Research Topics
| B E GidalSummaryAffiliation: University of Wisconsin Country: USA Publications
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Detail Information
Publications
Levetiracetam does not alter body weight: analysis of randomized, controlled clinical trialsBarry E Gidal
Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
Epilepsy Res 56:121-6. 2003..Levetiracetam (LEV) is indicated for adjunctive treatment of partial seizures. The objective of the present evaluation was to examine the effects of LEV treatment on body weight in adult patients...- Sexual dysfunction in patients with neuropsychiatric disorders: Challenges and opportunitiesBarry Gidal
Pharmacy Practice Division, University of Wisconsin-Madison School of Pharmacy, Madison, WI 53705, USA
CNS Spectr 11:4-5. 2006 - Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapyBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
Epilepsy Res 64:161-6. 2005..Our data indicate that hyperhomocysteinemia may not be a serious clinical problem among patients with epilepsy, who receive either LTG or VPA... - Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapyBarry E Gidal
Department of Neurology, School of Pharmacy, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
Epilepsy Res 57:85-93. 2003.... 
Debate: Substitution of generic drugs in epilepsy: is there cause for concern?Barry E Gidal
School of Pharmacy, Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705, USA
Epilepsia 49:56-62. 2008..Regulatory requirements, pharmacokinetic methodology, and biopharmaceutical considerations are discussed...- Assessment of potential drug interactions in patients with epilepsy: impact of age and sexBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
Neurology 72:419-25. 2009..To understand and quantify the exposure to concomitant medications other than antiepileptic drugs (AEDs) within an age-diverse group of men and women with epilepsy and explore the likelihood of relevant drug interactions as a result... - Bioequivalence of antiepileptic drugs: how close is close enough?Barry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
Curr Neurol Neurosci Rep 9:333-7. 2009.... - Inter- and intra-subject variability in gabapentin absorption and absolute bioavailabilityB E Gidal
Department of Neurology, School of Pharmacy, University of Wisconsin, 425 N Charter Street, Madison, WI 53706, USA
Epilepsy Res 40:123-7. 2000..Previous studies have demonstrated that gabapentin displays dose-dependent absorption... - Efficacy of lamotrigine in institutionalized, developmentally disabled patients with epilepsy: a retrospective evaluationB E Gidal
University of Wisconsin, School of Pharmacy and Department of Neurology, Madison 53706, USA
Seizure 9:131-6. 2000..Adjunctive treatment with lamotrigine appears to be an efficacious and well-tolerated treatment for seizures in a significant percentage of developmentally disabled patients with epilepsy... - Vigabatrin: a novel therapy for seizure disordersB E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, Madison 53706, USA
Ann Pharmacother 33:1277-86. 1999..To review the pharmacology, pharmacokinetics, efficacy, and adverse effects of vigabatrin and its role in the management of seizure disorders... - Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trialsBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
Epilepsy Res 64:1-11. 2005..Consequently, no need for adjusting the dosages of these AEDs is anticipated when levetiracetam is added on or removed from a patient's therapeutic regimen... - Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsyB E Gidal
School of Pharmacy, University of Wisconsin, Madison 53706, USA
Epilepsy Res 31:91-9. 1998..The recommended dosing schedule for GBP is t.i.d. At large daily doses, oral bioavailability (F) may be improved by giving the daily dose more frequently... - Gabapentin absorption: effect of mixing with foods of varying macronutrient compositionB E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, Madison 53706, USA
Ann Pharmacother 32:405-9. 1998..To compare the oral absorption profile of gabapentin following administration of the contents of opened capsules that were mixed with food vehicles of varied macronutrient (protein) composition... - Protracted ictal confusion in elderly patientsRaj D Sheth
Department of Neurology, University of Wisconsin Madison, 600 Highland Avenue, Box H6 574 CSC, Madison, WI 53792 5132, USA
Arch Neurol 63:529-32. 2006..Ictal confusion, particularly if protracted, often presents a diagnostic challenge... - New and emerging treatment options for neuropathic painBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
Am J Manag Care 12:S269-78. 2006..Of these, only pregabalin is indicated for both conditions... - Optimizing epilepsy management in teenagersRaj D Sheth
Department of Neurology, University of Wisconsin Madison, 600 Highland Avenue H6 575, Madison, WI 53792, USA
J Child Neurol 21:273-9. 2006..Successful management of epilepsy in teenagers requires that physicians not only understand the advantages that the newer antiepileptic drugs appear to provide but also consider the social impact of treatment on their patients... - Pathological fractures in epilepsyRaj D Sheth
