Affiliation: University of California
- Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse modelBelinda Gier
Larry L Hillblom Islet Research Center, University of California Los Angeles UCLA, David Geffen School of Medicine, Los Angeles, California, USA
Diabetes 61:1250-62. 2012..These data reveal that GLP-1 mimetic therapy may induce focal proliferation in the exocrine pancreas and, in the context of exocrine dysplasia, may accelerate formation of neoplastic PanIN lesions and exacerbate chronic pancreatitis...
- Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapiesMichael Elashoff
Larry L Hillblom Islet Research Center at David Geffen School of Medicine and Department of Biomathematics, University of California, Los Angeles, California 90095 7073, USA
Gastroenterology 141:150-6. 2011..There are also concerns that dipeptidyl peptidase-4 inhibitors could cause cancer, given their effects on immune function...
- Glucagon like peptide-1 receptor expression in the human thyroid glandBelinda Gier
Larry L Hillblom Islet Research Center, David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue 72 228 CHS, Los Angeles, California 90095 6904, USA
J Clin Endocrinol Metab 97:121-31. 2012..We sought to establish whether C cells in human medullary thyroid carcinoma, C cell hyperplasia, and normal human thyroid express the GLP-1 receptor...