Brian Giunta

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention
    Brian Giunta
    James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 9:185. 2012
  2. doi request reprint Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice
    Brian Giunta
    Department of Psychiatry and Behavioral Medicine, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    Neurosci Lett 471:134-8. 2010
  3. pmc Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
    Jon Salemi
    Department of Psychiatry and Neurosciences, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    Mol Neurodegener 6:3. 2011
  4. ncbi request reprint Psychiatric implications of hepatitis-C infection
    Brian Giunta
    Department of Psychiatry, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Crit Rev Neurobiol 19:79-118. 2007
  5. pmc Impact of the CD40-CD40L dyad in Alzheimer's disease
    Brian Giunta
    Department of Psychiatry and Behavioral Medicine, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
    CNS Neurol Disord Drug Targets 9:149-55. 2010
  6. pmc Inflammaging as a prodrome to Alzheimer's disease
    Brian Giunta
    Neuroimmunology Laboratory, Department of Psychiatry, Behavioral Medicine, Institute for Research in Psychiatry, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    J Neuroinflammation 5:51. 2008
  7. pmc Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders
    Brian Giunta
    Neuroimmunology Laboratory, Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Brain 4:23. 2011
  8. pmc Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
    William V Nikolic
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Stem Cells Dev 17:423-39. 2008
  9. pmc CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice
    Yuyan Zhu
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    J Neurosci 31:1355-65. 2011
  10. doi request reprint Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
    Ellisa Parker-Athill
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, University of South Florida, Tampa, FL 33613, USA
    J Neuroimmunol 217:20-7. 2009

