J H Gilmore

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Longitudinal development of cortical and subcortical gray matter from birth to 2 years
    John H Gilmore
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Cereb Cortex 22:2478-85. 2012
  2. pmc Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia
    John H Gilmore
    Conte Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 167:1083-91. 2010
  3. ncbi request reprint Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography
    J H Gilmore
    Schizophrenia Research Center and Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    AJNR Am J Neuroradiol 28:1789-95. 2007
  4. ncbi request reprint Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
  5. ncbi request reprint 3 Tesla magnetic resonance imaging of the brain in newborns
    John H Gilmore
    UNC Schizophrenia Research Center, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    Psychiatry Res 132:81-5. 2004
  6. ncbi request reprint Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development
    John H Gilmore
    UNC Schizophrenia Research Center, Chapel Hill, NC, USA
    Neuropsychopharmacology 29:1221-9. 2004
  7. pmc Genetic and environmental contributions to neonatal brain structure: A twin study
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, University of North Carolina, Chapel Hill, USA
    Hum Brain Mapp 31:1174-82. 2010
  8. ncbi request reprint Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
  9. ncbi request reprint Analysis of ependymal abnormalities in subjects with schizophrenia, bipolar disorder, and depression
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 57:267-71. 2002
  10. ncbi request reprint Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Ultrasound Med Biol 27:1143-6. 2001

Detail Information

Publications44

  1. pmc Longitudinal development of cortical and subcortical gray matter from birth to 2 years
    John H Gilmore
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Cereb Cortex 22:2478-85. 2012
    ..It is likely that these patterns of regional gray matter growth reflect maturation and development of underlying function, as they are consistent with cognitive and functional development in the first years of life...
  2. pmc Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophrenia
    John H Gilmore
    Conte Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 167:1083-91. 2010
    ..This study was conducted to identify structural brain abnormalities in the prenatal and neonatal periods associated with genetic risk for schizophrenia...
  3. ncbi request reprint Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractography
    J H Gilmore
    Schizophrenia Research Center and Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    AJNR Am J Neuroradiol 28:1789-95. 2007
    ....
  4. ncbi request reprint Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
    ..Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  5. ncbi request reprint 3 Tesla magnetic resonance imaging of the brain in newborns
    John H Gilmore
    UNC Schizophrenia Research Center, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    Psychiatry Res 132:81-5. 2004
    ..Fractional anisotropy (FA) increased significantly with gestational age in the genu and splenium of the corpus callosum. It is feasible to study brain development in unsedated newborns using 3 T MRI...
  6. ncbi request reprint Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development
    John H Gilmore
    UNC Schizophrenia Research Center, Chapel Hill, NC, USA
    Neuropsychopharmacology 29:1221-9. 2004
    ..These findings also support the hypothesis that cytokines play a key mechanistic role in the link between prenatal exposure to infection and risk for schizophrenia...
  7. pmc Genetic and environmental contributions to neonatal brain structure: A twin study
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, University of North Carolina, Chapel Hill, USA
    Hum Brain Mapp 31:1174-82. 2010
    ..More detailed studies of the changes in the relative genetic and environmental effects on brain structure throughout early childhood development are needed...
  8. ncbi request reprint Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
    ..Abnormal expression of neurotrophic factors represents a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  9. ncbi request reprint Analysis of ependymal abnormalities in subjects with schizophrenia, bipolar disorder, and depression
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 57:267-71. 2002
    ....
  10. ncbi request reprint Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Ultrasound Med Biol 27:1143-6. 2001
    ..3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development...
  11. pmc Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain
    John H Gilmore
    Schizophrenia Research Center and the Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    Biol Psychiatry 64:1069-76. 2008
    ..Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development...
  12. pmc Functional connectivity MR imaging reveals cortical functional connectivity in the developing brain
    W Lin
    Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    AJNR Am J Neuroradiol 29:1883-9. 2008
    ..This study aimed to determine the temporal and spatial patterns of rfc in healthy pediatric subjects between 2 weeks and 2 years of age...
  13. ncbi request reprint Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia
    C E Marx
    Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
    Biol Psychiatry 50:743-9. 2001
    ..If cytokine-mediated neuronal injury proves to be a common response to gestational insults associated with increased schizophrenia risk, the pharmacologic modulation of these molecules may have clinical utility...
