Don Gilden

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurol Sci 159:140-4. 1998
  2. ncbi Clinical and molecular pathogenesis of varicella virus infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Viral Immunol 16:243-58. 2003
  3. pmc Recurrent varicella zoster virus myelopathy
    Don Gilden
    Department of Neurology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    J Neurol Sci 276:196-8. 2009
  4. ncbi Multiple sclerosis exacerbations and infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Lancet Neurol 1:145. 2002
  5. ncbi Chronic varicella-zoster virus ganglionitis--a possible cause of postherpetic neuralgia
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurovirol 9:404-7. 2003
  6. ncbi Surgical induction of zoster in a contralateral homologous dermatomal distribution
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Arch Neurol 60:616-7. 2003
  7. ncbi The protean manifestations of varicella-zoster virus vasculopathy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurovirol 8:75-9. 2002
  8. ncbi Two patients with unusual forms of varicella-zoster virus vasculopathy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 347:1500-3. 2002
  9. doi Brain imaging abnormalities in CNS virus infections
    Donald H Gilden
    Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
    Neurology 70:84. 2008
  10. ncbi Clinical practice. Bell's Palsy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 351:1323-31. 2004

Research Grants

  1. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2007
  2. NEUROVIROLOGY-MOLECULAR BIOLOGY
    Donald Gilden; Fiscal Year: 2007
  3. NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 1993
  4. NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 1990
  5. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2009

Detail Information

Publications105 found, 100 shown here

  1. ncbi The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurol Sci 159:140-4. 1998
    ....
  2. ncbi Clinical and molecular pathogenesis of varicella virus infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Viral Immunol 16:243-58. 2003
    ....
  3. pmc Recurrent varicella zoster virus myelopathy
    Don Gilden
    Department of Neurology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    J Neurol Sci 276:196-8. 2009
    ..In contrast to earlier cases of recurrent VZV myelopathy in immunocompetent adults that developed weeks to months after the first episode of myelopathy, this is the first instance of recurrence years later...
  4. ncbi Multiple sclerosis exacerbations and infection
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Lancet Neurol 1:145. 2002
  5. ncbi Chronic varicella-zoster virus ganglionitis--a possible cause of postherpetic neuralgia
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurovirol 9:404-7. 2003
    ..The presence of fragments of VZV DNA in MNCs likely represents partial degradation of viral DNA in MNCs that trafficked through ganglia during productive infection...
  6. ncbi Surgical induction of zoster in a contralateral homologous dermatomal distribution
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Arch Neurol 60:616-7. 2003
    ..The mechanism by which unilateral surgery might affect homologous ganglia is likely to involve spinal cord pathways above the dermatomal level of surgical trauma...
  7. ncbi The protean manifestations of varicella-zoster virus vasculopathy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurovirol 8:75-9. 2002
    ..When VZV vasculopathy develops months after zoster, antiviral treatment is often effective...
  8. ncbi Two patients with unusual forms of varicella-zoster virus vasculopathy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 347:1500-3. 2002
  9. doi Brain imaging abnormalities in CNS virus infections
    Donald H Gilden
    Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
    Neurology 70:84. 2008
  10. ncbi Clinical practice. Bell's Palsy
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 351:1323-31. 2004
  11. ncbi VZV vasculopathy and postherpetic neuralgia: progress and perspective on antiviral therapy
    Donald H Gilden
    Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 8026, USA
    Neurology 64:21-5. 2005
    ..Few studies have used antiviral therapy to manage PHN with conflicting results. Larger, double-blind studies, which give IV antiviral drug, are needed...
  12. ncbi Infectious causes of multiple sclerosis
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Lancet Neurol 4:195-202. 2005
    ..A viral antigen against which the IgG in MS brain and CSF is directed might be identified...
  13. ncbi Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosis
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Mail Stop B182, Denver, CO 80262, USA
    Arch Neurol 58:43-8. 2001
    ..New sophisticated molecular immunologic techniques described herein should enhance our ability to identify putative antigen(s) targets in MS...
