Research Topics
Species | Don GildenSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virusD H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
J Neurol Sci 159:140-4. 1998....- Two patients with unusual forms of varicella-zoster virus vasculopathyDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
N Engl J Med 347:1500-3. 2002 - Herpesvirus infections of the nervous systemDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Nat Clin Pract Neurol 3:82-94. 2007.... - The protean manifestations of varicella-zoster virus vasculopathyDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurovirol 8:75-9. 2002..When VZV vasculopathy develops months after zoster, antiviral treatment is often effective... - Surgical induction of zoster in a contralateral homologous dermatomal distributionDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
Arch Neurol 60:616-7. 2003..The mechanism by which unilateral surgery might affect homologous ganglia is likely to involve spinal cord pathways above the dermatomal level of surgical trauma... - Infectious causes of multiple sclerosisDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Lancet Neurol 4:195-202. 2005..A viral antigen against which the IgG in MS brain and CSF is directed might be identified... - Chronic varicella-zoster virus ganglionitis--a possible cause of postherpetic neuralgiaDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Neurovirol 9:404-7. 2003..The presence of fragments of VZV DNA in MNCs likely represents partial degradation of viral DNA in MNCs that trafficked through ganglia during productive infection... - Multiple sclerosis exacerbations and infectionDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
Lancet Neurol 1:145. 2002 - Clinical and molecular pathogenesis of varicella virus infectionDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Viral Immunol 16:243-58. 2003.... - VZV vasculopathy and postherpetic neuralgia: progress and perspective on antiviral therapyDonald H Gilden
Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 8026, USA
Neurology 64:21-5. 2005..Few studies have used antiviral therapy to manage PHN with conflicting results. Larger, double-blind studies, which give IV antiviral drug, are needed... - Brain imaging abnormalities in CNS virus infectionsDonald H Gilden
Department of Neurology, Mail Stop B182, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
Neurology 70:84. 2008 - Molecular immunologic strategies to identify antigens and b-cell responses unique to multiple sclerosisD H Gilden
Department of Neurology, University of Colorado Health Sciences Center, 4200 E Ninth Ave, Mail Stop B182, Denver, CO 80262, USA
Arch Neurol 58:43-8. 2001..New sophisticated molecular immunologic techniques described herein should enhance our ability to identify putative antigen(s) targets in MS... - Clinical practice. Bell's PalsyDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
N Engl J Med 351:1323-31. 2004 - A search for virus in multiple sclerosisDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
Hybrid Hybridomics 21:93-7. 2002..These studies could confirm Dr. Koprowski's prophetic vision and identify the virus that causes MS, including the mechanism by which demyelination is produced... - Presence of VZV and HSV-1 DNA in human nodose and celiac gangliaD H Gilden
Department of Neurology, University of Colorado Health Sciences Center, School of Medicine, Denver 80262, USA
Virus Genes 23:145-7. 2001..The ability of reactivated VZV to produce serious, sometimes fatal neurological disease in the absence of rash, raises the possibility that VZV reactivation from autonomic ganglia might be involved in visceral disease... 
