T J Giordano

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
  2. ncbi request reprint Gene expression profiling of endocrine tumors using DNA microarrays: progress and promise
    Thomas J Giordano
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA
    Endocr Pathol 14:107-16. 2003
  3. ncbi request reprint Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0054, USA
    Endocr Pathol 17:355-63. 2006
  4. doi request reprint Transcriptome analysis of endocrine tumors: clinical perspectives
    T J Giordano
    Department of Pathology, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0669, USA
    Ann Endocrinol (Paris) 69:130-4. 2008
  5. doi request reprint Genome-wide studies in thyroid neoplasia
    Thomas J Giordano
    Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Endocrinol Metab Clin North Am 37:311-31, vii-viii. 2008
  6. ncbi request reprint Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
  7. pmc Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
    Thomas J Giordano
    Departments of Pathology, Pediatrics, Surgery, and Biostatistics, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 162:521-31. 2003
  8. doi request reprint Adrenocortical tumors: an integrated clinical, pathologic, and molecular approach at the University of Michigan
    Thomas J Giordano
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0669, USA
    Arch Pathol Lab Med 134:1440-3. 2010
  9. pmc Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
    Thomas J Giordano
    Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, Ann Arbor, MI 48109 0669, USA
    Clin Cancer Res 15:668-76. 2009
  10. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002

Detail Information

Publications83

  1. pmc Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data
    Kerby Shedden
    Department of Statistics, University of Michigan, Ann Arbor, Michigan, USA
    BMC Bioinformatics 6:26. 2005
    ....
  2. ncbi request reprint Gene expression profiling of endocrine tumors using DNA microarrays: progress and promise
    Thomas J Giordano
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA
    Endocr Pathol 14:107-16. 2003
    ..In this review, the progress to date is summarized and the promise of DNA microarray analysis in conjunction with tissue array immunohistochemistry to significantly impact endocrine tumor diagnosis and prognosis is discussed...
  3. ncbi request reprint Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0054, USA
    Endocr Pathol 17:355-63. 2006
    ..Here, the relevant molecular pathology of adrenal cortical tumors is reviewed with special reference to those methods (e.g., DNA microarrays) that hold promise for improved diagnosis and prognosis, and prediction of therapeutic response...
  4. doi request reprint Transcriptome analysis of endocrine tumors: clinical perspectives
    T J Giordano
    Department of Pathology, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0669, USA
    Ann Endocrinol (Paris) 69:130-4. 2008
    ..Here, some of the microarray studies that support the clinical use of transcriptome profiling for endocrine tumors are reviewed. In addition, some of the barriers to clinical implementation are discussed...
  5. doi request reprint Genome-wide studies in thyroid neoplasia
    Thomas J Giordano
    Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Endocrinol Metab Clin North Am 37:311-31, vii-viii. 2008
    ....
  6. ncbi request reprint Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    Thomas J Giordano
    Department of Pathology, UH 2G332 0054, University of Michigan Medical School, Ann Arbor, 48109 0054, USA
    Oncogene 24:6646-56. 2005
    ....
  7. pmc Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
    Thomas J Giordano
    Departments of Pathology, Pediatrics, Surgery, and Biostatistics, University of Michigan Health System, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 162:521-31. 2003
    ..Moreover, we identified several genes that represent potential diagnostic markers and may play a role in the pathogenesis of ACC...
  8. doi request reprint Adrenocortical tumors: an integrated clinical, pathologic, and molecular approach at the University of Michigan
    Thomas J Giordano
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0669, USA
    Arch Pathol Lab Med 134:1440-3. 2010
    ..The University of Michigan Health System has a rich tradition in the study and treatment of endocrine neoplasia. Recently, an integrated clinical and research program focused on primary cancer of the adrenal gland has been developed...
  9. pmc Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
    Thomas J Giordano
    Department of Pathology, 1150 West Medical Center Drive, MSRB 2, C570D, Ann Arbor, MI 48109 0669, USA
    Clin Cancer Res 15:668-76. 2009
    ..For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance?..
  10. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002
    ..Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas...
  11. ncbi request reprint Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors
    Guoan Chen
    Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:2298-305. 2002
    ..The goal of this study was to identify potential protein markers in lung adenocarcinomas...
