Ravinder Gill

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells
    Waddah A Alrefai
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, and Jesse Brown VA Medical Center, Chicago, Ilinois 60612, USA
    Dig Dis Sci 52:1270-8. 2007
  2. ncbi Function, expression, and characterization of the serotonin transporter in the native human intestine
    Ravinder K Gill
    Research Assistant Professor, Univ of Illinois at Chicago, Jesse Brown V A Medical Center, Medical Research Service 600 151 820 South Damen Ave, Chicago, IL 60612
    Am J Physiol Gastrointest Liver Physiol 294:G254-62. 2008
  3. ncbi Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts
    Fadi Annaba
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, IL, USA
    Am J Physiol Gastrointest Liver Physiol 294:G489-97. 2008
  4. pmc Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 304:C334-41. 2013
  5. pmc Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    J Clin Invest 117:428-37. 2007
  6. pmc Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells
    Ravinder K Gill
    Dept of Medicine, Univ of Illinois at Chicago, Medical Research Service, Jesse Brown VA Medical Center, 820 S Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 295:G700-8. 2008
  7. pmc Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown VA Medical Center, 60612, USA
    Am J Physiol Gastrointest Liver Physiol 300:G627-36. 2011
  8. pmc Modulation of ileal apical Na+-dependent bile acid transporter ASBT by protein kinase C
    Zaheer Sarwar
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinios 60612, USA
    Am J Physiol Gastrointest Liver Physiol 297:G532-8. 2009
  9. pmc B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 285:522-30. 2010
  10. pmc Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT
    Fadi Annaba
    Department of Medicine, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center, USA
    Am J Physiol Gastrointest Liver Physiol 298:G467-73. 2010

