Daniel Gioeli

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Signal transduction in prostate cancer progression
    Daniel Gioeli
    Department of Microbiology, University of Virginia Health System, PO Box 800734, Charlottesville, VA 22908, U S A
    Clin Sci (Lond) 108:293-308. 2005
  2. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
  3. ncbi request reprint Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells
    Robert E Bakin
    Department of Microbiology and Cancer Center and Paul Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1981-9. 2003
  4. pmc CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation
    Vicki Gordon
    University of Virginia, Department of Microbiology, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 24:2267-80. 2010
  5. pmc Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor
    Chun Song Yang
    Center for Cell Signaling, University of Virginia, Box 800577 Health Systems, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:1298-308. 2005
  6. ncbi request reprint Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    Sarah Kraus
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 66:11047-54. 2006
  7. ncbi request reprint Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor
    Cristina T Kesler
    Center for Cell Signaling, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 21:2071-84. 2007
  8. pmc Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen
    Hilary Whitworth
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e38950. 2012
  9. pmc The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    John DaSilva
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Cancer Res 69:7402-11. 2009
  10. ncbi request reprint Ras signaling in prostate cancer progression
    Michael J Weber
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:13-25. 2004

Collaborators

  • Michael J Weber
  • Julia D Wulfkuhle
  • Emanuel F Petricoin
  • Scott T Eblen
  • DAVID BRAUTIGAN
  • Carol A Lange
  • Stephen R Hammes
  • D Theodorescu
  • ROBERT SIKES
  • Bryce M Paschal
  • Mark Axelrod
  • Mark Conaway
  • Joshua B Kelley
  • Vicki Gordon
  • Robert E Bakin
  • Adam Spencer
  • Cristina T Kesler
  • Mark R Conaway
  • Chun Song Yang
  • Devin G Roller
  • Hilary Whitworth
  • Shriti Bhadel
  • John DaSilva
  • Leonard C Shank
  • Donald F Hunt
  • Jeffrey Shabanowitz
  • Dora Bigler
  • Sarah Kraus
  • Michael J Vitto
  • Ben E Black
  • Maofu Fu
  • Eric A Bissonette
  • Vicki L Gordon
  • Adel Tarcsafalvi
  • Daniel J Neitzke
  • Melissa Ivey
  • Karin Jensen
  • Heather Holemon
  • Ronald Hernan
  • Brian J Capaldo
  • Aaron Mackey
  • Andrea Spencer
  • Winfried Wunderlich
  • Scott B Ficarro
  • William C Hahn
  • Ashley M Talley
  • Ioannis Xenarios
  • Joann Zhang
  • Michael F Carey
  • Sahana A Mollah
  • Sarah J Parsons
  • Lizabeth A Allison
  • Tomas Vomastek
  • Benjamin A Garcia
  • Scott A Busby
  • Kathleen Rundell
  • Chenguang Wang
  • Kongming Wu
  • Richard G Pestell
  • Nima Afshar
  • Mahadev Rao
  • Xueping Zhang
  • Mohamed Hessien
  • Yee Guide Yeung

