Charles Glabe

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
  2. ncbi request reprint Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Neurology 66:S74-8. 2006
  3. pmc Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    Volker Luibl
    Beckman Macular Research Center, Doheny Eye Institute and Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Clin Invest 116:378-85. 2006
  4. ncbi request reprint Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Neurobiol Aging 27:570-5. 2006
  5. ncbi request reprint Conformation-dependent anti-amyloid oligomer antibodies
    Rakez Kayed
    UC Irvine, Department of Molecular Biology and Biochemistry, Irvine, CA, USA
    Methods Enzymol 413:326-44. 2006
  6. pmc Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
    SUHAIL RASOOL
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 7:37. 2012
  7. pmc Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
    Thuzar M Shin
    Zilhka Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Mol Neurodegener 3:16. 2008
  8. pmc Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    Kathryn E Nichol
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
    J Neuroinflammation 5:13. 2008
  9. ncbi request reprint Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
    C Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
    J Mol Neurosci 17:137-45. 2001
  10. ncbi request reprint Conformation-dependent antibodies target diseases of protein misfolding
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
    Trends Biochem Sci 29:542-7. 2004

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...
  2. ncbi request reprint Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Neurology 66:S74-8. 2006
    ....
  3. pmc Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
    Volker Luibl
    Beckman Macular Research Center, Doheny Eye Institute and Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Clin Invest 116:378-85. 2006
    ..These results suggest that amyloid oligomers may be involved in drusen biogenesis and that similar protein misfolding processes may occur in AMD and amyloid diseases...
  4. ncbi request reprint Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Neurobiol Aging 27:570-5. 2006
    ..Although, these upstream events may be unique to a particular disease related protein, their effects can be rationalized as having a primary effect of increasing the amount of mis-folded, potentially amyloidogenic proteins...
  5. ncbi request reprint Conformation-dependent anti-amyloid oligomer antibodies
    Rakez Kayed
    UC Irvine, Department of Molecular Biology and Biochemistry, Irvine, CA, USA
    Methods Enzymol 413:326-44. 2006
    ..The purpose of this chapter is to review the methods for the production, characterization, and application of this antibody to understanding the contribution of amyloid oligomers to the disease process...
  6. pmc Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
    SUHAIL RASOOL
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 7:37. 2012
    ..However, autoimmune side effects have halted the development of vaccines based on full length human Aβ. Further development of an effective vaccine depends on overcoming these side effects while maintaining an effective immune response...
  7. pmc Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin
    Thuzar M Shin
    Zilhka Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Mol Neurodegener 3:16. 2008
    ..The investigation of vitronectin aggregation is significant since the formation of oligomeric and fibrillar structures are common features of amyloid proteins...
  8. pmc Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
    Kathryn E Nichol
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
    J Neuroinflammation 5:13. 2008
    ..Our objective was to determine if exercise could induce a shift from the immune profile in aged (17-19 months) Tg2576 mice to a response that reduces Abeta pathology...
  9. ncbi request reprint Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
    C Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
    J Mol Neurosci 17:137-45. 2001
    ....
  10. ncbi request reprint Conformation-dependent antibodies target diseases of protein misfolding
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
    Trends Biochem Sci 29:542-7. 2004
    ..The common structures and mechanisms hold promise for the development of broad-spectrum drugs and vaccines that will be effective for the treatment of many of these diseases...
  11. pmc Structural classification of toxic amyloid oligomers
    Charles G Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 283:29639-43. 2008
    ..Classification of amyloid oligomers according to their underlying structures may be a more useful and rational approach than relying on differences in size and morphology...
  12. pmc Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Mol Neurodegener 5:57. 2010
    ..Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates...
  13. ncbi request reprint Biomedicine. Avoiding collateral damage in Alzheimer's disease treatment
    Charles Glabe
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Science 314:602-3. 2006
  14. pmc Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 2:18. 2007
    ..Conformation dependent antibodies have been reported that specifically recognize distinct assembly states of amyloids, including prefibrillar oligomers and fibrils...
  15. pmc Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 284:4230-7. 2009
    ..The annular anti-protofibril antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the antibody recognizes an epitope that is specific for a beta barrel structural motif...
  16. pmc A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain
    Floyd Sarsoza
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697, USA
    Acta Neuropathol 118:505-17. 2009
    ....
  17. pmc Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models
    Emily Mitchell Sontag
    Department of Biological Chemistry, Psychiatry and Human Behavior, University of California, Irvine, California 92697, USA
    J Neurosci 32:11109-19. 2012
    ..Furthermore, MB treatment also promoted an increase in levels of BDNF RNA and protein in vivo. Thus, MB, which is well tolerated and used in humans, has therapeutic potential for HD...
