JAY ROBERT GIBSON
Affiliation: University of Texas Southwestern Medical Center
- Role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neuronsJay R Gibson
Center for Basic Neuroscience, Southwestern Medical Center, University of Texas, Dallas, TX 75390 9111, USA
J Neurophysiol 96:420-32. 2006..Together with other studies, these data indicate that both inhibitory and excitatory neurons increase membrane excitability with chronic reduction in activity, but through different mechanisms...
- Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndromeJay R Gibson
Dept of Neuroscience, University of Texas, Southwestern Medical Center, Box 9111, Dallas, TX 75390 9111, USA
J Neurophysiol 100:2615-26. 2008..These circuit changes may be involved in sensory stimulus hypersensitivity, epilepsy, and cognitive impairment associated with Fragile X and autism...
- Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneuronsJay R Gibson
Department of Neuroscience and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Neurosci 29:13883-97. 2009..Thus, NL2 is not necessary for establishing unitary inhibitory synaptic connections but is selectively required for "scaling up" unitary connections originating from a subset of interneurons...
- Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2Alexander A Chubykin
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
Neuron 54:919-31. 2007..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
- Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuitsAundrea F Bartley
University of Texas, Southwestern Medical Center, Department of Neuroscience, Box 9111, Dallas, TX 75390 9111, USA
J Neurophysiol 100:1983-94. 2008..In summary, these results reveal that inhibitory circuitry is not uniformly regulated by activity levels and may provide insight into the mechanisms of both normal and pathological neocortical plasticity...
- Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardationLenora J Volk
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:11624-34. 2007..Our results reveal that multiple Gq-coupled receptors converge on a common protein synthesis-dependent LTD mechanism, which is aberrant in FXS. These findings suggest novel therapeutic strategies for FXS in the form of mAChR antagonists...
- The spatial dimensions of electrically coupled networks of interneurons in the neocortexYael Amitai
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 22:4142-52. 2002..These quantitative results have important implications for the effects of electrical coupling on the dynamic behavior of interneuron networks...
- Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4Jay R Gibson
Dept. of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
J Neurophysiol 93:467-80. 2005..Our results suggest that electrical synapses among inhibitory interneurons are most readily described as low-pass linear filters that promote firing synchrony...
- Two dynamically distinct inhibitory networks in layer 4 of the neocortexMichael Beierlein
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurophysiol 90:2987-3000. 2003..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...
- Cortical circuit changes and mechanisms in a mouse model of Fragile X SyndromeJAY ROBERT GIBSON; Fiscal Year: 2010..Our proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both Fragile X Syndrome and autism since both disorders often occur together. ..
- Cortical circuit changes and mechanisms in a mouse model of Fragile X SyndromeJAY GIBSON; Fiscal Year: 2009..Our proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both Fragile X Syndrome and autism since both disorders often occur together. ..