B E Gidal

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint The practical impact of altered dosing on perampanel plasma concentrations: Pharmacokinetic modeling from clinical studies
    Barry E Gidal
    School of Pharmacy, University of Wisconsin, Madison, WI, USA Electronic address
    Epilepsy Behav 35:6-12. 2014
  2. doi request reprint Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures
    Barry E Gidal
    University of Wisconsin, Madison, Wisconsin 53705, USA
    Epilepsia 54:1490-7. 2013
  3. ncbi request reprint Sexual dysfunction in patients with neuropsychiatric disorders: Challenges and opportunities
    Barry Gidal
    Pharmacy Practice Division, University of Wisconsin Madison School of Pharmacy, Madison, WI 53705, USA
    CNS Spectr 11:4-5. 2006
  4. ncbi request reprint Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 64:161-6. 2005
  5. ncbi request reprint Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 64:1-11. 2005
  6. doi request reprint Debate: Substitution of generic drugs in epilepsy: is there cause for concern?
    Barry E Gidal
    School of Pharmacy, Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705, USA
    Epilepsia 49:56-62. 2008
  7. doi request reprint Assessment of potential drug interactions in patients with epilepsy: impact of age and sex
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Neurology 72:419-25. 2009
  8. ncbi request reprint Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapy
    Barry E Gidal
    Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 57:85-93. 2003
  9. ncbi request reprint Levetiracetam does not alter body weight: analysis of randomized, controlled clinical trials
    Barry E Gidal
    Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 56:121-6. 2003
  10. ncbi request reprint Bioequivalence of antiepileptic drugs: how close is close enough?
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Curr Neurol Neurosci Rep 9:333-7. 2009

Detail Information

Publications34

  1. ncbi request reprint The practical impact of altered dosing on perampanel plasma concentrations: Pharmacokinetic modeling from clinical studies
    Barry E Gidal
    School of Pharmacy, University of Wisconsin, Madison, WI, USA Electronic address
    Epilepsy Behav 35:6-12. 2014
    ..Although perampanel is approved for once-daily dosing, some clinicians may elect to give perampanel as a divided dose (i.e., twice daily), so we also sought to examine the pharmacokinetic impact of twice- versus once-daily dosing...
  2. doi request reprint Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures
    Barry E Gidal
    University of Wisconsin, Madison, Wisconsin 53705, USA
    Epilepsia 54:1490-7. 2013
    ..The effects of concomitant enzyme-inducing AEDs (EIAEDs) and non-enzyme-inducing AEDs on the exposure, efficacy, and safety of perampanel are also considered...
  3. ncbi request reprint Sexual dysfunction in patients with neuropsychiatric disorders: Challenges and opportunities
    Barry Gidal
    Pharmacy Practice Division, University of Wisconsin Madison School of Pharmacy, Madison, WI 53705, USA
    CNS Spectr 11:4-5. 2006
  4. ncbi request reprint Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 64:161-6. 2005
    ..Our data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy, who receive either LTG or VPA...
  5. ncbi request reprint Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 64:1-11. 2005
    ..Consequently, no need for adjusting the dosages of these AEDs is anticipated when levetiracetam is added on or removed from a patient's therapeutic regimen...
  6. doi request reprint Debate: Substitution of generic drugs in epilepsy: is there cause for concern?
    Barry E Gidal
    School of Pharmacy, Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705, USA
    Epilepsia 49:56-62. 2008
    ..Regulatory requirements, pharmacokinetic methodology, and biopharmaceutical considerations are discussed...
  7. doi request reprint Assessment of potential drug interactions in patients with epilepsy: impact of age and sex
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Neurology 72:419-25. 2009
    ..To understand and quantify the exposure to concomitant medications other than antiepileptic drugs (AEDs) within an age-diverse group of men and women with epilepsy and explore the likelihood of relevant drug interactions as a result...
  8. ncbi request reprint Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapy
    Barry E Gidal
    Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 57:85-93. 2003
    ....