Research Grants

  1. Anion Transport in EPEC Induced Diarrhea
    Ravinder Gill; Fiscal Year: 2007

Collaborators

Detail Information

Publications38

  1. ncbi Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells
    Waddah A Alrefai
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, and Jesse Brown VA Medical Center, Chicago, Ilinois 60612, USA
    Dig Dis Sci 52:1270-8. 2007
    ..In conclusion, our studies provide direct evidence for inhibition of human intestinal apical Cl(-)/OH(-) exchange activity by bile acids via Ca(2+)-, PI3 kinase-, and PKC beta I-dependent pathways in Caco2 cells...
  2. ncbi Function, expression, and characterization of the serotonin transporter in the native human intestine
    Ravinder K Gill
    Research Assistant Professor, Univ of Illinois at Chicago, Jesse Brown V A Medical Center, Medical Research Service 600 151 820 South Damen Ave, Chicago, IL 60612
    Am J Physiol Gastrointest Liver Physiol 294:G254-62. 2008
    ....
  3. ncbi Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts
    Fadi Annaba
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, IL, USA
    Am J Physiol Gastrointest Liver Physiol 294:G489-97. 2008
    ....
  4. pmc Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: role of HDAC2
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 304:C334-41. 2013
    ..Our results identify a novel role of HDAC2 as a regulator of SERT gene expression in intestinal epithelial cells...
  5. pmc Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Illinois 60612, USA
    J Clin Invest 117:428-37. 2007
    ..Our data demonstrate that EspG and EspG2 play an important role in contributing to EPEC infection-associated inhibition of luminal membrane chloride transport via modulation of surface DRA expression...
  6. pmc Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells
    Ravinder K Gill
    Dept of Medicine, Univ of Illinois at Chicago, Medical Research Service, Jesse Brown VA Medical Center, 820 S Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 295:G700-8. 2008
    ....
  7. pmc Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown VA Medical Center, 60612, USA
    Am J Physiol Gastrointest Liver Physiol 300:G627-36. 2011
    ..Our findings define novel mechanisms of transcriptional regulation of SERT by EGF via EGFR at the promoter level that may contribute to the beneficial effects of EGF in gut disorders...
  8. pmc Modulation of ileal apical Na+-dependent bile acid transporter ASBT by protein kinase C
    Zaheer Sarwar
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinios 60612, USA
    Am J Physiol Gastrointest Liver Physiol 297:G532-8. 2009
    ..Our novel findings demonstrate a posttranscriptional modulation of ileal ASBT function and membrane expression by phorbol ester via a PKCzeta-dependent pathway...
  9. pmc B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 285:522-30. 2010
    ..Also, the commonly used food additive carrageenan can be added to the short list of known activators of both pathways...
  10. pmc Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT
    Fadi Annaba
    Department of Medicine, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center, USA
    Am J Physiol Gastrointest Liver Physiol 298:G467-73. 2010
    ..In conclusion, our data demonstrate a novel role of lipid rafts in the modulation of ASBT function by the dietary component EGCG, which may underlie the hypocholesterolemic effects of green tea...
  11. ncbi Rapid activation of Na+/H+ exchange by EPEC is PKC mediated
    Kim Hodges
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 291:G959-68. 2006
    ..Because EPEC markedly increases NHE2 activity, this pathogen provides an exceptional opportunity to improve our understanding of this less-characterized NHE isoform...
  12. pmc Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange
    Amika Singla
    Section of Digestive Diseases and Nutrition, Department of Physiology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 298:G182-9. 2010
    ..Our results demonstrate that LPA stimulates apical Cl(-)/OH(-) exchange activity and surface levels of DRA in intestinal epithelial cells. This increase in Cl(-)/OH(-) exchange may contribute to the antidiarrheal effects of LPA...
  13. pmc Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: involvement of NF-kappaB pathway
    Alip Borthakur
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    J Cell Biochem 103:1452-63. 2008
    ..Our results demonstrate the involvement of NF-kappaB pathway in the regulation of MCT1 promoter activity by butyrate...
  14. ncbi Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level
    Alip Borthakur
    Department of Medicine, University of Illinois at Chicago and Jesse Brown Veteran Affairs Medical Center, 820 South Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 290:G30-5. 2006
    ..This inhibition was dependent on a functional TTSS and the structural proteins EspA, -B, and -D of the translocation apparatus...
  15. pmc Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression
    Ali Esmaili
    Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Gastroenterology 137:2074-83. 2009
    ..The present studies examined the effects of EPEC infection on SERT activity and expression in intestinal epithelial cells and elucidated the underlying mechanisms...
  16. ncbi Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin
    Seema Saksena
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 280:11859-68. 2005
    ..viii) 5-HT stimulated tyrosine phosphorylation of c-Src kinase and PKC delta...
  17. pmc Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells
    Md Ruhul Amin
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, 840 S Wood Street, Chicago, IL 60612, USA
    Biochem Biophys Res Commun 382:620-5. 2009
    ..Our data indicate that 5-HT suppresses the transcriptional activity of the NHE3 promoter and this effect may be mediated by PKCalpha and modulation of DNA-binding affinities of Sp1 and Sp3...
  18. ncbi Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptors and activation of PKC alpha in human intestinal epithelial cells
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Jesse Brown VA Medical Center, IL 60612, USA
    Gastroenterology 128:962-74. 2005
    ..The present studies examined the acute effects of 5-hydroxytryptamine (5-HT) on NHE activity using Caco-2 cells as an in vitro model...
  19. ncbi Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells
    Gail Hecht
    Univ of Illinois at Chicago, Medical Research Service 600 151 Chicago Veterans Affairs Health Care System, 820 S Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 287:G370-8. 2004
    ..Additionally, NHEs do not appear to play any role in EPEC-mediated inflammation, because the NHE inhibitors amiloride and 5-(N-ethyl-N-isopropyl)amiloride did not prevent EPEC-mediated IkappaBalpha degradation...
  20. pmc Lactobacillus acidophilus stimulates the expression of SLC26A3 via a transcriptional mechanism
    Geetu Raheja
    Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, 60612, USA
    Am J Physiol Gastrointest Liver Physiol 298:G395-401. 2010
    ..In conclusion, increase in DRA promoter activity and expression may contribute to the upregulation of intestinal electrolyte absorption and might underlie the potential antidiarrheal effects of LA...
