Research Topics
| S GiguereSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Equine immunity to bacteriaS Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, USA
Vet Clin North Am Equine Pract 16:29-47, v-iv. 2000..This article summarizes the current state of knowledge on innate and adaptive immunity to bacterial pathogens and reviews various ways in which some bacteria have evolved in order to evade components of the host response...
Retrospective comparison of caffeine and doxapram for the treatment of hypercapnia in foals with hypoxic-ischemic encephalopathyS Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Intern Med 22:401-5. 2008..Despite a lack of data regarding their efficacy, both caffeine and doxapram have been recommended for treatment of hypercapnia in equine neonates with central nervous system damage...- Cardiac output measurement by partial carbon dioxide rebreathing, 2-dimensional echocardiography, and lithium-dilution method in anesthetized neonatal foalsSteeve Giguere
Departments of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
J Vet Intern Med 19:737-43. 2005..Volumetric echocardiography using the Bullet method provides an accurate and noninvasive estimate of CO in anesthetized neonatal foals and warrants investigation in critically ill conscious foals... - Accuracy of indirect measurement of blood pressure in neonatal foalsSteeve Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine University of Florida, Gainesville, FL 32610, USA
J Vet Intern Med 19:571-6. 2005..47. Indirect oscillometry with a cuff placed over the coccygeal artery or dorsal metatarsal artery is an acceptable method for measuring MAP in foals. Blood pressure does not correlate well with cardiac output in anesthetized foals... - Immunologic disorders in neonatal foalsSteeve Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100136, Southwest 16th Avenue, Gainesville, FL 32610, USA
Vet Clin North Am Equine Pract 21:241-72, v. 2005..This article summarizes the current understanding of the equine fetal and neonatal immune system and reviews common immunodeficiency disorders as well as disorders resulting from allogenic incompatibilities... - Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equi pneumoniaSteeve Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Intern Med 18:568-73. 2004..The combination clarithromycin-rifampin is superior to azithromycin-rifampin or erythromycin-rifampin for the treatment of pneumonia caused by R. equi in foals in a referral population... 
Performance of five serological assays for diagnosis of Rhodococcus equi pneumonia in foalsSteeve Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
Clin Diagn Lab Immunol 10:241-5. 2003..We conclude that current serological assays do not differentiate between diseased and clinically healthy foals...- Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionateSteeve Giguere
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, P O Box 100136, Gainesville, FL 32610, USA
Vet Immunol Immunopathol 85:147-58. 2002..These results demonstrate the clinical efficacy of inhaled fluticasone propionate for the treatment of heaves and suggest a role for cytokines in the development of lower airway inflammation in heaves-susceptible horses... - Disposition of oral telithromycin in foals and in vitro activity of the drug against macrolide-susceptible and macrolide-resistant Rhodococcus equi isolatesL H Javsicas
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
J Vet Pharmacol Ther 33:383-8. 2010..The MIC of telithromycin for macrolide-resistant isolates (MIC(50)=4.0 microg/mL) was significantly lower than that of clarithromycin (MIC(50)=24.0 microg/mL), azithromycin (MIC(50)=256 microg/mL) and erythromycin (MIC(50)=24 microg/mL)... - Relationship between infection, inflammation and premature parturition in mares with experimentally induced placentitisM M LeBlanc
Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA
Equine Vet J Suppl 44:8-14. 2012..By understanding how placentitis induces premature delivery, it may be possible to develop diagnostic markers and to delay premature delivery pharmacologically, thereby decreasing perinatal foal mortality... - Pharmacokinetics of oral doxycycline and concentrations in body fluids and bronchoalveolar cells of foalsA Womble
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
J Vet Pharmacol Ther 30:187-93. 2007.... - Pulmonary disposition of erythromycin, azithromycin, and clarithromycin in foalsG Suarez Mier