  14. ncbi Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia
    D H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262, USA
    Virus Genes 23:145-7. 2001
    ..The ability of reactivated VZV to produce serious, sometimes fatal neurological disease in the absence of rash, raises the possibility that VZV reactivation from autonomic ganglia might be involved in visceral disease...
  15. ncbi A search for virus in multiple sclerosis
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Hybrid Hybridomics 21:93-7. 2002
    ..These studies could confirm Dr. Koprowski's prophetic vision and identify the virus that causes MS, including the mechanism by which demyelination is produced...
  16. ncbi Herpesvirus infections of the nervous system
    Donald H Gilden
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Nat Clin Pract Neurol 3:82-94. 2007
    ....
  17. pmc Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    Neurology 80:2017-21. 2013
    ....
  18. pmc Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weakness
    Jean Tsai
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    J Neurol Sci 313:193-5. 2012
    ..Simultaneous reactivation of two alphaherpesviruses (HSV-1 and VZV) in our immunosuppressed patient underscores the need to consider opportunistic infection as a cause of facial weakness...
  19. pmc Varicella zoster virus infection of highly pure terminally differentiated human neurons
    Xiaoli Yu
    Department of Neurology, University of Colorado Denver School of Medicine, 12700 E 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
    J Neurovirol 19:75-81. 2013
    ..VZV infection of highly pure terminally differentiated human neurons provides a unique in vitro system to study the VZV-neuronal relationship and the potential to investigate mechanisms of VZV reactivation...
  20. pmc Human anti-varicella-zoster virus (VZV) recombinant monoclonal antibody produced after Zostavax immunization recognizes the gH/gL complex and neutralizes VZV infection
    Marius Birlea
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA
    J Virol 87:415-21. 2013
    ..An unlimited supply of this antibody provides the opportunity to analyze membrane fusion events that follow virus attachment and to identify multiple epitopes on VZV-specific proteins...
  21. pmc Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques
    Ravi Mahalingam
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Virol 84:12454-7. 2010
    ..Virus transcription and the detection of open reading frame (ORF) 63 protein in the cytoplasm of neurons were comparable. Thus, a 30-h delay after death did not affect varicella-zoster virus expression in latently infected ganglia...
  22. pmc Viruses and multiple sclerosis
    Gregory P Owens
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Neuroscientist 17:659-76. 2011
    ....
  23. pmc Latent simian varicella virus reactivates in monkeys treated with tacrolimus with or without exposure to irradiation
    Ravi Mahalingam
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurovirol 16:342-54. 2010
    ..These results indicate that tacrolimus treatment produced reactivation in more monkeys than irradiation and tacrolimus and irradiation increased the frequency of SVV reactivation as compared to either treatment alone...
  24. pmc Varicella-zoster virus transcriptome in latently infected human ganglia
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Virol 85:2276-87. 2011
    ..Comparison of the 10 VZV ORFs transcribed during latency to their herpes simplex virus type 1 homologues reveals that the latently transcribed VZV genes encode immediate-early, early, and late transcripts...
  25. pmc Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63
    Niklaus H Mueller
    Department of Neurology, University of Colorado Denver School of Medicine, Denver, USA
    J Gen Virol 91:1133-7. 2010
    ....
  26. pmc Array analysis of simian varicella virus gene transcription in productively infected cells in tissue culture
    Steven B Deitch
    Department of Neurology, Mail Stop B182, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Virol 79:5315-25. 2005
    ..The abundance of each SVV transcript was compared with that previously demonstrated for VZV in infected tissue culture cells...
  27. ncbi B-lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluid
    Kurt Haubold
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Neurol 56:97-107. 2004
    ....
  28. pmc Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid
    Gregory P Owens
    Department of Neurology, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    Ann Neurol 65:639-49. 2009
    ..Nevertheless, the target antigen of this response remains enigmatic...
  29. pmc Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment
    Don Gilden
    Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Lancet Neurol 8:731-40. 2009
    ..In recent years, the number of recognised VZV vasculopathies has grown, and accurate diagnosis is important for the effective treatment of these disorders...
