Affiliation: University of Pennsylvania
Country: USA


  1. request reprint
    Gibson C, Yuan Z, Hall B, Longenecker G, Chen E, Thyagarajan T, et al. Amelogenin-deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem. 2001;276:31871-5 pubmed
    ..These null mice will be useful for understanding the functions of amelogenin proteins during enamel formation and for developing therapeutic approaches for treating this developmental defect that affects the enamel. ..
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    Gibson C, Thomson N, Abrams W, Kirkham J. Nested genes: biological implications and use of AFM for analysis. Gene. 2005;350:15-23 pubmed
    ..The potential of this technology includes a greater molecular understanding of cellular decision making processes, leading to enhanced opportunities to intervene in disease progression through use of novel treatment modalities. ..
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    Gibson C, Yuan Z, Li Y, Daly B, Suggs C, Aragon M, et al. Transgenic mice that express normal and mutated amelogenins. J Dent Res. 2007;86:331-5 pubmed
    ..The phenotype argues for dominant-negative activity for the P70T amelogenin, and for the robust nature of the process of amelogenesis. ..
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    Gibson C. The amelogenin "enamel proteins" and cells in the periodontium. Crit Rev Eukaryot Gene Expr. 2008;18:345-60 pubmed