Research Topics
Genomes and GenesSpecies | Daniel G GioeliSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sitesDaniel Gioeli
Department of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Biol Chem 277:29304-14. 2002..These data provide a basis for analyzing mechanisms of cross-talk between growth factor signaling and androgen in prostate development, physiology, and cancer...
Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancerDaniel Gioeli
Department of Microbiology, PO Box 800734, University of Virginia Health System, Charlottesville, VA 22908, USA
Mol Cancer Ther 10:1581-90. 2011..Thus, the identification of compensatory signal transduction pathways paves the way for rational combinatorial therapies for the effective treatment of prostate cancer...- Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localizationDaniel Gioeli
Department of Microbiology, P O Box 800734, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Mol Endocrinol 20:503-15. 2006..Our data suggest that stress kinase signaling and nuclear export regulate AR transcriptional activity... - Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cellsRobert E Bakin
Department of Microbiology and Cancer Center and Paul Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
Cancer Res 63:1981-9. 2003..This provides a common mechanism for prostate cancer progression driven by diverse agonists... 
Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitroLeonard C Shank
Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Biol Chem 283:10568-80. 2008..We suggest that DNA-dependent protein kinase phosphorylation of the androgen receptor, or an interacting component, helps target the androgen receptor for export from the nucleus...- Attenuation of Ras signaling restores androgen sensitivity to hormone-refractory C4-2 prostate cancer cellsRobert E Bakin
Department of Microbiology, Cancer Center and Paul Mellon Prostate Cancer Institute, Charlottesville, Virginia 22908, USA
Cancer Res 63:1975-80. 2003.... - Signal transduction in prostate cancer progressionDaniel Gioeli
Department of Microbiology, University of Virginia Health System, PO Box 800734, Charlottesville, VA 22908, U S A
Clin Sci (Lond) 108:293-308. 2005..This review will focus on the role of growth factor signalling in prostate cancer progression to androgen independence and thus outline potential molecular areas of intervention to treat prostate cancer progression... - FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cellsLi Ni
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Mol Cell Biol 30:1243-53. 2010..Because the superchaperone complex plays a critical role in determining the ligand-binding competence and transcription function of AR, it provides an attractive target for inhibiting AR activity in prostate cancer cells... - Ras signaling in prostate cancer progressionMichael J Weber
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Cell Biochem 91:13-25. 2004..g., phosphorylations) of transcriptional cofactors might be responsible for modulating the function of the AR so that it is active even at low concentrations of androgen... - Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptorSarah Kraus
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA
Cancer Res 66:11047-54. 2006..Our results suggest that RACK1 mediates the cross-talk of AR with additional binding partners, such as Src, and facilitates the tyrosine phosphorylation and transcriptional activity of the AR... - Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptorChun-Song Yang
Center for Cell Signaling, University of Virginia, Box 800577 Health Systems, Charlottesville, VA 22908, USA
Mol Cell Biol 25:1298-308. 2005..Thus, ST functions as a transfer factor to specify PP2A targeting in the cell and modulates the transcriptional activity of AR... - The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptorJohn DaSilva
Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908 0734, USA
Cancer Res 69:7402-11. 2009..These events result in increased accumulation of AR and thus enhanced growth of prostate cancer cells at low levels of androgen... - Rap2 regulates androgen sensitivity in human prostate cancer cellsDora Bigler
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Prostate 67:1590-9. 2007..Here we ask if Rap proteins play a role in determining androgen sensitivity of human prostate cancer cells either alone or in the context of an activated Ras... - Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptorCristina T Kesler
Center for Cell Signaling, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Mol Endocrinol 21:2071-84. 2007..We propose that one function of nucleocytoplasmic shuttling is to integrate the signaling environment in the cytoplasm with AR activity in the nucleus... - Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactionsBen E Black
Center for Cell Signaling, Department of Biochemistry and Molecular Genetics, Box 800577 Health Systems, University of Virginia, Charlottesville, VA 22908, USA
Mol Endocrinol 18:834-50. 2004..Our working model is that the subnuclear foci are sites where AR undergoes ligand-dependent engagement with GRIP-1 and CBP, a recruitment step that occurs before Ser81 phosphorylation and association with promoters of target genes... - The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activityMaofu Fu
Department of Oncology, Georgetown University Medical Center, Washington, D C 20057, USA
J Biol Chem 279:29436-49. 2004..Together these studies suggest that acetylation and phosphorylation of the AR are linked events and that the conserved AR lysine motif contributes to a select subset of pathways governing AR activity... - Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancerCarol A Lange
Department of Medicine Division of Hematology, Oncology, and Transplant, USA
Annu Rev Physiol 69:171-99. 2007....
Research Grants
- Role of Androgen Receptor Phosphorylation in Prostate CancerDaniel Gioeli; Fiscal Year: 2009....
- Role of Androgen Receptor Phosphorylation in Prostate CancerDaniel G Gioeli; Fiscal Year: 2010....