  30. pmc Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literature
    Aaron Haug
    Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Neurol Sci 292:85-8. 2010
    ....
  31. pmc Varicella zoster virus ischemic optic neuropathy and subclinical temporal artery involvement
    Richard Salazar
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
    Arch Neurol 68:517-20. 2011
    ....
  32. pmc Synthesis and decay of varicella zoster virus transcripts
    Yevgeniy Azarkh
    Department of Neurology, School of Medicine, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
    J Neurovirol 17:281-7. 2011
    ..Thus, difference in mRNA synthesis, and not mRNA decay, is the major factor contributing to the difference in the relative abundance of VZV transcripts in infected cells...
  33. ncbi Simian varicella virus DNA is present and transcribed months after experimental infection of adult African green monkeys
    Tiffany M White
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Neurovirol 8:191-203. 2002
    ..Overall, intratracheal inoculation of SVV in African green monkeys resulted in the presence of viral DNA and transcription of multiple viral genes in many tissues for months after experimental infection...
  34. pmc Laser capture microdissection and single-cell RT-PCR without RNA purification
    Kathryne Melissa Keays
    Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, United States
    J Immunol Methods 302:90-8. 2005
    ..These techniques will streamline the identification of gene expression products in single cells from complex tissues and have the potential to identify IgGs expressed in the CNS of inflammatory diseases of unknown etiology...
  35. pmc Zoster paresis: asymptomatic MRI lesions far beyond the site of rash and focal weakness
    Jean Tsai
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    J Neurol Sci 330:119-20. 2013
    ..This report reveals a previously undescribed remarkable preponderance of MRI lesions far beyond the site of zoster rash and focal lower motor neuron weakness...
  36. pmc VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash
    Marc Mathias
    Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA
    J Neurol Sci 325:180-2. 2013
    ..The development of acute VZV retinal necrosis after ischemic optic neuropathy supports the notion that vasculitis is an important additional mechanism in the development of VZV retinal injury...
  37. pmc Varicella zoster virus vasculopathy: a treatable form of rapidly progressive multi-infarct dementia after 2 years' duration
    Brian Silver
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Neurol Sci 323:245-7. 2012
    ..VZV must be considered as a possible cause of neurological disease in any patient with idiopathic multifocal vasculopathy...
  38. pmc Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    Neurology 80:62-8. 2013
    ....
  39. pmc Molecular characterization of varicella zoster virus in latently infected human ganglia: physical state and abundance of VZV DNA, Quantitation of viral transcripts and detection of VZV-specific proteins
    Yevgeniy Azarkh
    Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Curr Top Microbiol Immunol 342:229-41. 2010
    ..New technologies, such as GeXPS multiplex PCR, have the sensitivity to detect multiple low abundance transcripts and thus provide a means to elucidate the entire VZV transcriptome during latency...
  40. pmc Varicella-zoster virus infection of differentiated human neural stem cells
    Subbiah Pugazhenthi
    Department of Neurology, Mail Stop B182, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
    J Virol 85:6678-86. 2011
    ..This model provides a unique in vitro system to study the VZV-neuronal relationship...
  41. pmc Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein
    Gregory P Owens
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
    J Virol 80:12121-30. 2006
    ..These results indicate the feasibility of using peptide screening for antigen discovery in central nervous system inflammatory diseases of unknown etiology, such as multiple sclerosis, neurosarcoidosis, or Behcet's syndrome...
  42. pmc Characterization of phage peptide interaction with antibody using phage mediated immuno-PCR
    Xiaoli Yu
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
    J Immunol Methods 326:33-40. 2007
    ..Phage-mediated RT-IPCR is a rapid, high-throughput technology that avoids the requirement for synthetic peptides and will facilitate the identification of candidate peptides that react with the IgG in MS CSF...
  43. ncbi Rapid and efficient identification of epitopes/mimotopes from random peptide libraries
    Xiaoli Yu
    Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
    J Immunol Methods 316:67-74. 2006
    ..This technique will expedite identification of MS-specific peptides that can be used to discover the corresponding protein antigens...
