William Giannobile

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo
    Qiming Jin
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 3:e1729. 2008
  2. pmc AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression
    J A Cirelli
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Gene Ther 16:426-36. 2009
  3. pmc C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction
    W V Giannobile
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor 48109 1078, USA
    Ann N Y Acad Sci 878:404-12. 1999
  4. ncbi request reprint Growth and amelogenin-like factors in periodontal wound healing. A systematic review
    William V Giannobile
    Department of Periodontics Prevention Geriatrics, Center for Craniofacial Regeneration, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    Ann Periodontol 8:193-204. 2003
  5. pmc Host-response therapeutics for periodontal diseases
    William V Giannobile
    Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Periodontol 79:1592-600. 2008
  6. pmc Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering
    W V Giannobile
    Department of Periodontics Prevention Geriatrics and Center for Biorestoration of Oral Health, The University of Michigan, Ann Arbor 48109 1078, USA
    J Periodontol 72:815-23. 2001
  7. pmc Immunoglobulin G (IgG) class, but Not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in subjects with periodontitis by a fluorescence enzyme-linked immunosorbent assay
    Domenica G Sweier
    Department of Cariology, Restorative Sciences and Endodontics, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Clin Vaccine Immunol 16:1766-73. 2009
  8. pmc Growth factor delivery for oral and periodontal tissue engineering
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Expert Opin Drug Deliv 3:647-62. 2006
  9. pmc Angiogenic and osteogenic potential of bone repair cells for craniofacial regeneration
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Tissue Eng Part A 16:2809-20. 2010
  10. pmc Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e1984. 2008

Research Grants

  1. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2001
  2. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2007
  3. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2007
  4. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2006
  5. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
  6. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2004
  7. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2003
  8. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2002
  9. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2009

