Linda Giudice

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, USA
    Environ Health Perspect 118:400-6. 2010
  2. pmc Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential
    T T Piltonen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0132, USA
    J Clin Endocrinol Metab 98:3765-75. 2013
  3. pmc Molecular probe technology detects bacteria without culture
    Richard W Hyman
    Departments of Biochemistry, Stanford University, Stanford, CA, USA
    BMC Microbiol 12:29. 2012
  4. ncbi request reprint Endometrium in PCOS: Implantation and predisposition to endocrine CA
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, M1496, Box 0132, San Francisco, CA 94143 0132, USA
    Best Pract Res Clin Endocrinol Metab 20:235-44. 2006
  5. ncbi request reprint Infertility and the environment: the medical context
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Semin Reprod Med 24:129-33. 2006
  6. pmc Application of functional genomics to primate endometrium: insights into biological processes
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus, M1496, Box 0132, San Francisco, CA 94143 0132, USA
    Reprod Biol Endocrinol 4:S4. 2006
  7. ncbi request reprint Altered gene expression profiling in endometrium: evidence for progesterone resistance
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0132, USA
    Semin Reprod Med 28:51-8. 2010
  8. pmc The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    Endocrinology 150:3863-70. 2009
  9. doi request reprint Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns
    Bernard Lo
    Program in Medical Ethics, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 4:115-23. 2009
  10. pmc Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning
    Bernard Lo
    Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Cell Stem Cell 6:16-20. 2010

