Susan S Girdler

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Psychoneuroendocrinology 37:543-53. 2012
  2. pmc Neurosteroids in the context of stress: implications for depressive disorders
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, United States
    Pharmacol Ther 116:125-39. 2007
  3. ncbi request reprint Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
    Psychosom Med 66:403-10. 2004
  4. ncbi request reprint Cigarette smoking, stress-induced analgesia and pain perception in men and women
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Pain 114:372-85. 2005
  5. pmc Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Health Psychol 26:201-13. 2007
  6. ncbi request reprint Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effects
    Susan S Girdler
    Departments of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Obstet Gynecol 103:169-80. 2004
  7. ncbi request reprint Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 65:849-56. 2003
  8. ncbi request reprint Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder
    Patricia A Straneva
    Department of Psychology, University of North Carolina at Chapel Hill, 27599 7175, USA
    Health Psychol 21:358-67. 2002
  9. ncbi request reprint Ethnic differences in allopregnanolone concentrations in women during rest and following mental stress
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychophysiology 43:331-6. 2006
  10. pmc Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical School Wing D, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 84:235-47. 2010

Detail Information

Publications37

  1. pmc A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Psychoneuroendocrinology 37:543-53. 2012
    ....
  2. pmc Neurosteroids in the context of stress: implications for depressive disorders
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, United States
    Pharmacol Ther 116:125-39. 2007
    ....
  3. ncbi request reprint Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
    Psychosom Med 66:403-10. 2004
    ....
  4. ncbi request reprint Cigarette smoking, stress-induced analgesia and pain perception in men and women
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Pain 114:372-85. 2005
    ..The reduced pain perception in smokers and absence of relationships between endogenous pain regulatory mechanisms and pain sensitivity may reflect a maladaptive response to chronic smoking...
  5. pmc Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Health Psychol 26:201-13. 2007
    ..To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation...
  6. ncbi request reprint Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effects
    Susan S Girdler
    Departments of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Obstet Gynecol 103:169-80. 2004
    ....
  7. ncbi request reprint Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 65:849-56. 2003
    ..To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls...
  8. ncbi request reprint Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder
    Patricia A Straneva
    Department of Psychology, University of North Carolina at Chapel Hill, 27599 7175, USA
    Health Psychol 21:358-67. 2002
    ..Results suggest that endogenous opioids may be pathophysiologically relevant to PMDD and that the hypothalamic-pituitary-gonadal axis may modulate pain sensitivity in PMDD...
  9. ncbi request reprint Ethnic differences in allopregnanolone concentrations in women during rest and following mental stress
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychophysiology 43:331-6. 2006
    ..05). Results are interpreted to reflect dysregulation in ALLO mechanisms in AA women and may have implications for ethnic differences in mood disorders...
  10. pmc Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical School Wing D, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 84:235-47. 2010
    ..These results suggest both unique phenotypic differences between women with PMDD and those with a history of MDD, but also indicate that histories of MDD may have special relevance for PMDD...
  11. ncbi request reprint Depressive symptoms are related to higher ambulatory blood pressure in people with a family history of hypertension
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 66:9-16. 2004
    ..We investigated whether parental history of hypertension (FH+) enhances the impact of depressed mood, indexed by Beck Depression Inventory (BDI), on ambulatory blood pressure (ABP)...
  12. ncbi request reprint Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:281-96. 2005
    ....
  13. ncbi request reprint Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesterone
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Psychoneuroendocrinology 31:1208-19. 2006
    ....
  14. ncbi request reprint Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and women
    Karen M Grewen
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Blood Press Monit 10:117-24. 2005
    ..Prospective studies link marriage to better cardiovascular health, but marital dissatisfaction and discord predict increased rates of hypertension, higher blood pressure (BP), greater reactivity to stress, and left ventricular mass...
  15. ncbi request reprint Cardiovascular effects of 6 months of hormone replacement therapy versus placebo: differences associated with years since menopause
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina, Chapel Hill, 27599 7175, USA
    Am J Obstet Gynecol 190:1052-8. 2004
    ....
  16. ncbi request reprint African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures
    M Beth Mechlin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 67:948-56. 2005
    ..To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroendocrine factors...
  17. ncbi request reprint Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement
    Kathleen C Light
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7175, USA
    Horm Behav 47:540-8. 2005
    ..The findings suggest that enhanced oxytocinergic activity may contribute to BP decreases associated with ERT in more responsive postmenopausal women...
  18. doi request reprint Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women
    Karen M Grewen
    Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, USA
    Ethn Health 13:219-41. 2008
    ....
  19. pmc Menstrual cycle phase does not influence gender differences in experimental pain sensitivity
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Eur J Pain 14:77-82. 2010
    ..These results indicate that although women are more sensitive to a variety of noxious stimuli than men, menstrual cycle phase does not appear to moderate those differences in healthy men and women...