  44. pmc Naturally acquired simian varicella virus infection in African green monkeys
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 76:8548-50. 2002
    ..This animal model provides an experimental system to gain information about varicella latency with direct relevance to the human disease...
  45. pmc Search for varicella zoster virus DNA in saliva of healthy individuals aged 20-59 years
    Marius Birlea
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado
    J Med Virol 86:360-2. 2014
    ..Further studies will determine whether VZV DNA in saliva correlates with VZV DNA or anti-VZV antibody in CSF in patients with neurological disease. J. Med. Virol. 86:360-362, 2014. © 2013 Wiley Periodicals, Inc. ..
  46. pmc Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
    J Neurovirol 19:181-5. 2013
    ..Thus, the presence of VZV antigen in cerebral arteries of patients with stroke is likely to be clinically significant...
  47. pmc GeXPS multiplex PCR analysis of the simian varicella virus transcriptome in productively infected cells in culture and acutely infected ganglia
    Maria A Nagel
    Department of Neurology, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
    J Virol Methods 193:151-8. 2013
    ..Except for two transcripts (ORFs 14 and 35), all transcripts found in infected tissue culture cells were also found in acutely infected monkey ganglia. ..
  48. pmc Human trigeminal ganglionic explants as a model to study alphaherpesvirus reactivation
    Yevgeniy Azarkh
    Department of Neurology, University of Colorado Denver Medical School, Aurora, CO, USA
    J Neurovirol 18:456-61. 2012
    ..The increase in HSV-1 DNA was fourfold greater than the increase in VZV DNA. Overall, we present a model for alphaherpesvirus latency in human neurons in which the key molecular events leading to virus reactivation can be studied...
  49. pmc Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 protein
    Niklaus H Mueller
    Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA
    J Virol 86:6345-9. 2012
    ....
  50. pmc Varicella zoster virus meningitis with hypoglycorrhachia in the absence of rash in an immunocompetent woman
    Ali A Habib
    Department of Neurology, New York Presbyterian Hospital Weill Cornell Medical College, New York, New York, USA
    J Neurovirol 15:206-8. 2009
    ..Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody...
  51. pmc Identification of measles virus epitopes using an ultra-fast method of panning phage-displayed random peptide libraries
    Xiaoli Yu
    Department of Neurology, University of Colorado Denver School of Medicine, 4200 East Ninth Avenue, Mail Stop B182, Denver, CO 80262, USA
    J Virol Methods 156:169-73. 2009
    ..The UFSP panning methodology will expedite identification of peptides reacting with antibodies generated in other diseases of unknown antigenic specificity such as multiple sclerosis (MS), sarcoidosis and Behcet's disease...
  52. pmc Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in culture
    Elizabeth Brazeau
    Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
    J Neurovirol 17:274-80. 2011
    ..The onset of CPE was much slower with the double-mutant transfectants (10 days vs. 3 days) and plaques were smaller. While SVV ORF 63 is not required for replication in culture, its expression leads to robust virus replication...
  53. ncbi Varicella zoster virus transcription in latently-infected human ganglia
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
    Anticancer Res 23:2063-9. 2003
    ..A model of VZV gene regulation during latent infection was tested and future directions in the study of VZV latency are discussed...
  54. ncbi Varicella virus-mononuclear cell interaction
    Tiffany M White
    Departments of Neurology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Adv Virus Res 62:1-17. 2003
    ..We also review SVV MNC interaction during naturally occurring simian varicella and after experimental infection of primates with SVV...
  55. pmc Construction of recombinant mouse IgG1 antibody directed against varicella zoster virus immediate early protein 63
    Niklaus H Mueller
    Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Hybridoma (Larchmt) 27:1-10. 2008
    ....
  56. pmc Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency
    Niklaus H Mueller
    Department of Neurology, University of Colorado School of Medicine, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
    Neurol Clin 26:675-97, viii. 2008
    ..This article discusses the clinical manifestations, treatment, and prevention of VZV infection and reactivation; pathogenesis of VZV infection; and current research focusing on VZV latency, reactivation, and animal models...
