Cecilia Giulivi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology
    Cecilia Giulivi
    University of California, Department of Molecular Biosciences, Davis, California 95616
    Am J Physiol Cell Physiol 291:C1225-31. 2006
  2. pmc Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism
    Eleonora Napoli
    Department of Molecular Biosciences, University of California, One Shields Ave, 1120 Haring Hall, Davis, CA, 95616, USA
    Mol Autism 4:2. 2013
  3. doi Metabolic pathways in Anopheles stephensi mitochondria
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Biochem J 415:309-16. 2008
  4. pmc Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 286:99-113. 2011
  5. pmc Mitochondrial dysfunction in autism
    Cecilia Giulivi
    University of California, School of Veterinary Medicine, Department of Molecular Biosciences, One Shields Avenue, 1120 Haring Hall, Davis, CA 95616, USA
    JAMA 304:2389-96. 2010
  6. pmc Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome
    Eleonora Napoli
    Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Hum Mol Genet 20:3079-92. 2011
  7. doi Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease
    Eleonora Napoli
    Department of Molecular Biosciences, University of California Davis, Davis, CA 95616, USA
    Hum Mol Genet 22:989-1004. 2013
  8. pmc Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53
    Eleonora Napoli
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e42504. 2012
  9. pmc Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA Medical Investigations of Neurodevelopmental Disorders MIND Institute, University of California, Davis, CA 95616, USA
    Mediators Inflamm 2013:609602. 2013
  10. pmc Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003180. 2013

Research Grants

  1. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2004
  2. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2002
  3. Regulation of Mitochondrial Nitric-oxide Synthase
    Cecilia Giulivi; Fiscal Year: 2003