  18. pmc Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    Emiley Pham
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    FEBS J 277:3051-67. 2010
    ..In conclusion, this study suggests that the presence of a subpopulation of amyloid-beta oligomers in the brains of patients with Alzheimer's disease might be related to alterations in selected synaptic proteins and cognitive impairment...
  19. ncbi request reprint Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4545, USA
    J Biol Chem 281:1599-604. 2006
    ..Therefore, Abeta oligomers may play a role in the induction of tau pathology, making the interference of Abeta oligomerization a valid therapeutic target...
  20. doi request reprint A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:3555-66. 2008
    ..Alternatively, clearing preexisting Abeta from the brain in a treatment study may be more efficacious for cognition if combined with a second intervention that restores neuron health...
  21. pmc Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation
    Jessica W Wu
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 285:6071-9. 2010
    ....
  22. ncbi request reprint Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 279:46363-6. 2004
    ....
  23. ncbi request reprint The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties
    Brian Soreghan
    Department of Molecular Biology and Bichemistry, University of California, Irvine, CA 92697 3900, USA
    Neuromolecular Med 1:81-94. 2002
    ..These results indicate that although beta-sheet conformation may be required for toxic activity, it is not sufficient and 6-10 nm fibril morphology is not an obligate requirement for neuronal toxicity...
  24. pmc The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein
    Noriko Kamei
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, USA
    Genes Dev 17:2502-7. 2003
    ..Thus,the species-specific domains of egg bindin receptor 1 (EBR1) from both species function as the egg surface receptor to mediate species-specific sperm adhesion...
  25. ncbi request reprint Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons
    Atul Deshpande
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Neurosci 26:6011-8. 2006
    ..Thus various Abeta species may play relevant roles in AD, causing neurotoxicity by distinct non-overlapping mechanisms affecting neuronal function and viability over multiple time courses...
  26. ncbi request reprint Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
    Qiu Lan Ma
    Department of Medicine, University of California, Los Angeles, California 91343, USA
    J Neurosci Res 83:374-84. 2006
    ..These data suggest that antibodies that are highly specific for toxic oligomer subspecies may reduce toxicity via reduction of GSK-3beta, which could be an important strategy for Alzheimer's disease (AD) therapeutics...
  27. doi request reprint Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers
    Hiromi Arai
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Biochim Biophys Acta 1820:1908-14. 2012
    ..The detailed structure of these amyloid oligomers is not known nor is the mechanism for the recognition of the generic epitope by conformation-dependent monoclonal antibodies...
  28. pmc Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure
    Yuri Sokolov
    Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697, USA
    J Gen Physiol 128:637-47. 2006
    ....
  29. ncbi request reprint Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42
    Yun Ru Chen
    Department of Molecular Biology and Biochemistry, The University of California, Irvine, California 92697, USA
    J Biol Chem 281:24414-22. 2006
    ..The distinct initial folding properties of Abeta40 and Abeta42 may play an important role in the higher aggregation potential and pathological significance of Abeta42...
  30. doi request reprint A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses
    Atul Deshpande
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 29:4004-15. 2009
    ..In AD brains, oligomers of different size colocalized with synaptic markers in hippocampus and cortex, where oligomer synaptic accumulation correlated with synaptic loss...
  31. ncbi request reprint Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
    Angelo Demuro
    Department of Neurobiology and Behavior and Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 280:17294-300. 2005
    ....
  32. pmc Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway
    Tatyana Gurlo
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7073, USA
    Am J Pathol 176:861-9. 2010
    ..Toxic oligomer-induced secretory pathway and mitochondrial membrane disruption is a novel mechanism to account for cellular dysfunction and apoptosis in T2DM...
  33. ncbi request reprint Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization
    Mihaela Necula
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    Biochemistry 46:8850-60. 2007
    ..If Abeta oligomers represent the primary pathogenic species, then inhibition of this highly toxic species via promotion of formation of less toxic aggregates may be therapeutically useful...
  34. ncbi request reprint Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct
    Mihaela Necula
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 282:10311-24. 2007
    ..In addition, these data suggest that small molecule inhibitors are useful for clarifying the mechanisms underlying protein aggregation and may represent potential therapeutic agents that target fundamental disease mechanisms...
  35. pmc Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo
    Emanuela Colla
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 32:3301-5. 2012
    ..These results indicate that αS oligomers with toxic conformation accumulate in ER, and αS oligomer-dependent ER stress is pathologically relevant for PD...
  36. pmc Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
    Jennifer L Tomic
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
    Neurobiol Dis 35:352-8. 2009
    ..These results indicate that fibrillar oligomers may play a key role in the pathology of AD and may be a new target for diagnostic and therapeutic development...
