O J Ginther

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Complex interrelationships among CL, preovulatory follicle, number of follicular waves, and right or left ovaries in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA Electronic address
    Theriogenology 81:481-9. 2014
  2. ncbi request reprint Regulation of circulating gonadotropins by the negative effects of ovarian hormones in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 73:315-23. 2005
  3. pmc Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 130:379-88. 2005
  4. ncbi request reprint Relationships of follicle versus oocyte maturity to ultrasound morphology, blood flow, and hormone concentrations of the preovulatory follicle in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 77:202-8. 2007
  5. ncbi request reprint Temporal associations among pulses of 13,14-dihydro-15-keto-PGF2alpha, luteal blood flow, and luteolysis in cattle
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 76:506-13. 2007
  6. ncbi request reprint Follicle deviation and diurnal variation in circulating hormone concentrations in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 100:197-203. 2007
  7. doi request reprint Follicle and systemic hormone interrelationships during spontaneous and ablation-induced ovulatory waves in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 106:181-7. 2008
  8. ncbi request reprint Effect of prostaglandin F2alpha on ovarian, adrenal, and pituitary hormones and on luteal blood flow in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, United States
    Domest Anim Endocrinol 32:315-28. 2007
  9. ncbi request reprint In vivo effects of an intrafollicular injection of insulin-like growth factor 1 on the mechanism of follicle deviation in heifers and mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 70:99-105. 2004
  10. ncbi request reprint Controlling interrelationships of progesterone/LH and estradiol/LH in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 95:144-50. 2006

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. doi request reprint Complex interrelationships among CL, preovulatory follicle, number of follicular waves, and right or left ovaries in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA Electronic address
    Theriogenology 81:481-9. 2014
    ..The hypothesis was supported that the ipsilateral versus contralateral relationship between the PF and CL is affected by the DF-CL relationship during the previous follicular waves and by the number and identity of waves per IOI. ..
  2. ncbi request reprint Regulation of circulating gonadotropins by the negative effects of ovarian hormones in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 73:315-23. 2005
    ..There was no indication of a positive ovarian effect on either FSH or LH...
  3. pmc Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 130:379-88. 2005
    ..Thus, mares may be useful research models for studying the role and mechanism of the action of FSH in emergence and deviation during the ovulatory follicular wave in women...
  4. ncbi request reprint Relationships of follicle versus oocyte maturity to ultrasound morphology, blood flow, and hormone concentrations of the preovulatory follicle in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 77:202-8. 2007
    ..Greater follicular-fluid progesterone and lower E2 and free IGF concentrations were associated temporally with maturation of the oocyte but not with maturation of the follicle...
  5. ncbi request reprint Temporal associations among pulses of 13,14-dihydro-15-keto-PGF2alpha, luteal blood flow, and luteolysis in cattle
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 76:506-13. 2007
    ..03) to baseline. Results supported the hypothesis that CL blood flow increased and decreased with individual PGFM pulses during spontaneous luteolysis...
  6. ncbi request reprint Follicle deviation and diurnal variation in circulating hormone concentrations in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 100:197-203. 2007
    ..The beginning of deviation was encompassed by a decline (P<0.003) in cortisol concentrations, and the concentrations remained low during the preovulatory period...
  7. doi request reprint Follicle and systemic hormone interrelationships during spontaneous and ablation-induced ovulatory waves in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 106:181-7. 2008
    ..The frequency of two dominant follicles/wave was not different between induced waves (7 of 21) and spontaneous waves (9 of 21), but both dominant follicles ovulated more frequently in induced waves (6 of 7 waves compared with 0 of 9)...
  8. ncbi request reprint Effect of prostaglandin F2alpha on ovarian, adrenal, and pituitary hormones and on luteal blood flow in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, United States
    Domest Anim Endocrinol 32:315-28. 2007
    ..Luteolysis, as indicated by decreasing progesterone, began well before the beginning of a decrease in luteal blood flow...
  9. ncbi request reprint In vivo effects of an intrafollicular injection of insulin-like growth factor 1 on the mechanism of follicle deviation in heifers and mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 70:99-105. 2004
    ....