  12. doi request reprint AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma
    Daniel L Albertus
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Thorac Oncol 3:1236-44. 2008
    ..Analysis of serum autoantibodies to tumor antigens combined with gene expression profiling of primary tumors may provide insight into the mechanisms underlying lung carcinogenesis and identify new AD biomarkers...
  13. pmc Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 11:388-96. 2009
    ..The expression, mechanisms of regulation, and functional impact of INHBA (activin A) in lung adenocarcinoma (AD) have not been fully elucidated...
  14. ncbi request reprint Proteomic analysis of eIF-5A in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
    Proteomics 3:496-504. 2003
    ..Moreover, the investigation on agents that inhibit eIF-5A function is encouraged...
  15. pmc Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:12507-12. 2005
    ....
  16. pmc Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity
    Amy L Silvers
    Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2009-21. 2010
    ....
  17. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
    ..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy...
  18. ncbi request reprint Squamous cell carcinoma of the thyroid: an aggressive tumor associated with tall cell variant of papillary thyroid carcinoma
    C G Kleer
    Department of Pathology, University of Michigan Medical Center, Ann Arbor, USA
    Mod Pathol 13:742-6. 2000
    ..Primary SCT is an aggressive neoplasm that may be found in association with TCV. p53 expression and high MIB1 labeling index occur in these tumors and may be useful prognosticators...
  19. ncbi request reprint RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
    ..The purpose of this study was to identify differences in global gene expression profiles between stage I NSCLC tumors with ALR (ALR+) and those without ALR (ALR-)...
  20. ncbi request reprint Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  21. ncbi request reprint The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma
    Charles E Binkley
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Pancreas 29:254-63. 2004
    ....
  22. pmc Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
    Kerby Shedden
    Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 14:822-7. 2008
    ..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas...
  23. pmc L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 6:74-84. 2004
    ..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1...
  24. ncbi request reprint Delineation, functional validation, and bioinformatic evaluation of gene expression in thyroid follicular carcinomas with the PAX8-PPARG translocation
    Thomas J Giordano
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 12:1983-93. 2006
    ..These results have implications for the neoplastic mechanism of these follicular carcinomas...
  25. ncbi request reprint HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma
    Raffaele Ciampi
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Endocr Relat Cancer 14:445-52. 2007
    ..Expression of the HOOK3-RET cDNA in NIH3T3 cells resulted in the formation of transformed foci and in tumor formation after injection into nude mice, confirming the oncogenic nature of HOOK3-RET...
  26. pmc Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast
    Michael J Hayes
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Clin Cancer Res 14:4038-44. 2008
    ..By immunohistochemistry, normal beta-catenin was seen as membrane staining, and it was aberrant when >5% of tumor cells had nuclear or cytoplasmic accumulation or reduced membrane staining...
  27. ncbi request reprint Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    Craig D Logsdon
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:2649-57. 2003
    ..These data provide new insights into the molecular pathology of pancreatic cancer that may be useful for detection, diagnosis, and treatment...
  28. ncbi request reprint Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
    ..Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas...
  29. ncbi request reprint Management of patients with adrenal cancer: recommendations of an international consensus conference
    D E Schteingart
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Endocr Relat Cancer 12:667-80. 2005
    ..Anti-angiogenic substances have only been applied in preclinical studies. The use of these and other agents in the treatment of adrenal cancer should be hypothesis-driven and based on a thorough analysis of tumor biology...
  30. doi request reprint Proposal for modification of the ENSAT staging system for adrenocortical carcinoma using tumor grade
    Barbra S Miller
    Division of Endocrine Surgery, University of Michigan, Ann Arbor, MI, USA
    Langenbecks Arch Surg 395:955-61. 2010
    ..We hypothesized that incorporating tumor grade into the current European Network for the Study of Adrenal Tumors (ENSAT) staging system would improve the ability to more accurately predict time to recurrence and death...
  31. ncbi request reprint Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    Lin Lin
    Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
    Genes Chromosomes Cancer 45:319-31. 2006
    ..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development...
  32. ncbi request reprint The Health Insurance Portability and Accountability Act of 1996 (HIPAA) privacy rule: implications for clinical research
    Rachel Nosowsky
    Office of the Vice President and General Counsel, University of Michigan, Ann Arbor, Michigan 48109, USA
    Annu Rev Med 57:575-90. 2006
    ....