Research Grants

Detail Information

Publications54

  1. pmc Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, USA
    Environ Health Perspect 118:400-6. 2010
    ..Bisphenol A (BPA), a chemical used as a plasticizer, is a potent endocrine disruptor that, even in low concentrations, disturbs normal development and functions of reproductive organs in different species...
  2. pmc Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential
    T T Piltonen
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0132, USA
    J Clin Endocrinol Metab 98:3765-75. 2013
    ..Endometrium in polycystic ovary syndrome (PCOS) presents altered gene expression indicating progesterone resistance and predisposing to reduced endometrial receptivity and endometrial cancer...
  3. pmc Molecular probe technology detects bacteria without culture
    Richard W Hyman
    Departments of Biochemistry, Stanford University, Stanford, CA, USA
    BMC Microbiol 12:29. 2012
    ..In this communication, we report the first results of employing our molecular probes to detect bacteria in clinical samples...
  4. ncbi request reprint Endometrium in PCOS: Implantation and predisposition to endocrine CA
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, M1496, Box 0132, San Francisco, CA 94143 0132, USA
    Best Pract Res Clin Endocrinol Metab 20:235-44. 2006
    ..The potential mechanisms underlying these disorders, specifically in women with PCOS, are complex and await additional transdisciplinary research for their complete elucidation...
  5. ncbi request reprint Infertility and the environment: the medical context
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Semin Reprod Med 24:129-33. 2006
    ....
  6. pmc Application of functional genomics to primate endometrium: insights into biological processes
    Linda C Giudice
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 505 Parnassus, M1496, Box 0132, San Francisco, CA 94143 0132, USA
    Reprod Biol Endocrinol 4:S4. 2006
    ..It also highlights challenges encountered in using human endometrial tissue in translational research in this context...
  7. ncbi request reprint Altered gene expression profiling in endometrium: evidence for progesterone resistance
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143 0132, USA
    Semin Reprod Med 28:51-8. 2010
    ....
  8. pmc The progesterone receptor coactivator Hic-5 is involved in the pathophysiology of endometriosis
    Lusine Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    Endocrinology 150:3863-70. 2009
    ....
  9. doi request reprint Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns
    Bernard Lo
    Program in Medical Ethics, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 4:115-23. 2009
    ..To maintain public trust, research institutions need to justify why they allow researchers to use lines whose derivation would not have been permitted locally...
  10. pmc Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning
    Bernard Lo
    Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Cell Stem Cell 6:16-20. 2010
    ..Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation...
  11. ncbi request reprint Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, National Center of Excellence in Women s Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Fertil Steril 89:e1-e20. 2008
    ....
  12. doi request reprint Reproductive environmental health
    Patrice Sutton
    Program on Reproductive Health and the Environment, University of California, San Francisco, Oakland, California, USA
    Curr Opin Obstet Gynecol 22:517-24. 2010
    ..This article provides an overview of the nature and extent of the science in the field of reproductive environmental health and its implications for OB/GYN clinical practice...
  13. ncbi request reprint Emerging role of genomics in endometriosis research
    Robert N Taylor
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco School of Medicine, 94143 0556, USA
    Fertil Steril 78:694-8. 2002
    ..In this report we briefly review some of the seminal technological advances that inspired the genomics revolution and describe their application in the field of endometriosis research...
  14. pmc Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary
    Tracey J Woodruff
    National Center of Excellence in Women s Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Fertil Steril 89:281-300. 2008
    ....
  15. ncbi request reprint Racial and ethnic disparities in benign gynecologic conditions and associated surgeries
    Vanessa L Jacoby
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA
    Am J Obstet Gynecol 202:514-21. 2010
    ..Further research is needed to better define racial and ethnic differences in these conditions and to examine the complex mechanisms that may result in associated health disparities...
  16. ncbi request reprint Racial and ethnic disparities in reproductive endocrinology and infertility
    Heather G Huddleston
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94115 0916, USA
    Am J Obstet Gynecol 202:413-9. 2010
    ..Reproductive aging differences appear to exist in all racial and ethnic groups. Awareness of racial and ethnic disparities is critical to a complete understanding of the health issues facing women of reproductive age...
  17. pmc The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis
    Lusine Aghajanova
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0132, USA
    Endocrinology 151:1341-55. 2010
    ....
  18. pmc The bone marrow-derived human mesenchymal stem cell: potential progenitor of the endometrial stromal fibroblast
    Lusine Aghajanova
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0132, USA
    Biol Reprod 82:1076-87. 2010
    ..In addition, we identified MSC-specific markers that distinguish them from other fibroblasts and, in particular, from hESF, which is of biologic relevance and practical value to the field of endometrial stem cell research...
  19. pmc Utility of screening for other causes of infertility in women with "known" polycystic ovary syndrome
    Peter G McGovern
    Department of Obstetrics, Gynecology and Women s Health, UMDNJ New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 87:442-4. 2007
    ..Other than failure to demonstrate laboratory evidence of hyperandrogenemia, the most common reasons for subject exclusion were persistent oligospermia and tubal factor infertility...
  20. pmc Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial
    Peter G McGovern
    Department of Obstetrics, UMDNJ, New Jersey Medical School, Newark, New Jersey 07101 1709, USA
    Fertil Steril 90:1283-6. 2008
    ....
  21. doi request reprint The interplay of insulin-like growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function
    Jakub Kwintkiewicz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, California 94143 0132, USA
    Semin Reprod Med 27:43-51. 2009
    ..Disruption of even one component of this system can lead to abnormal follicular development and function and compromised reproductive capacity...
  22. pmc Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1
    Michael C Velarde
    Department of Obstetrics, Center for Reproductive Sciences, University of California San Francisco, San Francisco, California 94143 0132, USA
    Endocrinology 150:4701-12. 2009
    ..These findings suggest that increased activation of ERK1/2 in endometrial cells from women with endometriosis may be responsible for persistent proliferative changes in secretory-phase endometrium...
  23. ncbi request reprint Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells
    Suzana Tulac
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 505 Parnassus Avenue M1496, San Francisco, CA 94143 0132, USA
    J Clin Endocrinol Metab 91:1453-61. 2006
    ....
  24. doi request reprint The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, Netherlands
    Reprod Sci 15:357-65. 2008
    ..These data suggest that dysregulation of the endometrial transcriptome in the stimulated cycle is not fully attributable to supraphysiological sex steroid levels at the folliculo-luteal transition...
  25. ncbi request reprint The immune environment in human endometrium during the window of implantation
    Shalini C Lobo
    Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, CA 94305 5317, USA
    Am J Reprod Immunol 52:244-51. 2004
    ....
  26. ncbi request reprint Absence of secretory endometrium after false-positive home urine luteinizing hormone testing
    Peter G McGovern
    Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA
    Fertil Steril 82:1273-7. 2004
    ..To examine the proportion of cases with proliferative endometrium on biopsies performed after positive home urine LH testing...
  27. ncbi request reprint Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth
    Nihar R Nayak
    Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
    Mol Hum Reprod 11:791-9. 2005
    ..These data suggest, for the first time, that Ang-1 may play a key role in the P-dependent growth of the unique spiral arteries in the primate endometrium...
  28. ncbi request reprint Developmental response to hypoxia
    S T Joseph Huang
    Department of Obstetrics and Gynecology, Stanford University Medical Center, California 94305 5317, USA
    FASEB J 18:1348-65. 2004
