F Gigliotti

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 70:1069-74. 2002
  2. pmc Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Infect Immun 74:6310-6. 2006
  3. ncbi request reprint Immunopathogenesis of Pneumocystis carinii pneumonia
    Francis Gigliotti
    University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Expert Rev Mol Med 7:1-16. 2005
  4. pmc Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:3852-6. 2003
  5. ncbi request reprint Pneumocystis carinii: has the name really been changed?
    Francis Gigliotti
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Clin Infect Dis 41:1752-5. 2005
  6. pmc Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, Department of Microbiology University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 104:1307-17. 1999
  7. ncbi request reprint Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells
    C G Haidaris
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Mol Biotechnol 9:91-7. 1998
  8. ncbi request reprint Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Infect Dis 178:235-42. 1998
  9. pmc Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 69:758-64. 2001
  10. ncbi request reprint Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A
    C G Haidaris
    Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    DNA Res 5:77-85. 1998

Research Grants

  1. P CARINII PNEUMONIA--IMMUNOPATHOGENESIS OF LUNG INJURY
    Francis Gigliotti; Fiscal Year: 2001
  2. MONOCLONAL ANTIBODIES FOR THE STUDY OF P CARINII
    Francis Gigliotti; Fiscal Year: 2003
  3. TRAINING IN PEDIATRIC INFECTIOUS DISEASES
    Francis Gigliotti; Fiscal Year: 2007
  4. P. carinii Pneumonia Lung Damage: CD8-driven Cellular and Molecular Events
    Terry W Wright; Fiscal Year: 2010
  5. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 1993
  6. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 2009