Collaborators

Detail Information

Publications54

  1. pmc Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo
    Qiming Jin
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 3:e1729. 2008
    ..This approach offers a technology to accurately control growth factor release to promote soft tissue engineering in vivo...
  2. pmc AAV2/1-TNFR:Fc gene delivery prevents periodontal disease progression
    J A Cirelli
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Gene Ther 16:426-36. 2009
    ..These findings suggest that delivery of AAV2/1-TNFR:Fc may be a viable approach to modulate periodontal disease progression...
  3. pmc C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction
    W V Giannobile
    Department of Periodontics Prevention Geriatrics, University of Michigan, Ann Arbor 48109 1078, USA
    Ann N Y Acad Sci 878:404-12. 1999
    ..Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease...
  4. ncbi request reprint Growth and amelogenin-like factors in periodontal wound healing. A systematic review
    William V Giannobile
    Department of Periodontics Prevention Geriatrics, Center for Craniofacial Regeneration, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    Ann Periodontol 8:193-204. 2003
    ....
  5. pmc Host-response therapeutics for periodontal diseases
    William V Giannobile
    Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Periodontol 79:1592-600. 2008
    ..The application of these bone-preservation strategies to periodontal management and treatment are discussed in the context of high-risk patients susceptible to disease reactivation or disease complications...
  6. pmc Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering
    W V Giannobile
    Department of Periodontics Prevention Geriatrics and Center for Biorestoration of Oral Health, The University of Michigan, Ann Arbor 48109 1078, USA
    J Periodontol 72:815-23. 2001
    ..Recent advances in gene therapy offer the advantage of delivering recombinant proteins to tissues for extended periods of time in vivo...
  7. pmc Immunoglobulin G (IgG) class, but Not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in subjects with periodontitis by a fluorescence enzyme-linked immunosorbent assay
    Domenica G Sweier
    Department of Cariology, Restorative Sciences and Endodontics, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Clin Vaccine Immunol 16:1766-73. 2009
    ..05). We suggest that anti-P. gingivalis HtpG P18alpha antibodies are protective in periodontal disease and may have prognostic value for guidance of individual patient treatment...
  8. pmc Growth factor delivery for oral and periodontal tissue engineering
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Expert Opin Drug Deliv 3:647-62. 2006
    ..In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral- and tooth-supporting structures, namely the periodontium and alveolar bone...
  9. pmc Angiogenic and osteogenic potential of bone repair cells for craniofacial regeneration
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Tissue Eng Part A 16:2809-20. 2010
    ..Taken together, these data provide evidence for the multilineage and clinical potential of BRCs for craniofacial regeneration...
  10. pmc Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients
    Charles E Shelburne
    Department of Biologic and Materials Sciences, The University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e1984. 2008
    ..We hypothesized that antibodies to the HSP90 homologue of P. gingivalis (HtpG) might be associated with protection/resistance against destructive periodontitis...
  11. ncbi request reprint Identification of pathogen and host-response markers correlated with periodontal disease
    Christoph A Ramseier
    Department of Periodontics and Oral Medicine, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, Ann Arbor, MI 48106, USA
    J Periodontol 80:436-46. 2009
    ..This clinical study sought to determine the ability of putative host- and microbially derived biomarkers to identify periodontal disease status from whole saliva and plaque biofilm...
  12. pmc Effect of rhPDGF-BB on bone turnover during periodontal repair
    David P Sarment
    Department of Periodontics and Oral Medicine, Center for Craniofacial Regeneration, School of Dentistry, University of Michigan, Ann Arbor, MI 48106, USA
    J Clin Periodontol 33:135-40. 2006
    ..The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB...
  13. pmc Effect of rhPDGF-BB delivery on mediators of periodontal wound repair
    Jason W Cooke
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA
    Tissue Eng 12:1441-50. 2006
    ..02). These results demonstrate contrasting inducible expression patterns of PDGF-AB, VEGF, and ICTP during periodontal wound healing in humans...
  14. ncbi request reprint Treatment of periodontal disease in a patient with Ehlers-Danlos syndrome. A case report and literature review
    Luis A Perez
    Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor, USA
    J Periodontol 73:564-70. 2002
    ..Dental findings have been reported with some types of EDS. This case report describes the periodontal findings in a patient with a previously undiagnosed EDS type VIII...
  15. doi request reprint Teriparatide and osseous regeneration in the oral cavity
    Jill D Bashutski
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    N Engl J Med 363:2396-405. 2010
    ..Although teriparatide has been evaluated for the treatment of osteoporosis and for the healing of fractures, clinical trials evaluating it for the treatment of osseous conditions of the oral cavity in humans are lacking...
  16. pmc Gene therapeutics for periodontal regenerative medicine
    Christoph A Ramseier
    Center for Craniofacial Regeneration and Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Dent Clin North Am 50:245-63, ix. 2006
    ..Ongoing investigations in ex vivo and in vivo gene transfer to periodontia seek to examine the extent of the potential effects in stimulating periodontal tissue engineering...
  17. ncbi request reprint Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK
    Jia Chang
    Department of Biologic and Materials Sciences, College of Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:30938-48. 2007
    ..Taken together, our results reveal that noncanonical Wnt signaling could also play a role in osteogenic differentiation. Wnt-4 may have a potential use in improving bone regeneration and repair of craniofacial defects...
  18. pmc The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
    Biomaterials 28:2087-96. 2007
    ..The approach offers a new delivery method of BMPs and a novel scaffold design for bone regeneration...
  19. pmc Novel host response therapeutic approaches to treat periodontal diseases
