Research Topics
Species | Don GildenSummaryAffiliation: University of Colorado Denver Country: USA Publications
Research Grants
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Detail Information
Publications
Varicella zoster virus ischemic optic neuropathy and subclinical temporal artery involvementRichard Salazar
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA
Arch Neurol 68:517-20. 2011....- Efficacy of live zoster vaccine in preventing zoster and postherpetic neuralgiaD Gilden
Department of Neurology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Intern Med 269:496-506. 2011..Nevertheless, zoster vaccine is safe, effective and highly recommended for immunization of immunocompetent individuals over age 60 years with no history of recent zoster... - Review: The neurobiology of varicella zoster virus infectionD Gilden
Department of Neurology, University of Colorado School of Medicine, USA
Neuropathol Appl Neurobiol 37:441-63. 2011.... - Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatmentDon Gilden
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Lancet Neurol 8:731-40. 2009..In recent years, the number of recognised VZV vasculopathies has grown, and accurate diagnosis is important for the effective treatment of these disorders... - Neurological disease produced by varicella zoster virus reactivation without rashDon Gilden
Departments of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:243-53. 2010..Virological confirmation requires the demonstration of amplifiable VZV DNA in cerebrospinal fluid (CSF) or in blood mononuclear cells, or the presence of anti-VZV IgG antibody in CSF or of anti-VZV IgM antibody in CSF or serum... - Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluidGregory P Owens
Department of Neurology, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
Ann Neurol 65:639-49. 2009..Nevertheless, the target antigen of this response remains enigmatic... - Latent simian varicella virus reactivates in monkeys treated with tacrolimus with or without exposure to irradiationRavi Mahalingam
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Neurovirol 16:342-54. 2010..These results indicate that tacrolimus treatment produced reactivation in more monkeys than irradiation and tacrolimus and irradiation increased the frequency of SVV reactivation as compared to either treatment alone... - Identification of peptide targets in neuromyelitis opticaXiaoli Yu
Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, United States
J Neuroimmunol 236:65-71. 2011..Competitive inhibition ELISA and immunocytochemistry demonstrated that these peptides represent epitopes of NMO autoantigen AQP4. Peptide epitopes/mimotopes may have potential uses for disease prognosis, monitoring, and therapy... - Reactivation of type 1 herpes simplex virus and varicella zoster virus in an immunosuppressed patient with acute peripheral facial weaknessJean Tsai
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
J Neurol Sci 313:193-5. 2012..Simultaneous reactivation of two alphaherpesviruses (HSV-1 and VZV) in our immunosuppressed patient underscores the need to consider opportunistic infection as a cause of facial weakness... - Viruses and multiple sclerosisGregory P Owens
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Neuroscientist 17:659-76. 2011.... - Intrathecally synthesized IgG in multiple sclerosis cerebrospinal fluid recognizes identical epitopes over timeXiaoli Yu
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, United States
J Neuroimmunol 240:129-36. 2011.... - Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63Niklaus H Mueller
Department of Neurology, University of Colorado Denver School of Medicine, Denver, USA
J Gen Virol 91:1133-7. 2010.... - Varicella-zoster virus transcriptome in latently infected human gangliaMaria A Nagel
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Virol 85:2276-87. 2011..Comparison of the 10 VZV ORFs transcribed during latency to their herpes simplex virus type 1 homologues reveals that the latently transcribed VZV genes encode immediate-early, early, and late transcripts... - Recurrent polymorphonuclear pleocytosis with increased red blood cells caused by varicella zoster virus infection of the central nervous system: Case report and review of the literatureAaron Haug
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Neurol Sci 292:85-8. 2010.... - Synthesis and decay of varicella zoster virus transcriptsYevgeniy Azarkh
Department of Neurology, School of Medicine, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
J Neurovirol 17:281-7. 2011..Thus, difference in mRNA synthesis, and not mRNA decay, is the major factor contributing to the difference in the relative abundance of VZV transcripts in infected cells... - Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaquesRavi Mahalingam
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Virol 84:12454-7. 2010..Virus transcription and the detection of open reading frame (ORF) 63 protein in the cytoplasm of neurons were comparable. Thus, a 30-h delay after death did not affect varicella-zoster virus expression in latently infected ganglia... - Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSFXiaoli Yu
Department of Neurology, University of Colorado Denver at Anschutz Medical Campus, 12700 E 19th Ave, Aurora, CO 80045, United States
J Neuroimmunol 233:192-203. 2011..Peptides derived from the candidate proteins were recognized by rAbs. Identification of peptide epitopes/mimotopes in MS may provide clues regarding disease-relevant antigens... - Recombinant monoclonal antibody recognizes a unique epitope on varicella-zoster virus immediate-early 63 proteinNiklaus H Mueller
Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA
J Virol 86:6345-9. 2012.... - Simian varicella virus open reading frame 63/70 expression is required for efficient virus replication in cultureElizabeth Brazeau
Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
J Neurovirol 17:274-80. 2011..The onset of CPE was much slower with the double-mutant transfectants (10 days vs. 3 days) and plaques were smaller. While SVV ORF 63 is not required for replication in culture, its expression leads to robust virus replication... - Varicella-zoster virus infection of differentiated human neural stem cellsSubbiah Pugazhenthi
