John J Gildea

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells
    John J Gildea
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 61:1021-7. 2013
  2. pmc Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells
    John J Gildea
    University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 60:396-403. 2012
  3. ncbi request reprint Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G
    Xiao Hong Jin
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 1414, USA
    Hypertension 43:1133-9. 2004
  4. pmc Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 59:437-45. 2012
  5. pmc Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 53:338-43. 2009
  6. pmc Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis
    DAVID C LIEB
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Hypertension 54:1278-83. 2009
  7. pmc A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy
    John J Gildea
    University of Virginia, Charlottesville, VA 22903, United States
    Clin Chim Acta 421:236-42. 2013
  8. pmc Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats
    John J Gildea
    Department of Pathology, The Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 300:F914-20. 2011
  9. pmc Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis
    Nilberto R F Nascimento
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 58:107-13. 2011
  10. doi request reprint Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor
    John J Gildea
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 51:360-6. 2008

Collaborators

Detail Information

Publications21

  1. pmc A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells
    John J Gildea
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 61:1021-7. 2013
    ..This novel pathway may be involved in the increase in blood pressure in hypertension that is mediated by increased activity of the renin-angiotensin system and decreased activity of the renal dopaminergic system...
  2. pmc Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells
    John J Gildea
    University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 60:396-403. 2012
    ..These studies shed new light on the regulation of renal sodium transport by the dopaminergic and angiotensin systems and potential new therapeutic targets for selectively treating hypertension...
  3. ncbi request reprint Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G
    Xiao Hong Jin
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 1414, USA
    Hypertension 43:1133-9. 2004
    ..In conclusion, pressure-natriuresis is mediated by RI cGMP and a PKG signaling pathway in target renal proximal tubule cells...
  4. pmc Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 59:437-45. 2012
    ..These studies provide novel insights regarding the mechanisms whereby renal D(1)Rs and AT(2)Rs act in concert to promote sodium excretion in vivo...
  5. pmc Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats
    Shetal H Padia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 53:338-43. 2009
    ..Identical manipulations fail to induce natriuresis or AT(2)R translocation in SHRs, suggesting that defects in AT(2)R-mediated natriuresis and trafficking may be important to the development of hypertension in SHRs...
  6. pmc Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis
    DAVID C LIEB
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Hypertension 54:1278-83. 2009
    ..The results support an intrarenal positive-feedback loop wherein RI cGMP increases RIHP, which, in turn, increases RI cGMP, contributing to the reinforcement of pressure-natriuresis...
  7. pmc A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy
    John J Gildea
    University of Virginia, Charlottesville, VA 22903, United States
    Clin Chim Acta 421:236-42. 2013
    ..We tested the hypothesis that urine-derived exfoliated renal proximal tubule cells (RPTCs) could diagnose the degree of an individual's SS of BP...
  8. pmc Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats
    John J Gildea
    Department of Pathology, The Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 300:F914-20. 2011
    ..Furthermore, chronic disruption of lipid rafts or CAV1 protein expression in the kidney induces hypertension...
  9. pmc Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis
    Nilberto R F Nascimento
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 58:107-13. 2011
    ....
  10. doi request reprint Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor
    John J Gildea
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Hypertension 51:360-6. 2008
    ..The discovery of differential regulation by D(1)R and D(5)R opens new avenues for the development of agonists selective to either receptor subtype as targeted antihypertensive agents that can decrease AT(1)R-mediated antinatriuresis...
  11. doi request reprint Intact microtubules are required for natriuretic responses to nitric oxide and increased renal perfusion pressure
    Jennifer Park
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 51:494-9. 2008
    ..These observations indicate that a functioning microtubulin network is required for the transport of cGMP into the extracellular space to modulate NO- and pressure-induced natriuresis...
  12. pmc Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure
    John J Gildea
    Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA
    Clin Biochem 46:1131-4. 2013
    ..To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake...
  13. ncbi request reprint Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism
    Leslie J Salomone
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 49:155-61. 2007
    ....
  14. pmc HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling
    John J Gildea
    University of Virginia, PO Box 801400, Charlottesville, VA 22908, USA
    Hypertension 56:505-11. 2010
    ..41+/-4.7% and -27.36+/-2.70%; P<0.001; n=6), which express wild-type GRK4. Despite the fact that HK-2 cells retain many functional characteristics of RPTCs, they are not normal from the perspective of dopaminergic function...
  15. pmc Caveolin-1 and dopamine-mediated internalization of NaKATPase in human renal proximal tubule cells
    John J Gildea
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Hypertension 54:1070-6. 2009
    ..We conclude that the scaffolding protein CAV1 is necessary for the association of D1-like receptors with G protein-coupled receptor kinase type 4 and the adapter protein 2-associated reduction in plasma membrane NaKATPase...
  16. pmc Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter
    Robert M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 60:1359-66. 2012
    ..2 × 10(-5)]; rs1017783 [P=1.1 × 10(-4)]). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of blood pressure in 2 separate white populations...
  17. doi request reprint Intrarenal ghrelin receptors regulate ENaC-dependent sodium reabsorption by a cAMP-dependent pathway
    Brandon A Kemp
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, University of Virginia School of Medicine, Charlottesville, Virginia 22908 1414, USA
    Kidney Int 84:501-8. 2013
    ..Thus, GRs expressed in the CCD regulate sodium reabsorption by cAMP-induced trafficking of ENaC to the apical membrane. ..
  18. ncbi request reprint Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells
    Shota Sasaki
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, USA
    Hypertension 43:286-91. 2004
    ..The cGMP cellular export system is critical in the regulation of RPT cellular Na+ absorption in humans...
  19. doi request reprint Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods
    John J Gildea
    Department of Pathology, The University of Virginia, Charlottesville, VA, USA
    Methods Mol Biol 945:329-45. 2013
    ..In addition, we describe new paradigms in 3D cell culture which allow the cells to maintain more in vivo-like morphology and function...
  20. pmc Dopamine and angiotensin as renal counterregulatory systems controlling sodium balance
    John J Gildea
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    Curr Opin Nephrol Hypertens 18:28-32. 2009
    ..To review the recent evidence demonstrating how the renal dopaminergic and angiotensin systems control renal electrolyte balance through various receptor-mediated pathways with counterregulatory interactions...
  21. doi request reprint TMS, a chemically modified herbal derivative of resveratrol, induces cell death by targeting Bax
    Sarah E Aiyar
    Division of Endocrinology and Metabolism, University of Virginia Health System, PO Box 801416, Charlottesville, VA 22908, USA
    Breast Cancer Res Treat 124:265-77. 2010
    ..TMS treatment was able to induce both caspase-independent and caspase-dependent death via the intrinsic death pathway...