Research Topics
| Cecilia GiuliviSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiologyCecilia Giulivi
University of California, Department of Molecular Biosciences, Davis, California 95616
Am J Physiol Cell Physiol 291:C1225-31. 2006..These temporospatial processes are biologically important to allow NO to act as an effective signal molecule to regulate mitochondrial events such as oxygen consumption and reactive oxygen species production...
Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autismEleonora Napoli
Department of Molecular Biosciences, University of California, One Shields Ave, 1120 Haring Hall, Davis, CA, 95616, USA
Mol Autism 4:2. 2013..abstract:..- Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in miceCecilia Giulivi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
J Biol Chem 286:99-113. 2011..Chronically elevated resting Ca(2+) in R163C skeletal muscle elicited the maintenance of a fast-twitch fiber program and the development of insulin resistance-like phenotype as part of a metabolic adaptation to the R163C RyR1 mutation... 
Metabolic pathways in Anopheles stephensi mitochondriaCecilia Giulivi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
Biochem J 415:309-16. 2008..However, the proline pathway appeared to differ from the currently accepted pathway, in that oxoglutarate could be catabolized completely by the tricarboxylic acid cycle or via transamination, depending on the ATP need...- Mitochondrial dysfunction in autismCecilia Giulivi
University of California, School of Veterinary Medicine, Department of Molecular Biosciences, One Shields Avenue, 1120 Haring Hall, Davis, CA 95616, USA
JAMA 304:2389-96. 2010..No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism... - Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndromeEleonora Napoli
Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
Hum Mol Genet 20:3079-92. 2011..In support of this hypothesis, Zn-treated fibroblasts showed a significant recovery of ATPB P:M, ATPase activity and doubling time, whereas Zn and desferrioxamine extended these recoveries and rescued Complex IV activity... - Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito controlJennifer Pon
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, USA
Malar J 10:318. 2011.... - Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in agingVirginia Haynes
University of California, Davis, Department of Molecular Biosciences, 1120 Haring Hall, One Shields Ave, Davis, CA 95616, USA
Am J Physiol Endocrinol Metab 298:E978-87. 2010..On the basis of our studies, we propose that targeted nitration of the beta-subunit is an early marker for nitrative stress and aging... - Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53Eleonora Napoli
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
PLoS ONE 7:e42504. 2012.... - Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndromeCatherine Ross-Inta
Department of Molecular Biosciences, University of California Davis, 95616, USA
Biochem J 429:545-52. 2010..Detection of MD is of critical importance to the management of FXTAS, since it opens up additional treatment options for this disorder... - The mitochondrial pool of free amino acids reflects the composition of mitochondrial DNA-encoded proteins: indication of a post- translational quality control for protein synthesisCatherine Ross-Inta
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
Biosci Rep 28:239-49. 2008.... - Mitochondria as generators and targets of nitric oxideCecilia Giulivi
Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
Novartis Found Symp 287:92-100; discussion 100-4. 2007..These temporospatial processes are biologically important to allow NO to act as an effective signal molecule to regulate mitochondrial events... - Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's diseaseEleonora Napoli
Department of Molecular Biosciences, University of California Davis, Davis, CA 95616, USA
Hum Mol Genet 22:989-1004. 2013..Finally, decreases in the mtDNA copy number, along with the accumulation of mtDNA deletions, provide a mechanism for the progressive neurodegeneration observed in HD patients... - Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito hostShirley Luckhart
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, United States of America
PLoS Pathog 9:e1003180. 2013..Further, quality control of mitochondrial function in the midgut is necessary for the maintenance of midgut health as reflected in energy homeostasis and tissue repair and renewal... - Critical overview of mitochondrial nitric-oxide synthaseKazunobu Kato
Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, USA
Front Biosci 11:2725-38. 2006..Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria... - Threonine-deficient diets induced changes in hepatic bioenergeticsCatherine M Ross-Inta
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
Am J Physiol Gastrointest Liver Physiol 296:G1130-9. 2009.... - Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity lossYasuko Fujisawa
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Biochem J 423:219-31. 2009..Nitration at this residue would be more relevant under conditions of low nitrative stress. Conversely, at high nitrative stress conditions, both tyrosine residues would contribute equally to ATPase inactivation... - Current analytical methods for the detection of dityrosine, a biomarker of oxidative stress, in biological samplesTheresa DiMarco