  10. ncbi request reprint Controlling interrelationships of progesterone/LH and estradiol/LH in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 95:144-50. 2006
    ..8 ng/ml/day for Day 22 to 1 day after the second ovulation. The end of the first segment and beginning of the second segment was 2 days before ovulation and was the day the ovulatory estradiol surge was at a peak...
  11. ncbi request reprint Dose-response study of intrafollicular injection of insulin-like growth factor-I on follicular fluid factors and follicle dominance in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 70:1063-9. 2004
    ..Hence, a physiologic intrafollicular dose of IGF-I did not stimulate estradiol production but reduced the production of androstenedione and stimulated the production of activin-A, inhibin-A, and VEGF during follicle selection in mares...
  12. ncbi request reprint Critical role of insulin-like growth factor system in follicle selection and dominance in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 70:1374-9. 2004
    ....
  13. doi request reprint Disruption of the periovulatory LH surge by a transient increase in circulating 17beta-estradiol at the time of ovulation in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA
    Anim Reprod Sci 117:178-82. 2010
    ..The source of the circulating estradiol was likely from the discharge of estradiol-laden follicular fluid into the abdomen during ovulation and rapid absorption of estradiol into the circulation...
  14. doi request reprint Physiologic and nonphysiologic effects of exogenous prostaglandin F2alpha on reproductive hormones in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA
    Theriogenology 72:417-24. 2009
    ..Past conclusions on the nature of the luteolytic mechanism are problematic if based on responses to treatment with a single luteolytic bolus of PGF...
  15. pmc Comparative study of the dynamics of follicular waves in mares and women
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 71:1195-201. 2004
    ..Similar follicle dynamics between mares and women indicate the mare may be a useful experimental model for study of folliculogenesis in women, with the advantage of larger follicle size...
  16. doi request reprint Progesterone responses to intravenous and intrauterine infusions of prostaglandin F2alpha in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 21:688-95. 2009
    ..05 and 0.1 mg i.v. groups and 2 days after treatment in the 0.5 and 1.0 mg i.v. groups. The results support the hypotheses of a systemic uteroluteal route for PGF transfer and that one pulse produces only partial luteolysis in mares...
  17. doi request reprint Follicle suppression of circulating follicle-stimulating hormone and luteinizing hormone before versus after emergence of the ovulatory wave in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 72:445-52. 2009
    ..5 ablation group or after the expected emergence of the ovulatory wave. The hypothesis of an association between low postovulatory concentrations of an ovarian steroid and low concentrations of LH after Day 15 was supported...
  18. doi request reprint Necessity of sequential pulses of prostaglandin F2alpha for complete physiologic luteolysis in cattle
    O J Ginther
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, corrected USA corrected
    Biol Reprod 80:641-8. 2009
    ..Results indicated that excessive PGF doses may stimulate nonphysiologic progesterone responses and supported the hypothesis that sequential PGF pulses are required to stimulate natural luteolysis in cattle...
  19. ncbi request reprint Effects of age on follicle and hormone dynamics during the oestrous cycle in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 20:955-63. 2008
    ..05) in the old group. The results indicate the importance of considering the potential confounding effects of age in experimental protocols and for considering age in the development of theriogenology programmes...
  20. ncbi request reprint Induction of haemorrhagic anovulatory follicles in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 20:947-54. 2008
    ....
  21. doi request reprint Treatment with human chorionic gonadotropin (hCG) for ovulation induction is associated with an immediate 17beta-estradiol decrease and a more rapid LH increase in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 114:311-7. 2009
    ....
  22. doi request reprint Development of one vs multiple ovulatory follicles and associated systemic hormone concentrations in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Domest Anim 44:441-9. 2009
    ....
  23. ncbi request reprint Characterisation of pulses of 13,14-dihydro-15-keto-PGF2alpha (PGFM) and relationships between PGFM pulses and luteal blood flow before, during, and after luteolysis in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 20:684-93. 2008
    ..Results indicated that a reported increase in luteal blood flow in heifers during the ascending portion of a PGFM pulse does not occur in mares...
  24. doi request reprint Passage of postovulatory follicular fluid into the peritoneal cavity and the effect on concentrations of circulating hormones in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 107:1-8. 2008
    ....