  20. ncbi request reprint Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Psychosom Med 67:531-8. 2005
    ....
  21. ncbi request reprint Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 71:2-11. 2006
    ....
  22. doi request reprint Ethnic differences in cardiovascular-somatosensory interactions and in the central processing of noxious stimuli
    Beth Mechlin
    Department of Psychology, Washington and Lee University, Lexington, Virginia 24450, USA
    Psychophysiology 48:762-73. 2011
    ..These results have implications for understanding biobehavioral factors contributing to ethnic disparities in clinical pain...
  23. pmc Race and histories of mood disorders modulate experimental pain tolerance in women
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    J Pain 8:861-8. 2007
    ..Persistent disturbance in pain modulatory mechanisms in women with a history of mood disorders may also have implications for the development of subsequent mood disturbances...
  24. ncbi request reprint Lack of beneficial effects of clonidine in the treatment of premenstrual dysphoric disorder: results of a double-blind, randomized study
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Psychopharmacol 20:33-9. 2005
    ..To test the effects of clonidine in comparison with active placebo on premenstrual symptoms, mood scores and norepinephrine (NE) concentration, in women with premenstrual dysphoric disorder (PMDD)...
  25. pmc The relationship of allopregnanolone immunoreactivity and HPA-axis measures to experimental pain sensitivity: Evidence for ethnic differences
    Beth Mechlin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Pain 131:142-52. 2007
    ..These results suggest that lower ALLO-ir concentrations are associated with decreased pain sensitivity in humans, especially in non-Hispanic Whites, and that this relationship may be mediated by HPA-axis function...
  26. pmc Asians differ from non-Hispanic Whites in experimental pain sensitivity
    Lauren N Rowell
    Department of Psychology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, United States
    Eur J Pain 15:764-71. 2011
    ..g. MAP and HR). The results may also have implications for understanding ethnic differences in clinical pain...
  27. pmc Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: association with histories of sexual abuse
    Adomas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7175, USA
    Psychosom Med 74:810-6. 2012
    ..In the present study, we sought to extend that work by examining the association of an SA history with HPT-axis disturbance in both women with MRMD and women without MRMD...
  28. ncbi request reprint Changes in hemodynamics and left ventricular structure after menopause
    Alan L Hinderliter
    University of North Carolina, Chapel Hill, North Carolina 27599 7075, USA
    Am J Cardiol 89:830-3. 2002
    ..These results suggest that menopause is associated with hemodynamic changes and left ventricular remodeling, which may contribute to the enhanced cardiovascular risk observed in postmenopausal women...
  29. ncbi request reprint Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exercise
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina, Chapel Hill 27599, USA
    Med Sci Sports Exerc 35:978-86. 2003
    ..This study examines the acute effects of moderate aerobic exercise on 1) hemodynamic and sympathetic activity during behavioral stress and 2) beta-adrenergic receptor responsivity in a biracial sample of 24 sedentary adults...
  30. doi request reprint Hormones, heart disease, and health: individualized medicine versus throwing the baby out with the bathwater
    David R Rubinow
    Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599 USA
    Depress Anxiety 28:E1-E15. 2011
    ..This review summarizes data supporting these contentions with the intent of placing depression and estrogen therapy in their proper physiologic context...
  31. ncbi request reprint Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients
    Patricia A Straneva-Meuse
    University of North Carolina at Chapel Hill, CB 7175, Medical Research Building A, Chapel Hill, NC 27599 7175, USA
    J Affect Disord 79:51-61. 2004
    ..There exists a need to identify safe and effective treatments for depression in patients with coronary heart disease (CHD)...
  32. pmc Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum
    Patrizia Porcu
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Steroids 74:463-73. 2009
    ..This method can be used to investigate the physiological and pathological role of neuroactive steroids and to develop biomarkers and new therapeutics for neurological and psychiatric disorders...
  33. ncbi request reprint Mood and thyroid immunity assessed by ultrasonographic imaging in a primary health care
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Affect Disord 97:85-90. 2007
    ..The aim of this study was to evaluate the impact of thyroid immunity, evident by hypo-echoic thyroid ultrasound pattern, on prevalence of depression and anxiety in a primary care setting...
  34. doi request reprint Hormones, heart disease, and health: individualized medicine versus throwing the baby out with the bathwater
    David R Rubinow
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Depress Anxiety 28:282-96. 2011
    ..This review summarizes data supporting this contention with the intent of placing depression and E2 therapy in their proper physiologic context...
  35. ncbi request reprint Warm partner contact is related to lower cardiovascular reactivity
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7175, USA
    Behav Med 29:123-30. 2003
    ..These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health...
  36. ncbi request reprint Depression and thyroid axis function in coronary artery disease: impact of cardiac impairment and gender
    Robertas Bunevicius
    Institute of Psychophysiology and Rehabilitation, Kaunas University of Medicine, Palanga, Lithuania
    Clin Cardiol 29:170-4. 2006
    ..Increased rates of depression are reported in coronary artery disease (CAD). In heart disease, depression increases disability, reduces quality of life, and increases mortality...
  37. ncbi request reprint Relationship of ethnicity, gender, and ambulatory blood pressure to pain sensitivity: effects of individualized pain rating scales
    Tavis S Campbell
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Pain 5:183-91. 2004
    ..In the context of clinical pain assessment, it may be important to consider the possibility that descriptions of painful sensations reflect, in part, demographic characteristics...

