MYRON GINSBERG

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Combating hyperthermia in acute stroke: a significant clinical concern
    M D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Fla 33101, USA
    Stroke 29:529-34. 1998
  2. ncbi request reprint The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report
    M D Ginsberg
    Department of Neurology, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Biochem Soc Trans 34:1323-6. 2006
  3. ncbi request reprint Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 34:214-23. 2003
  4. ncbi request reprint Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Ann Neurol 54:330-42. 2003
  5. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2100-6. 2006
  6. ncbi request reprint Diminution of metabolism/blood flow uncoupling following traumatic brain injury in rats in response to high-dose human albumin treatment
    M D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Florida 33101, USA
    J Neurosurg 94:499-509. 2001
  7. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis
    Yuko Y Palesch
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2107-14. 2006
  8. ncbi request reprint Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats
    Rainald Schmidt-Kastner
    Department of Neurology, Cerebral Vascular Disease Research Center, D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Brain Res 1052:28-39. 2005
  9. ncbi request reprint Pixel-based statistical analysis by a 3D clustering approach: application to autoradiographic images
    Weizhao Zhao
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124 0640, USA
    Comput Methods Programs Biomed 83:18-28. 2006
  10. ncbi request reprint A selective endothelin ET(A) receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in rats
    Yongbo Zhang
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Brain Res 1045:150-6. 2005

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Combating hyperthermia in acute stroke: a significant clinical concern
    M D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Fla 33101, USA
    Stroke 29:529-34. 1998
    ....
  2. ncbi request reprint The ALIAS (ALbumin In Acute Stroke) Phase III randomized multicentre clinical trial: design and progress report
    M D Ginsberg
    Department of Neurology, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Biochem Soc Trans 34:1323-6. 2006
    ..Approx. 60 North American clinical sites will participate. Subject enrollment is expected to commence in July 2006...
  3. ncbi request reprint Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 34:214-23. 2003
    ..This presentation first highlights insights into the ischemic penumbra enabled by a multimodal experimental approach; second, discusses gene expression in ischemia; and third, confronts the challenges of neuroprotectant therapy...
  4. ncbi request reprint Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia
    Myron D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Ann Neurol 54:330-42. 2003
    ..The potency of STAZN was orders-of-magnitude greater than other nitrones such as NXY-059. These results suggest that STAZN has great promise for ischemic stroke...
  5. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety results
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2100-6. 2006
    ..In preclinical stroke models, high-dose human albumin confers robust neuroprotection. We investigated the safety and tolerability of this therapy in patients with acute ischemic stroke...
  6. ncbi request reprint Diminution of metabolism/blood flow uncoupling following traumatic brain injury in rats in response to high-dose human albumin treatment
    M D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Florida 33101, USA
    J Neurosurg 94:499-509. 2001
    ..The intent of this study was to establish whether the use of human albumin therapy in a model of acute TBI would influence this phenomenon...
  7. ncbi request reprint The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis
    Yuko Y Palesch
    Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
    Stroke 37:2107-14. 2006
    ..A phase I dose-escalation study was conducted to assess the safety of ALB therapy in ischemic stroke. We analyzed the data for preliminary evidence of treatment efficacy...
  8. ncbi request reprint Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats
    Rainald Schmidt-Kastner
    Department of Neurology, Cerebral Vascular Disease Research Center, D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Brain Res 1052:28-39. 2005
    ..These results indicate that chronic BCCAO and, by inference, oligemia have a transient effect on the neocortex and a long-lasting effect on white matter structures...
  9. ncbi request reprint Pixel-based statistical analysis by a 3D clustering approach: application to autoradiographic images
    Weizhao Zhao
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124 0640, USA
    Comput Methods Programs Biomed 83:18-28. 2006
    ..Different methods were also performed on the same data sets. Comparison among these methods shows that this method is suitable for the statistical analysis of autoradiographic images...
  10. ncbi request reprint A selective endothelin ET(A) receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in rats
    Yongbo Zhang
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Brain Res 1045:150-6. 2005
    ..This study demonstrates that SB 234551 therapy results in significant improvement of local cerebral perfusion in the ischemic as well as in the non-ischemic hemispheres after permanent MCAo...
  11. ncbi request reprint Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in rats
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 36:1071-6. 2005
    ..In this study, we determined whether darbepoetin alfa would protect in a rat model of transient focal cerebral ischemia...
  12. ncbi request reprint Moderate loss of cerebellar Purkinje cells after chronic bilateral common carotid artery occlusion in rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Acta Neuropathol 113:549-58. 2007
    ..Remodeling of the basilar artery indicated that secondary vascular perturbations might be responsible for the effects of BCCAO on the cerebellar Purkinje cells...
  13. ncbi request reprint Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era
    Myron D Ginsberg
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Stroke 38:1967-72. 2007
    ....
  14. doi request reprint The albumin in acute stroke trial (ALIAS); design and methodology
    Michael D Hill
    Department of Clinical Neurosciences, Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Int J Stroke 2:214-9. 2007
    ....
