Daniel G Gioeli

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites
    Daniel Gioeli
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:29304-14. 2002
  2. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
  3. pmc Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer
    Daniel Gioeli
    Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cancer Ther 10:1581-90. 2011
  4. ncbi request reprint Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells
    Robert E Bakin
    Department of Microbiology and Cancer Center and Paul Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1981-9. 2003
  5. doi request reprint Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro
    Leonard C Shank
    Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:10568-80. 2008
  6. ncbi request reprint Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells
    Robert E Bakin
    Department of Microbiology, Cancer Center and Paul Mellon Prostate Cancer Institute, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1975-80. 2003
  7. pmc FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    Li Ni
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 30:1243-53. 2010
  8. ncbi request reprint Signal transduction in prostate cancer progression
    Daniel Gioeli
    Department of Microbiology, University of Virginia Health System, PO Box 800734, Charlottesville, VA 22908, U S A
    Clin Sci (Lond) 108:293-308. 2005
  9. ncbi request reprint Ras signaling in prostate cancer progression
    Michael J Weber
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:13-25. 2004
  10. ncbi request reprint Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    Sarah Kraus
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 66:11047-54. 2006

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites
    Daniel Gioeli
    Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:29304-14. 2002
    ..These data provide a basis for analyzing mechanisms of cross-talk between growth factor signaling and androgen in prostate development, physiology, and cancer...
  2. ncbi request reprint Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization
    Daniel Gioeli
    Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:503-15. 2006
    ..Our data suggest that stress kinase signaling and nuclear export regulate AR transcriptional activity...
  3. pmc Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer
    Daniel Gioeli
    Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
    Mol Cancer Ther 10:1581-90. 2011
    ..Thus, the identification of compensatory signal transduction pathways paves the way for rational combinatorial therapies for the effective treatment of prostate cancer...
  4. ncbi request reprint Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells
    Robert E Bakin
    Department of Microbiology and Cancer Center and Paul Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1981-9. 2003
    ..This provides a common mechanism for prostate cancer progression driven by diverse agonists...
  5. doi request reprint Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro
    Leonard C Shank
    Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 283:10568-80. 2008
    ..We suggest that DNA-dependent protein kinase phosphorylation of the androgen receptor, or an interacting component, helps target the androgen receptor for export from the nucleus...
  6. ncbi request reprint Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cells
    Robert E Bakin
    Department of Microbiology, Cancer Center and Paul Mellon Prostate Cancer Institute, Charlottesville, Virginia 22908, USA
    Cancer Res 63:1975-80. 2003
    ....
  7. pmc FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells
    Li Ni
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 30:1243-53. 2010
    ..Because the superchaperone complex plays a critical role in determining the ligand-binding competence and transcription function of AR, it provides an attractive target for inhibiting AR activity in prostate cancer cells...
  8. ncbi request reprint Signal transduction in prostate cancer progression
    Daniel Gioeli
    Department of Microbiology, University of Virginia Health System, PO Box 800734, Charlottesville, VA 22908, U S A
    Clin Sci (Lond) 108:293-308. 2005
    ..This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression...
  9. ncbi request reprint Ras signaling in prostate cancer progression
    Michael J Weber
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Cell Biochem 91:13-25. 2004
    ..g., phosphorylations) of transcriptional cofactors might be responsible for modulating the function of the AR so that it is active even at low concentrations of androgen...
  10. ncbi request reprint Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor
    Sarah Kraus
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 66:11047-54. 2006
    ..Our results suggest that RACK1 mediates the cross-talk of AR with additional binding partners, such as Src, and facilitates the tyrosine phosphorylation and transcriptional activity of the AR...
  11. pmc The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor
    John DaSilva
    Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
    Cancer Res 69:7402-11. 2009
    ..These events result in increased accumulation of AR and thus enhanced growth of prostate cancer cells at low levels of androgen...
  12. ncbi request reprint Rap2 regulates androgen sensitivity in human prostate cancer cells
    Dora Bigler
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Prostate 67:1590-9. 2007
    ..Here we ask if Rap proteins play a role in determining androgen sensitivity of human prostate cancer cells either alone or in the context of an activated Ras...
  13. pmc Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor
    Chun Song Yang
    Center for Cell Signaling, University of Virginia, Box 800577 Health Systems, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:1298-308. 2005
    ..Thus, ST functions as a transfer factor to specify PP2A targeting in the cell and modulates the transcriptional activity of AR...
  14. ncbi request reprint Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor
    Cristina T Kesler
    Center for Cell Signaling, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 21:2071-84. 2007
    ..We propose that one function of nucleocytoplasmic shuttling is to integrate the signaling environment in the cytoplasm with AR activity in the nucleus...
  15. pmc p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
    Mark J Axelrod
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA Department of Otolaryngology Head and Neck Surgery, University of Virginia, Charlottesville, VA, USA Electronic address
    Cell Signal 26:1627-35. 2014
    ..The ability of direct inhibitors of p70S6K to phenocopy co-inhibition of two upstream signaling targets indicates that identification and targeting of critical nodes can overcome adaptive resistance to targeted therapies. ..
  16. ncbi request reprint Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions
    Ben E Black
    Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, Box 800577 Health Systems, University of Virginia, Charlottesville, VA 22908, USA
    Mol Endocrinol 18:834-50. 2004
    ..Our working model is that the subnuclear foci are sites where AR undergoes ligand-dependent engagement with GRIP-1 and CBP, a recruitment step that occurs before Ser81 phosphorylation and association with promoters of target genes...
  17. ncbi request reprint The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity
    Maofu Fu
    Department of Oncology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 279:29436-49. 2004
    ..Together these studies suggest that acetylation and phosphorylation of the AR are linked events and that the conserved AR lysine motif contributes to a select subset of pathways governing AR activity...
  18. ncbi request reprint Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    Carol A Lange
    Department of Medicine Division of Hematology, Oncology, and Transplant, USA
    Annu Rev Physiol 69:171-99. 2007
    ....

Research Grants3