Research Grants20

  1. Childhood Trauma in the Adrenergic and HPA-Axis Regulation and Symptoms of PMDD
    SUSAN GIRDLER; Fiscal Year: 2009
    ..These results are intended to provide important insights into the pathophysiological significance of altered adrenergic activation in the subgroup of PMDD women with CA. ..
  2. Continuous OC Treatment in PMDD: Steroid Hormone Mechanisms
    SUSAN GIRDLER; Fiscal Year: 2009
    ..Confirmation of the role of hormonal change in precipitating PMDD will suggest therapeutic targets for future research. ..
  3. Childhood Trauma in the Adrenergic and HPA-Axis Regulation and Symptoms of PMDD
    Susan S Girdler; Fiscal Year: 2010
    ..These results are intended to provide important insights into the pathophysiological significance of altered adrenergic activation in the subgroup of PMDD women with CA. ..
  4. Continuous OC Treatment in PMDD: Steroid Hormone Mechanisms
    David R Rubinow; Fiscal Year: 2010
    ..Confirmation of the role of hormonal change in precipitating PMDD will suggest therapeutic targets for future research. ..
  5. Stress Responses, Psychosocial Stress and Pain Perception in African Americans
    Susan S Girdler; Fiscal Year: 2010
    ..This proposal is intended to forge new territory in the development of a bio-behavioral model relating to the development of clinical pain in African Americans. Project Description ..
  6. Childhood Trauma in the Adrenergic and HPA-Axis Regulation and Symptoms of PMDD
    SUSAN GIRDLER; Fiscal Year: 2007
    ..These results are intended to provide important insights into the pathophysiological significance of altered adrenergic activation in the subgroup of PMDD women with CA. ..
  7. GENDER,NICOTINE AND STRESS-INDUCED ANALGESIA
    SUSAN GIRDLER; Fiscal Year: 2004
    ..abstract_text> ..
  8. NEUROENDOCRINE MODULATION OF STRESS RESPONSES IN PMS
    SUSAN GIRDLER; Fiscal Year: 2003
    ..e. with versus without prior MD), yielding implications for clinical treatments. ..
  9. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2010
    ..Additionally, identification of predictors of benefits associated with short-term ERT would advance the goal of individualized medicine. ..