T J Giordano
Affiliation: University of Michigan
- Classification of adrenal cortical tumors: promise of the 'molecular' approachThomas J Giordano
University of Michigan Medical School, Department of Pathology, MSRB2, C570D, Ann Arbor, MI 48109, United States
Best Pract Res Clin Endocrinol Metab 24:887-92. 2010..Recent advances towards a molecular classification of adrenal cortical tumors are presented and discussed...
- Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profilesT J Giordano
Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109 0054, USA
Am J Pathol 159:1231-8. 2001....
- Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinomaC G Kleer
Department of Pathology, University of Michigan Medical Center, Ann Arbor, USA
Mod Pathol 13:742-6. 2000..Primary SCT is an aggressive neoplasm that may be found in association with TCV. p53 expression and high MIB1 labeling index occur in these tumors and may be useful prognosticators...
- Management of patients with adrenal cancer: recommendations of an international consensus conferenceD E Schteingart
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
Endocr Relat Cancer 12:667-80. 2005..Anti-angiogenic substances have only been applied in preclinical studies. The use of these and other agents in the treatment of adrenal cancer should be hypothesis-driven and based on a thorough analysis of tumor biology...
- Transcriptome analysis of endocrine tumors: clinical perspectivesT J Giordano
Department of Pathology, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0669, USA
Ann Endocrinol (Paris) 69:130-4. 2008..Here, some of the microarray studies that support the clinical use of transcriptome profiling for endocrine tumors are reviewed. In addition, some of the barriers to clinical implementation are discussed...
- Overexpression of CXC chemokines by an adrenocortical carcinoma: a novel clinical syndromeD E Schteingart
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Clin Endocrinol Metab 86:3968-74. 2001..Through their angiogenic and chemotactic properties these chemokines may play an important role in adrenal tumorigenesis...
- Identification and management of intravagal parathyroid adenomaT M Pawlik
Section of Endocrine Surgery, Department of Surgery, University of Michigan Medical Center, 2920 Taubman Health Care Center, 1500 E Medical Center Drive, Ann Arbor, Michigan 48109, USA
World J Surg 25:419-23. 2001..Examination of the vagus nerve should therefore be strongly considered when four normal glands are found, as intravagal adenomas appear to represent accessory ectopically located parathyroid tissue...
- Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breastC G Kleer
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
Mod Pathol 14:185-90. 2001..Neither Ki-67 nor p53 can reliably predict recurrence. Histologically high-grade malignant PT have a favorable prognosis if widely excised. We emphasize the importance of adequate margins in the treatment of benign and malignant PT...
- Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancerF Le Naour
Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Clin Cancer Res 7:3328-35. 2001..CONCLUSION: The presence of autoantibodies and/or circulating RS/DJ-1 protein in sera from patients with breast cancer may have clinical utility...
- Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinomaC T Miller
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Oncogene 25:409-18. 2006..The data indicate that upregulation of the MET pathway may contribute to the poor outcome of EA patients and that therapeutic agents targeting this pathway may help improve patient survival...
- An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancerF M Brichory
Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA
Proc Natl Acad Sci U S A 98:9824-9. 2001..The proteomic approach we have implemented has utility for the development of serum-based assays for cancer diagnosis as we report in this paper on the discovery of antiannexins I and/or II in sera from patients with lung cancer...