Recurrent varicella zoster virus myelopathyDon Gilden
Department of Neurology, University of Colorado Denver, School of Medicine, Denver, CO, USA
J Neurol Sci 276:196-8. 2009..In contrast to earlier cases of recurrent VZV myelopathy in immunocompetent adults that developed weeks to months after the first episode of myelopathy, this is the first instance of recurrence years later...- Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weaknessJean Tsai
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
J Neurol Sci 313:193-5. 2012..Simultaneous reactivation of two alphaherpesviruses (HSV-1 and VZV) in our immunosuppressed patient underscores the need to consider opportunistic infection as a cause of facial weakness... - Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaquesRavi Mahalingam
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Virol 84:12454-7. 2010..Virus transcription and the detection of open reading frame (ORF) 63 protein in the cytoplasm of neurons were comparable. Thus, a 30-h delay after death did not affect varicella-zoster virus expression in latently infected ganglia... - Viruses and multiple sclerosisGregory P Owens
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Neuroscientist 17:659-76. 2011.... - Latent simian varicella virus reactivates in monkeys treated with tacrolimus with or without exposure to irradiationRavi Mahalingam
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Neurovirol 16:342-54. 2010..These results indicate that tacrolimus treatment produced reactivation in more monkeys than irradiation and tacrolimus and irradiation increased the frequency of SVV reactivation as compared to either treatment alone... - Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63Niklaus H Mueller
Department of Neurology, University of Colorado Denver School of Medicine, Denver, USA
J Gen Virol 91:1133-7. 2010.... - Varicella-zoster virus transcriptome in latently infected human gangliaMaria A Nagel
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Virol 85:2276-87. 2011..Comparison of the 10 VZV ORFs transcribed during latency to their herpes simplex virus type 1 homologues reveals that the latently transcribed VZV genes encode immediate-early, early, and late transcripts... - Array analysis of simian varicella virus gene transcription in productively infected cells in tissue cultureSteven B Deitch
Department of Neurology, Mail Stop B182, 4200 E. 9th Avenue, Denver, CO 80262, USA
J Virol 79:5315-25. 2005..The abundance of each SVV transcript was compared with that previously demonstrated for VZV in infected tissue culture cells... - B-lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluidKurt Haubold
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann Neurol 56:97-107. 2004.... - Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatmentDon Gilden
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Lancet Neurol 8:731-40. 2009..In recent years, the number of recognised VZV vasculopathies has grown, and accurate diagnosis is important for the effective treatment of these disorders... - Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literatureAaron Haug
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Neurol Sci 292:85-8. 2010.... - Varicella zoster virus ischemic optic neuropathy and subclinical temporal artery involvementRichard Salazar
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
Arch Neurol 68:517-20. 2011.... - Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluidGregory P Owens
Department of Neurology, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
Ann Neurol 65:639-49. 2009..Nevertheless, the target antigen of this response remains enigmatic... - Synthesis and decay of varicella zoster virus transcriptsYevgeniy Azarkh
Department of Neurology, School of Medicine, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
J Neurovirol 17:281-7. 2011..Thus, difference in mRNA synthesis, and not mRNA decay, is the major factor contributing to the difference in the relative abundance of VZV transcripts in infected cells... - Laser capture microdissection and single-cell RT-PCR without RNA purificationKathryne Melissa Keays
Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, United States
J Immunol Methods 302:90-8. 2005..These techniques will streamline the identification of gene expression products in single cells from complex tissues and have the potential to identify IgGs expressed in the CNS of inflammatory diseases of unknown etiology... - Simian varicella virus DNA is present and transcribed months after experimental infection of adult African green monkeysTiffany M White
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
J Neurovirol 8:191-203. 2002..Overall, intratracheal inoculation of SVV in African green monkeys resulted in the presence of viral DNA and transcription of multiple viral genes in many tissues for months after experimental infection... - Varicella-zoster virus infection of differentiated human neural stem cellsSubbiah Pugazhenthi
Department of Neurology, Mail Stop B182, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