  25. doi request reprint Age-related dynamics of follicles and hormones during an induced ovulatory follicular wave in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 71:780-8. 2009
    ....
  26. ncbi request reprint Negative effect of estradiol on luteinizing hormone throughout the ovulatory luteinizing hormone surge in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 77:543-50. 2007
    ..Results also indicated that a reciprocal negative effect of LH on E2 does not develop until the E2 surge reaches a peak...
  27. doi request reprint Follicle diameters and hormone concentrations in the development of single versus double ovulations in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 69:583-90. 2008
    ....
  28. ncbi request reprint Intrafollicular effect of IGF1 on development of follicle dominance in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 105:417-23. 2008
    ..Results demonstrated that the IGF1 system plays a pivotal intrafollicular role in the deviation mechanism without altering systemic concentrations of the gonadotropins and ovarian follicular hormones...
  29. ncbi request reprint Luteal blood flow and progesterone production in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 99:213-20. 2007
    ..There was no indication that an acute increase or decrease in luteal blood flow occurred prior to the precipitous decrease in plasma progesterone...
  30. ncbi request reprint Activin A, estradiol, and free insulin-like growth factor I in follicular fluid preceding the experimental assumption of follicle dominance in cattle
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, 1656 Linden Drive, Madison, WI 53706, USA
    Biol Reprod 67:14-9. 2002
    ....
  31. doi request reprint Follicular-phase concentrations of progesterone, estradiol-17β, LH, FSH, and a PGF2α metabolite and daily clustering of prolactin pulses, based on hourly blood sampling and hourly detection of ovulation in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 79:918-28. 2013
    ....
  32. ncbi request reprint In vivo effects of pregnancy-associated plasma protein-A, activin-A and vascular endothelial growth factor on other follicular-fluid factors during follicle deviation in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 129:489-96. 2005
    ....
  33. doi request reprint Effect of HCG in the presence of HCG antibodies on the follicle, hormone concentrations, and oocyte in mares
    M A R Siddiqui
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Domest Anim 44:474-9. 2009
    ..001) mature (MII) oocytes than the antibody-negative group. Results were attributable to highly effective neutralization of the hCG in the antibody-positive group...
  34. ncbi request reprint Follicle and endocrine dynamics during experimental follicle deviation in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Biol Reprod 67:862-7. 2002
    ..05) in F2 than in F3 by the beginning of experimental deviation. Temporally, this result indicated that intrafollicular IGF-1 was involved in conversion of F2 from a destined subordinate follicle to a dominant follicle...
  35. doi request reprint Endocrinology of number of follicular waves per estrous cycle and contralateral or ipsilateral relationship between corpus luteum and preovulatory follicle in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, WI, US
    Domest Anim Endocrinol 45:64-71. 2013
    ..Extension of the luteal phase in the Contra-3W group was temporally associated with lower concentrations of LH and estradiol. ..
  36. doi request reprint Interrelationships among progesterone, LH, and luteal blood flow during a pulse of a PGF2α metabolite and functional role of LH in the progesterone rebound in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 79:1110-9. 2013
    ....
  37. doi request reprint Temporal interrelationships at 15-min intervals among oxytocin, LH, and progesterone during a pulse of a prostaglandin F2α metabolite in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 133:63-70. 2012
    ..The hypothesis that the progesterone rebound after the peak of a PGFM pulse is temporally related to an LH pulse was supported...
  38. doi request reprint Direct effect of PGF2α pulses on PRL pulses, based on inhibition of PRL or PGF2α secretion in heifers
    F L V Pinaffi
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Theriogenology 78:678-87. 2012
    ..The hypothesis was supported that the synchrony of PGFM and PRL pulses represents a positive effect of PGF(2α) on PRL, rather than an effect of PRL on PGF(2α)...
  39. doi request reprint Inhibition of prostaglandin biosynthesis during postluteolysis and effects on CL regression, prolactin, and ovulation in heifers
    G Pugliesi
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Theriogenology 78:443-54. 2012
    ..However, the hypotheses that pulses of PGFM and PRL were temporally related and that systemic FM treatment induced an anovulatory follicle were supported...