  57. ncbi Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis
    Alanna M Ritchie
    Department of Neurology, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 173:649-56. 2004
    ..Detection of plasma cell clones by single-cell PCR will facilitate the in vitro production of recombinant Abs useful in identifying disease-relevant Ags...
  58. ncbi The protean neurologic manifestations of varicella-zoster virus infection
    Maria A Nagel
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Cleve Clin J Med 74:489-94, 496, 498-9 passim. 2007
    ..These conditions can be difficult to recognize, especially as several can occur without rash...
  59. pmc Varicella zoster virus in the temporal artery of a patient with giant cell arteritis
    Maria A Nagel
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    J Neurol Sci 335:228-30. 2013
    ..Detection of VZV in areas of the TA with pathological features of GCA warrants further correlative pathological-virological analysis of VZV in GCA...
  60. pmc Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis
    Mark P Burgoon
    Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Ann Neurol 65:474-9. 2009
    ..VZV is not a disease-relevant antigen in MS...
  61. pmc Persistence of varicella zoster virus DNA in saliva after herpes zoster
    Maria A Nagel
    Departments of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
    J Infect Dis 204:820-4. 2011
    ..Because VZV infection can produce neurological and ocular disease without zoster rash, future studies are needed to establish whether VZV DNA can be detected in the saliva of such patients...
  62. ncbi Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid
    Gregory P Owens
    Department of Neurology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Mail Stop Box B182, Denver, CO 80262, USA
    J Immunol 171:2725-33. 2003
    ..The most immediate implications of identifying rearranged Ig sequences in MS B cells is the potential to accurately recreate recombinant Abs from these overrepresented H and L chains that can be used to discover the relevant Ag(s) in MS...
  63. pmc Characterization of varicella-zoster virus gene 21 and 29 proteins in infected cells
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 76:7228-38. 2002
    ..Together, the data reveal that while VZV gene 21 and HSV-1 UL37 share homology at the nucleic acid level, these proteins differ functionally...
  64. ncbi Persistence of simian varicella virus DNA in CD4(+) and CD8(+) blood mononuclear cells for years after intratracheal inoculation of African green monkeys
    Tiffany M White
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Virology 303:192-8. 2002
    ....
  65. pmc Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurovirol 12:398-402. 2006
    ..The intrathecal response may be useful in determining the causes of other inflammatory CNS diseases, such as multiple sclerosis, Behcet's disease, and neurosarcoidosis...
  66. pmc B cells in multiple sclerosis
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Front Biosci 9:786-96. 2004
    ..Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment...
  67. ncbi Varicella zoster virus latency, neurological disease and experimental models: an update
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Front Biosci 9:751-62. 2004
    ..Two varicella models in primates have proven useful: one that mimics varicella latency in humans, and one that can be used to study the efficacy of antiviral agent in driving varicella virus back to a latent state...
  68. pmc Varicella-zoster virus gene 66 transcription and translation in latently infected human Ganglia
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:6660-5. 2003
    ....
  69. ncbi Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 protein
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Virology 345:244-50. 2006
    ..This is the first study in which a varicella protein (ORF 63) expressed during latency has been shown to have a differential effect on a promoter that is also active during latency, in neuronal as compared to non-neuronal cells...
  70. ncbi Acyclovir responsive brain stem disease after the Ramsay Hunt syndrome
    Shuching Hu
    Department of Neurology, University of Washington, Box 356465, Seattle, WA 98195, USA
    J Neurol Sci 217:111-3. 2004
    ..This case demonstrates that after geniculate zoster, brainstem disease may develop even in an immunocompetent individual and effective antiviral therapy can be curative...
  71. pmc Array analysis of viral gene transcription during lytic infection of cells in tissue culture with Varicella-Zoster virus
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:11718-32. 2003
    ..Array analysis provides a formidable tool to analyze transcription of an important ubiquitous human pathogen...