  14. ncbi request reprint Fetal brain development of twins assessed in utero by ultrasound: implications for schizophrenia
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Schizophr Res 19:141-9. 1996
    ..These results indicate that in monozygotic twins, brain development is not identical. This difference in brain development may contribute to the observed concordance rates in monozygotic twins with schizophrenia...
  15. ncbi request reprint Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia
    C E Marx
    Department of Psychiatry, Campus Box 7160, University of North Carolina, 27599 7160, Chapel Hill, NC, USA
    Brain Res 871:104-12. 2000
    ..DHEA and DHEAS modulation of anoxia in embryonic neurons may be relevant to disorders of neurodevelopment involving this insult...
  16. ncbi request reprint Mild ventriculomegaly detected in utero with ultrasound: clinical associations and implications for schizophrenia
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Schizophr Res 33:133-40. 1998
    ....
  17. pmc Multivariate varying coefficient models for DTI tract statistics
    Hongtu Zhu
    Department of Biostatistics, Radiology, Psychiatry and Computer Science, and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA
    Med Image Comput Comput Assist Interv 13:690-7. 2010
    ..Significant time effects on the four diffusion properties were found...
  18. pmc Developmental regulation of neural cell adhesion molecule in human prefrontal cortex
    E T Cox
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuroscience 162:96-105. 2009
    ....
  19. pmc Temporal and spatial development of axonal maturation and myelination of white matter in the developing brain
    W Gao
    Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AJNR Am J Neuroradiol 30:290-6. 2009
    ..This study used FA and radial and axonal diffusivities in children younger than 2 years of age, aiming to determine the temporal and spatial development of axonal maturation and myelination of WM in healthy children...
  20. ncbi request reprint Developmental expression of Bcl-2 protein in human cortex
    L F Jarskog
    Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Brain Res Dev Brain Res 119:225-30. 2000
    ..4933, p=0.0006). This study demonstrates that Bcl-2 protein expression in human cortex is developmentally regulated and supports the hypothesis that Bcl-2 is involved in normal aging...
  21. pmc Diffusion tensor imaging detects abnormalities in the corticospinal tracts of neonates with infantile Krabbe disease
    M L Escolar
    Program for Neurodevelopmental Function in Rare Disorders at the Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    AJNR Am J Neuroradiol 30:1017-21. 2009
    ..The purpose of this study was to evaluate the use of diffusion tensor imaging (DTI) with fiber tracking in identifying early changes in major motor tracts of asymptomatic neonates with infantile Krabbe disease...
  22. ncbi request reprint Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Psychiatry Res 73:109-13. 1997
    ..7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection...
  23. ncbi request reprint Outcome in children with fetal mild ventriculomegaly: a case series
    J H Gilmore
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 48:219-26. 2001
    ..The study of fetal ventricle development with ultrasound may provide important insights into neurodevelopmental disorders and allow the identification of children at high risk...
  24. ncbi request reprint Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 32:95-102. 2007
    ..Although the association between antipsychotic treatment and increased pro-apoptotic caspase-3 is intriguing, further study is needed to understand its potential effects...
  25. pmc Maturational trajectories of cortical brain development through the pubertal transition: unique species and sex differences in the monkey revealed through structural magnetic resonance imaging
    Rebecca C Knickmeyer
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cereb Cortex 20:1053-63. 2010
    ..The authors discuss the possible implications of these findings for research using the rhesus macaque as a model for neurodevelopmental disorders...
  26. ncbi request reprint Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 161:109-15. 2004
    ..It was hypothesized that the Bax/Bcl-2 ratio, but not caspase-3, would be high in the temporal cortex of patients with chronic schizophrenia...
  27. pmc Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey
    Sarah J Short
    Department of Psychology, Harlow Center for Biological Psychology, University of Wisconsin, Madison, Wisconsin, USA
    Biol Psychiatry 67:965-73. 2010
    ..However, to verify the relevance of these findings to humans, research is needed in a primate species with more advanced prenatal corticogenesis...
  28. pmc FRATS: Functional Regression Analysis of DTI Tract Statistics
    Hongtu Zhu
    Department of Biostatistics, and Biomedical ResearchImaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC27599, USA
    IEEE Trans Med Imaging 29:1039-49. 2010
    ..The resulting analysis pipeline can be used for understanding normal brain development, the neural bases of neuropsychiatric disorders, and the joint effects of environmental and genetic factors on white matter fiber bundles...