  40. doi request reprint Circulating hormone concentrations within a pulse of a metabolite of prostaglandin F2α during preluteolysis and early luteolysis in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 122:253-8. 2010
    ....
  41. ncbi request reprint Miniature ponies: 2. Endocrinology of the oestrous cycle
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 20:386-90. 2008
    ....
  42. pmc Role of follicular estradiol-17beta in timing of luteolysis in heifers
    Reno R Araujo
    Department of Dairy Science, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biol Reprod 81:426-37. 2009
    ..In summary, ablation of follicles (>or=4 mm) delayed and treatment with E2 hastened luteolysis in heifers with ablated follicles. Thus, these results are consistent with an essential role for follicle E2 in timing of luteolysis...
  43. doi request reprint Temporal relationships and repeatability of follicle diameters and hormone concentrations within individuals in mares
    J C Jacob
    Eutheria Foundation, Cross Plains, WI, USA
    Reprod Domest Anim 44:92-9. 2009
    ..Results demonstrated measurable repeatability within mares for several end points between consecutive IOIs...
  44. doi request reprint Effect of dose of estradiol-17β on prominence of an induced 13,14-dihydro-15-keto-PGF(2α) (PGFM) pulse and relationship of prominence to progesterone, LH, and luteal blood flow in heifers
    G Pugliesi
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Domest Anim Endocrinol 41:98-109. 2011
    ..In addition, the extent of the effect of prostaglandin F(2α) on the increase in LH and changes in blood flow within the hours of a PGFM pulse was related positively to the prominence of the PGFM pulse...
  45. ncbi request reprint Effect of LH on circulating oestradiol and follicular fluid factor concentrations during follicle deviation in cattle
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Reproduction 122:103-10. 2001
    ....
  46. doi request reprint Effects of inhibition of prostaglandin F2α biosynthesis during preluteolysis and luteolysis in heifers
    G Pugliesi
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 76:640-51. 2011
    ..In conclusion, a reduction in prominence of PGFM pulses during luteolysis delayed completion of luteolysis, and treatment with FM inhibited PGFM production more during preluteolysis than during luteolysis...
  47. ncbi request reprint Follicular and hormonal response to experimental suppression of FSH during follicle deviation in cattle
    D R Bergfelt
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Theriogenology 54:1191-206. 2000
    ....
  48. ncbi request reprint Selection of the dominant follicle in cattle: establishment of follicle deviation in less than 8 hours through depression of FSH concentrations
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Theriogenology 52:1079-93. 1999
    ....
  49. doi request reprint Intrapulse changes in progesterone and LH concentrations and luteal blood flow during an estradiol-induced pulse of a metabolite of prostaglandin F2alpha in heifers
    S Imam
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 121:34-8. 2010
    ..Results were consistent with reports of changes in progesterone concentration within a PGFM pulse in cattle and demonstrated intrapulse changes in LH concentration and luteal blood flow during an E2-induced PGFM pulse...
  50. ncbi request reprint Follicle selection in cattle and horses: role of intrafollicular factors
    M A Beg
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    Reproduction 132:365-77. 2006
    ..The other follicles of the wave have the same future capability but do not have adequate time to attain a similar preparatory stage...
  51. doi request reprint Concentrations of circulating hormones normalized to pulses of a prostaglandin F2alpha metabolite during spontaneous luteolysis in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 72:1111-9. 2009
    ....
  52. doi request reprint Luteal blood flow and concentrations of circulating progesterone and other hormones associated with a simulated pulse of 13,14-dihydro-15-keto-prostaglandin F2alpha in heifers
    H K Shrestha
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 139:673-83. 2010
    ..The comparisons between progesterone and blood flow are novel...
  53. ncbi request reprint Hormone concentrations temporally associated with contralateral and ipsilateral relationships between the CL and preovulatory follicle during the third follicular wave in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA Electronic address
    Theriogenology 80:738-47. 2013
    ..The hypothesis that a minor FSH surge occurs most frequently in association with three follicular waves was not supported...
  54. ncbi request reprint Mechanisms that prevent and produce double ovulations in dairy cattle
    M C Wiltbank
    Endocrinology Reproductive Physiology Program, and Department of Dairy Science, University of Wisconsin Madison, 53706, USA
    J Dairy Sci 83:2998-3007. 2000
    ..Thus, FSH remains elevated for a time sufficient to allow follicles to undergo the physiological changes necessary to proceed to ovulation...
