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Genomes and Genes | J H GilmoreSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Longitudinal development of cortical and subcortical gray matter from birth to 2 yearsJohn H Gilmore
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Cereb Cortex 22:2478-85. 2012..It is likely that these patterns of regional gray matter growth reflect maturation and development of underlying function, as they are consistent with cognitive and functional development in the first years of life...- Prenatal and neonatal brain structure and white matter maturation in children at high risk for schizophreniaJohn H Gilmore
Conte Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 167:1083-91. 2010..This study was conducted to identify structural brain abnormalities in the prenatal and neonatal periods associated with genetic risk for schizophrenia... 
Early postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractographyJ H Gilmore
Schizophrenia Research Center and Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7160, USA
AJNR Am J Neuroradiol 28:1789-95. 2007....- Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the ratJohn H Gilmore
UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
J Neuroimmunol 159:106-12. 2005..Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders... - 3 Tesla magnetic resonance imaging of the brain in newbornsJohn H Gilmore
UNC Schizophrenia Research Center, University of North Carolina, Chapel Hill, NC 27599 7160, USA
Psychiatry Res 132:81-5. 2004..Fractional anisotropy (FA) increased significantly with gestational age in the genu and splenium of the corpus callosum. It is feasible to study brain development in unsedated newborns using 3 T MRI... - Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite developmentJohn H Gilmore
UNC Schizophrenia Research Center, Chapel Hill, NC, USA
Neuropsychopharmacology 29:1221-9. 2004..These findings also support the hypothesis that cytokines play a key mechanistic role in the link between prenatal exposure to infection and risk for schizophrenia... - Genetic and environmental contributions to neonatal brain structure: A twin studyJohn H Gilmore
UNC Schizophrenia Research Center, Department of Psychiatry, University of North Carolina, Chapel Hill, USA
Hum Brain Mapp 31:1174-82. 2010..More detailed studies of the changes in the relative genetic and environmental effects on brain structure throughout early childhood development are needed... - Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the ratJohn H Gilmore
Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
J Neuroimmunol 138:49-55. 2003..Abnormal expression of neurotrophic factors represents a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders... - Analysis of ependymal abnormalities in subjects with schizophrenia, bipolar disorder, and depressionJohn H Gilmore
Department of Psychiatry, CB 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Schizophr Res 57:267-71. 2002.... - Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imagingJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Ultrasound Med Biol 27:1143-6. 2001..3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development... - Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brainJohn H Gilmore
Schizophrenia Research Center and the Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7160, USA
Biol Psychiatry 64:1069-76. 2008..Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development... - Functional connectivity MR imaging reveals cortical functional connectivity in the developing brainW Lin
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
AJNR Am J Neuroradiol 29:1883-9. 2008..This study aimed to determine the temporal and spatial patterns of rfc in healthy pediatric subjects between 2 weeks and 2 years of age... - Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophreniaC E Marx
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
Biol Psychiatry 50:743-9. 2001..If cytokine-mediated neuronal injury proves to be a common response to gestational insults associated with increased schizophrenia risk, the pharmacologic modulation of these molecules may have clinical utility... - Fetal brain development of twins assessed in utero by ultrasound: implications for schizophreniaJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Schizophr Res 19:141-9. 1996..These results indicate that in monozygotic twins, brain development is not identical. This difference in brain development may contribute to the observed concordance rates in monozygotic twins with schizophrenia... - Neurosteroid modulation of embryonic neuronal survival in vitro following anoxiaC E Marx
Department of Psychiatry, Campus Box 7160, University of North Carolina, 27599 7160, Chapel Hill, NC, USA
Brain Res 871:104-12. 2000..DHEA and DHEAS modulation of anoxia in embryonic neurons may be relevant to disorders of neurodevelopment involving this insult... - Mild ventriculomegaly detected in utero with ultrasound: clinical associations and implications for schizophreniaJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Schizophr Res 33:133-40. 1998.... - Multivariate varying coefficient models for DTI tract statisticsHongtu Zhu
Department of Biostatistics, Radiology, Psychiatry and Computer Science, and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, USA
Med Image Comput Comput Assist Interv 13:690-7. 2010..Significant time effects on the four diffusion properties were found... - Developmental regulation of neural cell adhesion molecule in human prefrontal cortexE T Cox
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Neuroscience 162:96-105. 2009.... - Temporal and spatial development of axonal maturation and myelination of white matter in the developing brainW Gao
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
AJNR Am J Neuroradiol 30:290-6. 2009..This study used FA and radial and axonal diffusivities in children younger than 2 years of age, aiming to determine the temporal and spatial development of axonal maturation and myelination of WM in healthy children... - Developmental expression of Bcl-2 protein in human cortexL F Jarskog
Department of Psychiatry, C B 7160, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Brain Res Dev Brain Res 119:225-30. 2000..4933, p=0.0006). This study demonstrates that Bcl-2 protein expression in human cortex is developmentally regulated and supports the hypothesis that Bcl-2 is involved in normal aging... - Diffusion tensor imaging detects abnormalities in the corticospinal tracts of neonates with infantile Krabbe diseaseM L Escolar
Program for Neurodevelopmental Function in Rare Disorders at the Center for the Study of Development and Learning, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
AJNR Am J Neuroradiol 30:1017-21. 2009..The purpose of this study was to evaluate the use of diffusion tensor imaging (DTI) with fiber tracking in identifying early changes in major motor tracts of asymptomatic neonates with infantile Krabbe disease... - Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illnessJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Psychiatry Res 73:109-13. 1997..7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection... - Outcome in children with fetal mild ventriculomegaly: a case seriesJ H Gilmore