  72. pmc Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann Neurol 54:459-63. 2003
    ..This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause...
  73. ncbi Simian varicella virus reactivation in cynomolgus monkeys
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Virology 368:50-9. 2007
    ..Virus reactivation was confirmed not only by the occurrence of zoster in one monkey, but also by the presence of late SVV RNA in ganglia, and the detection of SVV DNA in non-ganglionic tissue, and SVV antigens in skin, ganglia and lung...
  74. pmc Prevalence and abundance of latently transcribed varicella-zoster virus genes in human ganglia
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
    J Virol 81:2950-6. 2007
    ....
  75. pmc Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies
    Mark P Burgoon
    Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:7245-50. 2005
    ..This strategy can be used to identify disease-relevant antigens in CNS inflammatory diseases of unknown etiology...
  76. ncbi Specificity of recombinant antibodies generated from multiple sclerosis cerebrospinal fluid probed with a random peptide library
    Xiaoli Yu
    Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
    J Neuroimmunol 172:121-31. 2006
    ..Our data demonstrate that MS rAb reflects the specificity of IgG in the CSF. Thus, the epitopes/mimotopes identified by MS rAb may provide clues to disease-relevant antigens...
  77. ncbi Acute cerebellar ataxia in a 41 year old woman
    Howard Moses
    Department of Neurology, Johns Hopkins Medical Institution, Baltimore, MD, USA
    Lancet Neurol 5:984-8. 2006
  78. pmc Comparison of virus transcription during lytic infection of the Oka parental and vaccine strains of Varicella-Zoster virus
    Randall J Cohrs
    Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
    J Virol 80:2076-82. 2006
    ..Together, our results indicate that mutations in V-Oka IE 62 alone are unlikely to account for vaccine virus attenuation...
  79. pmc Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal ganglia
    Lee Gary
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Virol 80:4921-6. 2006
    ..Together, these data indicate that the expression of the two latency-related VZV genes, ORFs 62 and 63, is regulated epigenetically through chromatin structure...
  80. ncbi VH4 gene segments dominate the intrathecal humoral immune response in multiple sclerosis
    Gregory P Owens
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 179:6343-51. 2007
    ..These results indicate a highly restricted B cell response in MS. Identifying the targets of CeSF plasma cells may yield insights into disease pathogenesis...
  81. pmc Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts
    Randall J Cohrs
    Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Med Virol 80:1116-22. 2008
    ..This is the first demonstration of shed of infectious VZV in the absence of disease...
  82. pmc CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndrome
    Jeffrey L Bennett
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, United States
    J Neuroimmunol 199:126-32. 2008
    ..Clinically, subjects with VH4 or VH2 CSF IgG repertoire bias rapidly progressed to definite MS, whereas individuals without repertoire bias did not develop MS after a minimum of 2 years of follow-up (p=0.01)...
  83. doi The variegate neurological manifestations of varicella zoster virus infection
    Don Gilden
    Department of Neurology and Microbiology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
    Curr Neurol Neurosci Rep 13:374. 2013
    ....
  84. pmc Does apoptosis play a role in varicella zoster virus latency and reactivation?
    Stephanie F James
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Viruses 4:1509-14. 2012
    ..Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV...
  85. pmc Subclinical reactivation of varicella zoster virus in all stages of HIV infection
    Marius Birlea
    Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Neurol Sci 304:22-4. 2011
    ..To rule out VZV infection of the nervous system, CSF must be tested for VZV DNA and anti-VZV IgG and IgM antibody...
  86. pmc Rapid and sensitive detection of 68 unique varicella zoster virus gene transcripts in five multiplex reverse transcription-polymerase chain reactions
    Maria A Nagel
    Department of Neurology, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
    J Virol Methods 157:62-8. 2009
    ..Only five multiplex RT-PCR assays were needed to analyze the entire VZV transcriptome. This technology will allow rapid analysis of all VZV genes transcribed during latency in human ganglia...
  87. pmc Phosphorylation of the nuclear form of varicella-zoster virus immediate-early protein 63 by casein kinase II at serine 186
    Niklaus H Mueller
    Department of Neurology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Virol 83:12094-100. 2009
    ....