  55. doi request reprint Stimulatory effect of PGF2α on PRL based on experimental inhibition of each hormone in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 78:1960-8. 2012
    ..0 ± 0.3 ng/mL). Results supported the hypothesis that the positive association between PGFM and PRL concentrations in mares represents an effect of PGF2α on PRL rather than an effect of PRL on PGF2α...
  56. ncbi request reprint Associated and independent comparisons between the two largest follicles preceding follicle deviation in cattle
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 68:524-9. 2003
    ..For free IGF-1 concentrations, a fluctuation (a significant increase followed by a significant decrease) occurred independently in F1 between the 7.4- to 7.8-mm groups and independently in F2 between the 7.0- to 7.4-mm groups...
  57. doi request reprint Follicle and systemic hormone interrelationships during induction of luteinized unruptured follicles with a prostaglandin inhibitor in mares
    J Cuervo-Arango
    Eutheria Foundation, Cross Plains, WI, USA
    Theriogenology 76:361-73. 2011
    ..In conclusion, systemic treatment with FM blocked ovulation in 73% of treated mares. Mares with LUFs had lower progesterone and higher LH concentrations than control mares...
  58. ncbi request reprint Mechanism of follicle deviation in monovular farm species
    O J Ginther
    Eutheria Foundation, 4343 Garfoot Road, Cross Plains, WI 53528, USA
    Anim Reprod Sci 78:239-57. 2003
    ..Results of in vitro studies, although frequently done in other species, support this conclusion...
  59. doi request reprint Circadian influence on the preovulatory LH surge, ovulation, and prolactin concentrations in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 79:528-33. 2013
    ..The median was 11:30 AM. The hypothesis was supported that the peak of the preovulatory LH surge, ovulation, and maximal PRL concentration during pulse clusters occur with greater frequency during certain clock hours in heifers...
  60. doi request reprint Role of LH in luteolysis and growth of the ovulatory follicle and estradiol regulation of LH secretion in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, 53528, USA
    Theriogenology 77:1442-52. 2012
    ....
  61. doi request reprint Concentrations of circulating hormones during the interval between pulses of a PGF2α metabolite in mares and heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 128:22-8. 2011
    ..05). Results indicated that estradiol plateaued in mares and fluctuated in heifers during the interval between PGFM pulses. Heifers also showed temporal relationships between estradiol and LH and apparently between estradiol and PRL...
  62. doi request reprint Follicle deviation in ovulatory follicular waves with one or two dominant follicles in mares
    J C Jacob
    Eutheria Foundation, Cross Plains, WI, USA
    Reprod Domest Anim 44:248-54. 2009
    ..Unlike reported results in heifers, the results in mares did not indicate a hormonal basis for the development of 2DF or two deviations...
  63. ncbi request reprint Follicle selection in cattle: role of luteinizing hormone
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 64:197-205. 2001
    ..In addition, the results indicated that LH is involved in the production of estradiol by the largest follicle and that free IGF-1 concentrations increase in the largest follicle during deviation...
  64. ncbi request reprint Response of estradiol and inhibin to experimentally reduced luteinizing hormone during follicle deviation in mares
    D R Bergfelt
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 65:426-32. 2001
    ..It was concluded that the increase in LH concentrations before diameter deviation played a role in the production of estradiol and inhibin by the largest follicle during deviation...
  65. doi request reprint Follicle and hormone dynamics in single versus double ovulating heifers
    M P Palhao
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 138:561-70. 2009
    ..In conclusion, the difference in hormone concentrations during the pre-ovulatory period was an effect rather than a cause of double ovulations...
  66. doi request reprint Role of increased estradiol on altering the follicle diameters and gonadotropin concentrations that have been reported for double-ovulating heifers
    M P Palhao
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 122:335-41. 2010
    ....
  67. doi request reprint Relationship of vascular perfusion of the wall of the preovulatory follicle to in vitro fertilisation and embryo development in heifers
    M A R Siddiqui
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reproduction 137:689-97. 2009
    ..05), and oestradiol was lower (P<0.05) for >8 cell embryos. Results supported the hypothesis that greater vascular perfusion of the wall of the preovulatory follicle was positively associated with IVF and embryo development...
