Parkash S Gill


Affiliation: University of Southern California
Country: USA


  1. Liu R, Ferguson B, Zhou Y, Naga K, Salgia R, Gill P, et al. EphB4 as a therapeutic target in mesothelioma. BMC Cancer. 2013;13:269 pubmed publisher
    ..A search for novel targets and therapeutics is underway, and recently identified targets include VEGF, Notch, and EphB4-Ephrin-B2. Each of these targets has dual activity, promoting tumor cell growth as well as tumor angiogenesis...
  2. Benedito R, Trindade A, Hirashima M, Henrique D, da Costa L, Rossant J, et al. Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol. 2008;8:117 pubmed publisher
    ..Together, these results strongly suggest that Notch signalling can increase arterial stability and calibre by decreasing the response of arterial endothelial cells to local gradients of pro-angiogenic factors like VEGF. ..
  3. Djokovic D, Trindade A, Gigante J, Badenes M, Silva L, Liu R, et al. Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer. 2010;10:641 pubmed publisher
    ..Combination targeting of Dll4/Notch and Ephrin-B2/EphB4 has potential for clinical investigation, providing cumulative efficacy and increased safety over Dll4/Notch inhibition alone. ..