  88. ncbi Multifocal varicella-zoster virus vasculopathy without rash
    Andrew N Russman
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arch Neurol 60:1607-9. 2003
    ..Treatment with intravenous acyclovir stabilized but did not significantly improve her neurological deficits...
  89. ncbi Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitis
    Arshad Majid
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Brain 125:159-65. 2002
    ..The mechanism by which EBV produces neurological disease is unknown. More correlative pathological, virological and immunological studies are needed in EBV-associated neurological disease...
  90. ncbi The B cell response in multiple sclerosis
    Gregory P Owens
    Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
    Neurol Res 28:236-44. 2006
    ..Together with histologic studies showing the presence of ectopic lymphoid follicles in the meninges of some MS patients, this data supports the notion of a targeted and compartmentalized humoral response in MS...
  91. ncbi Construction of infectious simian varicella virus expressing green fluorescent protein
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Biol 183:341-52. 2002
  92. ncbi Improvement of postherpetic neuralgia after treatment with intravenous acyclovir followed by oral valacyclovir
    Dianna Quan
    Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Arch Neurol 63:940-2. 2006
    ..If chronic pain reflects active infection, then antiviral therapy may help patients with PHN...
  93. ncbi Topical ketamine treatment of postherpetic neuralgia
    Dianna Quan
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Neurology 60:1391-2. 2003
  94. ncbi Recurrent dermatomal vesicular skin lesions: a clue to diagnosis of herpes simplex virus 2 meningitis
    Nicole Gonzales
    Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
    Arch Neurol 60:868-9. 2003
  95. ncbi Herpes simplex virus-1 and varicella-zoster virus latency in ganglia
    Bradley M Mitchell
    Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    J Neurovirol 9:194-204. 2003
    ..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation...
  96. pmc Varicella-zoster virus in the saliva of patients with herpes zoster
    Satish K Mehta
    Enterprise Advisory Services, Inc, USA
    J Infect Dis 197:654-7. 2008
    ..Analysis of human saliva has potential usefulness in the diagnosis of neurological disease produced by VZV without rash...
  97. ncbi Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeys
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
    Virus Genes 28:273-6. 2004
    ..These findings parallel the detection of varicella zoster virus in neurons of latently infected human ganglia. Natural exposure to SVV provides a model system to study varicella latency...
  98. ncbi Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts
    Kimberly M Winges
    Howard Hughes Medical Institute Research Fellow, Chevy Chase, MD 20815, USA
    J Neuroimmunol 192:226-34. 2007
    ....
  99. ncbi Stress-induced subclinical reactivation of varicella zoster virus in astronauts
    Satish K Mehta
    Enterprise Advisory Services Inc, Lyndon B Johnson Space Center, Houston, Texas
    J Med Virol 72:174-9. 2004
    ..No VZV DNA was detected in any of 88 saliva samples from 10 healthy control subjects. These results indicate that VZV can reactivate subclinically in healthy individuals after non-surgical stress...
  100. ncbi Cranial nerve palsies: herpes simplex virus type 1 and varizella-zoster virus latency
    Diethilde Theil
    Ann Neurol 51:273-4. 2002
  101. pmc Downregulation of varicella-zoster virus (VZV) immediate-early ORF62 transcription by VZV ORF63 correlates with virus replication in vitro and with latency
    Susan E Hoover
    Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 80:3459-68. 2006
    ..The ability of ORF63 to downregulate ORF62 transcription may play an important role in virus replication and latency...

Research Grants15

  1. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2007
    ..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..
  2. NEUROVIROLOGY-MOLECULAR BIOLOGY
    Donald Gilden; Fiscal Year: 2007
    ..Upon completion, post-doctorals are qualified to begin junior faculty positions as independent investigators to study neurovirologic or molecular biologic aspects of neurologic diseases. ..
  3. NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 1993
    ..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...
  4. NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 1990
    ..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...
  5. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2009
    ..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..