  68. ncbi request reprint Hormonal mechanism of follicle deviation as indicated by major versus minor follicular waves during the transition into the anovulatory season in mares
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reproduction 126:653-60. 2003
    ..A minor wave developed into a major wave when the largest follicle reached a diameter characteristic of the beginning of deviation in the presence of an adequate LH stimulus for continued growth of a dominant follicle...
  69. doi request reprint Short-term feed restriction decreases the systemic and intrafollicular concentrations of leptin and increases the vascularity of the preovulatory follicle in mares
    M O Gastal
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Theriogenology 73:1202-9. 2010
    ..60; P<0.02). Our favored interpretation is that the preovulatory follicle seems to compensate for a nutritional deficiency by increasing the blood flow in the follicle wall...
  70. doi request reprint Effect of suppression of FSH with a GnRH antagonist (acyline) before and during follicle deviation in the mare
    C M Checura
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Domest Anim 44:504-11. 2009
    ..In contrast, during the decline in the wave-stimulating FSH surge and before follicle deviation, growth of follicles was dependent on FSH...
  71. doi request reprint Positive effect of FSH but not LH on early development of the dominant follicle in mares
    C M Checura
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Reprod Fertil Dev 22:1092-9. 2010
    ..The results demonstrate a role for FSH but not LH in the growth of the largest follicle and intrafollicular concentrations of free IGF-1 and oestradiol during the 48 h after the beginning of deviation in mares...
  72. doi request reprint Effect of luteinizing hormone oscillations on progesterone concentrations based on treatment with a gonadotropin-releasing hormone antagonist in heifers
    O J Ginther
    Eutheria Foundation, Cross Plains, WI 53528, USA Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Domest Anim Endocrinol 40:119-27. 2011
    ..Results indicated that LH oscillations affect both the prominence and the rhythmicity of P4 oscillations during preluteolysis but not the onset and length of luteolysis...
  73. ncbi request reprint Changes in steady-state concentrations of messenger ribonucleic acids in luteal tissue during prostaglandin F2alpha induced luteolysis in mares
    M A Beg
    Department of Animal Health and Biomedical Sciences, 1656 Linden Drive, University of Wisconsin Madison, WI 53706, USA
    Anim Reprod Sci 90:273-85. 2005
    ..Thus, the findings are consistent with the concept that an intraluteal autocrine loop augments the luteolytic effect of uterine PGF2alpha in mares...
  74. ncbi request reprint Acute effects of prostaglandin F(2alpha) on systemic oxytocin and progesterone concentrations during the mid- or late-luteal phase in mares
    M D Utt
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA
    Anim Reprod Sci 97:63-73. 2007
    ..Treatment of mares with PGF on Day 8 resulted in an overall greater increase in systemic oxytocin concentrations compared to treatment on Day 13, and the increase on Day 8 was biphasic...
  75. ncbi request reprint Role of low circulating FSH concentrations in controlling the interval to emergence of the subsequent follicular wave in cattle
    O J Ginther
    Department of Animal Health and Biomedical Sciences, 1656 Linden Drive, University of Wisconsin, Madison 53706, USA
    Reproduction 124:475-82. 2002
    ..However, in one of seven rbFSH-treated heifers, the largest follicle from the apparent stimulation of rbFSH reached only 5.7 mm; therefore, the possibility of involvement of additional mechanisms cannot be dismissed...
  76. doi request reprint Functional relationships among intrafollicular insulin-like growth factor 1, circulatory gonadotropins, and development of the dominant follicle in mares
    C M Checura
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 118:270-8. 2010
    ..During the period of lesser gonadotropin concentrations from Acyline treatment, intrafollicular IGF1 stimulated follicular growth and inhibin concentrations, but not intrafollicular estradiol production...
  77. doi request reprint Disruption of periovulatory FSH and LH surges during induced anovulation by an inhibitor of prostaglandin synthesis in mares
    O J Ginther
    Eutheria Foundation, 4343 Cross Plains, WI 53528, USA
    Anim Reprod Sci 126:91-5. 2011
    ..Other routes from follicle to circulation for gonadotropin inhibitors played a role, based on similar depression in the ovulatory and anovulatory groups...