    Keith L Kirkwood
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    Periodontol 2000 43:294-315. 2007
  20. pmc LMP1 regulates periodontal ligament progenitor cell proliferation and differentiation
    Zhao Lin
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Bone 47:55-64. 2010
    ..Our findings advance the understanding of the physiological function of LMP1 and define a regulatory mechanism of LMP1 in PDL progenitor cells and other MSCs...
  21. pmc Three-dimensional micro-computed tomographic imaging of alveolar bone in experimental bone loss or repair
    Chan Ho Park
    Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI, USA
    J Periodontol 78:273-81. 2007
    ..The objective of this investigation was to develop a micro-CT methodology for quantifying tooth-supporting alveolar bone in 3-D following experimental preclinical situations of periodontitis or reconstructive therapy...
  22. doi request reprint Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial
    Ricardo Gapski
    Michigan Center for Oral Health Research and Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48106, USA
    J Clin Periodontol 36:149-56. 2009
    ....
  23. ncbi request reprint Growth factor delivery to re-engineer periodontal tissues
    Orasa Anusaksathien
    Center for Biorestoration of Oral Health, University of Michigan School of Dentistry, Ann Arbor 48109 1078, USA
    Curr Pharm Biotechnol 3:129-39. 2002
    ..This review will provide information on the status of growth factor therapies being applied in periodontology to treat advanced alveolar bone loss...
  24. pmc The effect of apically repositioned flap surgery on clinical parameters and the composition of the subgingival microbiota: 12-month data
    Rustin M Levy
    Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor, USA
    Int J Periodontics Restorative Dent 22:209-19. 2002
    ..The reduction in pocket depth by surgical means and the associated decrease in reservoirs of periodontal pathogens may be important in achieving sustained periodontal stability...
  25. pmc Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: a pilot study
    Sarosh F Dastoor
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 78:1887-96. 2007
    ....
  26. pmc Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis
    Jill E Rogers
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 78:550-8. 2007
    ..The aim of this study was to establish a model of aggressive inflammatory alveolar bone loss in rats using LPS derived from the periodontal pathogen Actinobacillus actinomycetemcomitans...
  27. pmc Oral fluid-based biomarkers of alveolar bone loss in periodontitis
    Janet S Kinney
    Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Ann N Y Acad Sci 1098:230-51. 2007
    ..Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost-effective treatment therapies...
  28. pmc RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis
    Qiming Jin
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    J Periodontol 78:1300-8. 2007
    ..The receptor activator of nuclear factor-kappa B ligand (RANKL) inhibitor osteoprotegerin (OPG) inhibits osteoclastogenesis and suppresses bone resorption...
  29. pmc Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease
    Aaron M Havens
    Department of Periodontics and Oral Medicine, University of Michigan Dental School, 1011 N University Avenue, Ann Arbor, MI 48109, USA
    J Periodontol 79:845-53. 2008
    ..The purpose of this study was to determine whether SDF-1alpha secreted by host cells plays a role in recruiting inflammatory cells into the periodontia during local inflammation...
  30. ncbi request reprint Comparative analysis of collagen membranes for the treatment of implant dehiscence defects
    Tae Ju Oh
    Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    Clin Oral Implants Res 14:80-90. 2003
    ....
  31. pmc Platelet-derived growth factor gene delivery stimulates ex vivo gingival repair
    Orasa Anusaksathien
    Center for Craniofacial Regeneration and Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Tissue Eng 9:745-56. 2003
    ..These results suggest that PDGF gene transfer has potential for periodontal soft tissue-engineering applications...
  32. pmc Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
    J Control Release 112:103-10. 2006
    ..The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration...
  33. pmc Cementoblast delivery for periodontal tissue engineering
    Ming Zhao
    Center for Craniofacial Regeneration and Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Periodontol 75:154-61. 2004
    ..The objective of this proof of concept investigation was to evaluate the ability of cementoblasts and dental follicle cells to promote periodontal regeneration in a rodent periodontal fenestration model...
  34. ncbi request reprint The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: a pilot human trial
    Lien Hui Huang
    Department of Periodontics Prevention Geriatrics, University of Michigan, School of Dentistry, Ann Arbor, MI 48109, USA
    J Periodontol 76:1768-77. 2005
    ..Platelet-rich plasma (PRP), containing autologous growth factors, has been shown to promote soft tissue healing. Therefore, the purpose of this study was to evaluate the effects of PRP in combination with CAF...
  35. pmc Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum
    Orasa Anusaksathien
    Center for Craniofacial Regeneration, Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 75:429-40. 2004
    ..Nonetheless, the role of PDGF in cementogenesis is not well understood. The aim of the present study was to determine the effect of sustained PDGF gene transfer on cementum formation in an ex vivo ectopic biomineralization model...
  36. pmc Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors
    Qiming Jin
    Center for Craniofacial Regeneration and Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Mol Ther 9:519-26. 2004
    ..Gene therapy utilizing PDGF-B may offer the potential for periodontal tissue engineering applications...
  37. pmc BMP gene delivery for alveolar bone engineering at dental implant defects
    Courtney A Dunn
    Department of Orthodontics and Pediatric Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Ther 11:294-9. 2005
    ..In vivo gene therapy of BMP-7 offers potential for alveolar bone engineering applications...
  38. ncbi request reprint Preclinical methods for the evaluation of periodontal regeneration in vivo
    Yang Jo Seol
    Department Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 666:285-307. 2010
    ..These methods will prepare investigators and assist them in identifying endpoints that can then be adapted to human clinical trial planning...