  9. ncbi request reprint Levetiracetam does not alter body weight: analysis of randomized, controlled clinical trials
    Barry E Gidal
    Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 56:121-6. 2003
    ..Levetiracetam (LEV) is indicated for adjunctive treatment of partial seizures. The objective of the present evaluation was to examine the effects of LEV treatment on body weight in adult patients...
  10. ncbi request reprint Bioequivalence of antiepileptic drugs: how close is close enough?
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Curr Neurol Neurosci Rep 9:333-7. 2009
    ....
  11. ncbi request reprint Inter- and intra-subject variability in gabapentin absorption and absolute bioavailability
    B E Gidal
    Department of Neurology, School of Pharmacy, University of Wisconsin, 425 N Charter Street, Madison, WI 53706, USA
    Epilepsy Res 40:123-7. 2000
    ..Previous studies have demonstrated that gabapentin displays dose-dependent absorption...
  12. ncbi request reprint Efficacy of lamotrigine in institutionalized, developmentally disabled patients with epilepsy: a retrospective evaluation
    B E Gidal
    University of Wisconsin, School of Pharmacy and Department of Neurology, Madison 53706, USA
    Seizure 9:131-6. 2000
    ..Adjunctive treatment with lamotrigine appears to be an efficacious and well-tolerated treatment for seizures in a significant percentage of developmentally disabled patients with epilepsy...
  13. ncbi request reprint Vigabatrin: a novel therapy for seizure disorders
    B E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison 53706, USA
    Ann Pharmacother 33:1277-86. 1999
    ..To review the pharmacology, pharmacokinetics, efficacy, and adverse effects of vigabatrin and its role in the management of seizure disorders...
  14. ncbi request reprint Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy
    B E Gidal
    School of Pharmacy, University of Wisconsin, Madison 53706, USA
    Epilepsy Res 31:91-9. 1998
    ..The recommended dosing schedule for GBP is t.i.d. At large daily doses, oral bioavailability (F) may be improved by giving the daily dose more frequently...
  15. ncbi request reprint Gabapentin absorption: effect of mixing with foods of varying macronutrient composition
    B E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison 53706, USA
    Ann Pharmacother 32:405-9. 1998
    ..To compare the oral absorption profile of gabapentin following administration of the contents of opened capsules that were mixed with food vehicles of varied macronutrient (protein) composition...
  16. ncbi request reprint Pathological fractures in epilepsy
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, Madison, WI 53792 5132, USA
    Epilepsy Behav 9:601-5. 2006
    ..Together these findings suggest that epilepsy, and/or its treatment, is a dominant influence in the pathogenesis of fractures and may exacerbate the effects of aging-related involutional osteoporosis...
  17. ncbi request reprint Optimizing epilepsy management in teenagers
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, 600 Highland Avenue H6 575, Madison, WI 53792, USA
    J Child Neurol 21:273-9. 2006
    ..Successful management of epilepsy in teenagers requires that physicians not only understand the advantages that the newer antiepileptic drugs appear to provide but also consider the social impact of treatment on their patients...
  18. ncbi request reprint Drug absorption in the elderly: biopharmaceutical considerations for the antiepileptic drugs
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 1032 Rennebohn Hall, 777 Highland Avenue, Madison, WI 53705, USA
    Epilepsy Res 68:S65-9. 2006
    ..These age-related physiological changes that may affect AED pharmacokinetics should be considered when treating elderly patients with epilepsy...
  19. ncbi request reprint Protracted ictal confusion in elderly patients
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, 600 Highland Avenue, Box H6 574 CSC, Madison, WI 53792 5132, USA
    Arch Neurol 63:529-32. 2006
    ..Ictal confusion, particularly if protracted, often presents a diagnostic challenge...
  20. ncbi request reprint New and emerging treatment options for neuropathic pain
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Am J Manag Care 12:S269-78. 2006
    ..Of these, only pregabalin is indicated for both conditions...
  21. doi request reprint Vigabatrin-associated retinal damage: potential biochemical mechanisms
    M K Heim
    School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
    Acta Neurol Scand 126:219-28. 2012
    ..Animal data suggest that GABA mediates neural excitotoxicity. The amino acid taurine is concentrated in retinal cells, and deficiency of this amino acid may be involved in VGB-mediated retinal degeneration and possible phototoxicity...
