Nicolas Gilbert

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Genomic deletions created upon LINE-1 retrotransposition
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell 110:315-25. 2002
  2. ncbi Multiple fates of L1 retrotransposition intermediates in cultured human cells
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109-0618, USA
    Mol Cell Biol 25:7780-95. 2005
  3. ncbi Distinct mechanisms for trans-mediated mobilization of cellular RNAs by the LINE-1 reverse transcriptase
    Jose L Garcia Perez
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Genome Res 17:602-11. 2007
  4. ncbi DNA repair mediated by endonuclease-independent LINE-1 retrotransposition
    Tammy A Morrish
    Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine Street, Ann Arbor, Michigan 48105 0618, USA
    Nat Genet 31:159-65. 2002
  5. ncbi Characterization of a mutagenic B1 retrotransposon insertion in the jittery mouse
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Hum Mutat 24:9-13. 2004
  6. ncbi Characterization of pre-insertion loci of de novo L1 insertions
    Stephen L Gasior
    Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center SL 66, 1430 Tulane Ave, New Orleans, LA 70112, United States
    Gene 390:190-8. 2007
  7. ncbi [Genomic instability associated with human LINE-1 rétrotransposition]
    Nicolas Gilbert
    Institut de Genetique Humaine, UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    J Soc Biol 198:419-24. 2004

Collaborators

Detail Information

Publications7

  1. ncbi Genomic deletions created upon LINE-1 retrotransposition
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell 110:315-25. 2002
    ..Thus, our data demonstrate multiple pathways for L1 integration in cultured cells, and show that L1 is not simply an insertional mutagen, but that its retrotransposition can result in significant deletions of genomic sequence...
  2. ncbi Multiple fates of L1 retrotransposition intermediates in cultured human cells
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109-0618, USA
    Mol Cell Biol 25:7780-95. 2005
    ..Indeed, the initial steps in L1 retrotransposition may define a host/parasite battleground that serves to limit the number of active L1s in the genome...
  3. ncbi Distinct mechanisms for trans-mediated mobilization of cellular RNAs by the LINE-1 reverse transcriptase
    Jose L Garcia Perez
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0618, USA
    Genome Res 17:602-11. 2007
    ..Thus, we propose that the LINE-1-encoded reverse transcriptase can mediate the retrotransposition of non-L1 RNAs by distinct mechanisms...
  4. ncbi DNA repair mediated by endonuclease-independent LINE-1 retrotransposition
    Tammy A Morrish
    Department of Human Genetics, University of Michigan Medical School, 1241 E Catherine Street, Ann Arbor, Michigan 48105 0618, USA
    Nat Genet 31:159-65. 2002
    ..Thus, our results suggest that LINE-1s can integrate into DNA lesions, resulting in retrotransposon-mediated DNA repair in mammalian cells...
  5. ncbi Characterization of a mutagenic B1 retrotransposon insertion in the jittery mouse
    Nicolas Gilbert
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Hum Mutat 24:9-13. 2004
    ..Together, these data demonstrate that B1 retrotransposition is ongoing in the mouse genome and is consistent with the hypothesis that the reverse transcriptase and endonuclease encoded by LINE-1 elements mediate B1 mobility...
  6. ncbi Characterization of pre-insertion loci of de novo L1 insertions
    Stephen L Gasior
    Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center SL 66, 1430 Tulane Ave, New Orleans, LA 70112, United States
    Gene 390:190-8. 2007
    ....
  7. ncbi [Genomic instability associated with human LINE-1 rétrotransposition]
    Nicolas Gilbert
    Institut de Genetique Humaine, UPR 1142, 141, rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    J Soc Biol 198:419-24. 2004
    ..L1 then can be considered as a major factor that has affected and shaped the human genome through several mechanisms...