  78. ncbi request reprint Follicle selection in monovular species
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, 1656 Linden Drive, Madison, WI 53706, USA
    Biol Reprod 65:638-47. 2001
    ..The smaller follicles have not reached a similar developmental stage and because of their continued and close dependency on FSH become susceptible to the low concentrations. Thereby, follicle selection is established...
  79. ncbi request reprint Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares
    T J Acosta
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Biol Reprod 71:637-42. 2004
    ....
  80. doi request reprint Local effect of the conceptus on uterine vascular perfusion during early pregnancy in heifers
    L A Silva
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 139:453-63. 2010
    ..Results support the hypothesis that vascular perfusion in each uterine horn during early pregnancy is mediated by direct contact between conceptus and uterus...
  81. ncbi request reprint Temporal relationships among LH, estradiol, and follicle vascularization preceding the first compared with later ovulations during the year in mares
    E L Gastal
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Anim Reprod Sci 102:314-21. 2007
    ..Results demonstrated that follicle vascularization and the LH surge were attenuated preceding the first ovulation of the year with no indication that estradiol was involved in the differences between the first and later ovulations...
  82. ncbi request reprint Regression and resurgence of the CL following PGF2alpha treatment 3 days after ovulation in mares
    D R Bergfelt
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Theriogenology 65:1605-19. 2006
    ..In conclusion, PGF treatment 3 days after ovulation resulted in structural and functional regression of the CL and hastened the interval to the next ovulation, despite post-treatment resurgences in progesterone...
  83. ncbi request reprint Effect of number and diameter of follicles on plasma concentrations of inhibin and FSH in mares
    F X Donadeu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Reproduction 121:897-903. 2001
    ..Thereafter, the largest follicle alone accounted for the continued FSH suppression...
  84. ncbi request reprint Follicle Selection in Cattle: Relationships among Growth Rate, Diameter Ranking, and Capacity for Dominance
    O J Ginther
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 65:345-50. 2001
    ..0 mm; and 4) the three largest subordinate follicles began to deviate simultaneously...
  85. ncbi request reprint Suppression of circulating concentrations of FSH and LH by inhibin and estradiol during the initiation of follicle deviation in mares
    F X Donadeu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706, USA
    Theriogenology 60:1423-34. 2003
    ..Results also indicated that the increase in estradiol induces suppression of LH...
  86. ncbi request reprint Interactions of follicular factors and season in the regulation of circulating concentrations of gonadotrophins in mares
    F X Donadeu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Reproduction 125:743-50. 2003
    ..An increase in circulating inhibin induced by the growth of follicles > 21 mm in diameter during the late-transitional and ovulatory periods counteracted a stimulatory effect on FSH mediated by season...
  87. ncbi request reprint Relationships of changes in B-mode echotexture and colour-Doppler signals in the wall of the preovulatory follicle to changes in systemic oestradiol concentrations and the effects of human chorionic gonadotrophin in mares
    E L Gastal
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 131:699-709. 2006
    ..The hypothesis that the latter portion of the ovulatory LH surge has a negative effect on systemic oestradiol was supported by the immediate decrease in oestradiol concentrations when hCG was injected...
  88. ncbi request reprint Follicular waves and circulating concentrations of gonadotrophins, inhibin and oestradiol during the anovulatory season in mares
    F X Donadeu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Reproduction 124:875-85. 2002
    ..0 mm in diameter for the wave at the beginning of the transitional period and for the subsequent waves was not attributable to a change in the characteristics of the associated FSH surges...
  89. ncbi request reprint Follicle selection in cattle: dynamics of follicular fluid factors during development of follicle dominance
    M A Beg
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 66:120-6. 2002
    ....
  90. ncbi request reprint Interrelationships of estradiol, inhibin, and gonadotropins during follicle deviation in pony mares
    F X Donadeu
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Theriogenology 61:1395-405. 2004
    ..The later increase in LH before the first ovulation was not attributable to estradiol, based on the similarity between the two ovulatory waves in the increasing estradiol concentrations...