  22. ncbi request reprint Potential interaction between warfarin and dicloxacillin
    A T Mailloux
    School of Pharmacy, University of Wisconsin, Madison 53706, USA
    Ann Pharmacother 30:1402-7. 1996
    ..To report a case and retrospective review of seven patients who experienced a decrease in prothrombin time during concomitant administration of warfarin and dicloxacillin...
  23. ncbi request reprint Antiepileptic drug formulation and treatment in the elderly: biopharmaceutical considerations
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705, USA
    Int Rev Neurobiol 81:299-311. 2007
    ..All of these effects observed in the aging patient, in turn, produce numerous opportunities for changes in AED absorption, particularly for those agents demonstrating poor water solubility or variable absorption patterns...
  24. doi request reprint The effect of carbapenem antibiotics on plasma concentrations of valproic acid
    Erin E Mancl
    Division of Pharmacy Practice, School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA
    Ann Pharmacother 43:2082-7. 2009
    ..To critically evaluate the mechanisms of the interaction between valproic acid and carbapenem antibiotics...
  25. ncbi request reprint Fractures, epilepsy, and antiepileptic drugs
    Richard H Mattson
    Department of Neurology, Yale University, 15 York Street, P O Box 208010, New Haven, CT 06520, USA
    Epilepsy Behav 5:S36-40. 2004
    ..Preventive measures include optimal control of seizures and supplementation with calcium and vitamin D. Whether newer AEDs prove to be without adverse effects on bone mineral metabolism remains to be determined...
  26. ncbi request reprint Oral absorption kinetics of levetiracetam: the effect of mixing with food or enteral nutrition formulas
    Monica A Fay
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
    Clin Ther 27:594-8. 2005
    ..Although previous studies have suggested that administration with food does not affect the overall absorption of LEV, there is a lack of data regarding concomitant administration with ENFs...
  27. ncbi request reprint Pharmacology of antiepileptic drugs during pregnancy and lactation
    Page B Pennell
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Epilepsy Behav 11:263-9. 2007
    ..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research...
  28. ncbi request reprint Gabapentin dosing in the treatment of epilepsy
    Michael J McLean
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    Clin Ther 25:1382-406. 2003
    ..However, recent studies have used higher doses and faster titration schedules than those used in the pivotal trials that established the efficacy of gabapentin in the treatment of partial seizures...
  29. ncbi request reprint Levetiracetam: a different approach to the pharmacotherapy of epilepsy
    Timothy E Welty
    Department of Pharmacy Practice, McWhorter School of Pharmacy, Samford University, 800 Lakeshore Dr, Birmingham, AL 35229 7027, USA
    Ann Pharmacother 36:296-304. 2002
    ..To review the pharmacology, pharmacokinetics, efficacy, and adverse effects of levetiracetam in the treatment of epilepsy...
  30. ncbi request reprint Patient page. Antiseizure drugs and reduced bone density
    Robert A Gross
    Neurology 62:E24-5. 2004
  31. ncbi request reprint Advances in antiepileptic drug treatments. A rational basis for selecting drugs for older patients with epilepsy
    Ilo E Leppik
    University of Minnesota, Minneapolis, USA
    Geriatrics 59:14-8, 22-4. 2004
    ..This paper reviews the present knowledge base and compares properties of the first generation AEDs with newer agents to develop a more rational approach for drug selection in older adults...
  32. ncbi request reprint Phenytoin and cognitive decline
    Sebastian Koch
    Stroke 36:2070-1; author reply 2071. 2005
  33. ncbi request reprint Conversions between monotherapies in epilepsy: expert consensus
    Erik K St Louis
    University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Epilepsy Behav 11:222-34. 2007
    ..This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy...
  34. ncbi request reprint Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin
    Gail D Anderson
    Department of Pharmacy, University of Washington, Seattle, USA
    Epilepsy Res 49:211-7. 2002
    ....