J Virol 85:6678-86. 2011..This model provides a unique in vitro system to study the VZV-neuronal relationship... - Molecular characterization of varicella zoster virus in latently infected human ganglia: physical state and abundance of VZV DNA, Quantitation of viral transcripts and detection of VZV-specific proteinsYevgeniy Azarkh
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:229-41. 2010..New technologies, such as GeXPS multiplex PCR, have the sensitivity to detect multiple low abundance transcripts and thus provide a means to elucidate the entire VZV transcriptome during latency... - Rapid and efficient identification of epitopes/mimotopes from random peptide librariesXiaoli Yu
Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
J Immunol Methods 316:67-74. 2006..This technique will expedite identification of MS-specific peptides that can be used to discover the corresponding protein antigens... - Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid proteinGregory P Owens
Department of Neurology, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
J Virol 80:12121-30. 2006..These results indicate the feasibility of using peptide screening for antigen discovery in central nervous system inflammatory diseases of unknown etiology, such as multiple sclerosis, neurosarcoidosis, or Behcet's syndrome... - Characterization of phage peptide interaction with antibody using phage mediated immuno-PCRXiaoli Yu
Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
J Immunol Methods 326:33-40. 2007..Phage-mediated RT-IPCR is a rapid, high-throughput technology that avoids the requirement for synthetic peptides and will facilitate the identification of candidate peptides that react with the IgG in MS CSF... - Naturally acquired simian varicella virus infection in African green monkeysRavi Mahalingam
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 76:8548-50. 2002..This animal model provides an experimental system to gain information about varicella latency with direct relevance to the human disease... - Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 proteinNiklaus H Mueller
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA
J Virol 86:6345-9. 2012.... - Identification of measles virus epitopes using an ultra-fast method of panning phage-displayed random peptide librariesXiaoli Yu
Department of Neurology, University of Colorado Denver School of Medicine, 4200 East Ninth Avenue, Mail Stop B182, Denver, CO 80262, USA
J Virol Methods 156:169-73. 2009..The UFSP panning methodology will expedite identification of peptides reacting with antibodies generated in other diseases of unknown antigenic specificity such as multiple sclerosis (MS), sarcoidosis and Behcet's disease... - Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in cultureElizabeth Brazeau
Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
J Neurovirol 17:274-80. 2011..The onset of CPE was much slower with the double-mutant transfectants (10 days vs. 3 days) and plaques were smaller. While SVV ORF 63 is not required for replication in culture, its expression leads to robust virus replication... - Varicella zoster virus meningitis with hypoglycorrhachia in the absence of rash in an immunocompetent womanAli A Habib
Department of Neurology, New York Presbyterian Hospital Weill Cornell Medical College, New York, New York, USA
J Neurovirol 15:206-8. 2009..Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody... - Construction of recombinant mouse IgG1 antibody directed against varicella zoster virus immediate early protein 63Niklaus H Mueller
Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
Hybridoma (Larchmt) 27:1-10. 2008.... - Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latencyNiklaus H Mueller
Department of Neurology, University of Colorado School of Medicine, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
Neurol Clin 26:675-97, viii. 2008..This article discusses the clinical manifestations, treatment, and prevention of VZV infection and reactivation; pathogenesis of VZV infection; and current research focusing on VZV latency, reactivation, and animal models... - Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosisAlanna M Ritchie
Department of Neurology, University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 173:649-56. 2004..Detection of plasma cell clones by single-cell PCR will facilitate the in vitro production of recombinant Abs useful in identifying disease-relevant Ags... - Varicella zoster virus transcription in latently-infected human gangliaRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
Anticancer Res 23:2063-9. 2003..A model of VZV gene regulation during latent infection was tested and future directions in the study of VZV latency are discussed... - The protean neurologic manifestations of varicella-zoster virus infectionMaria A Nagel
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
Cleve Clin J Med 74:489-94, 496, 498-9 passim. 2007..These conditions can be difficult to recognize, especially as several can occur without rash... - Varicella virus-mononuclear cell interactionTiffany M White
