JAY ROBERT GIBSON

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neurons
    Jay R Gibson
    Center for Basic Neuroscience, Southwestern Medical Center, University of Texas, Dallas, TX 75390 9111, USA
    J Neurophysiol 96:420-32. 2006
  2. ncbi Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
    Jay R Gibson
    Dept of Neuroscience, University of Texas, Southwestern Medical Center, Box 9111, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:2615-26. 2008
  3. ncbi Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons
    Jay R Gibson
    Department of Neuroscience and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neurosci 29:13883-97. 2009
  4. ncbi Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
  5. ncbi Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits
    Aundrea F Bartley
    University of Texas, Southwestern Medical Center, Department of Neuroscience, Box 9111, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:1983-94. 2008
  6. ncbi Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation
    Lenora J Volk
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:11624-34. 2007
  7. ncbi The spatial dimensions of electrically coupled networks of interneurons in the neocortex
    Yael Amitai
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 22:4142-52. 2002
  8. ncbi Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4
    Jay R Gibson
    Dept. of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
    J Neurophysiol 93:467-80. 2005
  9. ncbi Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003

Research Grants

  1. Cortical circuit changes and mechanisms in a mouse model of Fragile X Syndrome
    JAY ROBERT GIBSON; Fiscal Year: 2010
  2. Cortical circuit changes and mechanisms in a mouse model of Fragile X Syndrome
    JAY GIBSON; Fiscal Year: 2009

Collaborators

Detail Information

Publications9

  1. ncbi Role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neurons
    Jay R Gibson
    Center for Basic Neuroscience, Southwestern Medical Center, University of Texas, Dallas, TX 75390 9111, USA
    J Neurophysiol 96:420-32. 2006
    ..Together with other studies, these data indicate that both inhibitory and excitatory neurons increase membrane excitability with chronic reduction in activity, but through different mechanisms...
  2. ncbi Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
    Jay R Gibson
    Dept of Neuroscience, University of Texas, Southwestern Medical Center, Box 9111, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:2615-26. 2008
    ..These circuit changes may be involved in sensory stimulus hypersensitivity, epilepsy, and cognitive impairment associated with Fragile X and autism...
  3. ncbi Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons
    Jay R Gibson
    Department of Neuroscience and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Neurosci 29:13883-97. 2009
    ..Thus, NL2 is not necessary for establishing unitary inhibitory synaptic connections but is selectively required for "scaling up" unitary connections originating from a subset of interneurons...
  4. ncbi Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  5. ncbi Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits
    Aundrea F Bartley
    University of Texas, Southwestern Medical Center, Department of Neuroscience, Box 9111, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:1983-94. 2008
    ..In summary, these results reveal that inhibitory circuitry is not uniformly regulated by activity levels and may provide insight into the mechanisms of both normal and pathological neocortical plasticity...
  6. ncbi Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation
    Lenora J Volk
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:11624-34. 2007
    ..Our results reveal that multiple Gq-coupled receptors converge on a common protein synthesis-dependent LTD mechanism, which is aberrant in FXS. These findings suggest novel therapeutic strategies for FXS in the form of mAChR antagonists...
  7. ncbi The spatial dimensions of electrically coupled networks of interneurons in the neocortex
    Yael Amitai
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 22:4142-52. 2002
    ..These quantitative results have important implications for the effects of electrical coupling on the dynamic behavior of interneuron networks...
  8. ncbi Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4
    Jay R Gibson
    Dept. of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
    J Neurophysiol 93:467-80. 2005
    ..Our results suggest that electrical synapses among inhibitory interneurons are most readily described as low-pass linear filters that promote firing synchrony...
  9. ncbi Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003
    ..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...

Research Grants3

  1. Cortical circuit changes and mechanisms in a mouse model of Fragile X Syndrome
    JAY ROBERT GIBSON; Fiscal Year: 2010
    ..Our proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both Fragile X Syndrome and autism since both disorders often occur together. ..
  2. Cortical circuit changes and mechanisms in a mouse model of Fragile X Syndrome
    JAY GIBSON; Fiscal Year: 2009
    ..Our proposed line of study investigating these alterations will provide potential cellular targets for genetic and drug treatments for both Fragile X Syndrome and autism since both disorders often occur together. ..