Research Topics
Genomes and Genes | Phyllis A GimottySummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Identification of high-risk patients among those diagnosed with thin cutaneous melanomasPhyllis A Gimotty
The Melanoma Program of the Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Oncol 25:1129-34. 2007..However, some develop metastatic disease that is often fatal. We evaluated established prognostic factors to develop classification schemes with better discrimination than current American Joint Committee on Cancer (AJCC) staging...- Regional nodal metastatic disease is the strongest predictor of survival in patients with thin vertical growth phase melanomas: a case for SLN Staging biopsy in these patientsGiorgos C Karakousis
Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Ann Surg Oncol 14:1596-603. 2007.... - Predictors of regional nodal disease in patients with thin melanomasGiorgos C Karakousis
Department of Surgery, University of Pennsylvania Health System, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 13:533-41. 2006..These factors may help to identify subgroups of these patients that have clinically significant risks of SLN positivity... 
Tissue-based immune monitoring II: multiple tumor sites reveal immunologic homogeneity in serous ovarian carcinomaAndrea R Hagemann
Ovarian Cancer Research Center, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, USA
Cancer Biol Ther 12:367-77. 2011..In conclusion, between-site heterogeneity exists in some patients with metastatic serous ovarian cancer. The predictive value of biopsies should be considered in clinical trial design...- Predicting sentinel node status in AJCC stage I/II primary cutaneous melanomaLaura L Kruper
Melanoma Program of the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 107:2436-45. 2006.... - Lymphatic invasion is independently prognostic of metastasis in primary cutaneous melanomaXiaowei Xu
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Clin Cancer Res 18:229-37. 2012..Lymphatic invasion (LI) in primary cutaneous melanomas was recently found to be common. In this study, we evaluated LI as an independent prognostic factor... - Tumor vascular proteins as biomarkers in ovarian cancerRonald J Buckanovich
Center for Research on Reproduction and Women s Health, Abramson Family Cancer Research Institute, Department of Medicine Division of Hematology Oncology, Philadelphia, PA, USA
J Clin Oncol 25:852-61. 2007..This study aimed to identify novel ovarian cancer biomarkers and potential therapeutic targets through molecular analysis of tumor vascular cells... - Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomasSusan B Kesmodel
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Ann Surg Oncol 12:449-58. 2005..To confirm these results, the predictive value of MR for SLN positivity needs to be validated in other populations of thin-melanoma patients... - Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosisXiaowei Xu
Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Pathol 39:901-9. 2008..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease... - A population-based validation of the American Joint Committee on Cancer melanoma staging systemPhyllis A Gimotty
The Melanoma Program of the Abramson Cancer Center of the University of Pennsylvania, Philadelphia, USA
J Clin Oncol 23:8065-75. 2005..This staging system has not been validated in a US population-based cohort... 
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cellsAndrea Facciabene
Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 475:226-30. 2011..Thus, peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumour growth...- Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancerSarah F Adams
Department of Obstetrics and Gynecology, Ovarian Cancer Research Center, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer 115:2891-902. 2009.... - Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18Ioannis Alagkiozidis
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Transl Med 7:104. 2009..Its active drug, doxorubicin, has interesting immunomodulatory properties. Here, the effects of Doxil on surviving tumor cell immunophenotype were investigated... - Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapyRonald J Buckanovich
Center for Research on Ovarian Cancer Early Detection and Cure, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Med 14:28-36. 2008..These findings highlight a molecular mechanism with the potential to be pharmacologically manipulated to enhance the efficacy of tumor immunotherapy in humans... - Tissue-based immune monitoring I: tumor core needle biopsies allow in-depth interrogation of the tumor microenvironmentAndrea R Hagemann
Ovarian Cancer Research Center, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, USA
Cancer Biol Ther 12:357-66. 2011..Our results demonstrate a feasible and reproducible method of immune monitoring using CT-compatible needle biopsies from tumor tissue, thereby paving the way for sophisticated translational studies during tumor biological therapy... - Thin primary cutaneous malignant melanoma: a prognostic tree for 10-year metastasis is more accurate than American Joint Committee on Cancer stagingPhyllis A Gimotty
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Oncol 22:3668-76. 2004.... - Prognostication in thin cutaneous melanomasPhyllis A Gimotty
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, 19104 6021, USA