    ..Furthermore, induction of inflammation-related genes in placentas exposed to long-term hypoxia (11 days) suggests a mechanism for placental dysfunction and impaired pregnancy outcome accompanying in utero hypoxia...
  29. ncbi request reprint Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis
    Richard O Burney
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Endocrinology 148:3814-26. 2007
    ..Collectively these findings provide a framework for further investigations on causality and mechanisms underlying attenuated progesterone response in endometrium of women with endometriosis...
  30. ncbi request reprint Microarray expression profiling reveals candidate genes for human uterine receptivity
    Linda C Giudice
    Department of Gynecology and Obstetrics, Center for Research on Women s Health and Reproduction, Stanford University School of Medicine, Stanford, California, USA
    Am J Pharmacogenomics 4:299-312. 2004
    ..Global profiling of genes in the endometrium, decidua, and at the interface between the trophoblast and the decidua, has provided remarkable in sight into endometrial maturation and implantation...
  31. ncbi request reprint Genomics' role in understanding the pathogenesis of endometriosis
    Linda C Giudice
    Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH333, Stanford, CA 94305 5317, USA
    Semin Reprod Med 21:119-24. 2003
    ..Recent advances in molecular biology and genomics suggest an intrinsic abnormality in the eutopic endometrium of women with endometriosis that predisposes to these processes. These are discussed herein...
  32. ncbi request reprint Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation
    Emily P Tierney
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Physiol Genomics 16:47-66. 2003
    ....
  33. ncbi request reprint Elucidating endometrial function in the post-genomic era
    Linda C Giudice
    Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Hum Reprod Update 9:223-35. 2003
    ..This monograph reviews some of the salient features of the new technologies and summarizes current information on endometrial biology derived from these approaches...
  34. ncbi request reprint The molecular basis for implantation failure in endometriosis: on the road to discovery
    Linda C Giudice
    Center for Research on Women s Health and Reproductive Medicine, Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305, USA
    Ann N Y Acad Sci 955:252-64; discussion 293-5, 396-406. 2002
    ....
  35. ncbi request reprint The science behind 25 years of ovarian stimulation for in vitro fertilization
    Nick S Macklon
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Endocr Rev 27:170-207. 2006
    ..After a brief discussion of the relevant aspect of ovarian physiology, the development, application, and consequences of ovarian stimulation strategies are reviewed in detail...
  36. ncbi request reprint Prediction of the individual follicle-stimulating hormone threshold for gonadotropin induction of ovulation in normogonadotropic anovulatory infertility: an approach to increase safety and efficiency
    Babak Imani
    Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Fertil Steril 77:83-90. 2002
    ..To predict the FSH response (threshold) dose in normogonadotropic, anovulatory infertile women undergoing gonadotropin induction of ovulation...
  37. ncbi request reprint Silencing lamin A/C in human endometrial stromal cells: a model to investigate endometrial gene function and regulation
    Suzana Tulac
    Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305, USA
    Mol Hum Reprod 10:705-11. 2004
    ....
  38. pmc Maternal-fetal conflict--lessons from a transgene
    Linda C Giudice
    Center for Research on Women s Health and Reproductive Medicine, 300 Pasteur Drive, Stanford University, Stanford, California 94305 5317, USA
    J Clin Invest 110:307-9. 2002
  39. ncbi request reprint Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses
    Johan Verhaeghe
    Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven
    Am J Obstet Gynecol 188:485-91. 2003
    ..Our purpose was to evaluate which factors regulate insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses...
  40. ncbi request reprint Interferon-related and other immune genes are downregulated in peripheral blood leukocytes in the luteal phase of the menstrual cycle
    Chrysoula Dosiou
    Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 89:2501-4. 2004
    ..These results support significant hormonal regulation of the immune system and may have therapeutic implications in diseases of autoimmunity in women...
  41. ncbi request reprint Role of activin A as a mediator of in vitro endometrial stromal cell decidualization via the cyclic adenosine monophosphate pathway
    Emily P Tierney
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305 5317, USA
    Fertil Steril 81:899-903. 2004
    ..To elucidate the regulation and role of activin A in endometrial stromal decidualization...
  42. pmc Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
    D Andrew Crain
    Maryville College, Maryville, Tennessee, USA
    Fertil Steril 90:911-40. 2008
    ..Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health...
  43. ncbi request reprint Metabolic and ovarian effects of rosiglitazone treatment for 12 weeks in insulin-resistant women with polycystic ovary syndrome
    Nicholas A Cataldo
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Hum Reprod 21:109-20. 2006
    ..Insulin sensitizers have favourable metabolic and ovarian effects in polycystic ovary syndrome (PCOS). This study examined rosiglitazone, a thiazolidinedione, in PCOS...
  44. ncbi request reprint Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing
    Meiyi Tang
    Department of Obstetrics and Gynecology, Stony Brook University, New York 11794, USA
    Endocrinology 146:5313-20. 2005
    ..Taken together, the findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A...
  45. pmc Microbes on the human vaginal epithelium
    Richard W Hyman
    Stanford Genome Technology Center and Departments of Biochemistry, Genetics, and Obstetrics and Gynecology, Stanford University, 855 California Avenue, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:7952-7. 2005
    ..Eight subjects presented complex mixtures of Lactobacillus and other microbes. The remaining eight subjects had no Lactobacillus. Instead, Bifidobacterium, Gardnerella, Prevotella, Pseudomonas, or Streptococcus predominated...
  46. ncbi request reprint Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory follicles
    You Qiang Su
    Department of Obstetrics and Gynecology, Stanford University, Stanford, California 94305, USA
    Biol Reprod 75:859-67. 2006
    ....
  47. ncbi request reprint Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometrium
    Ariane Germeyer
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, California 94305 5317, USA
    J Clin Endocrinol Metab 90:1783-90. 2005
    ..The findings extend our understanding of VEGF action in the primate endometrium...
  48. ncbi request reprint Endometriosis
    Linda C Giudice
    Division of Reproductive Endocrinology and Infertility, Center for Research on Women s Health and Reproduction, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Lancet 364:1789-99. 2004
    ..Clinicians should assess and follow up affected women for these and other associated disorders. There will probably be a new repertoire of approaches for treatment and perhaps cure of this enigmatic disorder in the near future...
  49. ncbi request reprint Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, M S Hershey Medical Center, Hershey, PA 17033, USA
    N Engl J Med 356:551-66. 2007
    ..The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior...
  50. ncbi request reprint The influence of hydrosalpinx on markers of endometrial receptivity
    Ricardo Francalacci Savaris
    Departamento de Ginecologia e Obstetricia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Semin Reprod Med 25:476-82. 2007
    ..In addition, the evidence for treatment options to improve pregnancy rates is also discussed...
  51. pmc Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University, M S Hershey Medical Center, 500 University Drive, H103, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 93:792-800. 2008
    ..Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood...
  52. pmc Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome
    Nicholas A Cataldo
    Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Endocrinol Metab 93:3124-7. 2008
    ..It has been suggested that metformin in combination with clomiphene can restore ovulation to some clomiphene-resistant anovulators with polycystic ovary syndrome (PCOS)...
  53. pmc VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
    Xiujun Fan
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    FASEB J 22:3571-80. 2008
    ..In summary, we provide novel experimental data indicating that VEGF is essential for endometrial neoangiogenesis during postmenstrual/postpartum repair...
  54. ncbi request reprint The dilemma of endometriosis: is consensus possible with an enigma?
    Camran Nezhat
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California, USA
    Fertil Steril 84:1587-8. 2005
    ..The findings of our study add another dimension to management of endometriosis in the setting of infertility and emphasize the importance of keeping laparoscopy in the infertility management equation...

