R B Gibbs

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Psychoneuroendocrinology 29:741-8. 2004
  2. pmc Testosterone and estradiol produce different effects on cognitive performance in male rats
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 48:268-77. 2005
  3. ncbi request reprint Effects of long-term hormone treatment and of tibolone on monoamines and monoamine metabolites in the brains of ovariectomised, Cynomologous monkeys
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    J Neuroendocrinol 18:643-54. 2006
  4. ncbi request reprint Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task
    Robert B Gibbs
    Department of Pharmaceuticl Sciences, University of Pittsburg School of Pharmacy, Pennsylvania 15261, USA
    Horm Behav 42:245-57. 2002
  5. pmc Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy
    R B Gibbs
    Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Neurobiol Learn Mem 88:19-32. 2007
  6. ncbi request reprint Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 52:352-9. 2007
  7. ncbi request reprint Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Neuroscience 101:931-8. 2000
  8. pmc Sex-specific effects of gonadectomy and hormone treatment on acquisition of a 12-arm radial maze task by Sprague Dawley rats
    Robert B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, Pennsylvania 15261, USA
    Endocrinology 149:3176-83. 2008
  9. pmc Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis
    R B Gibbs
    University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Horm Behav 56:73-83. 2009
  10. pmc Estrogen therapy and cognition: a review of the cholinergic hypothesis
    Robert B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, Pennsylvania 15261, USA
    Endocr Rev 31:224-53. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Psychoneuroendocrinology 29:741-8. 2004
    ....
  2. pmc Testosterone and estradiol produce different effects on cognitive performance in male rats
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 48:268-77. 2005
    ..These data demonstrate that, as in females, gonadal hormones influence cognitive performance in males and suggest that estradiol and testosterone affect distinct cognitive domains...
  3. ncbi request reprint Effects of long-term hormone treatment and of tibolone on monoamines and monoamine metabolites in the brains of ovariectomised, Cynomologous monkeys
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    J Neuroendocrinol 18:643-54. 2006
    ....
  4. ncbi request reprint Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task
    Robert B Gibbs
    Department of Pharmaceuticl Sciences, University of Pittsburg School of Pharmacy, Pennsylvania 15261, USA
    Horm Behav 42:245-57. 2002
    ..The data suggest that basal forebrain cholinergic projections are necessary for hormone-mediated enhancement of DMP acquisition...
  5. pmc Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy
    R B Gibbs
    Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Neurobiol Learn Mem 88:19-32. 2007
    ....
  6. ncbi request reprint Estradiol enhances DMP acquisition via a mechanism not mediated by turning strategy but which requires intact basal forebrain cholinergic projections
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 52:352-9. 2007
    ....
  7. ncbi request reprint Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Neuroscience 101:931-8. 2000
    ..These findings could have important implications for the effective use of hormone replacement strategies in the prevention and treatment of Alzheimer's disease and age-related cognitive decline in women...
  8. pmc Sex-specific effects of gonadectomy and hormone treatment on acquisition of a 12-arm radial maze task by Sprague Dawley rats
    Robert B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, Pennsylvania 15261, USA
    Endocrinology 149:3176-83. 2008
    ..Collectively, the data demonstrate robust effects of gonadectomy and hormone treatment on acquisition of this modified radial arm maze task in females, with lesser effects in males...
  9. pmc Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis
    R B Gibbs
    University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Horm Behav 56:73-83. 2009
    ..Whether donepezil has similar restorative effects on other estrogen-sensitive tasks needs to be explored...
  10. pmc Estrogen therapy and cognition: a review of the cholinergic hypothesis
    Robert B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, Pennsylvania 15261, USA
    Endocr Rev 31:224-53. 2010
    ....
  11. pmc Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons
    R B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 59:503-11. 2011
    ....
  12. pmc Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats
    R B Gibbs
    University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 60:607-16. 2011
    ..This could be of particular benefit to older women who have not used hormone therapy for many years and are beginning to show signs of mild cognitive impairment. Potential mechanisms for these effects are discussed...
  13. ncbi request reprint Estrogen and cognition: applying preclinical findings to clinical perspectives
    Robert B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci Res 74:637-43. 2003
    ..The application of these data to recent clinical findings is discussed...
  14. pmc GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus
    R Hammond
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Psychoneuroendocrinology 36:182-92. 2011
    ..This may account for the effects of G-1 on DMP acquisition previously reported...
  15. pmc Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young female rats
    R Hammond
    University of Pittsburgh Department of Pharmaceutical Sciences, 1009 Salk Hall, Pittsburgh, PA 15261, USA
    Horm Behav 62:367-74. 2012
    ..These data suggest that GPR30 can play an important role in mediating the effects of estradiol on spatial learning, possibly by mediating estradiol effects on basal forebrain cholinergic function...