Collaborators

Detail Information

Publications29

  1. pmc The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention
    Brian Giunta
    James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 9:185. 2012
    ..In the end, a better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI to later AD...
  2. doi request reprint Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice
    Brian Giunta
    Department of Psychiatry and Behavioral Medicine, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    Neurosci Lett 471:134-8. 2010
    ..001). Fish oil and EGCG had a synergetic effect on inhibition of cerebral Abeta deposits (P<0.001) suggesting moderate supplementation with EGCG and fish oil having significant therapeutic potential for the treatment of AD...
  3. pmc Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
    Jon Salemi
    Department of Psychiatry and Neurosciences, Neuroimmunology Laboratory, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    Mol Neurodegener 6:3. 2011
    ....
  4. ncbi request reprint Psychiatric implications of hepatitis-C infection
    Brian Giunta
    Department of Psychiatry, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
    Crit Rev Neurobiol 19:79-118. 2007
    ..These comorbidities have significant effects on both treatments and outcomes, and thus are reviewed herein...
  5. pmc Impact of the CD40-CD40L dyad in Alzheimer's disease
    Brian Giunta
    Department of Psychiatry and Behavioral Medicine, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA
    CNS Neurol Disord Drug Targets 9:149-55. 2010
    ..Importantly, therapeutic approaches focusing on CD40-CD40L dyad regulation, either alone or in combination with amyloid-beta immunotherapy, may provide for a safe and effective AD prophylaxis or treatment in the near future...
  6. pmc Inflammaging as a prodrome to Alzheimer's disease
    Brian Giunta
    Neuroimmunology Laboratory, Department of Psychiatry, Behavioral Medicine, Institute for Research in Psychiatry, University of South Florida, College of Medicine, Tampa, FL 33613, USA
    J Neuroinflammation 5:51. 2008
    ..In addition, we explain how three novel treatments, (1) human umbilical cord blood cells (HUCBC), (2) flavanoids, and (3) Abeta vaccination oppose the forces of inflammaging and AD-like pathology in various mouse models...
  7. pmc Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: implications for HIV-associated neurocognitive disorders
    Brian Giunta
    Neuroimmunology Laboratory, Department of Psychiatry and Neurosciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Brain 4:23. 2011
    ..Therefore these compounds may consequently contribute to cognitive decline observed in HIV associated neurocognitive disorders (HAND)...
  8. pmc Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice
    William V Nikolic
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Stem Cells Dev 17:423-39. 2008
    ..Increased microglial phagocytic activity in this scenario was inhibited by addition of recombinant CD40L protein. These data suggest that HUCBC infusion mitigates AD-like pathology by disrupting CD40L activity...
  9. pmc CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice
    Yuyan Zhu
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    J Neurosci 31:1355-65. 2011
    ..These data show that deficiency in CD45 activity leads to brain accumulation of neurotoxic Aβ oligomers and validate CD45-mediated microglial clearance of oligomeric Aβ as a novel AD therapeutic target...
  10. doi request reprint Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
    Ellisa Parker-Athill
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, University of South Florida, Tampa, FL 33613, USA
    J Neuroimmunol 217:20-7. 2009
    ..Diosmin's molecular inhibition of JAK2/STAT3 pathway may underlie the attenuation of abnormal social interaction in IL-6/MIA adult offspring...
  11. pmc Multiple low-dose infusions of human umbilical cord blood cells improve cognitive impairments and reduce amyloid-β-associated neuropathology in Alzheimer mice
    Donna Darlington
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Morsani College of Medicine, University of South Florida, Tampa, Florida 33613, USA
    Stem Cells Dev 22:412-21. 2013
    ..As such, this report lays the groundwork for an HUCBC therapy as potentially novel alternative to oppose AD at the disease-modifying level...
  12. pmc Rapamycin promotes beta-amyloid production via ADAM-10 inhibition
    Sheqing Zhang
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, College of Medicine, University of South Florida, Tampa, FL 33613, USA
    Biochem Biophys Res Commun 398:337-41. 2010
    ..5ng/mL by high performance liquid chromatography (HPLC). These data suggest that although rapamycin may increase the lifespan in some mouse models, it may not decrease the risk for age-associated neurodegenerative disorders such as AD...
  13. pmc Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology
    Yuyan Zhu
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, College of Medicine, University of South Florida, Tampa, FL 33613, USA
    J Cell Mol Med 15:327-38. 2011
    ..These data show that haematopoietic cells bearing the mhPS1 transgene exacerbate AD-like pathology, suggesting a novel therapeutic strategy for AD based on targeting PS1 in peripheral immune cells...
  14. pmc CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation
    Yuyan Zhu
    Rashid Laboratory Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 3:e2135. 2008
    ..Additionally we have shown agonism of the RB isoform of CD45 (CD45RB) abrogates lipopolysaccharide (LPS)-induced microglial activation...
  15. doi request reprint Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease
    Adam Smith
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    Int J Pharm 389:207-12. 2010