Collaborators

Detail Information

Publications33

  1. ncbi Nitric oxide regulation of mitochondrial oxygen consumption I: cellular physiology
    Cecilia Giulivi
    University of California, Department of Molecular Biosciences, Davis, California 95616
    Am J Physiol Cell Physiol 291:C1225-31. 2006
    ..These temporospatial processes are biologically important to allow NO to act as an effective signal molecule to regulate mitochondrial events such as oxygen consumption and reactive oxygen species production...
  2. pmc Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism
    Eleonora Napoli
    Department of Molecular Biosciences, University of California, One Shields Ave, 1120 Haring Hall, Davis, CA, 95616, USA
    Mol Autism 4:2. 2013
    ..abstract:..
  3. doi Metabolic pathways in Anopheles stephensi mitochondria
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, 1 Shields Avenue, Davis, CA 95616, USA
    Biochem J 415:309-16. 2008
    ..However, the proline pathway appeared to differ from the currently accepted pathway, in that oxoglutarate could be catabolized completely by the tricarboxylic acid cycle or via transamination, depending on the ATP need...
  4. pmc Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 286:99-113. 2011
    ..Chronically elevated resting Ca(2+) in R163C skeletal muscle elicited the maintenance of a fast-twitch fiber program and the development of insulin resistance-like phenotype as part of a metabolic adaptation to the R163C RyR1 mutation...
  5. pmc Mitochondrial dysfunction in autism
    Cecilia Giulivi
    University of California, School of Veterinary Medicine, Department of Molecular Biosciences, One Shields Avenue, 1120 Haring Hall, Davis, CA 95616, USA
    JAMA 304:2389-96. 2010
    ..No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism...
  6. pmc Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome
    Eleonora Napoli
    Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Hum Mol Genet 20:3079-92. 2011
    ..In support of this hypothesis, Zn-treated fibroblasts showed a significant recovery of ATPB P:M, ATPase activity and doubling time, whereas Zn and desferrioxamine extended these recoveries and rescued Complex IV activity...
  7. doi Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease
    Eleonora Napoli
    Department of Molecular Biosciences, University of California Davis, Davis, CA 95616, USA
    Hum Mol Genet 22:989-1004. 2013
    ..Finally, decreases in the mtDNA copy number, along with the accumulation of mtDNA deletions, provide a mechanism for the progressive neurodegeneration observed in HD patients...
  8. pmc Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53
    Eleonora Napoli
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e42504. 2012
    ....
  9. pmc Gestational exposure to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring
    Cecilia Giulivi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA Medical Investigations of Neurodevelopmental Disorders MIND Institute, University of California, Davis, CA 95616, USA
    Mediators Inflamm 2013:609602. 2013
    ....
  10. pmc Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003180. 2013
    ..Further, quality control of mitochondrial function in the midgut is necessary for the maintenance of midgut health as reflected in energy homeostasis and tissue repair and renewal...
  11. pmc Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control
    Jennifer Pon
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, USA
    Malar J 10:318. 2011
    ....
  12. pmc Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging
    Virginia Haynes
    University of California, Davis, Department of Molecular Biosciences, 1120 Haring Hall, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 298:E978-87. 2010
    ..On the basis of our studies, we propose that targeted nitration of the beta-subunit is an early marker for nitrative stress and aging...
  13. pmc Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome
    Catherine Ross-Inta
    Department of Molecular Biosciences, University of California Davis, 95616, USA
    Biochem J 429:545-52. 2010
    ..Detection of MD is of critical importance to the management of FXTAS, since it opens up additional treatment options for this disorder...
  14. doi The mitochondrial pool of free amino acids reflects the composition of mitochondrial DNA-encoded proteins: indication of a post- translational quality control for protein synthesis
    Catherine Ross-Inta
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Biosci Rep 28:239-49. 2008
    ....
  15. ncbi Mitochondria as generators and targets of nitric oxide
    Cecilia Giulivi
    Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
    Novartis Found Symp 287:92-100; discussion 100-4. 2007
    ..These temporospatial processes are biologically important to allow NO to act as an effective signal molecule to regulate mitochondrial events...
  16. pmc Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background
    Eleonora Napoli
    Department of Molecular Biosciences, University of California, Davis, CA, USA
    Toxicol Sci 132:196-210. 2013
    ..PBDE-mediated MD per se or enhanced by a background that confers susceptibility to this exposure may have profound implications in the energy balance of brain...
  17. ncbi Critical overview of mitochondrial nitric-oxide synthase
    Kazunobu Kato
    Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, USA
    Front Biosci 11:2725-38. 2006
    ..Thus, future studies will be required to validate the physiological significance of mtNOS, and to elucidate its regulatory mechanisms on cellular energy metabolism in mitochondria...
  18. pmc Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Dis Model Mech 6:443-56. 2013
    ..These results suggest that postoperative increases in circulating cholic acid concentration contribute to improvements in glucose homeostasis after IT surgery by ameliorating ER stress...
  19. pmc Threonine-deficient diets induced changes in hepatic bioenergetics
    Catherine M Ross-Inta
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1130-9. 2009
