Research Topics
| Sid GilmanSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Hereditary neuronal intranuclear inclusion disease with autonomic failure and cerebellar degenerationRaffaella Zannolli
Department of Pediatrics, Obstetrics, and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
Arch Neurol 59:1319-26. 2002..The disease has been found in monozygotic twins and in siblings. In 2 previously described families, the disorder has affected 2 generations...- Consensus statement on the diagnosis of multiple system atrophyS Gilman
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
J Neurol Sci 163:94-8. 1999..The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation... - Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSAS Gilman
Department of Neurology University of Michigan, Ann Arbor, USA
Neurology 61:35-9. 2003..To explore the neurochemical basis of obstructive sleep apnea (OSA) in multiple-system atrophy (MSA)... - Striatal monoamine terminals in Lewy body dementia and Alzheimer's diseaseSid Gilman
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0316, USA
Ann Neurol 55:774-80. 2004..We conclude that PET with (+)-[(11)C]DTBZ differentiates DLB from AD, and decreased binding in AD may indicate subclinical DLB pathology in addition to AD pathology... - Functional imaging with positron emission tomography in multiple system atrophyS Gilman
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0489, USA
J Neural Transm 112:1647-55. 2005.... - Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testingSid Gilman
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0489, USA
Exp Neurol 191:S95-S103. 2005..Neuropsychological testing also differentiates the groups, and family ratings of motor functioning are as robust as PET in these later stages of the disorders... - Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trialS Gilman
Department of Neurology, University of Michigan, 300 N Ingalls 3D15, Ann Arbor, MI 48109 0489, USA
Neurology 64:1553-62. 2005..The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis in 6% of immunized patients... 
Second consensus statement on the diagnosis of multiple system atrophyS Gilman
Department of Neurology, University of Michigan, 300 N Ingalls St, 3D15, Ann Arbor, MI 48109 5489, USA
Neurology 71:670-6. 2008..Since then, clinical, laboratory, neuropathologic, and imaging studies have advanced the field, requiring a fresh evaluation of diagnostic criteria. We held a second consensus conference in 2007 and present the results here...- The North American Multiple System Atrophy Study GroupS Gilman
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0489, USA
J Neural Transm 112:1687-94. 2005.... - Time course and outcome of recovery from stroke: relevance to stem cell treatmentSid Gilman
Department of Neurology, University of Michigan, 300 North Ingalls St, Ann Arbor, MI 48109, USA
Exp Neurol 199:37-41. 2006.... - Pharmacologic management of ischemic stroke: relevance to stem cell therapySid Gilman
Department of Neurology, The University of Michigan, 300 North Ingalls Street 3D15, Ann Arbor, MI 48105 0495, USA
Exp Neurol 199:28-36. 2006.... - Parkinsonian syndromesSid Gilman
Department of Neurology, University of Michigan, 300 North Ingalls, 3D15, Ann Arbor, MI 48109 0489, USA
Clin Geriatr Med 22:827-42, vi. 2006..This article reviews the epidemiology, pathology, clinical features, diagnosis, and management of these disorders... - REM sleep behavior disorder is related to striatal monoaminergic deficit in MSAS Gilman
Department of Neurology, University of Michigan, Ann Arbor, USA
Neurology 61:29-34. 2003..To explore the neurochemical basis of REM sleep behavior disorder (RBD) in multiple-system atrophy (MSA)... - Joint position sense and vibration sense: anatomical organisation and assessmentS Gilman
Department of Neurology, University of Michigan Medical Center, 1500 E Medical Center Drive, 1914 Taubman Center, Ann Arbor 48109 0316, USA
J Neurol Neurosurg Psychiatry 73:473-7. 2002..Clinical testing of these modalities requires simultaneous stimulation of tactile receptors; hence this review will include information about the receptors and pathways responsible for tactile sensation... - Consensus statement on the diagnosis of multiple system atrophy. American Autonomic Society and American Academy of NeurologyS Gilman
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
Clin Auton Res 8:359-62. 1998..The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poor levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation... - Consensus statement on the diagnosis of multiple system atrophyS Gilman
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109 0316, USA
J Auton Nerv Syst 74:189-92. 1998..The diagnosis of probable MSA requires the criterion for autonomic failure/urinary dysfunction plus poorly levodopa responsive parkinsonism or cerebellar ataxia. The diagnosis of definite MSA requires pathological confirmation... - Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairmentRoger L Albin
VA Ann Arbor Health System Geriatrics Research, Education, and Clinical Center, and Department of Neurology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Arch Neurol 67:440-6. 2010.... 
Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomographyRobert A Koeppe
Division of Nuclear Medicine, Department of Radiology, The University of Michigan, Ann Arbor, MI, USA
Alzheimers Dement 4:S67-76. 2008..We used positron emission tomography (PET) in attempts to differentiate these disorders...- 11C-DTBZ and 18F-FDG PET measures in differentiating dementiasRobert A Koeppe
Division of Nuclear Medicine, Department of Radiology, University of Michigan School of Medicine, 3480 Kresge III, Box 0552, Ann Arbor, MI 48109, USA
J Nucl Med 46:936-44. 2005.... - Assessment of mild dementia with amyloid and dopamine terminal positron emission tomographyJames F Burke
Department of Neurology, University of Michigan, and University of Michigan Hospitals, Room B1 G505 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0028, USA
Brain 134:1647-57. 2011.... - Heterogeneity of cholinergic denervation in Parkinson's disease without dementiaNicolaas I Bohnen
Department of Radiology, Division of Nuclear Medicine, University of Michigan, Ann Arbor, Michigan 48105 9755, USA
J Cereb Blood Flow Metab 32:1609-17. 2012..Results also show independent cognitive effects for both cholinergic and dopaminergic system changes in nondemented PD subjects... - Validation of a polysomnographic score for REM sleep behavior disorderFlavia B Consens
University of Michigan, Ann Arbor, MI, USA
Sleep 28:993-7. 2005..We sought to validate this method in a larger sample of patients and control subjects... - Pattern of cardiac sympathetic denervation in idiopathic Parkinson disease studied with 11C hydroxyephedrine PETKa Kit Wong
Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical Center, University of Michigan, 1500 E Medical Center Dr, B1G505G, Ann Arbor, MI 48105, USA
Radiology 265:240-7. 2012.... - PET measurement of cardiac and nigrostriatal denervation in Parkinsonian syndromesDavid M Raffel
Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA
J Nucl Med 47:1769-77. 2006..Also, the relationship between cardiac denervation and nigrostriatal denervation was investigated by measuring striatal presynaptic monoaminergic nerve density with PET and (11)C-dihydrotetrabenazine ((11)C-DTBZ)... - EMG variance during polysomnography as an assessment for REM sleep behavior disorderJoseph W Burns
Michigan Tech Research Institute, Michigan Technological University, Ann Arbor, MI 48105, USA
Sleep 30:1771-8. 2007..We therefore developed a computerized metric to assess EMG variance and compared the results to those previously published for visual scoring, bed partner-rated RBD symptom scores, and clinical assessments by sleep medicine specialists... - PET measures of benzodiazepine receptors in progressive supranuclear palsyN L Foster
Department of Neurology, University of Michigan at Ann Arbor, 48109 0316, USA
Neurology 54:1768-73. 2000..To evaluate the integrity of neurons containing benzodiazepine receptors in metabolically affected regions of the brain in patients with clinically diagnosed progressive supranuclear palsy (PSP)... - Unilateral striatal lesions in the cat disrupt well-learned motor plans in a GO/NO-GO reaching taskJ W Aldridge
Department of Neurology, University of Michigan, Ann Arbor 48104 1687, USA
Exp Brain Res 113:379-93. 1997..Our findings suggest that the basal ganglia facilitate the fluent and rapid execution of sequences of well-learned sensorimotor behavior, but the representations of motor plans are not stored in the basal ganglia... - Patterns of neuropsychological performance in multiple system atrophy compared to sporadic and hereditary olivopontocerebellar atrophyS Berent
Division of Neuropsychology, Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109 0840, USA
Brain Cogn 50:194-206. 2002..Patients with MSA had greater neuropsychological dysfunction, particularly in memory and other "higher order" cognitive processes, than patients with either sOPCA or dOPCA... - Cerebral cortical and subcortical cholinergic deficits in parkinsonian syndromesS Gilman
Department of Neurology, University of Michigan Health System, Ann Arbor, USA
Neurology 74:1416-23. 2010..We studied cholinergic innervation in these disorders as compared to age-appropriate normal control subjects... - Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failureAxel Lipp
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 66:742-50. 2009.... - Autoradiographic localization of inhibitory and excitatory amino acid neurotransmitter receptors in human normal and olivopontocerebellar atrophy cerebellar cortexR L Albin
Department of Neurology, University of Michigan, Ann Arbor 48104
Brain Res 522:37-45. 1990..Our normal human and OPCA data are largely consistent with animal data about the cellular localization of cerebellar cortical amino acid neurotransmitter receptors... - Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsyJ W McDonald
Department of Neurology, University of Michigan, Ann Arbor
Ann Neurol 29:529-41. 1991..The data indicate that excitatory and inhibitory amino acid receptors are altered in the hippocampus of patients with temporal lobe epilepsy... - G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophyLaurie J Ozelius
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
Mov Disord 22:546-9. 2007..We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA... - Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)Gregor K Wenning
Department of Neurology, University of Innsbruck, Austria
Mov Disord 19:1391-402. 2004..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients... - What do people at risk for Alzheimer disease think about surrogate consent for research?Dale B Schenk
Neurology 66:1785-6. 2006 - A roadmap for the prevention of dementia: the inaugural Leon Thal SymposiumZaven S Khachaturian
Alzheimers Dement 4:156-63. 2008 - Sir Victor Horsley, Mr John Marshall, the nervi nervorum, and pain: more than a century ahead of their timeJoel A Vilensky
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Fort Wayne 46805, USA
Arch Neurol 62:499-501. 2005 - Relationship between neuropsychological and emotional functioning in severe chronic alcoholismDoug Johnson-Greene
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21239, USA
Clin Neuropsychol 16:300-9. 2002.... - Horsley was the first to use electrical stimulation of the human cerebral cortex intraoperativelyJoel A Vilensky
Department of Anatomy, Indiana University School of Medicine, Fort Wayne, Indiana, USA
Surg Neurol 58:425-6. 2002..Sir Victor Horsley apparently first used electrical stimulation diagnostically in 1884 and slightly later (1886) to define epileptic foci... - Unexpected abundance of pathological tau in progressive supranuclear palsy white matterVictoria Zhukareva
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 60:335-45. 2006.... - Potential outcome measures and trial design issues for multiple system atrophySusanne May
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0717, USA
Mov Disord 22:2371-7. 2007..The UMSARS Motor Examination score exhibited the most favorable characteristics as an outcome measure for a therapeutic trial in MSA with 1 year of follow-up...
Research Grants
- Conference on the Diagnosis of Multiple System AtrophySid Gilman; Fiscal Year: 2006..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. ..