Carol A Gilchrist

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Virulence factors of Entamoeba histolytica
    C A Gilchrist
    Division of Infectious Diseases, Department of Internal Medicine, University of Virginia HSC, MR4 Building, Room 2115, Charlottesville, VA 22908, USA
    Curr Opin Microbiol 2:433-7. 1999
  2. pmc Targets of the Entamoeba histolytica transcription factor URE3-BP
    Carol A Gilchrist
    Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Negl Trop Dis 2:e282. 2008
  3. ncbi request reprint Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Mol Biochem Parasitol 147:163-76. 2006
  4. pmc A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence
    Carol A Gilchrist
    Departments of Medicine, School of Medicine, University of Virginia, Charlottesville, VA, USA
    BMC Microbiol 12:151. 2012
  5. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
  6. pmc Phospholipid-binding protein EhC2A mediates calcium-dependent translocation of transcription factor URE3-BP to the plasma membrane of Entamoeba histolytica
    Heriberto Moreno
    Division of Infectious Diseases and International Health, University of Virginia, P O Box 801340, Charlottesville, VA 22908, USA
    Eukaryot Cell 9:695-704. 2010
  7. pmc Using differential gene expression to study Entamoeba histolytica pathogenesis
    Carol A Gilchrist
    Division of Infectious Diseases and International Health, Departments of Medicine, Microbiology and Pathology, University of Virginia, PO Box 801340, Charlottesville, VA 22908 1340, USA
    Trends Parasitol 25:124-31. 2009
  8. pmc Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis
    Sarah N Buss
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 1340, USA
    Int J Parasitol 40:833-43. 2010
  9. ncbi request reprint Calcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BP
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:4646-53. 2003
  10. pmc Development of the Gateway system for cloning and expressing genes in Entamoeba histolytica
    Mayuresh M Abhyankar
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Parasitol Int 58:95-7. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Virulence factors of Entamoeba histolytica
    C A Gilchrist
    Division of Infectious Diseases, Department of Internal Medicine, University of Virginia HSC, MR4 Building, Room 2115, Charlottesville, VA 22908, USA
    Curr Opin Microbiol 2:433-7. 1999
    ..histolytica virulence. The characterization of the CP5 cysteine protease and the induction of apoptosis in host target cells has led to a better comprehension of the mechanisms by which trophozoites can lyse target cells...
  2. pmc Targets of the Entamoeba histolytica transcription factor URE3-BP
    Carol A Gilchrist
    Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Negl Trop Dis 2:e282. 2008
    ..histolytica in response to a calcium signal. Induction of URE3-BP leads to an increase in tranwell migration, suggesting a possible role in the regulation of cellular motility...
  3. ncbi request reprint Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Mol Biochem Parasitol 147:163-76. 2006
    ....
  4. pmc A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence
    Carol A Gilchrist
    Departments of Medicine, School of Medicine, University of Virginia, Charlottesville, VA, USA
    BMC Microbiol 12:151. 2012
    ..histolytica Reference genome (strain HM-1:IMSS) and are highly variable...
  5. pmc Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection
    Mayuresh M Abhyankar
    Departments of Medicine, University of Virginia, Charlottesville, VA 22908 1340, USA
    Eukaryot Cell 7:1565-72. 2008
    ..We concluded that EhHMGB1 was a bona fide HMGB protein with the capacity to recapitulate part of the modulation of parasite gene expression seen during adaptation to the host intestine...
  6. pmc Phospholipid-binding protein EhC2A mediates calcium-dependent translocation of transcription factor URE3-BP to the plasma membrane of Entamoeba histolytica
    Heriberto Moreno
    Division of Infectious Diseases and International Health, University of Virginia, P O Box 801340, Charlottesville, VA 22908, USA
    Eukaryot Cell 9:695-704. 2010
    ..Based on these results, we propose a model for EhC2A-mediated regulation of the transcriptional activities of URE3-BP via Ca(2+)-dependent anchoring of the transcription factor to the amebic plasma membrane...
  7. pmc Using differential gene expression to study Entamoeba histolytica pathogenesis
    Carol A Gilchrist
    Division of Infectious Diseases and International Health, Departments of Medicine, Microbiology and Pathology, University of Virginia, PO Box 801340, Charlottesville, VA 22908 1340, USA
    Trends Parasitol 25:124-31. 2009
    ..The association and potential contribution of differential gene expression to the life cycle and the virulence of this protozoan parasite of humans are reviewed here...
  8. pmc Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis
    Sarah N Buss
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 1340, USA
    Int J Parasitol 40:833-43. 2010
    ..histolytica Gal/GalNAc lectin. Overall, our data indicates that multiple members of the novel E. histolytica TMK family are utilised for non-redundant functions by the parasite...
  9. ncbi request reprint Calcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BP
    Carol A Gilchrist
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:4646-53. 2003
    ..Modulation of URE3-BP by calcium may represent an important mechanism of control of gene expression in E. histolytica...
  10. pmc Development of the Gateway system for cloning and expressing genes in Entamoeba histolytica
    Mayuresh M Abhyankar
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Parasitol Int 58:95-7. 2009
    ..This expression vector with the Gateway((R)) system should facilitate investigation into the functions of novel proteins in E. histolytica...
  11. ncbi request reprint Histone acetyltransferases and deacetylase in Entamoeba histolytica
    Girija Ramakrishnan
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 138:205-16. 2004
    ..histolytica trophozoites. Our results suggest that mechanisms for histone acetylation and deacetylation are operational in E. histolytica...
  12. ncbi request reprint Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly
    Upinder Singh
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 120:107-16. 2002
    ..The differing effect on transcription initiation in the hgl5 and fdx genes upon mutation of the GAAC element suggests a context-dependence of the GAAC-binding protein in gene expression...
  13. pmc Multiplex real-time PCR assay using Scorpion probes and DNA capture for genotype-specific detection of Giardia lamblia on fecal samples
    Cherie T Ng
    Division of Infectious Diseases and International Health, University of Virginia, MR4 Building, Room 2144, P O Box 801340, Charlottesville, VA 22908, USA
    J Clin Microbiol 43:1256-60. 2005
    ..This single-reaction multiplex qPCR assay distinguishes assemblage A Giardia infections from assemblage B infections directly on fecal samples and may aid epidemiologic investigation...