    ..We found that forming nanolipidic EGCG particles improves the neuronal (SweAPP N2a cells) alpha-secretase enhancing ability in vitro by up to 91% (P<001) and it's oral bioavailability in vivo by more than two-fold over free EGCG...
  16. doi request reprint Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury
    Darrell Sawmiller
    James A Haley Veteran s Administration Hospital, Tampa, FL 33612, USA
    Int J Mol Sci 15:895-904. 2014
    ..This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI. ..
  17. pmc Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage
    William V Nikolic
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    Proc Natl Acad Sci U S A 104:2507-12. 2007
    ..Together, these data suggest that t.c. immunization constitutes an effective and potentially safe treatment strategy for AD...
  18. pmc Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase
    Yuyan Zhu
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Medicine, University of South Florida College of Medicine, Tampa, Florida 33613, USA
    Rejuvenation Res 11:891-901. 2008
    ..Thus, these data may explain the previously observed behavioral recovery in PSAPP mice and suggest a means by which dietary supplementation could mitigate an undesirable microglial response toward fibrillar A beta...
  19. pmc Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model
    She Qing Zhang
    Department of Neurology, Shanghai Changhai Hospital, Shanghai, China
    J Neurosci Res 91:1239-46. 2013
    ..Our findings suggest that baicalein promotes nonamyloidogenic processing of APP, thereby reducing Aβ production and improving cognitive performance, by activating GABAA receptors...
  20. pmc Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
    Demian Obregon
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Neuroscience, Morsani College of Medicine, University of South Florida, Tampa 33613, Florida, USA
    Nat Commun 3:777. 2012
    ..Therefore, restoration of sAPP-α or enhancement of its association with BACE may be viable strategies to ameliorate imbalances in APP processing that can lead to AD pathogenesis...
  21. pmc Autoreactive-Aβ antibodies promote APP β-secretase processing
    Juan Deng
    Rashid Laboratory for Developmental Neurobiology, Department of Psychiatry and Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
    J Neurochem 120:732-40. 2012
    ....
  22. ncbi request reprint EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia
    Brian Giunta
    Neuroimmunology Laboratory, Silver Child Development Center, Institute for Research in Psychiatry, Department of Psychiatry and Behavioral Medicine, University of South Florida, 3515 East Fletcher Avenue Tampa, FL 33613, USA
    Brain Res 1123:216-25. 2006
    ..Thus EGCG may represent a novel natural copound for the prevention and treatment of HAD...
  23. pmc Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation
    She Qing Zhang
    Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America Department of Neurology, Shanghai Changhai Hospital, Shanghai, China
    PLoS ONE 8:e71913. 2013
    ..These data indicate that OG increases anti-amyloidogenic APP α-secretase processing by activation of ERα/PI3k/Akt signaling and ADAM10, suggesting that this compound may be an effective treatment for AD. ..
  24. pmc HIV-1 Tat Contributes to Alzheimer's Disease-like Pathology in PSAPP Mice
    Brian Giunta
    Department of Psychiatry and Behavioral Medicine, Neuroimmunology Laboratory, University of South Florida College of Medicine Tampa, Florida 33613, USA
    Int J Clin Exp Pathol 2:433-43. 2009
    ..Additional works will be needed to fully characterize the mechanism(s) of HIV- induced amyloid deposition, and also to uncover viral mechanisms promoting AD-like pathology in general...
  25. doi request reprint Normal brain aging clinical, immunological, neuropsychological, and neuroimaging features
    MARIA T CASERTA
    Department of Psychiatry and Behavioral Medicine, University of South Florida, 3515 East Fletcher Avenue, MDC 14, Tampa, Florida 33613, USA
    Int Rev Neurobiol 84:1-19. 2009
    ..Factors identified for healthy cognitive (brain) aging are multifactorial, and likely incorporate biological systems as well as cognitive reserve...
  26. pmc Improving lithium therapeutics by crystal engineering of novel ionic cocrystals
    Adam J Smith
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States
    Mol Pharm 10:4728-38. 2013
    ..Indeed, the studies detailed herein represent an important advancement in a crystal engineering approach to a new generation of lithium therapeutics. ..
  27. doi request reprint Molecular and contextual markers of hepatitis C virus and drug abuse
    Paul Shapshak
    Division of Infectious Disease and International Medicine, Department of Internal Medicine, Tampa General Hospital, University of South Florida, College of Medicine, Tampa, Florida, USA
    Mol Diagn Ther 13:153-79. 2009
    ..In this review, we discuss recent findings concerning the impact of drug abuse, epidemiology, social behavior, virology, immunopathology, and genetics on HCV infection and the course of disease...
  28. pmc Microinfusion of pituitary adenylate cyclase-activating polypeptide into the central nucleus of amygdala of the rat produces a shift from an active to passive mode of coping in the shock-probe fear/defensive burying test
    Gabor Legradi
    Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    Neural Plast 2007:79102. 2007
    ..These findings are potentially significant toward enhancing our understanding of the involvement of PACAP and the CeA in the neural basis of fear and anxiety...
  29. pmc The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome
    Samantha Portis
    Rashid Laboratory for Developmental Neurobiology, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida 3515 E Fletcher Ave, Tampa, FL 33612
    Int J Physiol Pathophysiol Pharmacol 4:140-8. 2012
    ....