  21. pmc The probiotic Lactobacillus acidophilus stimulates chloride/hydroxyl exchange activity in human intestinal epithelial cells
    Alip Borthakur
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
    J Nutr 138:1355-9. 2008
    ..Our results suggest that LA secretes soluble effector molecule(s) into the culture medium that stimulate apical Cl(-)/OH(-) exchange activity via phosphatidylinositol-3 kinase mediated mechanism...
  22. pmc Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells
    Sumit Bhattacharyya
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 283:10550-8. 2008
    ..Because CGN is a commonly used food additive in the Western diet, clarification of its effects and mechanisms of action are vital to issues of food safety...
  23. pmc Ileal apical Na+-dependent bile acid transporter ASBT is upregulated in rats with diabetes mellitus induced by low doses of streptozotocin
    Fadi Annaba
    Department of Medicine, University of Illinois at Chicago, USA
    Am J Physiol Gastrointest Liver Physiol 299:G898-906. 2010
    ..The increase in ASBT expression may contribute to disturbances in cholesterol homeostasis associated with diabetes mellitus...
  24. ncbi Cholesterol modulates human intestinal sodium-dependent bile acid transporter
    Waddah A Alrefai
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veteran Affairs Medical Center, Medical Research Service 600 151 820 South Damen Ave, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 288:G978-85. 2005
    ..These data provide novel evidence for the direct regulation of human ASBT function by cholesterol and suggest that this phenomenon may play a central role in cholesterol homeostasis...
  25. pmc Stimulation of apical Cl⁻/HCO₃⁻(OH⁻) exchanger, SLC26A3 by neuropeptide Y is lipid raft dependent
    Seema Saksena
    Dept of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 299:G1334-43. 2010
    ..Our findings suggest that the alteration in the association of DRA with lipid rafts may contribute to the proabsorptive effects of NPY in the human intestine...
  26. pmc Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-{gamma}
    Seema Saksena
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 298:G159-66. 2010
    ..Mutations in the potential GAS element abrogated the inhibitory effects of IFN-gamma. These studies provide evidence for the involvement of STAT1 in the inhibition of SLC26A3 gene expression by IFN-gamma in the human intestine...
  27. ncbi Regulation of NHE3 by nitric oxide in Caco-2 cells
    Ravinder K Gill
    Section of Digestive and Liver Diseases, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 283:G747-56. 2002
    ..These data provide novel evidence that NO inhibits NHE3 activity via activation of soluble guanylate cyclase, resulting in an increase in intracellular cGMP levels and activation of protein kinase G...
  28. ncbi Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter
    Christos Hadjiagapiou
    Univ of Illinois at Chicago, Medical Research Service 600 151 Jesse Brown VA Medical Center, 820 South Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1118-26. 2005
    ..The two potential SP1 binding sites found in the same region of the promoter were found not to be involved in its regulation...
  29. ncbi Expression and membrane localization of MCT isoforms along the length of the human intestine
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Medical Research Service 600 151, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Ave, Chicago, Illinois 60612, USA
    Am J Physiol Cell Physiol 289:C846-52. 2005
    ..We speculate that distinct MCT isoforms may be involved in SCFA transport across the apical or basolateral membranes in polarized colonic epithelial cells...
  30. ncbi Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2
    Waddah A Alrefai
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois, and Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 292:G369-76. 2007
    ..Our study demonstrated the modulation of human NPC1L1 expression and promoter activity by cholesterol in a SREBP-2-dependent mechanism...
  31. ncbi Bile acid transporters: structure, function, regulation and pathophysiological implications
    Waddah A Alrefai
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Pharm Res 24:1803-23. 2007
    ..This review will highlight current knowledge about structure, function and molecular characterization of bile acid transporters and discuss the implications of their defects in various hepatic and intestinal disorders...
  32. pmc PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 296:G275-83. 2009
    ..These findings showing the regulation of MCT1 promoter by PKC and AP2 are of significant importance for an understanding of the molecular regulation of SCFA absorption in the human intestine...
  33. pmc Characterization of the 5'-flanking region and regulation of expression of human anion exchanger SLC26A6
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
    J Cell Biochem 105:454-66. 2008
    ..Mutations in the potential ISRE site abrogated the inhibitory effects of IFNgamma. These studies provided novel evidence for the involvement of IRF-1 in the regulation of SLC26A6 gene expression by IFNgamma in the human intestine...
  34. pmc Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells
    Seema Saksena
    Section of Digestive Diseases and Nutrition, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 297:G878-85. 2009
    ..Our findings demonstrate that increased MCT1 association with CD147 at the apical membrane in response to SST is p38 MAP kinase dependent and underlies the stimulatory effects of SST on butyrate uptake...
  35. ncbi Inhibition of apical Cl-/OH- exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon
    Seema Saksena
    Section of Digestive and Liver Diseases, Department of Medicine, University of Illinois at Chicago and West Side Department of Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
    Am J Physiol Cell Physiol 283:C1492-500. 2002
    ....
  36. pmc Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago, Jesse Brown VA Medical Center, Chicago, IL 60612, USA
    Biochem J 416:99-108. 2008
    ....
  37. ncbi Modulation of Cl-/OH- exchange activity in Caco-2 cells by nitric oxide
    Seema Saksena
    Section of Digestive and Liver Diseases, Department of Medicine, University of Illinois at Chicago and Chicago Veteran s Affairs System West Side Division, Chicago, Illinois 60612, USA
    Am J Physiol Gastrointest Liver Physiol 283:G626-33. 2002
    ..Our results suggest that NO-induced inhibition of Cl-/OH- exchange may play an important role in the pathophysiology of diarrhea associated with inflammatory bowel diseases...
  38. ncbi Mechanisms of calcium transport in human colonic basolateral membrane vesicles
    Seema Saksena
    Department of Medicine, University of Illinois at Chicago and Chicago VA System, 60612, USA
    Dig Dis Sci 47:2306-15. 2002
    ..Our results demonstrate the presence of a Mg2+/ATP-dependent calmodulin-regulated Ca2+ transport system and a Na+-Ca2+ exchange process in the human colonic basolateral membranes...

Research Grants2

  1. Anion Transport in EPEC Induced Diarrhea
    Ravinder Gill; Fiscal Year: 2007
    ....