Departments of Neurology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Adv Virus Res 62:1-17. 2003..We also review SVV MNC interaction during naturally occurring simian varicella and after experimental infection of primates with SVV... - Varicella zoster virus is not a disease-relevant antigen in multiple sclerosisMark P Burgoon
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Ann Neurol 65:474-9. 2009..VZV is not a disease-relevant antigen in MS... - Persistence of varicella zoster virus DNA in saliva after herpes zosterMaria A Nagel
Departments of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
J Infect Dis 204:820-4. 2011..Because VZV infection can produce neurological and ocular disease without zoster rash, future studies are needed to establish whether VZV DNA can be detected in the saliva of such patients... - Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZVMark P Burgoon
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann Neurol 54:459-63. 2003..This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause... - VH4 gene segments dominate the intrathecal humoral immune response in multiple sclerosisGregory P Owens
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 179:6343-51. 2007..These results indicate a highly restricted B cell response in MS. Identifying the targets of CeSF plasma cells may yield insights into disease pathogenesis... - Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodiesMark P Burgoon
Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 102:7245-50. 2005..This strategy can be used to identify disease-relevant antigens in CNS inflammatory diseases of unknown etiology... - Characterization of varicella-zoster virus gene 21 and 29 proteins in infected cellsRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 76:7228-38. 2002..Together, the data reveal that while VZV gene 21 and HSV-1 UL37 share homology at the nucleic acid level, these proteins differ functionally... - Asymptomatic reactivation and shed of infectious varicella zoster virus in astronautsRandall J Cohrs
Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
J Med Virol 80:1116-22. 2008..This is the first demonstration of shed of infectious VZV in the absence of disease... - CSF IgG heavy-chain bias in patients at the time of a clinically isolated syndromeJeffrey L Bennett
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, United States
J Neuroimmunol 199:126-32. 2008..Clinically, subjects with VH4 or VH2 CSF IgG repertoire bias rapidly progressed to definite MS, whereas individuals without repertoire bias did not develop MS after a minimum of 2 years of follow-up (p=0.01)... - Varicella zoster virus latency, neurological disease and experimental models: an updateRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Front Biosci 9:751-62. 2004..Two varicella models in primates have proven useful: one that mimics varicella latency in humans, and one that can be used to study the efficacy of antiviral agent in driving varicella virus back to a latent state... - B cells in multiple sclerosisMark P Burgoon
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Front Biosci 9:786-96. 2004..Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment... - Acyclovir responsive brain stem disease after the Ramsay Hunt syndromeShuching Hu
Department of Neurology, University of Washington, Box 356465, Seattle, WA 98195, USA
J Neurol Sci 217:111-3. 2004..This case demonstrates that after geniculate zoster, brainstem disease may develop even in an immunocompetent individual and effective antiviral therapy can be curative... - Array analysis of viral gene transcription during lytic infection of cells in tissue culture with Varicella-Zoster virusRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:11718-32. 2003..Array analysis provides a formidable tool to analyze transcription of an important ubiquitous human pathogen... - Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal gangliaLee Gary
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Virol 80:4921-6. 2006..Together, these data indicate that the expression of the two latency-related VZV genes, ORFs 62 and 63, is regulated epigenetically through chromatin structure... - Comparison of virus transcription during lytic infection of the Oka parental and vaccine strains of Varicella-Zoster virusRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
J Virol 80:2076-82. 2006..Together, our results indicate that mutations in V-Oka IE 62 alone are unlikely to account for vaccine virus attenuation... - Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluidGregory P Owens
Department of Neurology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Mail Stop Box B182, Denver, CO 80262, USA
J Immunol 171:2725-33. 2003..The most immediate implications of identifying rearranged Ig sequences in MS B cells is the potential to accurately recreate recombinant Abs from these overrepresented H and L chains that can be used to discover the relevant Ag(s) in MS... - Specificity of recombinant antibodies generated from multiple sclerosis cerebrospinal fluid probed with a random peptide libraryXiaoli Yu
Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, Colorado 80262, USA
J Neuroimmunol 172:121-31. 2006..Our data demonstrate that MS rAb reflects the specificity of IgG in the CSF. Thus, the epitopes/mimotopes identified by MS rAb may provide clues to disease-relevant antigens... - Acute cerebellar ataxia in a 41 year old womanHoward Moses
Department of Neurology, Johns Hopkins Medical Institution, Baltimore, MD, USA
Lancet Neurol 5:984-8. 2006 - Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virusMark P Burgoon
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurovirol 12:398-402. 2006..The intrathecal response may be useful in determining the causes of other inflammatory CNS diseases, such as multiple sclerosis, Behcet's disease, and neurosarcoidosis... - Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 proteinRavi Mahalingam
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Virology 345:244-50. 2006..This is the first study in which a varicella protein (ORF 63) expressed during latency has been shown to have a differential effect on a promoter that is also active during latency, in neuronal as compared to non-neuronal cells... - Prevalence and abundance of latently transcribed varicella-zoster virus genes in human gangliaRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Mail Stop B182, Denver, CO 80262, USA
J Virol 81:2950-6. 2007.... - Persistence of simian varicella virus DNA in CD4(+) and CD8(+) blood mononuclear cells for years after intratracheal inoculation of African green monkeysTiffany M White
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Virology 303:192-8. 2002.... - Simian varicella virus reactivation in cynomolgus monkeysRavi Mahalingam
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Virology 368:50-9. 2007..Virus reactivation was confirmed not only by the occurrence of zoster in one monkey, but also by the presence of late SVV RNA in ganglia, and the detection of SVV DNA in non-ganglionic tissue, and SVV antigens in skin, ganglia and lung... - Varicella-zoster virus gene 66 transcription and translation in latently infected human GangliaRandall J Cohrs
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:6660-5. 2003.... - Varicella zoster virus vasculopathy: A treatable form of rapidly progressive multi-infarct dementia after 2years' durationBrian Silver
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA
J Neurol Sci 323:245-7. 2012..VZV must be considered as a possible cause of neurological disease in any patient with idiopathic multifocal vasculopathy... - Subclinical reactivation of varicella zoster virus in all stages of HIV infectionMarius Birlea
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Neurol Sci 304:22-4. 2011..To rule out VZV infection of the nervous system, CSF must be tested for VZV DNA and anti-VZV IgG and IgM antibody... - Rapid and sensitive detection of 68 unique varicella zoster virus gene transcripts in five multiplex reverse transcription-polymerase chain reactionsMaria A Nagel
Department of Neurology, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
J Virol Methods 157:62-8. 2009..Only five multiplex RT-PCR assays were needed to analyze the entire VZV transcriptome. This technology will allow rapid analysis of all VZV genes transcribed during latency in human ganglia... - Phosphorylation of the nuclear form of varicella-zoster virus immediate-early protein 63 by casein kinase II at serine 186Niklaus H Mueller
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
J Virol 83:12094-100. 2009.... - Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitisArshad Majid
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Brain 125:159-65. 2002..The mechanism by which EBV produces neurological disease is unknown. More correlative pathological, virological and immunological studies are needed in EBV-associated neurological disease... - Multifocal varicella-zoster virus vasculopathy without rashAndrew N Russman
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Arch Neurol 60:1607-9. 2003..Treatment with intravenous acyclovir stabilized but did not significantly improve her neurological deficits... 
Human trigeminal ganglionic explants as a model to study alphaherpesvirus reactivationYevgeniy Azarkh
Department of Neurology, University of Colorado Denver Medical School, Aurora, CO, USA
J Neurovirol 18:456-61. 2012..The increase in HSV-1 DNA was fourfold greater than the increase in VZV DNA. Overall, we present a model for alphaherpesvirus latency in human neurons in which the key molecular events leading to virus reactivation can be studied...- The B cell response in multiple sclerosisGregory P Owens
Department of Neurology, University of Colorado Health Sciences Center, Denver, 80262, USA
Neurol Res 28:236-44. 2006..Together with histologic studies showing the presence of ectopic lymphoid follicles in the meninges of some MS patients, this data supports the notion of a targeted and compartmentalized humoral response in MS... - Topical ketamine treatment of postherpetic neuralgiaDianna Quan