  33. ncbi request reprint Discordant protein and mRNA expression in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 1:304-13. 2002
    ..Using a quantitative analysis of mRNA and protein expression within the same lung adenocarcinomas, we showed that only a subset of the proteins exhibited a significant correlation with mRNA abundance...
  34. ncbi request reprint Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Clin Cancer Res 8:788-93. 2002
    ..Several reports have claimed expression of the HER2/neu (c-erbB-2) gene in a high percentage of OSs and that its expression is a poor prognostic factor and have advocated monoclonal antibody therapy in those cases...
  35. ncbi request reprint Genetic variation in 8q24 associated with risk of colorectal cancer
    Stephen B Gruber
    Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher, Ann Arbor, Michigan 48109, USA
    Cancer Biol Ther 6:1143-7. 2007
    ..2 (95% bootstrap CI = 1.16-17.8). Genetic variation at rs10505477 on 8q24 potentially accounts for 14% of CRC in this population and should be replicated in other studies...
  36. pmc An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer
    Xiao Song Wang
    Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
    Nat Biotechnol 27:1005-11. 2009
    ..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery...
  37. pmc Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway
    Eduardo Vilar
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 15:2829-39. 2009
    ..Our objective was to identify low molecular weight compounds with preferential activity against MSI colorectal cancers using combined gene expression data sets...
  38. doi request reprint Classification of adrenal cortical tumors: promise of the 'molecular' approach
    Thomas J Giordano
    University of Michigan Medical School, Department of Pathology, MSRB2, C570D, Ann Arbor, MI 48109, United States
    Best Pract Res Clin Endocrinol Metab 24:887-92. 2010
    ..Recent advances towards a molecular classification of adrenal cortical tumors are presented and discussed...
  39. pmc Thyroid carcinoma metastasis to skull with infringement of brain: treatment with radioiodine
    James C Sisson
    Division of Nuclear Medicine and Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan 48109 0028, USA
    Thyroid 19:297-303. 2009
    ..A patient with an enlarging metastasis of thyroid carcinoma to the skull that was impinging on the brain illustrates diagnostic and therapeutic strategies applicable to the treatment of metastatic carcinoma...
  40. doi request reprint Utility of cytology microarray constructed from effusion cell blocks for immunomarker validation
    Robert T Pu
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 114:300-6. 2008
    ..To our knowledge, there has been no report of constructing cytology microarray using effusion cell blocks and testing its utility in immunochemical marker validation...
  41. pmc Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma
    Ferdous M Barlaskar
    Department of Internal Medicine Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, 1502 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA
    J Clin Endocrinol Metab 94:204-12. 2009
    ..Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is largely empirical and ineffective. New treatments directed at molecular targets critical to the pathophysiology of ACC may prove more efficacious...
  42. ncbi request reprint Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mapping
    Jia Zhao
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 6:987-99. 2007
    ..These differentially expressed proteins may have utility as useful candidate markers of esophageal adenocarcinoma...
  43. doi request reprint Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses
    Israel Hodish
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109, USA
    Head Neck 31:699-706. 2009
    ..The majority of ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are localized in the chest or abdomen. Occasionally, these tumors are found in the paranasal sinuses...
  44. pmc First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome
    James C Sisson
    Department of Radiology, Division of Nuclear Medicine, University of Michigan Health System, UH B1 G505D, Ann Arbor, MI 48109 0028, USA
    Endocr Pathol 19:289-93. 2008
    ..The initial report of the proband preceded the publications defining both MTC and MEN 2A. The values of in-depth family histories and genetic analyses are exemplified...
  45. ncbi request reprint Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma
    Dennis P M Hughes
    Department of Pediatrics and Infectious Diseases, Division of Pediatric Hematology Oncology, University of Michigan Medical Center, L2110 Women s Hospital, 0238, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0238, USA
    Cancer Res 64:2047-53. 2004
    ..Therapy directed against this family of receptors may be beneficial for patients with osteosarcoma...
  46. pmc Protein profiles associated with survival in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:13537-42. 2003
    ..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer...
  47. ncbi request reprint Transforming properties of a Q18-->E mutation of the microtubule regulator Op18
    David E Misek
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 2:217-28. 2002
    ..These results suggest that the somatic mutation identified in Op18 has profound effects on cell homeostasis that may lead to tumorigenicity...
