Research Topics
Genomes and Genes | Brian GiuntaSummaryAffiliation: University of South Florida Country: USA Publications
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Publications
The immunology of traumatic brain injury: a prime target for Alzheimer's disease preventionBrian Giunta
James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
J Neuroinflammation 9:185. 2012..In the end, a better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI to later AD...- Impact of the CD40-CD40L dyad in Alzheimer's diseaseBrian Giunta
Department of Psychiatry and Behavioral Medicine, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
CNS Neurol Disord Drug Targets 9:149-55. 2010..Importantly, therapeutic approaches focusing on CD40-CD40L dyad regulation, either alone or in combination with amyloid-beta immunotherapy, may provide for a safe and effective AD prophylaxis or treatment in the near future... - Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)Jon Salemi
Department of Psychiatry and Neurosciences, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
Mol Neurodegener 6:3. 2011.... - Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disordersBrian Giunta
Neuroimmunology Laboratory, Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
Mol Brain 4:23. 2011..Therefore these compounds may consequently contribute to cognitive decline observed in HIV associated neurocognitive disorders (HAND)... 
Psychiatric implications of hepatitis-C infectionBrian Giunta
Department of Psychiatry, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
Crit Rev Neurobiol 19:79-118. 2007..These comorbidities have significant effects on both treatments and outcomes, and thus are reviewed herein...- Inflammaging as a prodrome to Alzheimer's diseaseBrian Giunta
Neuroimmunology Laboratory, Department of Psychiatry, Behavioral Medicine, Institute for Research in Psychiatry, University of South Florida, College of Medicine, Tampa, FL 33613, USA
J Neuroinflammation 5:51. 2008..In addition, we explain how three novel treatments, (1) human umbilical cord blood cells (HUCBC), (2) flavanoids, and (3) Abeta vaccination oppose the forces of inflammaging and AD-like pathology in various mouse models... 
Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 miceBrian Giunta
Department of Psychiatry and Behavioral Medicine, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
Neurosci Lett 471:134-8. 2010..001). Fish oil and EGCG had a synergetic effect on inhibition of cerebral Abeta deposits (P<0.001) suggesting moderate supplementation with EGCG and fish oil having significant therapeutic potential for the treatment of AD...- Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer miceWilliam V Nikolic
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
Stem Cells Dev 17:423-39. 2008..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity... - CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease miceYuyan Zhu
Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
J Neurosci 31:1355-65. 2011..These data show that deficiency in CD45 activity leads to brain accumulation of neurotoxic Aβ oligomers and validate CD45-mediated microglial clearance of oligomeric Aβ as a novel AD therapeutic target... - Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autismEllisa Parker-Athill
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, University of South Florida, Tampa, FL 33613, USA
J Neuroimmunol 217:20-7. 2009..Diosmin's molecular inhibition of JAK2/STAT3 pathway may underlie the attenuation of abnormal social interaction in IL-6/MIA adult offspring... - Rapamycin promotes beta-amyloid production via ADAM-10 inhibitionSheqing Zhang
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, College of Medicine, University of South Florida, Tampa, FL 33613, USA
Biochem Biophys Res Commun 398:337-41. 2010..5ng/mL by high performance liquid chromatography (HPLC). These data suggest that although rapamycin may increase the lifespan in some mouse models, it may not decrease the risk for age-associated neurodegenerative disorders such as AD... - Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathologyYuyan Zhu
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, College of Medicine, University of South Florida, Tampa, FL 33613, USA
J Cell Mol Med 15:327-38. 2011..These data show that haematopoietic cells bearing the mhPS1 transgene exacerbate AD-like pathology, suggesting a novel therapeutic strategy for AD based on targeting PS1 in peripheral immune cells... - Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's diseaseAdam Smith
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