Detail Information

Publications52

  1. pmc Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 70:1069-74. 2002
    ..An IgG1 switch variant of one of the IgM monoclonal antibodies was also protective. These experiments provide a model for exploring the utility of this approach in protecting at-risk patients from infection with P. carinii...
  2. pmc Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia
    Francis Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Infect Immun 74:6310-6. 2006
    ..Thus, in the absence of CD4+ T cells, CD8+ T cells are a key contributor to the inflammatory lung injury associated with PCP. However, we were unable to demonstrate an in vivo effect of these cells on the course of P. carinii infection...
  3. ncbi request reprint Immunopathogenesis of Pneumocystis carinii pneumonia
    Francis Gigliotti
    University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 690, Rochester, NY 14642, USA
    Expert Rev Mol Med 7:1-16. 2005
    ..carinii determines the ultimate outcome of PCP. A better understanding of the pathophysiology of PCP should lead to the development of improved therapies for the treatment of PCP...
  4. pmc Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 71:3852-6. 2003
    ..We speculate, based on these results, that transmission from normal host to normal host, as an asymptomatic or minimally symptomatic infection, could be a way to maintain this opportunistic pathogen in the environment...
  5. ncbi request reprint Pneumocystis carinii: has the name really been changed?
    Francis Gigliotti
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Clin Infect Dis 41:1752-5. 2005
    ..Use of the newly proposed names for P. carinii should not be mandated by journal reviewers or editors...
  6. pmc Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, Department of Microbiology University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Clin Invest 104:1307-17. 1999
    ..carinii directly impairs pulmonary function and contributes to the pathogenesis of PCP. Furthermore, CD8(+) T cells likely contribute to the respiratory compromise observed during PCP...
  7. ncbi request reprint Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells
    C G Haidaris
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Mol Biotechnol 9:91-7. 1998
    ..carinii surface glycoprotein were conserved in the recombinant polypeptide, and to investigate its glycosylation by insect cells. B-cell epitopes were retained, but the insect cells appeared to hyperglycosylate the recombinant protein...
  8. ncbi request reprint Recognition of Pneumocystis carinii antigens by local antibody-secreting cells following resolution of P. carinii pneumonia in mice
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Infect Dis 178:235-42. 1998
    ..The antigens identified by these MAbs merit further investigation regarding protective immunity to P. carinii because they were recognized by B cells in the context of recovery from P. carinii pneumonia...
  9. pmc Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia
    T W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 69:758-64. 2001
    ..carinii. Moreover, CD8(+) lymphocytes are involved in the mechanism leading to surfactant dysfunction...
  10. ncbi request reprint Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A
    C G Haidaris
    Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    DNA Res 5:77-85. 1998
    ..carinii demonstrated 156 identical residues, including 46 cysteines, further supporting the hypothesis for conserved secondary structure, as well as function, for gpA from all P. carinii...
  11. pmc Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia
    F Gigliotti
    University of Rochester School of Medicine, Rochester, New York 14642, USA
    Infect Immun 66:3179-82. 1998
    ..These studies suggest that other antigens in addition to gpA need to be evaluated for their role in protective immunity against P. carinii...
  12. pmc Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia
    P J Simpson-Haidaris
    Departments of Medicine Vascular Medicine Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Infect Immun 66:4431-9. 1998
    ..carinii to the lung epithelium...
  13. ncbi request reprint Lack of relation of granulocyte antibodies (antineutrophil antibodies) to neutropenia in children with human immunodeficiency virus infection
    G A Weinberg
    Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Pediatr Infect Dis J 16:881-4. 1997
    ....
  14. ncbi request reprint Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro
    Zhengdong Wang
    Dept of Pediatrics, Box 850, Univ of Rochester School of Medicine, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1124-31. 2005
    ....
  15. pmc Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia
    Jesse Wells
    University of Rochester School of Medicine and Dentistry, Department of Pediatrics, Box 690, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Infect Immun 74:390-3. 2006
    ..The necessity of complement for optimal PCP prophylaxis by MAb 4F11(G1) suggests that complement may play a role in antibody-mediated protection against development of PCP...
  16. ncbi request reprint Pneumocystis carinii infection sensitizes lung to radiation-induced injury after syngeneic marrow transplantation: role of CD4+ T cells
    Lauren Bruckner
    Division of Hematology Oncology Bone Marrow Transplant, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1087-96. 2006
    ..carinii alone or undepleted P. carinii/TBI mice. Together, these results indicate that P. carinii infection can sensitize the lung to subsequent TBI-mediated lung injury via a process dependent on non-alloreactive CD4(+) T cells...
  17. pmc Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen
    Jesse Wells
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 690, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 74:2446-8. 2006
    ..Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii...
  18. ncbi request reprint Viridans group streptococcal infections among children with cancer and the importance of emerging antibiotic resistance
    Lauren Bruckner
    Department of Pediatrics, Division of Hematology Oncology HSCT, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Semin Pediatr Infect Dis 17:153-60. 2006
    ....
  19. ncbi request reprint Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism
    Jing Wang
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1495-505. 2007
    ..carinii-stimulated AECs. These data demonstrate that AECs respond to P. carinii in a proinflammatory manner that may contribute to the generation of immune-mediated lung injury...
  20. pmc Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia
    Gloria S Pryhuber
    Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 181:1409-19. 2008
    ..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells...
  21. pmc Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 184:497-502. 2010
    ..Thus, the anti-human CD3 monoclonal Ab OKT3, which is already in clinical use, has the potential to be developed as an adjunctive therapy for PcP...
  22. ncbi request reprint Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease
    Samir P Bhagwat
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1256-66. 2006
    ..In the absence of CD4(+) cells, CD8(+) T cells produced a nonprotective, pathological immune response. These data suggest that the interplay of CD4(+) and CD8(+) T cells affects the ultimate outcome of PcP-related IRD...
  23. pmc Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis
    Matthew D Disney
    Department of Chemistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Antimicrob Agents Chemother 49:1326-30. 2005
    ....
  24. ncbi request reprint Immune reconstitution syndrome after successful treatment of Pneumocystis carinii pneumonia in a man with human immunodeficiency virus type 1 infection
    Christine E Koval
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Infect Dis 35:491-3. 2002
    ..carinii DNA. We hypothesize that this patient's clinical presentation denotes immune reconstitution syndrome in response to residual P. carinii antigen in the lung...