Department of Neurology, Mail Stop B182, University of Colorado School of Medicine, 12700 E 19th Ave, Aurora, CO 80045, USA
J Virol 85:6678-86. 2011..This model provides a unique in vitro system to study the VZV-neuronal relationship... - Molecular characterization of varicella zoster virus in latently infected human ganglia: physical state and abundance of VZV DNA, Quantitation of viral transcripts and detection of VZV-specific proteinsYevgeniy Azarkh
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:229-41. 2010..New technologies, such as GeXPS multiplex PCR, have the sensitivity to detect multiple low abundance transcripts and thus provide a means to elucidate the entire VZV transcriptome during latency... - Simian varicella virus pathogenesisRavi Mahalingam
Departments of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:309-21. 2010..Experimental immunosuppression of monkeys latently infected with SVV results in zoster, thus providing a new model system to study how the loss of adaptive immunity modulates virus reactivation... - Persistence of varicella zoster virus DNA in saliva after herpes zosterMaria A Nagel
Departments of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
J Infect Dis 204:820-4. 2011..Because VZV infection can produce neurological and ocular disease without zoster rash, future studies are needed to establish whether VZV DNA can be detected in the saliva of such patients... - Recurrent varicella zoster virus myelopathyDon Gilden
Department of Neurology, University of Colorado Denver, School of Medicine, Denver, CO, USA
J Neurol Sci 276:196-8. 2009..In contrast to earlier cases of recurrent VZV myelopathy in immunocompetent adults that developed weeks to months after the first episode of myelopathy, this is the first instance of recurrence years later... - Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteriesMaria A Nagel
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA
Neurology 80:62-8. 2013.... - Varicella zoster virus vasculopathy: a treatable form of rapidly progressive multi-infarct dementia after 2 years' durationBrian Silver
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA
J Neurol Sci 323:245-7. 2012..VZV must be considered as a possible cause of neurological disease in any patient with idiopathic multifocal vasculopathy... - Subclinical reactivation of varicella zoster virus in all stages of HIV infectionMarius Birlea
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
J Neurol Sci 304:22-4. 2011..To rule out VZV infection of the nervous system, CSF must be tested for VZV DNA and anti-VZV IgG and IgM antibody... - Phosphorylation of the nuclear form of varicella-zoster virus immediate-early protein 63 by casein kinase II at serine 186Niklaus H Mueller
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
J Virol 83:12094-100. 2009.... - Varicella zoster virus is not a disease-relevant antigen in multiple sclerosisMark P Burgoon
Department of Neurology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Ann Neurol 65:474-9. 2009..VZV is not a disease-relevant antigen in MS... - Rapid and sensitive detection of 68 unique varicella zoster virus gene transcripts in five multiplex reverse transcription-polymerase chain reactionsMaria A Nagel
Department of Neurology, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Mail Stop B182, Aurora, CO 80045, USA
J Virol Methods 157:62-8. 2009..Only five multiplex RT-PCR assays were needed to analyze the entire VZV transcriptome. This technology will allow rapid analysis of all VZV genes transcribed during latency in human ganglia... - Identification of measles virus epitopes using an ultra-fast method of panning phage-displayed random peptide librariesXiaoli Yu
Department of Neurology, University of Colorado Denver School of Medicine, 4200 East Ninth Avenue, Mail Stop B182, Denver, CO 80262, USA
J Virol Methods 156:169-73. 2009..The UFSP panning methodology will expedite identification of peptides reacting with antibodies generated in other diseases of unknown antigenic specificity such as multiple sclerosis (MS), sarcoidosis and Behcet's disease... - Human trigeminal ganglionic explants as a model to study alphaherpesvirus reactivationYevgeniy Azarkh
Department of Neurology, University of Colorado Denver Medical School, Aurora, CO, USA
J Neurovirol 18:456-61. 2012..The increase in HSV-1 DNA was fourfold greater than the increase in VZV DNA. Overall, we present a model for alphaherpesvirus latency in human neurons in which the key molecular events leading to virus reactivation can be studied... - Does apoptosis play a role in varicella zoster virus latency and reactivation?Stephanie F James
Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Viruses 4:1509-14. 2012..Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV... - Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis opticaJeffrey L Bennett
Department of Neurology and Ophthalmology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Ann Neurol 66:617-29. 2009..Our objectives were to determine the source of central nervous system (CNS) NMO-IgGs and their role in disease pathogenesis... - Varicella zoster virus meningitis with hypoglycorrhachia in the absence of rash in an immunocompetent womanAli A Habib
Department of Neurology, New York Presbyterian Hospital Weill Cornell Medical College, New York, New York, USA
J Neurovirol 15:206-8. 2009..Cerebrospinal fluid (CSF) examination revealed the presence of VZV DNA, anti-VZV immunoglobulin G (IgG) antibody, and intrathecal production of anti-VZV IgG antibody... - Varicella zoster virus vasculopathy: analysis of virus-infected arteriesM A Nagel
Department of Neurology, University of Colorado School of Medicine, 12700 E 19th Avenue, Box B182, Aurora, CO 80045, USA
Neurology 77:364-70. 2011..Thus, we analyzed cerebral and temporal arteries from 3 patients with VZV vasculopathy to identify features that will help in diagnosis and lead to a better understanding of VZV-induced vascular remodeling...
Research Grants
- NEUROBIOLOGY OF VARICELLA ZOSTER VIRUSDonald H Gilden; Fiscal Year: 2010....