Int J Pharm 389:207-12. 2010..We found that forming nanolipidic EGCG particles improves the neuronal (SweAPP N2a cells) alpha-secretase enhancing ability in vitro by up to 91% (P<001) and it's oral bioavailability in vivo by more than two-fold over free EGCG... - CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activationYuyan Zhu
Rashid Laboratory Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida, United States of America
PLoS ONE 3:e2135. 2008..Additionally we have shown agonism of the RB isoform of CD45 (CD45RB) abrogates lipopolysaccharide (LPS)-induced microglial activation... - Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhageWilliam V Nikolic
Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
Proc Natl Acad Sci U S A 104:2507-12. 2007..Together, these data suggest that t.c. immunization constitutes an effective and potentially safe treatment strategy for AD... - Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer miceDonna Darlington
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613, USA
Stem Cells Dev 22:412-21. 2013..As such, this report lays the groundwork for an HUCBC therapy as potentially novel alternative to oppose AD at the disease-modifying level... - Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinaseYuyan Zhu
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida 33613, USA
Rejuvenation Res 11:891-901. 2008..Thus, these data may explain the previously observed behavioral recovery in PSAPP mice and suggest a means by which dietary supplementation could mitigate an undesirable microglial response toward fibrillar A beta... - Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generationDemian Obregon
Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Neuroscience, Morsani College of Medicine, University of South Florida, Tampa 33613, Florida, USA
Nat Commun 3:777. 2012..Therefore, restoration of sAPP-α or enhancement of its association with BACE may be viable strategies to ameliorate imbalances in APP processing that can lead to AD pathogenesis... - Autoreactive-Aβ antibodies promote APP β-secretase processingJuan Deng
Rashid Laboratory for Developmental Neurobiology, Department of Psychiatry and Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
J Neurochem 120:732-40. 2012.... - EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementiaBrian Giunta
Neuroimmunology Laboratory, Silver Child Development Center, Institute for Research in Psychiatry, Department of Psychiatry and Behavioral Medicine, University of South Florida, 3515 East Fletcher Avenue Tampa, FL 33613, USA
Brain Res 1123:216-25. 2006..Thus EGCG may represent a novel natural copound for the prevention and treatment of HAD... - Normal brain aging clinical, immunological, neuropsychological, and neuroimaging featuresMARIA T CASERTA
Department of Psychiatry and Behavioral Medicine, University of South Florida, 3515 East Fletcher Avenue, MDC 14, Tampa, Florida 33613, USA
Int Rev Neurobiol 84:1-19. 2009..Factors identified for healthy cognitive (brain) aging are multifactorial, and likely incorporate biological systems as well as cognitive reserve... - HIV-1 Tat Contributes to Alzheimer's Disease-like Pathology in PSAPP MiceBrian Giunta
Department of Psychiatry and Behavioral Medicine, Neuroimmunology Laboratory, University of South Florida College of Medicine Tampa, Florida 33613, USA
Int J Clin Exp Pathol 2:433-43. 2009..Additional works will be needed to fully characterize the mechanism(s) of HIV- induced amyloid deposition, and also to uncover viral mechanisms promoting AD-like pathology in general... - Molecular and contextual markers of hepatitis C virus and drug abusePaul Shapshak
Division of Infectious Disease and International Medicine, Department of Internal Medicine, Tampa General Hospital, University of South Florida, College of Medicine, Tampa, Florida, USA
Mol Diagn Ther 13:153-79. 2009..In this review, we discuss recent findings concerning the impact of drug abuse, epidemiology, social behavior, virology, immunopathology, and genetics on HCV infection and the course of disease... - Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying testGabor Legradi
Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
Neural Plast 2007:79102. 2007..These findings are potentially significant toward enhancing our understanding of the involvement of PACAP and the CeA in the neural basis of fear and anxiety... - The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndromeSamantha Portis
Rashid Laboratory for Developmental Neurobiology, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida 3515 E Fletcher Ave, Tampa, FL 33612
Int J Physiol Pathophysiol Pharmacol 4:140-8. 2012....