  39. pmc Biomimetic hybrid scaffolds for engineering human tooth-ligament interfaces
    Chan Ho Park
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Biomaterials 31:5945-52. 2010
    ..This approach offers potential for the clinical implementation of customized periodontal scaffolds that may enable regeneration of multi-tissue interfaces required for oral, dental and craniofacial engineering applications...
  40. pmc Adenoviral gene transfer of PDGF downregulates gas gene product PDGFalphaR and prolongs ERK and Akt/PKB activation
    Qi Ping Chen
    Center for Biorestoration of Oral Health, Department of Periodontics, University of Michigan, 1011 N University Ave, Ann Arbor, MI 48109 1078, USA
    Am J Physiol Cell Physiol 282:C538-44. 2002
    ..These findings demonstrate the prolonged effects of adenoviral delivery of PDGF and aid in the better understanding of sustained PDGF signaling...
  41. pmc Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use
    Po Chun Chang
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Gene Ther 20:486-96. 2009
    ..These results indicate that AdPDGF-B delivered in a collagen matrix exhibits acceptable safety profiles for possible use in human clinical studies...
  42. ncbi request reprint Tissue engineering: what does it mean? Why is it important?
    Ray C Williams
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Compend Contin Educ Dent 26:54, 56, 58 passim. 2005
  43. pmc Diagnostic biomarkers for oral and periodontal diseases
    Mario Taba
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Dent Clin North Am 49:551-71, vi. 2005
    ..Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented...
  44. ncbi request reprint Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers
    Paulo Mascarenhas
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Periodontol 76:426-36. 2005
    ..This study was designed to determine the efficacy of azithromycin (AZM) when combined with scaling and root planing (SRP) for the treatment of moderate to severe chronic periodontitis in smokers...
  45. ncbi request reprint Healing and osseointegration of submerged microtextured oral implants
    Tae Ju Oh
    Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109 1078, USA
    Clin Oral Implants Res 14:643-50. 2003
    ..81 mm vs. 0.56 mm). In conclusion, this study found minimal change in BIC over time (from 4 to 16 weeks) in unloaded microtextured implants, while the mean f-BIC value significantly increased during this same observation period...
  46. ncbi request reprint The impact of primary hyperparathyroidism on the oral cavity
    Allan D Padbury
    D D S, Department of Periodontics and Oral Medicine, University of Michigan, 1011 North University Avenue, Ann Arbor, Michigan 48109 1078, USA
    J Clin Endocrinol Metab 91:3439-45. 2006
    ..The older literature records that HPT is associated with loss of radicular lamina dura and brown tumors of the bone, but contemporary studies are lacking...
  47. ncbi request reprint Comparative histologic analysis of coronally advanced flap with and without collagen membrane for root coverage
    Eun Ju Lee
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    J Periodontol 73:779-88. 2002
    ..Therefore, the aims of this study were to clinically and histologically evaluate the efficacy of GTR-based root coverage using collagen membrane (GTRC) and to compare the healing response to that of coronally advanced flaps (CAF)...
  48. ncbi request reprint Modified-release subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease
    Philip M Preshaw
    Department of Periodontology, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, U K
    J Periodontol 79:440-52. 2008
    ..The aim of this study was to investigate the efficacy of SDD-40 when used as an adjunct to SRP for the treatment of periodontitis...
  49. ncbi request reprint Matrix molecules and growth factors as indicators of periodontal disease activity
    William V Giannobile
    Periodontol 2000 31:125-34. 2003
  50. ncbi request reprint Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial
    Myron Nevins
    Harvard School of Dental Medicine, Boston, MA, USA
    J Periodontol 76:2205-15. 2005
    ....
  51. ncbi request reprint The first descriptions of bone morphogenetic protein in the dental literature appeared more than a decade ago, yet there is no commercially viable application for this product. Comment on the likelihood that this material will become available to the gene
    Robert E Marx
    Division of Oral and Maxillofacial Surgery, University of Miami Miller School of Medicine, USA
    Int J Oral Maxillofac Implants 21:148-53. 2006
  52. pmc Integrated microfluidic platform for oral diagnostics
    Amy E Herr
    Biosystems Research Department, Sandia National Laboratories, Livermore, CA 94551 0969, USA
    Ann N Y Acad Sci 1098:362-74. 2007
    ..Our microchip-based analysis can readily be extended to detection of biomarkers of other diseases, both oral and systemic, in saliva and other oral fluids...
  53. pmc Microfluidic immunoassays as rapid saliva-based clinical diagnostics
    Amy E Herr
    Biosystems Research Department, Sandia National Laboratories, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 104:5268-73. 2007
    ..The microchip-based POC diagnostic demonstrated is applicable to rapid, reliable measurement of proteinaceous disease biomarkers in biological fluids...
  54. ncbi request reprint What does the future hold for periodontal tissue engineering?
    William V Giannobile
    Int J Periodontics Restorative Dent 22:6-7. 2002

Research Grants10

  1. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2001
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  2. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2007
    ..abstract_text> ..
  3. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2007
    ....
  4. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2006
    ....
  5. TNFR:Fc Gene Transfer for Treatment of Periodontitis
    William Giannobile; Fiscal Year: 2006
    ..The use of AAV-TNF: Fc has significant potential as a therapeutic regimen to treat aggressive periodontitis that is governed by an exuberant inflammatory response. ..
  6. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2004
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  7. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2003
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  8. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2002
    ..Knowledge gained from these studies will produce new insights into the use of gene therapy technologies to restore the periodontium as well as other mineral-associated tissues. ..
  9. GENE THERAPY FOR RECONSTRUCTING PERIODONTAL TISSUES
    William Giannobile; Fiscal Year: 2009
    ..abstract_text> ..