  48. ncbi request reprint Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    Dafydd G Thomas
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109 0602, USA
    Cancer 103:830-8. 2005
    ..Accordingly, there is a need for alternate therapies, such as those recently developed against the receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and HER-2/neu...
  49. ncbi request reprint Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
    ..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers...
  50. ncbi request reprint Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation
    Chad J Creighton
    Bioinformatics Program, Department of Pathology, University of Michigan, 4237 Med Sci I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Cancer Res 3:119-29. 2005
    ..Thus, analysis of tumor xenografts by gene expression profiling has the potential for identifying genes involved in tumor development that may not be expressed in cancer cells grown in vitro...
  51. ncbi request reprint Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  52. ncbi request reprint Molecular profiling and the identification of genes associated with metastatic oral cavity/pharynx squamous cell carcinoma
    Cecelia E Schmalbach
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0656, USA
    Arch Otolaryngol Head Neck Surg 130:295-302. 2004
    ..To investigate differences in gene expression profiles between oral cavity/oropharynx squamous cell carcinoma (OC/OP SCC) primary tumors that have metastasized to cervical lymph nodes and nonmetastatic OC/OP SCC tumors...
  53. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...
  54. ncbi request reprint CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium
    Takao Hinoi
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Gastroenterology 128:946-61. 2005
    ..To enhance knowledge of CDX2 function, we sought to define CDX2-regulated genes...
  55. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  56. ncbi request reprint An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer
    Su Hyung Hong
    Department of Pediatrics, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Cancer Res 64:5504-10. 2004
    ..The detection of autoantibodies to calreticulin isoforms may have utility for the early diagnosis of pancreatic cancer...
  57. pmc Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:1062-71. 2006
    ..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme...
  58. pmc IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype
    Guido T Bommer
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:1928-38. 2010
    ..Our findings add to the growing body of data implicating IRS1 as a critical signaling component in cancer development and progression...
  59. ncbi request reprint Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma
    Hassan R Dhaini
    Department of Environmental Health Sciences, Toxicology Program, University of Michigan, Ann Arbor 48109, USA
    J Clin Oncol 21:2481-5. 2003
    ..One of these, CYP3A4/5 is involved in metabolic activation and detoxification of a wide number of carcinogens and chemotherapeutic agents, including many drugs that are useful in the treatment of osteosarcomas...
  60. pmc Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines
    Edith J Mensah-Osman
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Cancer 109:957-65. 2007
    ....
  61. pmc Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles
    T J Giordano
    Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Am J Pathol 159:1231-8. 2001
    ....
  62. ncbi request reprint Overexpression of CXC chemokines by an adrenocortical carcinoma: a novel clinical syndrome
    D E Schteingart
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 86:3968-74. 2001
    ..Through their angiogenic and chemotactic properties these chemokines may play an important role in adrenal tumorigenesis...
  63. ncbi request reprint Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer
    F Le Naour
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 7:3328-35. 2001
    ..CONCLUSION: The presence of autoantibodies and/or circulating RS/DJ-1 protein in sera from patients with breast cancer may have clinical utility...
  64. doi request reprint INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Thorac Oncol 4:455-62. 2009
    ..The expression, mechanisms of regulation, and functional impact of activin (INHBA) in esophageal adenocarcinoma (EAC) have not been fully defined...
  65. ncbi request reprint Interferon regulatory factor 1 (IRF-1) and IRF-2 expression in breast cancer tissue microarrays
    Judith M Connett
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0654, USA
    J Interferon Cytokine Res 25:587-94. 2005
    ..These data support a model in which alterations of the expression of intracellular effectors of IFN-gamma signaling may diminish the immune-mediated tumor control mechanisms of IFN-gamma...
  66. ncbi request reprint Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    Donald R Schwartz
    Departments of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4722-9. 2002
    ..Moreover, these studies provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer...
  67. ncbi request reprint p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
    ..The role of p53 in transcription of other types of RNAs, such as microRNAs (miRNAs) is essentially unknown...
  68. ncbi request reprint Leiomyoma of the adrenal gland presenting as a non-functioning adrenal incidentaloma: case report and review of the literature
    Jingmei Lin
    Department of Pathology, University of Michigan Health System, 1150 West Medical Center Drive, MSRB 2, C570D, Ann Arbor, MI 48109 0669, USA
    Endocr Pathol 18:239-43. 2007
    ..This case illustrates that benign tumors such as leiomyomas, when large and heterogeneous on imaging, can clinically mimic adrenal cortical carcinomas and should be included in the differential diagnosis of adrenal incidentalomas...