  25. pmc Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA
    Jesse Wells
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Infect Immun 72:1548-56. 2004
    ..carinii derived from multiple hosts and will permit testing of the epitopes recognized by this antibody in immunization against P. carinii...
  26. ncbi request reprint TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia
    Terry W Wright
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Immunol 172:2511-21. 2004
    ....
  27. ncbi request reprint Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development
    Min Yee
    Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006
    ..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells...
  28. doi request reprint Murine mechanical ventilation stimulates alveolar epithelial cell proliferation
    Patricia Rose Chess
    Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA patricia
    Exp Lung Res 36:331-41. 2010
    ..Ventilation did not increase apoptosis in alveolar type II cells, as measured by TUNEL staining. Ventilation at low tidal volumes leads to a mild inflammatory response and alveolar epithelial cell proliferation...
  29. pmc Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells
    Emily A Desmet
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Virology 400:224-32. 2010
    ..These findings support a role for MLK3 in viral production during influenza infection...
  30. pmc Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells
    Jing Wang
    Department of Pediatrics, P O Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Infect Immun 73:2766-77. 2005
    ..Given the global regulatory functions of the NF-kappaB family, these findings suggest that Pneumocystis directly alters AEC gene expression in a manner that promotes pulmonary immune and inflammatory responses...
  31. pmc Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 52:17-24. 2009
    ..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment...
  32. pmc Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)
    Rhonda J Staversky
    Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 161:1383-93. 2002
    ..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury...
  33. pmc p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth
    Peter F Vitiello
    Department of Environmental Medicine, Box 850, The University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Pathol 168:1838-47. 2006
    ..Taken together, these data show that p21-mediated cytoprotection against hyperoxia involves regulation of Bcl-XL and is uncoupled from its ability to inhibit proliferation...
  34. ncbi request reprint Identification of Pneumocystis carinii in the lungs of infants dying of sudden infant death syndrome
    D J Morgan
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Pediatr Infect Dis J 20:306-9. 2001
    ..CONCLUSIONS: These data suggest that a possible link between some cases of SIDS and infection with P. carinii should be further evaluated and that infection of young infants may serve as an important reservoir for human P. carinii...
  35. pmc Impact of medications prescribed for treatment of attention-deficit hyperactivity disorder on physical growth in children and adolescents with HIV
    Patricia A Sirois
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Dev Behav Pediatr 30:403-12. 2009
    ..To examine the relationships between physical growth and medications prescribed for symptoms of attention-deficit hyperactivity disorder in children with HIV...
  36. ncbi request reprint High incidence of penicillin resistance among alpha-hemolytic streptococci isolated from the blood of children with cancer
    Lauren B Bruckner
    Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Pediatr 140:20-6. 2002
    ..To survey the susceptibility profiles to several beta-lactam antibiotics and to identify factors related to resistance among blood isolates of alpha-hemolytic streptococci (AHS) obtained from children with cancer...
  37. ncbi request reprint Alpha-hemolytic streptococcal infections among immunocompromised hosts: increasing incidence, severity and antibiotic resistance
    Lauren Bruckner
    Department of Pediatrics, University of Rochester, NY, USA
    Pediatr Infect Dis J 21:343-5. 2002
  38. ncbi request reprint Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine
    E J McFarland
    Department of Pediatrics, University of Colorado Health Science Center, Denver, CO 80262, USA
    J Infect Dis 184:1331-5. 2001
    ..These results provide support for further studies of vaccine strategies to prevent mother-to-infant HIV-1 transmission...
  39. pmc Toxicities associated with dual nucleoside reverse-transcriptase inhibitor regimens in HIV-infected children
    Russell B Van Dyke
    Department of Pediatrics, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Infect Dis 198:1599-608. 2008
    ..Human immunodeficiency virus (HIV) therapy includes a backbone of nucleoside reverse-transcriptase inhibitors (NRTIs). Toxicities associated with NRTIs are not fully defined in children...
  40. ncbi request reprint Short course directly observed therapy to monitor compliance with antiretroviral therapy in human immunodeficiency virus-infected children
    F Gigliotti
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY, USA
    Pediatr Infect Dis J 20:716-8. 2001
    ..Four to 8 days of DOT resulted in a significant drop in the viral load of all six children, demonstrating that short course DOT is an effective way to document poor compliance with antiretroviral therapy...
  41. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  42. pmc Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected children
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:189-96. 2010
    ..Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children...
  43. pmc Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old
    Myron J Levin
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:197-204. 2010
    ..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children...
  44. ncbi request reprint Vancomycin usage in central venous catheters in a neonatal intensive care unit
    Nahed O Elhassan
    Division of Neonatology, Golisano Children s Hospital at Strong, Rochester, NY, USA
    Pediatr Infect Dis J 23:201-6. 2004
    ..The use of vancomycin was reserved for documented infections with vancomycin-susceptible organisms...
  45. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  46. pmc Exposure of immunocompetent adult mice to Pneumocystis carinii f. sp. muris by cohousing: growth of P. carinii f. sp. muris and host immune response
    Chun Li An
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Infect Immun 71:2065-70. 2003
    ..Once an acquired immune response was initiated, the P. carinii f. sp. muris organisms were quickly eliminated without clinical signs of disease...
  47. pmc Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice
    Steve D Swain
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717, USA
    Infect Immun 72:5722-32. 2004
    ..We also show that there is no difference in Pneumocystis burdens between wild-type and knockout mice, which supports the idea that neutrophils do not have a major role in the clearance of this organism...
  48. pmc Passive immunization of neonatal mice against Pneumocystis carinii f. sp. muris enhances control of infection without stimulating inflammation
    Kerry M Empey
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky Medical Center, 800 Rose St, Lexington 40536 0298, USA
    Infect Immun 72:6211-20. 2004
    ..These findings indicate that specific antibody plays an important role in Pneumocystis clearance from lungs of infected neonates; moreover, this process occurs without inducing inflammation in the lungs...
  49. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  50. ncbi request reprint Pneumocystis carinii nomenclature: response to Cushion and Stringer
    Francis Gigliotti
    Clin Infect Dis 42:1208-9. 2006
  51. pmc Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study
    Paige L Williams
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Am J Epidemiol 167:1375-86. 2008
    ..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention...