Research Grants25

  1. HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    Linda Giudice; Fiscal Year: 2003
    ..abstract_text> ..
  2. Federally Registered Human Embryonic Stem Cell Center
    Linda Giudice; Fiscal Year: 2006
    ..Thus, the extension of this program will support the utility of hES cells for both the research and clinical communities. ..
  3. Role of IGF-II in Human Trophoblast-Decidua Interactions
    Linda Giudice; Fiscal Year: 2006
    ..The investigators work with the human model because of the uniqueness of implantation in humans...
  4. Women's Reproductive Health Research
    Linda Giudice; Fiscal Year: 2007
    ..abstract_text> ..
  5. Origins and Biological Consequences of Human Infertility
    Linda Giudice; Fiscal Year: 2007
    ....
  6. GORDON RESEARCH CONFERENCE ON REPRODUCTIVE TRACT BIOLOGY
    Linda Giudice; Fiscal Year: 2002
    ....
  7. HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    Linda Giudice; Fiscal Year: 2002
    ..abstract_text> ..
  8. HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    Linda Giudice; Fiscal Year: 2000
    ..abstract_text> ..
  9. HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    Linda Giudice; Fiscal Year: 2001
    ..abstract_text> ..
  10. Summit on Environmental Challenges to Reproductive Health and Fertility
    Linda Giudice; Fiscal Year: 2007
    ..A federation comprising professional societies' environmental health representatives (to include the American Society of Reproductive Medicine, the Endocrine Society, and others) will be established. ..