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
Neurology 60:1391-2. 2003 - Construction of infectious simian varicella virus expressing green fluorescent proteinRavi Mahalingam
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, USA
Methods Mol Biol 183:341-52. 2002 - Improvement of postherpetic neuralgia after treatment with intravenous acyclovir followed by oral valacyclovirDianna Quan
Department of Neurology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Arch Neurol 63:940-2. 2006..CONCLUSION: Clinical improvement reported by most of our patients warrants further investigation in a larger, randomized, double-blind, placebo-controlled trial... - Recurrent dermatomal vesicular skin lesions: a clue to diagnosis of herpes simplex virus 2 meningitisNicole Gonzales
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
Arch Neurol 60:868-9. 2003 - Multifocal vasculopathy due to Varicella-Zoster Virus (VZV): serial analysis of VZV DNA and intrathecal synthesis of VZV antibody in cerebrospinal fluidAndreas Kronenberg
Division of Infectious Diseases and Hospital Epidemiology, University Hospital, CH 8091 Zurich, Switzerland
Clin Infect Dis 35:330-3. 2002..Reduced ratios of VZV antibody in serum to that in CSF were also demonstrated... - Cranial nerve palsies: herpes simplex virus type 1 and varizella-zoster virus latencyDiethilde Theil
Ann Neurol 51:273-4. 2002 - Herpes simplex virus-1 and varicella-zoster virus latency in gangliaBradley M Mitchell
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
J Neurovirol 9:194-204. 2003..For each virus, remaining questions and future studies to understand the mechanism of latency are discussed with respect to prevention of serious cutaneous, ocular, and neurologic disease produced by virus reactivation... - An unusual cause of trigeminal-distribution pain and tumourRobert Hevner
Department of Pathology, University of Washington, Seattle, WA, USA
Lancet Neurol 2:567-71. 2003 - Downregulation of varicella-zoster virus (VZV) immediate-early ORF62 transcription by VZV ORF63 correlates with virus replication in vitro and with latencySusan E Hoover
Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Virol 80:3459-68. 2006..The ability of ORF63 to downregulate ORF62 transcription may play an important role in virus replication and latency... - Stress-induced subclinical reactivation of varicella zoster virus in astronautsSatish K Mehta
Enterprise Advisory Services Inc, Lyndon B. Johnson Space Center, Houston, Texas
J Med Virol 72:174-9. 2004..No VZV DNA was detected in any of 88 saliva samples from 10 healthy control subjects. These results indicate that VZV can reactivate subclinically in healthy individuals after non-surgical stress... - Varicella-zoster virus vaccine--grown-ups need it, tooDonald H Gilden
N Engl J Med 352:2344-6. 2005 - Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeysPeter G E Kennedy
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, Scotland, UK
Virus Genes 28:273-6. 2004..These findings parallel the detection of varicella zoster virus in neurons of latently infected human ganglia. Natural exposure to SVV provides a model system to study varicella latency... - Bell's palsy--is glucocorticoid treatment enough?Donald H Gilden
N Engl J Med 357:1653-5. 2007 - Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blastsKimberly M Winges
Howard Hughes Medical Institute Research Fellow, Chevy Chase, MD 20815, USA
J Neuroimmunol 192:226-34. 2007.... - Varicella-zoster virus in the saliva of patients with herpes zosterSatish K Mehta
Enterprise Advisory Services, Inc, USA
J Infect Dis 197:654-7. 2008..Analysis of human saliva has potential usefulness in the diagnosis of neurological disease produced by VZV without rash...
Research Grants
- NEUROBIOLOGY OF VARICELLA ZOSTER VIRUSDonald Gilden; Fiscal Year: 2007..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..
- NEUROVIROLOGY-MOLECULAR BIOLOGYDonald Gilden; Fiscal Year: 2007..Upon completion, post-doctorals are qualified to begin junior faculty positions as independent investigators to study neurovirologic or molecular biologic aspects of neurologic diseases. ..
- NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUSDonald Gilden; Fiscal Year: 1993..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...
- NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUSDonald Gilden; Fiscal Year: 1990..These studies will yield information on the molecular basis of viral latency and reactivation which in turn provides the foundation for future studies designed to eradicate neurologic disease in the elderly produced by VZV...
- NEUROBIOLOGY OF VARICELLA ZOSTER VIRUSDonald Gilden; Fiscal Year: 2009..Understanding latency will lead to approaches designed to prevent the cascade of events leading to virus reactivation, a cause of serious neurologic disease in the rapidly increasing elderly and immunocompromised populations. ..