Research Grants31

  1. P CARINII PNEUMONIA--IMMUNOPATHOGENESIS OF LUNG INJURY
    Francis Gigliotti; Fiscal Year: 2001
    ..If this hypothesis is proven correct, the information gained from the proposed studies can be utilized to develop new therapeutic modalities to improve the morbidity and mortality resulting from PCP. ..
  2. MONOCLONAL ANTIBODIES FOR THE STUDY OF P CARINII
    Francis Gigliotti; Fiscal Year: 2003
    ..carinii. Information resulting from these experiments will serve to define the feasibility of using an immunologic approach to the control of PCP in immunocompromised humans. ..
  3. TRAINING IN PEDIATRIC INFECTIOUS DISEASES
    Francis Gigliotti; Fiscal Year: 2007
    ..This training program has as its goal producing well-trained physician-scientists who are capable of developing their own independent research programs in areas relevant to infections in the immunocompromised host. ..
  4. P. carinii Pneumonia Lung Damage: CD8-driven Cellular and Molecular Events
    Terry W Wright; Fiscal Year: 2010
    ..The experiments outlined in this proposal are designed to lead to a translational clinical trial designed to improve the management of patients with P. carinii pneumonia. ..
  5. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 1993
    ..Successful completion of this project will aid in the presentation, diagnosis and treatment of PCP...
  6. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 2009
    ..We will also determine the microbiologic effect of combining passive antibody therapy with conventional antimicrobial therapy. ..