Arch Pathol Lab Med 134:1758-63. 2010..Thin melanomas are common and approximately one-quarter of all melanoma-related deaths result from thin primary tumors. Patients with thin melanoma commonly have sentinel lymph node biopsies that are uncommonly positive... - Biologic and prognostic significance of dermal Ki67 expression, mitoses, and tumorigenicity in thin invasive cutaneous melanomaPhyllis A Gimotty
Melanoma Program of the Abramson Cancer Center, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
J Clin Oncol 23:8048-56. 2005..In this study, we characterized three biomarkers of proliferation (Ki67 expression, dermal mitotic rate [MR], and tumorigenicity) in thin (< or = 1.00 mm) primary cutaneous melanomas and examined their association with prognosis... - Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancerLin Zhang
Center for Research on Early Detection and Cure of Ovarian Cancer and Gynecology, Department of Obstetrics, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:7004-9. 2008..Therefore, our results suggest that miRNAs may offer new biomarkers and therapeutic targets in epithelial ovarian cancer... - Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remissionChristina S Chu
Department of Obstetrics and Gynecology and Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Immunol Immunother 61:629-41. 2012..In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy... - Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologistsMichael Shapiro
Department of Dermatology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
J Cutan Pathol 31:523-30. 2004..CONCLUSIONS: Despite attempts to unify nomenclature for microscopically dysplastic nevi through the NIH Consensus Conference, wide variation in terminology persists... - Immune prognostic factors in ovarian cancer: lessons from translational researchPhyllis A Gimotty
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Dis Markers 23:445-52. 2007 - The microRNAs miR-373 and miR-520c promote tumour invasion and metastasisQihong Huang
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Nat Cell Biol 10:202-10. 2008..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs... - Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcomeJia Huang
Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Genes Chromosomes Cancer 50:606-18. 2011..Both mutation as well as copy number changes can be used as predictive markers for this purpose... - Should tumor VEGF expression influence decisions on combining low-dose chemotherapy with antiangiogenic therapy? Preclinical modeling in ovarian cancerDavid O Holtz
Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, USA
J Transl Med 6:2. 2008..This is the first preclinical study that models interactions of LD paclitaxel chemotherapy with antiangiogenic therapy and tumor VEGF expression and offers important lessons for the rational design of clinical trials... - Cutaneous melanoma: estimating survival and recurrence risk based on histopathologic featuresDavid E Elder
Melanoma Program of the Abramson Cancer Center, Divison of Anatomic Pathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Dermatol Ther 18:369-85. 2005..In this monograph, the focus will be the discussion of factors related to the prognosis of melanomas that at diagnosis are clinically localized to the primary site... - Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage displayRolf K Swoboda
Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Cancer Res 67:3555-9. 2007..The RPL8 antigen may represent a relevant vaccine target for patients with melanoma, glioma, and breast carcinoma whose tumors express this protein... - Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammationHongxia Z Imtiyaz
Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6160, USA
J Clin Invest 120:2699-714. 2010..Collectively, our data identify HIF-2alpha as an important regulator of innate immunity, suggesting it may be a useful therapeutic target for treating inflammatory disorders and cancer... - Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomasDevraj Basu
Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
Cell Cycle 10:2008-16. 2011..Further, they provide evidence of mesenchymal-like subsets being well-represented across advanced stage SCCs, suggesting that intrinsic drug resistance in this subpopulation has high clinical relevance... - microRNAs exhibit high frequency genomic alterations in human cancerLin Zhang
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:9136-41. 2006..These findings support the notion that copy number alterations of miRNAs and their regulatory genes are highly prevalent in cancer and may account partly for the frequent miRNA gene deregulation reported in several tumor types... - Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphomaCharalambos Andreadis
Abramson Cancer Center, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Blood 109:3409-16. 2007.... - Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemiaMark Y Chiang
Division of Hematology Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:3181-94. 2008..Even when Notch1 participates secondarily, the resulting tumors show "addiction" to Notch, providing a further rationale for evaluating Notch signaling pathway inhibitors in leukemia... - Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomasBenjamin S Bleier
Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104 4206, USA
Arch Otolaryngol Head Neck Surg 132:779-82. 2006.... - Evolution of sleep quantity, sleep deprivation, mood disturbances, empathy, and burnout among internsIlene M Rosen
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Acad Med 81:82-5. 2006..To explore the relationships between sleep deprivation and the evolution of mood disturbances, empathy, and burnout among a cohort of interns... - Morbidity and mortality of colorectal carcinoma surgery differs by insurance statusRachel Rapaport Kelz
Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer 101:2187-94. 2004.... - A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factorsShinya Ohashi
Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer Res 71:6836-47. 2011.... - Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KJessie Villanueva
The Wistar Institute, Philadelphia, PA 19104, USA
Cancer Cell 18:683-95. 2010..Increased IGF-1R and pAKT levels in a post-relapse human tumor sample are consistent with a role for IGF-1R/PI3K-dependent survival in the development of resistance to BRAF inhibitors... - Validity of patient self-reported history of skin cancerMichael E Ming
Departments of Dermatology and Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Arch Dermatol 140:730-5. 2004..To determine the validity of patient self-report of skin cancer history... - Effect of guidelines on primary care physician use of PSA screening: results from the Community Tracking Study Physician SurveyCarmen E Guerra
Division of General Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Med Decis Making 28:681-9. 2008..The objective of this study was to determine the association between physicians' perceived effect of guidelines on clinical practice and self-reported prostate-specific antigen (PSA) screening patterns... - Interpretation of intra-operative PTH changes in patients with multi-glandular primary hyperparathyroidism (pHPT)Giorgos Constantine Karakousis
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Surgery 142:845-50; discussion 850.e1-2. 2007.... - Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cellsJose R Conejo-Garcia
Center for Research in Reproduction and Women s Health, University of Pennsylvania Medical Center, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Res 64:2175-82. 2004..We propose that Letal could be used for the ex vivo expansion of apoptosis-resistant tumor-reactive cytotoxic lymphocytes for adoptive transfer... - Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysisAdam Cuker
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Blood 120:4160-7. 2012..14 (0.09-0.22) and 0.64 (0.40-0.82), respectively. A low probability 4Ts score appears to be a robust means of excluding HIT. Patients with intermediate and high probability scores require further evaluation... - Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularizationSelene Nunez-Cruz
Penn Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neoplasia 14:994-1004. 2012..Finally, the mouse VEGF(164) transcript was underexpressed in C3(KO) livers compare to C3(WT) livers. Thus, we conclude that complement inhibition blocks tumor outgrowth by altering EC function and VEGF(165) expression... - Use of immuno-LCM to identify the in situ expression profile of cellular constituents of the tumor microenvironmentRonald J Buckanovich
Center for Research on Reproduction and Women's Health, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 5:635-42. 2006..We propose that immuno-LCM coupled with transcriptional profiling is a convenient tool for dissecting molecular and cellular events in complex biological systems such as the tumor microenvironment... - Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinomaDavid A Tuveson
Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, USA
Cancer Res 66:242-7. 2006..These findings suggest that Mist1-expressing cells represent a permissive compartment for transformation by oncogenic Kras in pancreatic tumorigenesis... - Delivery of preventive health services for breast cancer control: a longitudinal view of a randomized controlled trialPhyllis A Gimotty
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Health Serv Res 37:65-85. 2002..CONCLUSIONS: Longitudinal models that examine rates of referral over time and include information about outcomes on previous visits can enhance our understanding of how intervention strategies work in practice... - Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen-embedded fibroblasts in organotypic cultureJiri Kalabis
The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
FASEB J 17:1115-7. 2003.... - Using benchmarks based on historical survival rates for screening new therapies for stage IV melanoma patientsPhyllis A Gimotty
J Clin Oncol 26:517-8. 2008 - Intratumoral T cells, recurrence, and survival in epithelial ovarian cancerLin Zhang
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
N Engl J Med 348:203-13. 2003..The absence of intratumoral T cells was associated with increased levels of vascular endothelial growth factor. CONCLUSIONS: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma... - Validation of prognostic models for melanomaPhyllis A Gimotty
Am J Clin Pathol 118:489-91. 2002 - Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanomaCynthia Spittle
Clinical Translational Medicine, Oncology, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19426, USA
J Mol Diagn 9:464-71. 2007..Pyro-sequencing serves as an excellent platform for BRAF genotyping of tumors from patients entering clinical trial... - The effect of adding Pap smear information to a mammography reminder system in an HMO: results of randomized controlled trialRobert C Burack
Department of Internal Medicine, University Health Center 5C, 4201 St Antoine, Detroit, MI 48201, USA
Prev Med 36:547-54. 2003..While reminders can promote cancer screening in primary care, little is known about the potential interaction between multiple reminders...
Research Grants
- Cancer Biostatistics Training GrantPhyllis Gimotty; Fiscal Year: 2007..abstract_text> ..