  29. ncbi request reprint Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis
    Isabelle Corouge
    Department of Computer Science, University of North Carolina, Chapel Hill, USA
    Med Image Comput Comput Assist Interv 8:131-9. 2005
    ..Examples from a clinical neuroimaging study of the early developing brain illustrate the potential of this new method to assess white matter fiber maturation and integrity...
  30. ncbi request reprint Apoptotic mechanisms in the pathophysiology of schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005
    ..Although the exact role of apoptosis in schizophrenia remains uncertain, the potential involvement of non-lethal localized apoptosis is intriguing, especially in earlier stages of the illness...
  31. pmc SPHERE: SPherical Harmonic Elastic REgistration of HARDI data
    Pew Thian Yap
    Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Neuroimage 55:545-56. 2011
    ..Experimental results show marked increase in accuracy over a state-of-the-art DTI registration algorithm...
  32. pmc Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Schizophr Res 118:292-9. 2010
    ..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia...
  33. ncbi request reprint Automatic segmentation of MR images of the developing newborn brain
    Marcel Prastawa
    Department of Computer Science, University of North Carolina, CB 3175 Sitterson Hall, Chapel Hill, NC 27599, USA
    Med Image Anal 9:457-66. 2005
    ..Our results demonstrate that the method is able to segment the brain tissue and identify myelinated and non-myelinated white matter regions...
  34. pmc Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood
    L A Glantz
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Neuroscience 149:582-91. 2007
    ....
  35. pmc A structural MRI study of human brain development from birth to 2 years
    Rebecca C Knickmeyer
    Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599 7160, USA
    J Neurosci 28:12176-82. 2008
    ..These results suggest the structural underpinnings of cognitive and motor development in early childhood, as well as the potential pathogenesis of neurodevelopmental disorders...
  36. pmc Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
    Maile A Henson
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
    Cereb Cortex 18:2560-73. 2008
    ..These data provide insights into NMDAR functions in the developing CNS and will contribute to designing pharmacotherapies for neurological disorders...
  37. ncbi request reprint Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unit
    Guihua Zhai
    Department of Biomedical Engineering, University of North Carolina at Chapel Hill, CB 7515, Chapel Hill, NC 27599, USA
    Radiology 229:673-81. 2003
    ..To evaluate the normal brains of adults and neonates for regional and age-related differences in apparent diffusion coefficient (ADC) and fractional anisotropy (FA)...
  38. ncbi request reprint Apoptotic mechanisms and the synaptic pathology of schizophrenia
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 81:47-63. 2006
    ..This paper will review converging lines of data that implicate synaptic deficits in the pathophysiology of schizophrenia and propose an underlying role for apoptotic dysregulation...
  39. pmc Construction of multi-region-multi-reference atlases for neonatal brain MRI segmentation
    Feng Shi
    IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC 27599, USA
    Neuroimage 51:684-93. 2010
    ..e., 0.86 (SD 0.02) for GM, 0.83 (SD 0.03) for WM, and 0.80 (SD 0.05) for CSF. The proposed method also outperforms two other average-shape atlas-based segmentation methods...
  40. doi request reprint Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex
    Kayvon Salimi
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Synapse 62:273-82. 2008
    ....
  41. pmc Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain
    John H Gilmore
    UNC Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:1255-60. 2007
    ..These findings also indicate that whereas some adult patterns of sexual dimorphism and cerebral asymmetries are present at birth, others develop after birth...
  42. pmc Neonatal brain image segmentation in longitudinal MRI studies
    Feng Shi
    IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 106 Mason Farm Road, Chapel Hill, NC 27599, USA
    Neuroimage 49:391-400. 2010
    ..Experimental results show that the utilization of a subject-specific probabilistic atlas can substantially improve tissue segmentation of neonatal brain images...
  43. ncbi request reprint Fetal and neonatal brain development
    John H Gilmore
    Am J Psychiatry 163:2046. 2006
  44. ncbi request reprint Recent advances in the neurobiology of schizophrenia
    Seiya Miyamoto
    St Marianna University School of Medicine, Kawasaki 216 8511, Japan
    Mol Interv 3:27-39. 2003
    ..Rapidly advancing research into schizophrenia includes diverse etiological hypotheses, and offers directions for future research and treatments...