Department of Molecular Biosciences, University of California, Davis, California 95616, USA
Mass Spectrom Rev 26:108-20. 2007..The continued development of, and increased accessibility to, improved mass spectrometric instrumentation will expand the capability, feasibility, and sensitivity with which specific biomarkers like dityrosine can be measured... - Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidaseMasahiro Sugawara
The Division of Endocrinology and Metabolism, West Los Angeles Veterans Affairs Medical Center and the Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90073, USA
Exp Biol Med (Maywood) 227:141-6. 2002..If thyroid cells happen to be exposed to significant amount of reactive oxygen species, TPO and subsequent thyroid hormone formation are inhibited... - Superoxide dismutases and their impact upon human healthFelicity Johnson
Department of Molecular Biosciences, University of California, 1311 Haring Hall, One Shields Ave, Davis, CA 95616, USA
Mol Aspects Med 26:340-52. 2005..Finally, human pathologies associated with either SOD dysfunction or decreased activity are discussed with current progress on the development of novel therapies... - Biochemistry of mitochondrial nitric-oxide synthaseSarah Liv Elfering
Department of Chemistry, University of Minnesota, Duluth, Minnesota 55812, USA
J Biol Chem 277:38079-86. 2002..The latter modification could be linked to enzymatic regulation. These results are discussed in terms of the role that nitric oxide may have in cellular bioenergetics... - Characterization and function of mitochondrial nitric-oxide synthaseCecilia Giulivi
Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
Free Radic Biol Med 34:397-408. 2003..Nitric oxide is the first molecule that fulfills this role (it is a competitive inhibitor, produced at a fair rate near the target site) extending the oxygen gradient to tissues... - Mitochondrial nitric-oxide synthase: role in pathophysiologyVirginia Haynes
Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
IUBMB Life 55:599-603. 2003.... - Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycleNathaniel Traaseth
Department of Chemistry, University of Minnesota, 10 University Drive, Duluth, MN 55812, USA
Biochim Biophys Acta 1658:64-71. 2004..This would ensue in changes in the NADH/NAD and ATP/ADP ratios, which would influence the rate of the cycle and the oxygen diffusion... - Mitochondrial nitric-oxide synthase: enzyme expression, characterization, and regulationVirginia Haynes
Department of Chemistry, University of Minnesota, Duluth, Minnesota 55812, USA
J Bioenerg Biomembr 36:341-6. 2004..This review describes the identification of mtNOS and the role of posttranslational modifications on mtNOS' activity and regulation... - Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumptionJoseph Solien
Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
Comp Biochem Physiol A Mol Integr Physiol 142:111-7. 2005..In this way, oxygen depletion at the latter sites is prevented. This, in turn, assures continued aerobic metabolism which may involve the activated dehydrogenases... - Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiologyChris E Cooper
Dept of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom
Am J Physiol Cell Physiol 292:C1993-2003. 2007..However, a detailed mapping of NO and oxygen levels, combined with direct measures of cytochrome oxidase/NO binding, in physiology is still awaited... - Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosisMerry Jo Oursler
Department of Biology, University of Minnesota, Duluth, Minnesota, USA
Am J Physiol Cell Physiol 288:C156-68. 2005..Cytosolic cytochrome c participated in activating caspase-3 and -9, both required for apoptosis. Collectively, our data indicate that the mitochondria-dependent apoptotic pathway is one of the major routes operating in osteoclasts... - Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthaseS L Elfering
Department of Chemistry, University of Minnesota, 10 Univ. Dr, Duluth, MN 55812, USA
Am J Physiol Heart Circ Physiol 286:H22-9. 2004..Finally, this study allows one to gain understanding on the mechanism and nitrating species underlying mitochondrial protein nitration...
Research Grants
- Antioxidants and oxidative damage in mitochondriaCecilia Giulivi; Fiscal Year: 2004..Structure-activity association of naturally occurring flavonoids in the abrogation of protein nitration, and 4. Bioavailability of flavonoids containing diets in nitrative stress. ..
- Antioxidants and oxidative damage in mitochondriaCecilia Giulivi; Fiscal Year: 2002..The antioxidant effect of flavonoids, coumarins, and catechins will be studied in terms hydroxyl substitution, conjugation of rings, and o- methylation of hydroxyl groups to elucidate an association between structure and function. ..
- Regulation of Mitochondrial Nitric-oxide SynthaseCecilia Giulivi; Fiscal Year: 2003..Studying the biochemistry of mtNOS will provide a better understanding of the role of nitric oxide in the cell-mitochondria interactions relevant to physiological situations. ..