    ....
  20. doi Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity loss
    Yasuko Fujisawa
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biochem J 423:219-31. 2009
    ..Nitration at this residue would be more relevant under conditions of low nitrative stress. Conversely, at high nitrative stress conditions, both tyrosine residues would contribute equally to ATPase inactivation...
  21. pmc Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line
    Ana Cristina G Grodzki
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e54926. 2013
    ....
  22. ncbi Current analytical methods for the detection of dityrosine, a biomarker of oxidative stress, in biological samples
    Theresa DiMarco
    Department of Molecular Biosciences, University of California, Davis, California 95616, USA
    Mass Spectrom Rev 26:108-20. 2007
    ..The continued development of, and increased accessibility to, improved mass spectrometric instrumentation will expand the capability, feasibility, and sensitivity with which specific biomarkers like dityrosine can be measured...
  23. ncbi Superoxide dismutases and their impact upon human health
    Felicity Johnson
    Department of Molecular Biosciences, University of California, 1311 Haring Hall, One Shields Ave, Davis, CA 95616, USA
    Mol Aspects Med 26:340-52. 2005
    ..Finally, human pathologies associated with either SOD dysfunction or decreased activity are discussed with current progress on the development of novel therapies...
  24. ncbi Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase
    Masahiro Sugawara
    The Division of Endocrinology and Metabolism, West Los Angeles Veterans Affairs Medical Center and the Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California 90073, USA
    Exp Biol Med (Maywood) 227:141-6. 2002
    ..If thyroid cells happen to be exposed to significant amount of reactive oxygen species, TPO and subsequent thyroid hormone formation are inhibited...
  25. ncbi Biochemistry of mitochondrial nitric-oxide synthase
    Sarah Liv Elfering
    Department of Chemistry, University of Minnesota, Duluth, Minnesota 55812, USA
    J Biol Chem 277:38079-86. 2002
    ..The latter modification could be linked to enzymatic regulation. These results are discussed in terms of the role that nitric oxide may have in cellular bioenergetics...
  26. ncbi Characterization and function of mitochondrial nitric-oxide synthase
    Cecilia Giulivi
    Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
    Free Radic Biol Med 34:397-408. 2003
    ..Nitric oxide is the first molecule that fulfills this role (it is a competitive inhibitor, produced at a fair rate near the target site) extending the oxygen gradient to tissues...
  27. ncbi Mitochondrial nitric-oxide synthase: role in pathophysiology
    Virginia Haynes
    Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
    IUBMB Life 55:599-603. 2003
    ....
  28. ncbi Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycle
    Nathaniel Traaseth
    Department of Chemistry, University of Minnesota, 10 University Drive, Duluth, MN 55812, USA
    Biochim Biophys Acta 1658:64-71. 2004
    ..This would ensue in changes in the NADH/NAD and ATP/ADP ratios, which would influence the rate of the cycle and the oxygen diffusion...
  29. ncbi Mitochondrial nitric-oxide synthase: enzyme expression, characterization, and regulation
    Virginia Haynes
    Department of Chemistry, University of Minnesota, Duluth, Minnesota 55812, USA
    J Bioenerg Biomembr 36:341-6. 2004
    ..This review describes the identification of mtNOS and the role of posttranslational modifications on mtNOS' activity and regulation...
  30. ncbi Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption
    Joseph Solien
    Department of Chemistry, University of Minnesota, Duluth, MN 55812, USA
    Comp Biochem Physiol A Mol Integr Physiol 142:111-7. 2005
    ..In this way, oxygen depletion at the latter sites is prevented. This, in turn, assures continued aerobic metabolism which may involve the activated dehydrogenases...
  31. ncbi Nitric oxide regulation of mitochondrial oxygen consumption II: Molecular mechanism and tissue physiology
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom
    Am J Physiol Cell Physiol 292:C1993-2003. 2007
    ..However, a detailed mapping of NO and oxygen levels, combined with direct measures of cytochrome oxidase/NO binding, in physiology is still awaited...
  32. ncbi Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase
    S L Elfering
    Department of Chemistry, University of Minnesota, 10 Univ Dr, Duluth, MN 55812, USA
    Am J Physiol Heart Circ Physiol 286:H22-9. 2004
    ..Finally, this study allows one to gain understanding on the mechanism and nitrating species underlying mitochondrial protein nitration...
  33. ncbi Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis
    Merry Jo Oursler
    Department of Biology, University of Minnesota, Duluth, Minnesota, USA
    Am J Physiol Cell Physiol 288:C156-68. 2005
    ..Cytosolic cytochrome c participated in activating caspase-3 and -9, both required for apoptosis. Collectively, our data indicate that the mitochondria-dependent apoptotic pathway is one of the major routes operating in osteoclasts...

Research Grants3

  1. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2004
    ..Structure-activity association of naturally occurring flavonoids in the abrogation of protein nitration, and 4. Bioavailability of flavonoids containing diets in nitrative stress. ..
  2. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2002
    ..The antioxidant effect of flavonoids, coumarins, and catechins will be studied in terms hydroxyl substitution, conjugation of rings, and o- methylation of hydroxyl groups to elucidate an association between structure and function. ..
  3. Regulation of Mitochondrial Nitric-oxide Synthase
    Cecilia Giulivi; Fiscal Year: 2003
    ..Studying the biochemistry of mtNOS will provide a better understanding of the role of nitric oxide in the cell-mitochondria interactions relevant to physiological situations. ..