Department of Neurology, University of Wisconsin Madison, Madison, WI 53792 5132, USA
Epilepsy Behav 9:601-5. 2006..Together these findings suggest that epilepsy, and/or its treatment, is a dominant influence in the pathogenesis of fractures and may exacerbate the effects of aging-related involutional osteoporosis... - Drug absorption in the elderly: biopharmaceutical considerations for the antiepileptic drugsBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, 1032 Rennebohn Hall, 777 Highland Avenue, Madison, WI 53705, USA
Epilepsy Res 68:S65-9. 2006..These age-related physiological changes that may affect AED pharmacokinetics should be considered when treating elderly patients with epilepsy... - Vigabatrin-associated retinal damage: potential biochemical mechanismsM K Heim
School of Pharmacy, University of Wisconsin Madison, Madison, WI 53705, USA
Acta Neurol Scand 126:219-28. 2012..Animal data suggest that GABA mediates neural excitotoxicity. The amino acid taurine is concentrated in retinal cells, and deficiency of this amino acid may be involved in VGB-mediated retinal degeneration and possible phototoxicity... - Potential interaction between warfarin and dicloxacillinA T Mailloux
School of Pharmacy, University of Wisconsin, Madison 53706, USA
Ann Pharmacother 30:1402-7. 1996..To report a case and retrospective review of seven patients who experienced a decrease in prothrombin time during concomitant administration of warfarin and dicloxacillin... - The effect of carbapenem antibiotics on plasma concentrations of valproic acidErin E Mancl
Division of Pharmacy Practice, School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA
Ann Pharmacother 43:2082-7. 2009..To critically evaluate the mechanisms of the interaction between valproic acid and carbapenem antibiotics... - Fractures, epilepsy, and antiepileptic drugsRichard H Mattson
Department of Neurology, Yale University, 15 York Street, P O Box 208010, New Haven, CT 06520, USA
Epilepsy Behav 5:S36-40. 2004..Preventive measures include optimal control of seizures and supplementation with calcium and vitamin D. Whether newer AEDs prove to be without adverse effects on bone mineral metabolism remains to be determined... - Antiepileptic drug formulation and treatment in the elderly: biopharmaceutical considerationsBarry E Gidal
School of Pharmacy and Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705, USA
Int Rev Neurobiol 81:299-311. 2007..All of these effects observed in the aging patient, in turn, produce numerous opportunities for changes in AED absorption, particularly for those agents demonstrating poor water solubility or variable absorption patterns... - Oral absorption kinetics of levetiracetam: the effect of mixing with food or enteral nutrition formulasMonica A Fay
School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
Clin Ther 27:594-8. 2005..The data suggest that peak serum concentrations of LEV may be slightly reduced after mixing with ENFs, although the difference was not significant compared with control values... - Gabapentin dosing in the treatment of epilepsyMichael J McLean
Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
Clin Ther 25:1382-406. 2003..However, recent studies have used higher doses and faster titration schedules than those used in the pivotal trials that established the efficacy of gabapentin in the treatment of partial seizures... - Pharmacology of antiepileptic drugs during pregnancy and lactationPage B Pennell
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Epilepsy Behav 11:263-9. 2007..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research... - Levetiracetam: a different approach to the pharmacotherapy of epilepsyTimothy E Welty
Department of Pharmacy Practice, McWhorter School of Pharmacy, Samford University, 800 Lakeshore Dr, Birmingham, AL 35229 7027, USA
Ann Pharmacother 36:296-304. 2002..To review the pharmacology, pharmacokinetics, efficacy, and adverse effects of levetiracetam in the treatment of epilepsy... - Phenytoin and cognitive declineSebastian Koch
Stroke 36:2070-1; author reply 2071. 2005 - Patient page. Antiseizure drugs and reduced bone densityRobert A Gross
Neurology 62:E24-5. 2004 - Advances in antiepileptic drug treatments. A rational basis for selecting drugs for older patients with epilepsyIlo E Leppik
University of Minnesota, Minneapolis, USA
Geriatrics 59:14-8, 22-4. 2004..This paper reviews the present knowledge base and compares properties of the first generation AEDs with newer agents to develop a more rational approach for drug selection in older adults... - Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoinGail D Anderson
Department of Pharmacy, University of Washington, Seattle, USA
Epilepsy Res 49:211-7. 2002..Importantly, these data suggest that LTG concentrations would not be expected to increase until the concomitant inducer is almost completely removed... - Conversions between monotherapies in epilepsy: expert consensusErik K St Louis
University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Epilepsy Behav 11:222-34. 2007..This expert guidance will aid in the period of transitional polytherapy with AEDs from monotherapy to monotherapy...