  91. ncbi request reprint Follicle selection in cattle: follicle deviation and codominance within sequential waves
    L J Kulick
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    Biol Reprod 65:839-46. 2001
    ..Waves that developed codominant follicles differed in hormone as well as follicle dynamics...
  92. doi request reprint Uterine blood flow and perfusion in mares with uterine cysts: effect of the size of the cystic area and age
    J C Ferreira
    Eutheria Foundation, Cross Plains, Wisconsin 53528, USA
    Reproduction 135:541-50. 2008
    ..01) than young mares. Results demonstrated, for the first time in any species, reduced uterine vascular perfusion in mares with uterine cysts and a positive association between size of the cystic area and disturbed uterine hemodynamics...
  93. doi request reprint Blood flow in the wall of the preovulatory follicle and its relationship to pregnancy establishment in heifers
    M A R Siddiqui
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 113:287-92. 2009
    ..Results supported the hypothesis of a positive relationship between the extent of blood flow of the preovulatory follicle and successful establishment of pregnancy in cattle...
  94. ncbi request reprint Role of oestradiol in growth of follicles and follicle deviation in heifers
    M A Beg
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA and The Eutheria Foundation, Cross Plains, WI 53528, USA
    Reproduction 125:847-54. 2003
    ..Therefore, the follicle effect can be attributed to inadequate intrafollicular oestradiol. This interpretation implies a functional local role for oestradiol in the deviation process, independent of the systemic negative effect on FSH...
  95. ncbi request reprint Follicular deviation and acquisition of ovulatory capacity in bovine follicles
    R Sartori
    Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 65:1403-9. 2001
    ..We speculate that acquisition of ovulatory capacity may involve an increased expression of LH receptors on granulosa cells of the dominant follicle and that this change may also be important for further growth of the dominant follicle...
  96. doi request reprint Vascular perfusion of reproductive organs in pony mares and heifers during sedation with detomidine or xylazine
    Reno R Araujo
    Eutheria Foundation, 4343 Garfoot Rd, Cross Plains, WI 53528, USA
    Am J Vet Res 70:141-8. 2009
    ..To assess the vascular effects of detomidine and xylazine in pony mares and heifers, respectively, as determined in a major artery and by extent of vascular perfusion of reproductive organs...
  97. doi request reprint Dynamic progesterone responses to simulation of a natural pulse of a metabolite of prostaglandin F(2alpha) in heifers
    H K Shrestha
    Eutheria Foundation, Cross Plains, WI 53528, USA
    Anim Reprod Sci 118:118-23. 2010
    ....
  98. ncbi request reprint Changes in concentrations of follicular fluid factors during follicle selection in mares
    F X Donadeu
    Department of Animal Health and Biomedical Sciences, University of Wisconsin, 1656 Linden Drive, Madison, WI 53706, USA
    Biol Reprod 66:1111-8. 2002
    ..In addition, these four factors as well as progesterone, androstenedione, IGFBP-2, and inhibin-B may have been involved in the subsequent differential development of the follicles...
  99. ncbi request reprint Selection of the dominant follicle in cattle: role of two-way functional coupling between follicle-stimulating hormone and the follicles
    O J Ginther
    Department of Animal Health and Biomedical Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 62:920-7. 2000
    ..It is postulated that the essence of the selection of a dominant follicle is a close two-way functional coupling between changing FSH concentrations and follicular growth...
  100. doi request reprint Characteristics of pulses of 13,14-dihydro-15-keto-prostaglandin f2alpha before, during, and after spontaneous luteolysis and temporal intrapulse relationships with progesterone concentrations in cattle
    O J Ginther
    Eutheria Foundation, Cross Plains, Wisconsin, USA
    Biol Reprod 82:1049-56. 2010
    ..These findings should be considered in future proposals on the mechanisms involved in the effects of PGF on progesterone concentrations...
  101. ncbi request reprint Miniature ponies: 1. Follicular, luteal and endometrial dynamics during the oestrous cycle
    E L Gastal
    Department of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA
    Reprod Fertil Dev 20:376-85. 2008
    ..Considering the small number of follicles per ovulatory wave, Miniature mares are a potential model for comparative studies in folliculogenesis within and among species...