  37. ncbi request reprint Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure
    Joshua C Yoburn
    Department of Chemistry, University of California, Irvine, California 92697, USA
    Chem Res Toxicol 16:531-5. 2003
    ..Thus, the fibrillar structure of Abeta enhances formation of dityrosine cross-links, but dityrosine cross-links do not seem to enhance local secondary structure...
  38. doi request reprint Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro
    Erene W Mina
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    J Mol Biol 391:577-85. 2009
    ....
  39. pmc Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy
    Alina Maloyan
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5995-6000. 2007
    ..The data demonstrate that voluntary exercise slows the progression to HF in the CryAB(R120G) DRM model and that PAO accumulation is mediated, at least in part, by decreased neprilysin activity...
  40. ncbi request reprint Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid
    George S Bloom
    Departments of Biology, and Cell Biology, University of Virginia, Charlottesville, VA 22903, USA
    Biochim Biophys Acta 1739:116-24. 2005
    ....
  41. pmc Metabolite-initiated protein misfolding may trigger Alzheimer's disease
    Qinghai Zhang
    Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:4752-7. 2004
    ....
  42. ncbi request reprint Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    Fusheng Yang
    Department of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 280:5892-901. 2005
    ..These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD...
  43. pmc Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis
    Atsushi Sanbe
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, Children s Hospital Research Foundation, Mail Location Code 7020, 3333 Burnet Avenue, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:10132-6. 2004
    ..These oligomeric amyloid intermediates are present also in cardiomyocytes derived from many human dilated and hypertrophic cardiomyopathies...
  44. ncbi request reprint Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling
    Marianna Török
    Department of Biochemistry and Molecular Biology, Neurogenetic Institute and Arnold and Mabel Beckman Macular Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Biol Chem 277:40810-5. 2002
    ..Despite their different aggregation properties and roles in disease, the two peptides, Abeta40 and Abeta42, homogeneously co-mix in amyloid fibrils suggesting that they possess the same structural architecture...
  45. ncbi request reprint Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain
    Hideko Kokubo
    Gunma University School of Health Sciences, 3 39 15 Showa Machi, Maebashi 371 8514, Japan
    Brain Res 1031:222-8. 2005
    ..These findings imply that soluble Abeta oligomers might be related to synaptic dysfunction in AD brain...
  46. ncbi request reprint ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ....
  47. pmc Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers
    Grigor Mamikonyan
    Department of Immunology, The Institute for Molecular Medicine, Huntington Beach, California 92647, USA
    J Biol Chem 282:22376-86. 2007
    ....
  48. ncbi request reprint Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice
    Chia Yu Lin
    Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 7345, USA
    Diabetes 56:1324-32. 2007
    ....
  49. ncbi request reprint A specific amyloid-beta protein assembly in the brain impairs memory
    Sylvain Lesne
    Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 440:352-7. 2006
    ..We propose that Abeta*56 impairs memory independently of plaques or neuronal loss, and may contribute to cognitive deficits associated with Alzheimer's disease...
  50. ncbi request reprint Pore-forming proteins share structural and functional homology with amyloid oligomers
    Yuji Yoshiike
    Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Neuromolecular Med 9:270-5. 2007
    ..These results indicate that pore forming proteins (PFP) and amyloid oligomers share structural homology and suggest that PFPs and amyloid oligomers share the same mechanism of membrane permeabilization...
  51. pmc Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy
    Atsushi Sanbe
    Division of Molecular Cardiovascular Biology and Howard Hughes Medical Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 102:13592-7. 2005
    ..Blocking cardiac amyloid oligomer formation, even after cardiac dysfunction presents, may be a therapeutic strategy in DRM as well as in other types of cardiac disease in which significant amyloid accumulation occurs...
  52. ncbi request reprint NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production
    Sylvain Lesne
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 6185, Centre Cyceron, France
    J Neurosci 25:9367-77. 2005
    ..These results suggest that even mild deregulation of the glutamatergic neurotransmission may increase Abeta production and represent a causal risk factor for developing AD...
  53. ncbi request reprint Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain
    Hideko Kokubo
    Gunma University School of Health Sciences, 3 39 15 Showa Machi, Maebashi 371 8514, Japan
    Brain Res 1045:224-8. 2005
    ..The oligomer was less frequently colocalized to flotillin-1-immunoreactive rafts than Abeta42, suggesting that rafts are one of the sites of polymeric Abeta deposition, but not of oligomeric proteins including Abeta...
  54. pmc Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid
    Michelle E King
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    J Cell Biol 175:541-6. 2006
    ..These results suggest that a seminal cell biological event in AD pathogenesis is acute, tau-dependent loss of microtubule integrity caused by exposure of neurons to readily diffusible Abeta...
  55. doi request reprint Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
    Marcus Kostka
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
    J Biol Chem 283:10992-1003. 2008
    ..Moreover, scanning for intensely fluorescent targets allows high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy...