Phyllis A Gimotty

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Identification of high-risk patients among those diagnosed with thin cutaneous melanomas
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 25:1129-34. 2007
  2. ncbi request reprint Predictors of regional nodal disease in patients with thin melanomas
    Giorgos C Karakousis
    Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 13:533-41. 2006
  3. ncbi request reprint Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patients
    Giorgos C Karakousis
    Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Surg Oncol 14:1596-603. 2007
  4. pmc Tissue-based immune monitoring II: multiple tumor sites reveal immunologic homogeneity in serous ovarian carcinoma
    Andrea R Hagemann
    Ovarian Cancer Research Center, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, USA
    Cancer Biol Ther 12:367-77. 2011
  5. ncbi request reprint Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma
    Laura L Kruper
    Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 107:2436-45. 2006
  6. pmc Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 18:229-37. 2012
  7. ncbi request reprint Tumor vascular proteins as biomarkers in ovarian cancer
    Ronald J Buckanovich
    Center for Research on Reproduction and Women s Health, Abramson Family Cancer Research Institute, Department of Medicine Division of Hematology Oncology, Philadelphia, PA, USA
    J Clin Oncol 25:852-61. 2007
  8. pmc Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18
    Ioannis Alagkiozidis
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Transl Med 7:104. 2009
  9. doi request reprint Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    Andrea Facciabene
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 475:226-30. 2011
  10. ncbi request reprint A population-based validation of the American Joint Committee on Cancer melanoma staging system
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center of the University of Pennsylvania, Philadelphia, USA
    J Clin Oncol 23:8065-75. 2005

Research Grants

  1. Cancer Biostatistics Training Grant
    Phyllis Gimotty; Fiscal Year: 2007

Detail Information

Publications56

  1. ncbi request reprint Identification of high-risk patients among those diagnosed with thin cutaneous melanomas
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 25:1129-34. 2007
    ..However, some develop metastatic disease that is often fatal. We evaluated established prognostic factors to develop classification schemes with better discrimination than current American Joint Committee on Cancer (AJCC) staging...
  2. ncbi request reprint Predictors of regional nodal disease in patients with thin melanomas
    Giorgos C Karakousis
    Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 13:533-41. 2006
    ..In this study, we evaluated a large population of patients with thin melanoma from the pre-SLN era to identify predictors of regional nodal disease (RND) that may serve as a surrogate for SLN positivity...
  3. ncbi request reprint Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patients
    Giorgos C Karakousis
    Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Ann Surg Oncol 14:1596-603. 2007
    ....
  4. pmc Tissue-based immune monitoring II: multiple tumor sites reveal immunologic homogeneity in serous ovarian carcinoma
    Andrea R Hagemann
    Ovarian Cancer Research Center, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, USA
    Cancer Biol Ther 12:367-77. 2011
    ..In conclusion, between-site heterogeneity exists in some patients with metastatic serous ovarian cancer. The predictive value of biopsies should be considered in clinical trial design...
  5. ncbi request reprint Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma
    Laura L Kruper
    Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 107:2436-45. 2006
    ....
  6. pmc Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanoma
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Cancer Res 18:229-37. 2012
    ..Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor...
  7. ncbi request reprint Tumor vascular proteins as biomarkers in ovarian cancer
    Ronald J Buckanovich
    Center for Research on Reproduction and Women s Health, Abramson Family Cancer Research Institute, Department of Medicine Division of Hematology Oncology, Philadelphia, PA, USA
    J Clin Oncol 25:852-61. 2007
    ..This study aimed to identify novel ovarian cancer biomarkers and potential therapeutic targets through molecular analysis of tumor vascular cells...
  8. pmc Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18
    Ioannis Alagkiozidis
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Transl Med 7:104. 2009
    ..Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Doxil on surviving tumor cell immunophenotype were investigated...
  9. doi request reprint Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    Andrea Facciabene
    Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 475:226-30. 2011
    ..Thus, peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumour growth...
  10. ncbi request reprint A population-based validation of the American Joint Committee on Cancer melanoma staging system
    Phyllis A Gimotty
    The Melanoma Program of the Abramson Cancer Center of the University of Pennsylvania, Philadelphia, USA
    J Clin Oncol 23:8065-75. 2005
    ..This staging system has not been validated in a US population-based cohort...
  11. pmc Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer
    Sarah F Adams
    Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer 115:2891-902. 2009
    ....
  12. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
    ..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease...
  13. pmc Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
    Lin Zhang
    Center for Research on Early Detection and Cure of Ovarian Cancer and Gynecology, Department of Obstetrics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:7004-9. 2008
    ..Therefore, our results suggest that miRNAs may offer new biomarkers and therapeutic targets in epithelial ovarian cancer...
  14. ncbi request reprint Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
    Ronald J Buckanovich
    Center for Research on Ovarian Cancer Early Detection and Cure, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 14:28-36. 2008
    ..These findings highlight a molecular mechanism with the potential to be pharmacologically manipulated to enhance the efficacy of tumor immunotherapy in humans...
  15. ncbi request reprint Lymphatic invasion as a prognostic biomarker in primary cutaneous melanoma
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Hospital of University of Pennsylvania, Philadelphia, PA, USA
    Methods Mol Biol 1102:275-86. 2014
    ....
  16. pmc Tissue-based immune monitoring I: tumor core needle biopsies allow in-depth interrogation of the tumor microenvironment
    Andrea R Hagemann
    Ovarian Cancer Research Center, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, USA
    Cancer Biol Ther 12:357-66. 2011
    ..Our results demonstrate a feasible and reproducible method of immune monitoring using CT-compatible needle biopsies from tumor tissue, thereby paving the way for sophisticated translational studies during tumor biological therapy...
  17. doi request reprint Prognostication in thin cutaneous melanomas
    Phyllis A Gimotty
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104 6021, USA
    Arch Pathol Lab Med 134:1758-63. 2010
    ..Thin melanomas are common and approximately one-quarter of all melanoma-related deaths result from thin primary tumors. Patients with thin melanoma commonly have sentinel lymph node biopsies that are uncommonly positive...
  18. ncbi request reprint Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanoma
    Phyllis A Gimotty
    Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Oncol 23:8048-56. 2005
    ..In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis...
  19. ncbi request reprint Thin primary cutaneous malignant melanoma: a prognostic tree for 10-year metastasis is more accurate than American Joint Committee on Cancer staging
    Phyllis A Gimotty
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 22:3668-76. 2004
    ....
  20. pmc Prognosis of patients with melanoma and microsatellitosis undergoing sentinel lymph node biopsy
    Edmund K Bartlett
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Ann Surg Oncol 21:1016-23. 2014
    ..Melanoma microsatellitosis is classified as stage IIIB/C disease and is associated with a poor prognosis. Prognostic factors within this group, however, have not been well characterized...
  21. pmc Clark level risk stratifies patients with mitogenic thin melanomas for sentinel lymph node biopsy
    Edmund K Bartlett
    Department of Surgery, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA
    Ann Surg Oncol 21:643-9. 2014
    ..The role for sentinel lymph node biopsy (SLNB) in patients with thin melanoma (≤1 mm) remains controversial. We examined a large cohort of patients with thin melanoma to better define predictors of SLN positivity...
  22. doi request reprint Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission
    Christina S Chu
    Department of Obstetrics and Gynecology and Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Immunol Immunother 61:629-41. 2012
    ..In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy...
  23. pmc Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancer
    David O Holtz
    Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, USA
    J Transl Med 6:2. 2008
    ..This is the first preclinical study that models interactions of LD paclitaxel chemotherapy with antiangiogenic therapy and tumor VEGF expression and offers important lessons for the rational design of clinical trials...
  24. pmc Immune prognostic factors in ovarian cancer: lessons from translational research
    Phyllis A Gimotty
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dis Markers 23:445-52. 2007
  25. doi request reprint The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    Qihong Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Nat Cell Biol 10:202-10. 2008
    ..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs...
  26. ncbi request reprint Cutaneous melanoma: estimating survival and recurrence risk based on histopathologic features
    David E Elder
    Melanoma Program of the Abramson Cancer Center, Divison of Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Dermatol Ther 18:369-85. 2005
    ..In this monograph, the focus will be the discussion of factors related to the prognosis of melanomas that at diagnosis are clinically localized to the primary site...
  27. ncbi request reprint Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists
    Michael Shapiro
    Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Cutan Pathol 31:523-30. 2004
    ..A 1992 National Institutes of Health (NIH) Consensus Conference sought to unify nomenclature and suggested that the term "nevus with architectural disorder" be used along with a comment on melanocytic atypia...
  28. pmc Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome
    Jia Huang
    Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Genes Chromosomes Cancer 50:606-18. 2011
    ..Both mutation as well as copy number changes can be used as predictive markers for this purpose...
  29. ncbi request reprint Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas
    Susan B Kesmodel
    Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Surg Oncol 12:449-58. 2005
    ..We sought to determine whether mitotic rate (MR) is associated with SLN positivity in thin-melanoma patients and, therefore, whether it may be used to risk-stratify and select patients for LM/SL...
  30. ncbi request reprint Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display
    Rolf K Swoboda
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 67:3555-9. 2007
    ..The RPL8 antigen may represent a relevant vaccine target for patients with melanoma, glioma, and breast carcinoma whose tumors express this protein...
  31. pmc Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas
    Devraj Basu
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Cell Cycle 10:2008-16. 2011
    ..Further, they provide evidence of mesenchymal-like subsets being well-represented across advanced stage SCCs, suggesting that intrinsic drug resistance in this subpopulation has high clinical relevance...
  32. pmc Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
    Charalambos Andreadis
    Abramson Cancer Center, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Blood 109:3409-16. 2007
    ....
  33. pmc Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    Hongxia Z Imtiyaz
    Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 120:2699-714. 2010
    ..Collectively, our data identify HIF-2alpha as an important regulator of innate immunity, suggesting it may be a useful therapeutic target for treating inflammatory disorders and cancer...
  34. pmc Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
    Mark Y Chiang
    Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:3181-94. 2008
    ..Even when Notch1 participates secondarily, the resulting tumors show "addiction" to Notch, providing a further rationale for evaluating Notch signaling pathway inhibitors in leukemia...
  35. ncbi request reprint Morbidity and mortality of colorectal carcinoma surgery differs by insurance status
    Rachel Rapaport Kelz
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 101:2187-94. 2004
    ....
  36. ncbi request reprint Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among interns
    Ilene M Rosen
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Acad Med 81:82-5. 2006
    ..To explore the relationships between sleep deprivation and the evolution of mood disturbances, empathy, and burnout among a cohort of interns...
  37. ncbi request reprint Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT)
    Giorgos Constantine Karakousis
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Surgery 142:845-50; discussion 850.e1-2. 2007
    ....
  38. pmc Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization
    Selene Nunez-Cruz
    Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neoplasia 14:994-1004. 2012
    ..Finally, the mouse VEGF(164) transcript was underexpressed in C3(KO) livers compare to C3(WT) livers. Thus, we conclude that complement inhibition blocks tumor outgrowth by altering EC function and VEGF(165) expression...
  39. pmc A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors
    Shinya Ohashi
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 71:6836-47. 2011
    ....
  40. pmc Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    Jessie Villanueva
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cancer Cell 18:683-95. 2010
    ..Increased IGF-1R and pAKT levels in a post-relapse human tumor sample are consistent with a role for IGF-1R/PI3K-dependent survival in the development of resistance to BRAF inhibitors...
  41. ncbi request reprint Validity of patient self-reported history of skin cancer
    Michael E Ming
    Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 140:730-5. 2004
    ..To determine the validity of patient self-report of skin cancer history...
  42. pmc The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells
    Dawson M Gerhardt
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 28:576-93. 2014
    ..Together, these studies reveal an essential role for the Notch1 TAD in fetal development and identify important cell-autonomous functions for Notch1 signaling in fetal HSC homeostasis. ..
  43. pmc microRNAs exhibit high frequency genomic alterations in human cancer
    Lin Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:9136-41. 2006
    ..These findings support the notion that copy number alterations of miRNAs and their regulatory genes are highly prevalent in cancer and may account partly for the frequent miRNA gene deregulation reported in several tumor types...
  44. pmc Effect of guidelines on primary care physician use of PSA screening: results from the Community Tracking Study Physician Survey
    Carmen E Guerra
    Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Med Decis Making 28:681-9. 2008
    ..The objective of this study was to determine the association between physicians' perceived effect of guidelines on clinical practice and self-reported prostate-specific antigen (PSA) screening patterns...
  45. ncbi request reprint Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells
    Jose R Conejo-Garcia
    Center for Research in Reproduction and Women s Health, University of Pennsylvania Medical Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Res 64:2175-82. 2004
    ..We propose that Letal could be used for the ex vivo expansion of apoptosis-resistant tumor-reactive cytotoxic lymphocytes for adoptive transfer...
  46. ncbi request reprint Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas
    Benjamin S Bleier
    Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104 4206, USA
    Arch Otolaryngol Head Neck Surg 132:779-82. 2006
    ....
  47. pmc Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis
    Adam Cuker
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Blood 120:4160-7. 2012
    ..14 (0.09-0.22) and 0.64 (0.40-0.82), respectively. A low probability 4Ts score appears to be a robust means of excluding HIT. Patients with intermediate and high probability scores require further evaluation...
  48. ncbi request reprint Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironment
    Ronald J Buckanovich
    Center for Research on Reproduction and Women s Health, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:635-42. 2006
    ..We propose that immuno-LCM coupled with transcriptional profiling is a convenient tool for dissecting molecular and cellular events in complex biological systems such as the tumor microenvironment...
  49. ncbi request reprint Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma
    David A Tuveson
    Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, USA
    Cancer Res 66:242-7. 2006
    ..These findings suggest that Mist1-expressing cells represent a permissive compartment for transformation by oncogenic Kras in pancreatic tumorigenesis...
  50. ncbi request reprint Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic culture
    Jiri Kalabis
    The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    FASEB J 17:1115-7. 2003
    ....
  51. ncbi request reprint Delivery of preventive health services for breast cancer control: a longitudinal view of a randomized controlled trial
    Phyllis A Gimotty
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Health Serv Res 37:65-85. 2002
    ..To develop a longitudinal model to characterize the delivery of mammography services using repeated observations of mammography referral rates during a randomized controlled trial (RCT) of physician mammography reminders...
  52. doi request reprint Using benchmarks based on historical survival rates for screening new therapies for stage IV melanoma patients
    Phyllis A Gimotty
    J Clin Oncol 26:517-8. 2008
  53. ncbi request reprint Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    N Engl J Med 348:203-13. 2003
    ..Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established...
  54. ncbi request reprint Validation of prognostic models for melanoma
    Phyllis A Gimotty
    Am J Clin Pathol 118:489-91. 2002
  55. pmc Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma
    Cynthia Spittle
    Clinical Translational Medicine, Oncology, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19426, USA
    J Mol Diagn 9:464-71. 2007
    ..Pyro-sequencing serves as an excellent platform for BRAF genotyping of tumors from patients entering clinical trial...
  56. ncbi request reprint The effect of adding Pap smear information to a mammography reminder system in an HMO: results of randomized controlled trial
    Robert C Burack
    Department of Internal Medicine, University Health Center 5C, 4201 St Antoine, Detroit, MI 48201, USA
    Prev Med 36:547-54. 2003
    ..While reminders can promote cancer screening in primary care, little is known about the potential interaction between multiple reminders...

Research Grants2

  1. Cancer Biostatistics Training Grant
    Phyllis Gimotty; Fiscal Year: 2007
    ..abstract_text> ..