  16. ncbi request reprint Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Brain Res 787:259-68. 1998
    ....
  17. pmc Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats
    R Hammond
    University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15261, USA
    Horm Behav 56:309-14. 2009
    ..These data suggest that estradiol can work through any of several estrogen receptors to enhance the rate of acquisition on this task...
  18. ncbi request reprint Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Neurobiol Aging 21:107-16. 2000
    ....
  19. ncbi request reprint Estrogen-mediated regulation of cholinergic expression in basal forebrain neurons requires extracellular-signal-regulated kinase activity
    J L Pongrac
    Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neuroscience 124:809-16. 2004
    ....
  20. ncbi request reprint Effects of ageing and long-term hormone replacement on cholinergic neurones in the medial septum and nucleus basalis magnocellularis of ovariectomized rats
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    J Neuroendocrinol 15:477-85. 2003
    ..Collectively, the data suggest that ageing combined with long-term loss of ovarian function has a severe negative impact on basal forebrain cholinergic function, but not on cholinergic cell survival per se...
  21. pmc Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections
    Nicholas F Fitz
    Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Brain Res Bull 69:660-5. 2006
    ..Results show that intraperitoneal saline attenuated the impairment in DMP acquisition in SAP lesioned rats. These results suggest that a mild aversive stimulus can attenuate cognitive deficits caused by medial septal cholinergic lesions...
  22. ncbi request reprint Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    Brain Res 749:143-6. 1997
    ..The data suggest that estrogen may help to maintain cholinergic function under conditions where cholinergic afferents to the hippocampal formation and cortex are challenged or impaired...
  23. ncbi request reprint Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Brain Res 844:20-7. 1999
    ..These effects may, in turn, contribute to the effects of estrogen replacement on hippocampal connectivity and cognitive processes that have recently been reported...
  24. ncbi request reprint Effects of estrogen on basal forebrain cholinergic neurons vary as a function of dose and duration of treatment
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    Brain Res 757:10-6. 1997
    ....
  25. ncbi request reprint Expression of estrogen receptor-like immunoreactivity by different subgroups of basal forebrain cholinergic neurons in gonadectomized male and female rats
    R B Gibbs
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, PA 15261, USA
    Brain Res 720:61-8. 1996
    ..females and in different subregions of the female basal forebrain are not due to differences in the percentage of cholinergic neurons expressing estrogen receptors...
  26. ncbi request reprint Effects of long-term hormone replacement and of tibolone on choline acetyltransferase and acetylcholinesterase activities in the brains of ovariectomized, cynomologus monkeys
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, 1004 Salk Hall, Pittsburgh, PA 15261, USA
    Neuroscience 113:907-14. 2002
    ....
  27. ncbi request reprint Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm
    David A Johnson
    Division of Pharmacology Toxicology, Mylan School of Pharmacy, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Brain Res 943:132-41. 2002
    ..We propose that acquisition of the DMP task is a sensitive behavioral assay for the selective loss of basal forebrain cholinergic projections...
  28. pmc GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance
    R Hammond
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Brain Res 1379:53-60. 2011
    ..Here we briefly review the cholinergic hypothesis and summarize our findings to date showing effects of a GPR30 agonist and antagonist on basal forebrain cholinergic function and cognitive performance...
  29. ncbi request reprint Nerve growth factor induces Fos-like immunoreactivity within identified cholinergic neurons in the adult rat basal forebrain
    R B Gibbs
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, PA 15261, USA
    Brain Res 753:141-51. 1997
    ....
  30. pmc Selective lesion of septal cholinergic neurons in rats impairs acquisition of a delayed matching to position T-maze task by delaying the shift from a response to a place strategy
    Nicholas F Fitz
    Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Brain Res Bull 77:356-60. 2008
    ..a place strategy, thereby affecting the ability to switch from one strategy to another...
  31. pmc Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macaca mulatta) as revealed by double immunofluorescence and confocal microscopy
    Suresh Ramaswamy
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 149:4387-95. 2008
    ....
  32. ncbi request reprint Estrogen enhances potassium-stimulated acetylcholine release in the rat hippocampus
    Rachel Gabor
    Juniata College, Huntingdon, PA 16652, USA
    Brain Res 962:244-7. 2003
    ..These data are consistent with the hypothesis that estrogen-mediated effects on cholinergic neurons can contribute to the effects of long-term estrogen replacement on cognitive performance recently described...
  33. ncbi request reprint A role for the basal forebrain cholinergic system in estrogen-induced disinhibition of hippocampal pyramidal cells
    Charles N Rudick
    Department of Neurobiology and Physiology and Northwestern University Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 23:4479-90. 2003
    ....