8514, Japan
Brain Res 1045:224-8. 2005..The oligomer was less frequently colocalized to flotillin-1-immunoreactive rafts than Abeta42, suggesting that rafts are one of the sites of polymeric Abeta deposition, but not of oligomeric proteins including Abeta... - Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloidMichelle E King
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
J Cell Biol 175:541-6. 2006..These results suggest that a seminal cell biological event in AD pathogenesis is acute, tau-dependent loss of microtubule integrity caused by exposure of neurons to readily diffusible Abeta... - Single particle characterization of iron-induced pore-forming alpha-synuclein oligomersMarcus Kostka
CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
J Biol Chem 283:10992-1003. 2008..Moreover, scanning for intensely fluorescent targets allows high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy...