Beatrice M Girard

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Modulation of pituitary adenylate cyclase-activating polypeptide (PACAP) expression in explant-cultured guinea pig cardiac neurons
    Beatrice M Girard
    University of Vermont College of Medicine, Department of Anatomy and Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA
    Ann N Y Acad Sci 1070:298-302. 2006
  2. ncbi request reprint Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:730-43. 2012
  3. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
  4. pmc Pituitary adenylate cyclase 1 receptor internalization and endosomal signaling mediate the pituitary adenylate cyclase activating polypeptide-induced increase in guinea pig cardiac neuron excitability
    Laura A Merriam
    Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Neurosci 33:4614-22. 2013
  5. pmc PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:378-89. 2010
  6. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
  7. pmc Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture
    Beatrice M Girard
    Dept of Neurological Sciences, College of Medicine, Univ of Vermont, Burlington, VT 05405
    Am J Physiol Renal Physiol 305:F1504-12. 2013
  8. pmc Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats
    Bopaiah P Cheppudira
    Dept of Neurology, Univ of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 297:F1038-44. 2009
  9. ncbi request reprint Galanin expression in the mouse major pelvic ganglia during explant culture and following cavernous nerve transection
    Beatrice M Girard
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:713-20. 2012
  10. pmc Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT, USA
    J Mol Neurosci 36:188-99. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Modulation of pituitary adenylate cyclase-activating polypeptide (PACAP) expression in explant-cultured guinea pig cardiac neurons
    Beatrice M Girard
    University of Vermont College of Medicine, Department of Anatomy and Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA
    Ann N Y Acad Sci 1070:298-302. 2006
    ..Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels...
  2. ncbi request reprint Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:730-43. 2012
    ..These studies are consistent with target-derived NGF and other inflammatory mediators affecting neurochemical plasticity and the reflex function of micturition pathways...
  3. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
    ....
  4. pmc Pituitary adenylate cyclase 1 receptor internalization and endosomal signaling mediate the pituitary adenylate cyclase activating polypeptide-induced increase in guinea pig cardiac neuron excitability
    Laura A Merriam
    Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Neurosci 33:4614-22. 2013
    ..Our results demonstrate that PACAP/PAC1R complex endocytosis is a key step for the PACAP modulation of cardiac neuron excitability...
  5. pmc PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:378-89. 2010
    ..Changes in PACAP, VIP, and associated receptor transcripts and protein expression in micturition pathways resemble some, but not all, changes observed after induction of urinary bladder inflammation known to involve NGF production...
  6. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
    ..The current data demonstrate PACAP and PAC1 regulation in micturition pathways with inflammation and PACAP-mediated ATP release from urothelium...
  7. pmc Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture
    Beatrice M Girard
    Dept of Neurological Sciences, College of Medicine, Univ of Vermont, Burlington, VT 05405
    Am J Physiol Renal Physiol 305:F1504-12. 2013
    ....
  8. pmc Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats
    Bopaiah P Cheppudira
    Dept of Neurology, Univ of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 297:F1038-44. 2009
    ..These studies demonstrate a potential role for JAK-STAT signaling pathways in bladder hyperreflexia and referred pain induced by CYP-induced bladder inflammation...
  9. ncbi request reprint Galanin expression in the mouse major pelvic ganglia during explant culture and following cavernous nerve transection
    Beatrice M Girard
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:713-20. 2012
    ..As reported previously for PACAP, there is an injury-induced increase in MPG galanin expression, which occurs preferentially in the parasympathetic postganglionic neurons...
  10. pmc Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT, USA
    J Mol Neurosci 36:188-99. 2008
    ..This shift in balance may contribute to increased bladder dysfunction in VIP(-/-) mice with bladder inflammation and altered neurochemical expression in micturition pathways...
  11. pmc Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis
    Lauren Arms
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F589-600. 2010
    ..01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation...
  12. pmc Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation
    Lauren Arms
    Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 305:F111-22. 2013
    ..These studies suggest that chemokines/receptors may be novel targets with therapeutic potential in the context of urinary bladder inflammation. ..
  13. pmc Microarray analyses of pituitary adenylate cyclase activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons
    Karen M Braas
    Department of Anatomy and Neurobiology, The University of Vermont College of Medicine, Burlington, VT 05405, United States
    Peptides 28:1856-70. 2007
    ....
  14. ncbi request reprint Bone morphogenetic protein down-regulation of neuronal pituitary adenylate cyclase-activating polypeptide and reciprocal effects on vasoactive intestinal peptide expression
    Kristen A Pavelock
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Neurochem 100:603-16. 2007
    ..Furthermore, the liberation of SCG neurons from target-derived BMP inhibition following axotomy may be one participating mechanism associated with injury-induced neuropeptidergic plasticity...
  15. pmc Pretreatment with nonselective cationic channel inhibitors blunts the PACAP-induced increase in guinea pig cardiac neuron excitability
    Laura A Merriam
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:721-9. 2012
    ..The present results also demonstrate that nonselective cationic channel inhibitors could have other actions, which might contribute to the inhibition of the PACAP-induced excitability increase...
  16. pmc Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 300:F345-55. 2011
    ..01) increased in urinary bladder of NGF-OE mice. The NGF-OE-induced changes in neurotrophic factor/receptor expression in urinary bladder may represent compensatory changes to reduce voiding frequency in the NGF-OE mouse...
  17. pmc VIP and PACAP effects on mouse major pelvic ganglia neurons
    John D Tompkins
    Departments of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:390-6. 2010
    ..The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PAC1 receptors can modulate the activity of the autonomic neurons innervating pelvic organs...
  18. doi request reprint Neurturin suppresses injury-induced neuronal activating transcription factor 3 expression in cultured guinea pig cardiac ganglia
    Beth A Young
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Comp Neurol 508:795-805. 2008
    ..It is proposed that the loss of target-derived neurturin is a potential mechanism stimulating injury-induced expression of ATF-3 in cardiac neurons...
  19. pmc Expression and function of transforming growth factor-β isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis
    Eric J Gonzalez
    Univ of Vermont College of Medicine, Dept of Neurological Sciences, D415A Given Research Bldg, Burlington, VT 05405
    Am J Physiol Renal Physiol 305:F1265-76. 2013
    ....
  20. pmc Autonomic dysfunction and plasticity in micturition reflexes in human α-synuclein mice
    Robert W Hamill
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Dev Neurobiol 72:918-36. 2012
    ..SYN-OE mice provide an opportunity to examine early events underlying the molecular and cellular plasticity of autonomic nervous system pathways underlying synucleinopathies...
  21. ncbi request reprint Pituitary adenylate cyclase activating polypeptide and PAC1 receptor signaling increase Homer 1a expression in central and peripheral neurons
    Beatrice M Girard
    Departments of Anatomy and Neurobiology, and Pharmacology, University of Vermont College of Medicine, 149 Beaumont Avenue, HSRF 428, Burlington, VT 05405, USA
    Regul Pept 123:107-16. 2004
    ..In modulating H1a transcript and protein expression, these studies may implicate broad roles for PACAP and PAC1 receptor signaling in synaptic development and plasticity...
  22. pmc Increased expression of interleukin-6 family members and receptors in urinary bladder with cyclophosphamide-induced bladder inflammation in female rats
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine Burlington, VT, USA
    Front Neurosci 5:20. 2011
    ..These studies suggest that IL-6 and LIF may be potential upstream chemical mediators that activate JAK/STAT signaling in urinary bladder pathways...
  23. pmc Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis
    Bopaiah P Cheppudira
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 295:F826-36. 2008
    ..Functional role(s) for the VEGF-VEGF receptor system in urinary bladder inflammation remain to be determined...
  24. pmc Increased TRPV4 expression in urinary bladder and lumbosacral dorsal root ganglia in mice with chronic overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Neurological Sciences, University of Vermont College of Medicine, D415A Given Research Building, Burlington, VT, 05405, USA
    J Mol Neurosci 51:602-14. 2013
    ..These studies demonstrate regulation of TRPV4 expression by NGF in lower urinary tract tissues. Ongoing studies are characterizing the functional roles of TRPV4 expression in the sensory limb (DRG, urothelium) of the micturition reflex...
  25. pmc Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis
    Kimberly Corrow
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F1130-9. 2010
    ..Future studies are necessary to determine ASIC isoform contributions to micturition reflexes in control and inflamed urinary bladder...
  26. pmc Somatic ATP release from guinea pig sympathetic neurons does not require calcium-induced calcium release from internal stores
    Laura A Merriam
    Department of Anatomy and Neurobiology, Univ of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Cell Physiol 299:C836-43. 2010
    ..Although a caffeine-induced release of Ca(2+) from internal stores can elicit both SICs and ASTICs in dissociated sympathetic neurons, CICR is not required for the somatic release of ATP...
  27. pmc PACAP expression in explant cultured mouse major pelvic ganglia
    Beatrice M Girard
    Departments of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:370-7. 2010
    ....
  28. ncbi request reprint Regulation of neurotrophic peptide expression in sympathetic neurons: quantitative analysis using radioimmunoassay and real-time quantitative polymerase chain reaction
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Regul Pept 109:89-101. 2002
    ..The shorter depolarization-induced PACAP transcripts exhibit longer half-lives, suggesting that the short proPACAP mRNA variant may function to impart PACAP translational efficiency and sustain PACAP peptide production...