Detail Information

Publications22

  1. ncbi request reprint Signal transduction in prostate cancer progression
    Daniel Gioeli
    Department of Microbiology, University of Virginia Health System, PO Box 800734, Charlottesville, VA 22908, U S A
    Clin Sci (Lond) 108:293-308. 2005
    ..This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression...
  2. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
    ..Our data suggest that stress kinase signaling and nuclear export regulate AR transcriptional activity...
  3. ncbi request reprint Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells
    Robert E Bakin
    Department of Microbiology and Cancer Center and Paul Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1981-9. 2003
    ..This provides a common mechanism for prostate cancer progression driven by diverse agonists...
  4. pmc CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation
    Vicki Gordon
    University of Virginia, Department of Microbiology, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 24:2267-80. 2010
    ..Collectively these results suggest that CDK9 phosphorylation of AR S81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth...
  5. pmc Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor
    Chun Song Yang
    Center for Cell Signaling, University of Virginia, Box 800577 Health Systems, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:1298-308. 2005
    ..Thus, ST functions as a transfer factor to specify PP2A targeting in the cell and modulates the transcriptional activity of AR...
  6. ncbi request reprint Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    Sarah Kraus
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 66:11047-54. 2006
    ..Our results suggest that RACK1 mediates the cross-talk of AR with additional binding partners, such as Src, and facilitates the tyrosine phosphorylation and transcriptional activity of the AR...
  7. ncbi request reprint Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor
    Cristina T Kesler
    Center for Cell Signaling, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 21:2071-84. 2007
    ..We propose that one function of nucleocytoplasmic shuttling is to integrate the signaling environment in the cytoplasm with AR activity in the nucleus...
  8. pmc Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen
    Hilary Whitworth
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 7:e38950. 2012
    ..The thorough evaluation of these kinase targets will pave the way for developing more effective treatments for castration-resistant prostate cancer...
  9. pmc The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    John DaSilva
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Cancer Res 69:7402-11. 2009
    ..These events result in increased accumulation of AR and thus enhanced growth of prostate cancer cells at low levels of androgen...
  10. ncbi request reprint Ras signaling in prostate cancer progression
    Michael J Weber
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:13-25. 2004
    ..g., phosphorylations) of transcriptional cofactors might be responsible for modulating the function of the AR so that it is active even at low concentrations of androgen...
  11. pmc Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer
    Daniel Gioeli
    Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cancer Ther 10:1581-90. 2011
    ..Thus, the identification of compensatory signal transduction pathways paves the way for rational combinatorial therapies for the effective treatment of prostate cancer...
  12. pmc Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma
    Devin G Roller
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Jordan Hall Rm 2 16, Box 800734, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Mol Cancer Ther 11:2505-15. 2012
    ..This study has uncovered novel functional drug combinations and suggests that the underlying signaling networks that control responses to targeted agents can vary substantially, depending on unexplored components of the cell genotype...
  13. pmc Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms
    Mark Axelrod
    Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, USA
    Oncotarget 4:622-35. 2013
    ..In addition, we identified BAD as a node of convergence between these two pathways that may be playing a role in the enhanced apoptosis observed upon combination treatment...
  14. doi request reprint Post-translational modification of the androgen receptor
    Daniel Gioeli
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    Mol Cell Endocrinol 352:70-8. 2012
    ..Here, we review how post-translational modification contributes to AR function as a transcription factor with particular emphasis on phosphorylation and dephosphorylation mechanisms...
  15. pmc Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors
    Joshua B Kelley
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    BMC Cell Biol 11:63. 2010
    ..To date, six importin alpha family members, encoded by separate genes, have been described in humans...
  16. ncbi request reprint Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions
    Ben E Black
    Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, Box 800577 Health Systems, University of Virginia, Charlottesville, VA 22908, USA
    Mol Endocrinol 18:834-50. 2004
    ..Our working model is that the subnuclear foci are sites where AR undergoes ligand-dependent engagement with GRIP-1 and CBP, a recruitment step that occurs before Ser81 phosphorylation and association with promoters of target genes...
  17. ncbi request reprint Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells
    Robert E Bakin
    Department of Microbiology, Cancer Center and Paul Mellon Prostate Cancer Institute, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1975-80. 2003
    ....
  18. ncbi request reprint Rap2 regulates androgen sensitivity in human prostate cancer cells
    Dora Bigler
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Prostate 67:1590-9. 2007
    ..Here we ask if Rap proteins play a role in determining androgen sensitivity of human prostate cancer cells either alone or in the context of an activated Ras...
  19. ncbi request reprint The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity
    Maofu Fu
    Department of Oncology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 279:29436-49. 2004
    ..Together these studies suggest that acetylation and phosphorylation of the AR are linked events and that the conserved AR lysine motif contributes to a select subset of pathways governing AR activity...
  20. ncbi request reprint Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    Carol A Lange
    Department of Medicine Division of Hematology, Oncology, and Transplant, USA
    Annu Rev Physiol 69:171-99. 2007
    ....
  21. doi request reprint Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro
    Leonard C Shank
    Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:10568-80. 2008
    ..We suggest that DNA-dependent protein kinase phosphorylation of the androgen receptor, or an interacting component, helps target the androgen receptor for export from the nucleus...
  22. ncbi request reprint Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites
    Daniel Gioeli
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:29304-14. 2002
    ..These data provide a basis for analyzing mechanisms of cross-talk between growth factor signaling and androgen in prostate development, physiology, and cancer...