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Pharmacol Ther 30:109-15. 2007..Peak azithromycin and clarithromycin activity was significantly higher in BAL cells, followed by PELF, and serum. In contrast, peak erythromycin activity in BAL cells was not significantly different from that of serum... - Plasma and pulmonary disposition of ceftiofur and its metabolites after intramuscular administration of ceftiofur crystalline free acid in weanling foalsB C Credille
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
J Vet Pharmacol Ther 35:259-64. 2012..2 μg/mL for at least 4 days and would be expected to be an effective treatment for pneumonia caused by Streptococcus equi subsp. zooepidemicus at doses similar to the adult label... - Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: innate vs. adaptive immune responseJ K Belknap
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio 43210, USA
Equine Vet J 39:42-7. 2007..Characterisation of the type of immune response (i.e. innate vs. adaptive) is essential in order to develop therapeutic strategies to counteract these deleterious events... - The effects of deferoxamine mesylate on iron elimination after blood transfusion in neonatal foalsJ R Elfenbein
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 32602, USA
J Vet Intern Med 24:1475-82. 2010..Hepatic failure is one of the more common complications in foals requiring blood transfusion to treat neonatal isoerythrolysis. Iron intoxication is likely the cause of hepatic injury... - Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitisM L Macpherson
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA, USA Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA
J Vet Pharmacol Ther 36:59-67. 2013..Treatment did not appear to improve foal survival (CEFT: 0/3; COMBO: 2/6; UNTREAT: 2/3). Bacteria were recovered from the uterus of most mares postpartum and from blood cultures of most foals regardless of treatment... - Increased pulmonary activation of nuclear factor-kappaB (NF-kappaB) in foals inoculated with Rhodococcus equi is associated with increased expression of inflammatory cytokinesE W Uhl
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32610 0145, USA
Vet Pathol 39:132-6. 2002..Southwestern histochemistry revealed activated NF-kappaB in multinucleated giant cells that often contained bacteria. These results indicate that the cytokine response to R. equi is at least partially mediated by NF-kappaB activation... - Treatment efficacy of trimethoprim sulfamethoxazole, pentoxifylline and altrenogest in experimentally induced equine placentitisC S Bailey
University of Florida, Dept of LACS, College of Veterinary Medicine, PO Box 100136, Gainesville, FL 32610, USA
Theriogenology 74:402-12. 2010..The authors inferred that administration of trimethoprim sulfamethoxazole, pentoxifylline and altrenogest may improve the viability of foals from mares with experimentally induced placentitis... - Infectious agents detected in the feces of diarrheic foals: a retrospective study of 233 cases (2003-2008)J Frederick
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
J Vet Intern Med 23:1254-60. 2009..Diarrhea is common in foals but there are no studies investigating the relative prevalence of common infectious agents in a population of hospitalized diarrheic foals... - Factors associated with outcome in foals with neonatal isoerythrolysis (72 cases, 1988-2003)A C Polkes
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Intern Med 22:1216-22. 2008..Neonatal foals with isoerythrolysis (NI) often die, but the risk factors for death have not been identified... - Effect of age, feeding, and omeprazole administration on gastric tonometry in healthy neonatal foalsL C Sanchez
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
J Vet Intern Med 22:406-10. 2008..Gastric tonometry is commonly used in humans as an assessment of intestinal mucosal perfusion. Values in healthy foals are currently unknown... - Pharmacokinetics of intravenous ceftiofur sodium and concentration in body fluids of foalsS Meyer
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
J Vet Pharmacol Ther 32:309-16. 2009..5 microg/mL. Intravenous administration of ceftiofur sodium at the rate of 5 mg/kg every 12 h would provide sufficient coverage for the treatment of susceptible bacterial isolates... - Relationship between infection, inflammation and premature parturition in mares with experimentally induced placentitisM M LeBlanc
Department of Large Animal Clinical Sciences, University of Florida, Gainesville, Florida, USA
Equine Vet J 44:8-14. 2012..By understanding how placentitis induces premature delivery, it may be possible to develop diagnostic markers and to delay premature delivery pharmacologically, thereby decreasing perinatal foal mortality...