  69. ncbi request reprint Pathologic, immunohistochemical, and molecular features of benign and malignant phyllodes tumors of the breast
    C G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Mod Pathol 14:185-90. 2001
    ..Neither Ki-67 nor p53 can reliably predict recurrence. Histologically high-grade malignant PT have a favorable prognosis if widely excised. We emphasize the importance of adequate margins in the treatment of benign and malignant PT...
  70. ncbi request reprint Identification and management of intravagal parathyroid adenoma
    T M Pawlik
    Section of Endocrine Surgery, Department of Surgery, University of Michigan Medical Center, 2920 Taubman Health Care Center, 1500 E Medical Center Drive, Ann Arbor, Michigan 48109, USA
    World J Surg 25:419-23. 2001
    ..Examination of the vagus nerve should therefore be strongly considered when four normal glands are found, as intravagal adenomas appear to represent accessory ectopically located parathyroid tissue...
  71. ncbi request reprint Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma
    C T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 25:409-18. 2006
    ..The data indicate that upregulation of the MET pathway may contribute to the poor outcome of EA patients and that therapeutic agents targeting this pathway may help improve patient survival...
  72. pmc An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer
    F M Brichory
    Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA
    Proc Natl Acad Sci U S A 98:9824-9. 2001
    ..The proteomic approach we have implemented has utility for the development of serum-based assays for cancer diagnosis as we report in this paper on the discovery of antiannexins I and/or II in sera from patients with lung cancer...
  73. ncbi request reprint Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition
    Dennis P M Hughes
    Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 46:614-23. 2006
    ..We wished to determine if erbB kinases in osteosarcoma were phosphorylated, and if this was required for growth...
  74. ncbi request reprint Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    Adebowale J Adeniran
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Am J Surg Pathol 30:216-22. 2006
    ..These findings demonstrate that BRAF, RET/PTC, and RAS mutations are associated with distinct microscopic, clinical, and biologic features of thyroid papillary carcinomas...
  75. ncbi request reprint Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    Qinghua Zeng
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 8:13-23. 2005
    ..Our results elucidate a novel mechanism by which the direct interplay between tumor cells and ECs promotes angiogenesis through MAPK and Notch signaling pathways...
  76. doi request reprint Perspectives for improved and more accurate classification of thyroid epithelial tumors
    Markus Eszlinger
    Third Medical Department, University of Leipzig, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 93:3286-94. 2008
    ....
  77. ncbi request reprint Expression levels of protein kinase C-alpha in non-small-cell lung cancer
    Michael Lahn
    Oncology Product Development, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Lung Cancer 6:184-9. 2004
    ..We found that PKC-alpha is highly expressed in < or = 20% of patients with NSCLC. We also found that PKC-alpha was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung...
  78. pmc EML4-ALK fusion lung cancer: a rare acquired event
    Sven Perner
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA
    Neoplasia 10:298-302. 2008
    ..Furthermore, we confirmed the NKX2-1 high-level amplification in a significant subset of NSCLC and found this amplification to be mutually exclusive to ALK and EML4 rearrangements...
  79. ncbi request reprint Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays
    Kevin K Dobbin
    Cancer Diagnosis Program, National Cancer Institute NIH, Bethesda, MD 20894, USA
    Clin Cancer Res 11:565-72. 2005
    ..The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study...
  80. ncbi request reprint Molecular profiling and personalized predictive pathology: challenge to the academic surgical pathology community
    Thomas J Giordano
    Am J Surg Pathol 30:402-4. 2006
  81. doi request reprint Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma
    Tobias Else
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 2200, USA
    J Clin Endocrinol Metab 93:1442-9. 2008
    ..Telomere maintenance mechanisms (TMMs) are critical for the persistence of the malignant phenotype, but little is known about these mechanisms or their diagnostic value in adrenocortical lesions...
  82. ncbi request reprint Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 10:6703-9. 2004
    ....
  83. ncbi request reprint Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 67:3461-7. 2007
    ..These studies indicate that autoantibody profiles, as well as individual candidates, may be useful for the noninvasive detection of lung adenocarcinoma...