  15. pmc Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy study
    Hee Pyoung Park
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Stroke 39:1556-62. 2008
    ..Here, we explored the microvascular hemodynamic effects of this combined therapy in a laboratory model of cortical arteriolar thrombosis...
  16. pmc Neuroprotection for ischemic stroke: past, present and future
    Myron D Ginsberg
    Department of Neurology D4 5, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuropharmacology 55:363-89. 2008
    ..The potential of combination therapies is highlighted. Issues of clinical-trial funding, the need for improved translational strategies and clinical-trial design, and "thinking outside the box" are emphasized...
  17. doi request reprint Fluid resuscitation in traumatic brain injury
    Myron D Ginsberg
    Crit Care Med 36:661-2. 2008
  18. pmc Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laser-scanning microscopy study
    Anitha Nimmagadda
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Stroke 39:198-204. 2008
    ..To explore the hypothesis that albumin's protective effect is mediated in part by salutary intravascular mechanisms, we assessed microvascular hemodynamics in a model of laser-induced cortical arteriolar thrombosis...
  19. pmc Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic window
    James J Ley
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5 University of Miami Miller School of Medicine PO Box 016960 Miami, Florida 33101, USA
    Brain Res 1180:101-10. 2007
    ..0 ml/kg, n=6) was administered at 3, 5, 24 and 48 h. STAZN treatment initiated at 2 or 3 h after the onset of MCAo improved neurological scores (p<0.001) and reduced total infarction (42.2%, p<0.05) compared to controls...
  20. pmc Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injury
    James J Ley
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33101, United States
    Biochem Pharmacol 75:448-56. 2008
    ....
  21. ncbi request reprint Experimental intracerebral hematoma in the rat: characterization by sequential magnetic resonance imaging, behavior, and histopathology. Effect of albumin therapy
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
    Brain Res 1157:146-55. 2007
    ..Taken together, sequential MRI plus histopathology provides a comprehensive characterization of experimental ICH. Albumin treatment improves neurological deficit after ICH but does not affect MRI or histological hematoma size...
  22. ncbi request reprint Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation
    Ami P Raval
    Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
    J Cereb Blood Flow Metab 25:730-41. 2005
    ..Our results support the deleterious role of deltaPKC in reperfusion injury. We propose that early cytochrome c release and caspase 3 activation promote deltaPKC translocation/cleavage...
  23. ncbi request reprint Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokinetics
    James J Ley
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    J Pharmacol Exp Ther 313:1090-100. 2005
    ..These results establish that STAZN confers enduring ischemic neuroprotection, has a long circulating half-life, and penetrates well into brain and other organs-characteristics favoring its potential therapeutic utility...
  24. ncbi request reprint Albumin treatment reduces neurological deficit and protects blood-brain barrier integrity after acute intracortical hematoma in the rat
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Stroke 36:326-31. 2005
    ....
  25. ncbi request reprint Therapeutic trials for traumatic brain injury--a journey in progress
    Myron D Ginsberg
    Crit Care Med 30:935-6. 2002
  26. ncbi request reprint Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats
    Ludmila Belayev
    Department of Neurology, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
    J Neurosurg 96:1077-83. 2002
    ..In this study, the authors assessed the potential efficacy of STAZN in a rodent model of fluid-percussion brain injury, which results in a consistent cortical contusion...
  27. ncbi request reprint Effect of ischemic preconditioning on the expression of putative neuroprotective genes in the rat brain
    Jessie Truettner
    The Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 16960, Miami, FL 33101, USA
    Brain Res Mol Brain Res 103:106-15. 2002
    ..The increase in expression of these stress-related, neurotrophic and immediate early genes in response to a mild preconditioning insult may help mediate the protection of vulnerable neurons to subsequent lethal ischemic insults...
  28. ncbi request reprint Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin
    Elena B Rodriguez de Turco
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA
    J Neurochem 83:515-24. 2002
    ....
  29. ncbi request reprint DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat
    Rainald Schmidt-Kastner
    Department of Neurology D4 5, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, P O Box 016960, FL 33101, USA
    Brain Res Mol Brain Res 108:81-93. 2002
    ..DNA microarray analysis allows one to develop novel working hypotheses for responses to brain ischemia based on the regulation of annotated genes...
  30. ncbi request reprint Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat
    Panomkhawn Riyamongkol
    Department of Electrical and Computer Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124 0640, USA
    J Neurosci Methods 122:79-90. 2002
    ..Cerebral perfusion data acquired in a pixel-based manner from different anatomic locations of the registered LD image sequence are also presented over the whole time-course of the experiment...
  31. ncbi request reprint Enriched environment delays the onset of hippocampal damage after global cerebral ischemia in rats
    Andrey Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Brain Res 964:121-7. 2003
    ..5+/-7.2 vs. 2.6+/-0.6, respectively). The present data suggest that housing in EE for 2 months before and 6 days after ischemia can delay the onset of damage to hippocampal pyramidal neurons, which eventually occurs despite 2-month EE...
  32. ncbi request reprint Neuroprotective effect of SolCD39, a novel platelet aggregation inhibitor, on transient middle cerebral artery occlusion in rats
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
    Stroke 34:758-63. 2003
    ..The purpose of this study was to examine the effect of solCD39 on neurological deficit, infarct size, and extent of edema after transient middle cerebral artery occlusion (MCAO) in rats...
  33. ncbi request reprint Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection model
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    Stroke 34:2221-7. 2003
    ..We investigated the effect of intrastriatal injection of blood or cerebrospinal fluid (CSF) on cerebral blood flow (CBF), neurological score, hematoma volume, and brain swelling...
  34. ncbi request reprint Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Stroke 36:118-23. 2005
    ..Among its actions in ischemia, albumin induces the systemic mobilization of n-3 polyunsaturated fatty acids and may help to replenish polyunsaturated fatty acids lost from neural membranes...
  35. ncbi request reprint Mild cardiopulmonary arrest promotes synaptic dysfunction in rat hippocampus
    Kunjan R Dave
    Department of Neurology and Neuroscience, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 1024:89-96. 2004
    ..These data suggest that synaptic dysfunction occurs before and without overt histopathology. We suggest that the synaptic dysfunction precedes and may be an early marker for delayed neuronal cell death in the hippocampus after CA...
  36. ncbi request reprint Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
    Stroke 33:1077-84. 2002
    ....
  37. ncbi request reprint Caffeinol confers cortical but not subcortical neuroprotection after transient focal cerebral ischemia in rats
    Ludmila Belayev
    Department of Neurology D4 5, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Brain Res 1008:278-83. 2004
    ..Caffeinol therapy significantly improved the neurological score, reduced the total infarct volume (by 52%) and cortical infarct areas at multiple coronal levels, but subcortical infarction and brain swelling were not affected...
  38. ncbi request reprint Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus
    Rainald Schmidt-Kastner
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Brain Res 1001:133-42. 2004
    ..Nuclear location of BNIP3 after brain ischemia indicates a novel role for the regulation of cell survival in neurons or a general disturbance of the nuclear envelope...
  39. ncbi request reprint Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats
    Ludmila Belayev
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Brain Res 998:243-6. 2004
    ..9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects...
  40. ncbi request reprint Mitochondria consume energy and compromise cellular membrane potential by reversing ATP synthetase activity during focal ischemia in rats
    Yoshimasa Takeda
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, FL, USA
    J Cereb Blood Flow Metab 24:986-92. 2004
    ..04). These observations suggest that mitochondria consume ATP during ischemia by reversing ATP synthetase activity, which compromises cellular membrane potential by consuming ATP...
  41. ncbi request reprint Semi-automated image processing system for micro- to macro-scale analysis of immunohistopathology: application to ischemic brain tissue
    Chunyan Wu
    Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124 0621, USA
    Comput Methods Programs Biomed 78:75-86. 2005
    ..Reliability tests show that the results obtained from immunostained images at high magnification and relatively low magnification are virtually the same...
  42. ncbi request reprint Hyperglycemia and stroke outcome: vindication of the ischemic penumbra
    Myron D Ginsberg
    Ann Neurol 52:5-6. 2002

Research Grants9

  1. SHARED CONFOCAL MICROSCOPY FACILITY
    MYRON GINSBERG; Fiscal Year: 2003
    ..4) The consequences of chronic cerebrovascular occlusions. 5) Ischemic preconditioning and mitochondrial mechanisms. 6) Programmed death signaling pathways in cardiac ischemia and reperfusion, and the therapeutic role of angiogenesis. ..
  2. HUMAN ALBUMIN THERAPY-TREATMENT OF ACUTE ISCHEMIC STROKE
    MYRON GINSBERG; Fiscal Year: 2003
    ..In our view, the multiple unique physiochemical properties of the albumin molecule are integral to its neuroprotective effect and render it uniquely suited as a therapeutic agent to combat ischemic brain injury. ..
  3. ALIAS II/III Trial:Albumin Therapy in Ischemic Stroke
    MYRON GINSBERG; Fiscal Year: 2004
    ..At a minimum clinical effect size of 10%, a total of approximately 410 patients is required for the futility trial, and -1,950 for the efficacy trial. The primary outcome measure is the modified Rankin score at 3 months. ..
  4. Azulenyl nitrones: neuroprotectants in stroke and trauma
    MYRON GINSBERG; Fiscal Year: 2006
    ..Two world-renowned authorities in oxygen-radical biochemistry and vascular pharmacology drawn from both academia and the pharmaceutical industry will serve as External Advisors to guide us throughout this project. ..
  5. ALIAS Phase lll Trial Albumin in Acute Ischemic Stroke
    MYRON GINSBERG; Fiscal Year: 2007
    ..The ALIAS Trial affords the unique opportunity to apply a preclinically highly effective strategy to treat stroke using a dose and timing that closely replicate the experimental setting in which efficacy was shown. ..