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
Schizophr Res 48:219-26. 2001..The study of fetal ventricle development with ultrasound may provide important insights into neurodevelopmental disorders and allow the identification of children at high risk... - Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychoticsL Fredrik Jarskog
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Neuropsychopharmacology 32:95-102. 2007..Although the association between antipsychotic treatment and increased pro-apoptotic caspase-3 is intriguing, further study is needed to understand its potential effects... - Maturational trajectories of cortical brain development through the pubertal transition: unique species and sex differences in the monkey revealed through structural magnetic resonance imagingRebecca C Knickmeyer
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cereb Cortex 20:1053-63. 2010..The authors discuss the possible implications of these findings for research using the rhesus macaque as a model for neurodevelopmental disorders... - Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activationL Fredrik Jarskog
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
Am J Psychiatry 161:109-15. 2004..It was hypothesized that the Bax/Bcl-2 ratio, but not caspase-3, would be high in the temporal cortex of patients with chronic schizophrenia... - Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkeySarah J Short
Department of Psychology, Harlow Center for Biological Psychology, University of Wisconsin, Madison, Wisconsin, USA
Biol Psychiatry 67:965-73. 2010..However, to verify the relevance of these findings to humans, research is needed in a primate species with more advanced prenatal corticogenesis... - FRATS: Functional Regression Analysis of DTI Tract StatisticsHongtu Zhu
Department of Biostatistics, and Biomedical ResearchImaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC27599, USA
IEEE Trans Med Imaging 29:1039-49. 2010..The resulting analysis pipeline can be used for understanding normal brain development, the neural bases of neuropsychiatric disorders, and the joint effects of environmental and genetic factors on white matter fiber bundles... - Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysisIsabelle Corouge
Department of Computer Science, University of North Carolina, Chapel Hill, USA
Med Image Comput Comput Assist Interv 8:131-9. 2005..Examples from a clinical neuroimaging study of the early developing brain illustrate the potential of this new method to assess white matter fiber maturation and integrity... - Apoptotic mechanisms in the pathophysiology of schizophreniaL Fredrik Jarskog
Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005..Although the exact role of apoptosis in schizophrenia remains uncertain, the potential involvement of non-lethal localized apoptosis is intriguing, especially in earlier stages of the illness... - SPHERE: SPherical Harmonic Elastic REgistration of HARDI dataPew Thian Yap
Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Neuroimage 55:545-56. 2011..Experimental results show marked increase in accuracy over a state-of-the-art DTI registration algorithm... - Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depressionLeisa A Glantz
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Schizophr Res 118:292-9. 2010..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia... - Automatic segmentation of MR images of the developing newborn brainMarcel Prastawa
Department of Computer Science, University of North Carolina, CB #3175 Sitterson Hall, Chapel Hill, NC 27599, USA
Med Image Anal 9:457-66. 2005..Our results demonstrate that the method is able to segment the brain tissue and identify myelinated and non-myelinated white matter regions... - Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthoodL A Glantz
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
Neuroscience 149:582-91. 2007.... - A structural MRI study of human brain development from birth to 2 yearsRebecca C Knickmeyer
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599 7160, USA
J Neurosci 28:12176-82. 2008..These results suggest the structural underpinnings of cognitive and motor development in early childhood, as well as the potential pathogenesis of neurodevelopmental disorders... - Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortexMaile A Henson
Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
Cereb Cortex 18:2560-73. 2008..These data provide insights into NMDAR functions in the developing CNS and will contribute to designing pharmacotherapies for neurological disorders... - Comparisons of regional white matter diffusion in healthy neonates and adults performed with a 3.0-T head-only MR imaging unitGuihua Zhai
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, CB #7515, Chapel Hill, NC 27599, USA
Radiology 229:673-81. 2003..CONCLUSION: There were regional differences in FA and ADC values in the neonates; such variations were less remarkable in the adults... - Apoptotic mechanisms and the synaptic pathology of schizophreniaLeisa A Glantz
Department of Psychiatry, University of North Carolina-Chapel Hill, CB# 7160, Chapel Hill, NC 27599-7160, USA
Schizophr Res 81:47-63. 2006..This paper will review converging lines of data that implicate synaptic deficits in the pathophysiology of schizophrenia and propose an underlying role for apoptotic dysregulation... - Construction of multi-region-multi-reference atlases for neonatal brain MRI segmentationFeng Shi
IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC 27599, USA
Neuroimage 51:684-93. 2010..e., 0.86 (SD 0.02) for GM, 0.83 (SD 0.03) for WM, and 0.80 (SD 0.05) for CSF. The proposed method also outperforms two other average-shape atlas-based segmentation methods... 
Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortexKayvon Salimi
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Synapse 62:273-82. 2008....- Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brainJohn H Gilmore
UNC Schizophrenia Research Center and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Neurosci 27:1255-60. 2007..These findings also indicate that whereas some adult patterns of sexual dimorphism and cerebral asymmetries are present at birth, others develop after birth... - Neonatal brain image segmentation in longitudinal MRI studiesFeng Shi
IDEA Lab, Department of Radiology and BRIC, University of North Carolina at Chapel Hill, 106 Mason Farm Road, Chapel Hill, NC 27599, USA
Neuroimage 49:391-400. 2010..Experimental results show that the utilization of a subject-specific probabilistic atlas can substantially improve tissue segmentation of neonatal brain images... - Fetal and neonatal brain developmentJohn H Gilmore
Am J Psychiatry 163:2046. 2006 - Recent advances in the neurobiology of schizophreniaSeiya Miyamoto
St. Marianna University School of Medicine, Kawasaki 216-8511, Japan
Mol Interv 3:27-39. 2003..Rapidly advancing research into schizophrenia includes diverse etiological hypotheses, and offers directions for future research and treatments...