Sara Gianella

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 90:3944-52. 2016
  2. doi request reprint Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men
    Sara Gianella
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Int J Environ Res Public Health 12:7585-92. 2015
  3. doi request reprint Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy
    Sara Gianella
    University of California San Diego, 500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    BMC Infect Dis 16:24. 2016
  4. pmc Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 88:7818-27. 2014
  5. pmc Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men
    Sara Gianella
    University of California, San Diego, La Jolla, CA 92093 0679, USA
    Clin Infect Dis 57:441-7. 2013
  6. pmc Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA
    Sara Gianella
    University of California San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093 0679, USA
    J Infect Dis 207:898-902. 2013
  7. pmc Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract
    Sara Gianella
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0679, USA
    AIDS 27:39-47. 2013
  8. pmc Role of seminal shedding of herpesviruses in HIV Type 1 Transmission
    Sara Gianella
    University of California San Diego, La Jolla 92093 0679, USA
    J Infect Dis 207:257-61. 2013
  9. pmc Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells
    Sara Gianella
    University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 434:2-4. 2012
  10. pmc Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen
    Sara Gianella
    University of California San Diego, La Jolla, California 92093 0679, USA
    J Med Virol 84:1703-9. 2012

Collaborators

Detail Information

Publications30

  1. doi request reprint Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 90:3944-52. 2016
    ..001) and increased unspliced cellular HIV RNA transcription (P= 0.010). These observations suggest that replication of HHV may help maintain a larger HIV DNA reservoir, but the underlying mechanisms remain unclear...
  2. doi request reprint Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men
    Sara Gianella
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Int J Environ Res Public Health 12:7585-92. 2015
    ....
  3. doi request reprint Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy
    Sara Gianella
    University of California San Diego, 500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    BMC Infect Dis 16:24. 2016
    ..However, the natural history and factors associated with persistent HPV infection among HIV-infected men who have sex with men (MSM) are unclear...
  4. pmc Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 88:7818-27. 2014
    ..These results suggest that CMV reactivation might play a role in the maintenance of the HIV DNA reservoir during suppressive ART and that it could be a target of pharmacologic intervention in future studies...
  5. pmc Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men
    Sara Gianella
    University of California, San Diego, La Jolla, CA 92093 0679, USA
    Clin Infect Dis 57:441-7. 2013
    ..Current antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) in blood to undetectable levels in most infected individuals; however, some men shed HIV in semen despite suppressed levels in blood...
  6. pmc Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA
    Sara Gianella
    University of California San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093 0679, USA
    J Infect Dis 207:898-902. 2013
    ..These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir...
  7. pmc Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract
    Sara Gianella
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0679, USA
    AIDS 27:39-47. 2013
    ..To further understand the role that chronic viral infections of the male genital tract play on HIV-1 dynamics and replication...
  8. pmc Role of seminal shedding of herpesviruses in HIV Type 1 Transmission
    Sara Gianella
    University of California San Diego, La Jolla 92093 0679, USA
    J Infect Dis 207:257-61. 2013
    ....
  9. pmc Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells
    Sara Gianella
    University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 434:2-4. 2012
    ..Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event...
  10. pmc Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen
    Sara Gianella
    University of California San Diego, La Jolla, California 92093 0679, USA
    J Med Virol 84:1703-9. 2012
    ..In conclusion, the effects of CMV replication on HIV-1 viral and immunologic dynamics within the male genital tract are not significant enough to perturb evolution or disrupt compartmentalization in the genital tract...
  11. pmc Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants
    Sara Gianella
    niversity of California San Diego, San Diego, California, USA
    J Virol 85:8359-67. 2011
    ..The majority of low-frequency DRM detected using UDS are likely errors inherent to UDS methodology or a consequence of error-prone HIV-1 replication...
  12. pmc Associations between virologic and immunologic dynamics in blood and in the male genital tract
    Sara Gianella
    University of California, San Diego, La Jolla, California
    J Virol 86:1307-15. 2012
    ..These factors likely influence replication dynamics, sexual transmission risk, and disease outcomes for all three viruses...
  13. pmc Virologic correlates of anti-CMV IgG levels in HIV-1-infected men
    Sara Gianella
    University of California San Diego, La Jolla
    J Infect Dis 209:452-6. 2014
    ....
  14. pmc Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection
    Gabriel A Wagner
    University of California San Diego, La Jolla, CA 92093, USA
    J Infect Dis 208:271-4. 2013
    ..12), suggesting a weak statistical trend toward occurrence of superinfection and acquiring X4 usage...
  15. pmc Highly precise measurement of HIV DNA by droplet digital PCR
    Matthew C Strain
    University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e55943. 2013
    ..The improved sensitivity and precision of measurement of these rare events should facilitate measurements to characterize the latent HIV reservoir and interventions to eradicate it...
  16. doi request reprint Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy
    Marta Massanella
    University of California San Diego, La Jolla, CA, United States
    Sci Rep 5:13179. 2015
    ..Meth use is also associated with a loss of control of CMV replication, which could be related to loss of immune response to pathogens. Future studies should consider meth use as a potential modulator of T-cell responses. ..
  17. doi request reprint Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART
    Michelli Faria de Oliveira
    University of California San Diego, La Jolla, CA, USA
    Sci Rep 5:17094. 2015
    ..Correlates of neurocognitive impairment might differ between younger and older adults, suggesting that future treatment and prevention strategies for HIV-associated neurocognitive disorders likely need to be tailored based on age...
  18. doi request reprint Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men
    Sara Gianella
    University of California, San Diego, La Jolla, California, United States of America
    PLoS ONE 10:e0130410. 2015
    ..While behavioral factors are important in STI acquisition, other biological factors such as immune modulation due to chronic viral infection may further predispose to STI acquisition...
  19. pmc Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation
    Erick T Tatro
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Clin Vaccine Immunol 21:46-50. 2014
    ..01). HIV-positive individuals had higher anti-A. xylosoxidans IgG titers than HIV-uninfected individuals (P = 0.04). The results suggest an abnormal adaptive immune activation to gut microflora during HIV infection. ..
  20. pmc HIV migration between blood and cerebrospinal fluid or semen over time
    Antoine Chaillon
    University of California San Diego, La Jolla
    J Infect Dis 209:1642-52. 2014
    ..These findings imply that viral subpopulations in anatomical sites are an active part of the whole viral population and that compartmental reservoirs could have implications in future eradication studies. ..
  21. pmc Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco VA Medical Center SFVAMC and University of California, San Francisco UCSF, San Francisco, California, USA
    AIDS 24:2451-60. 2010
    ..To determine whether raltegravir-containing antiretroviral therapy (ART) intensification reduces HIV levels in the gut...
  22. doi request reprint No evidence of posttreatment control after early initiation of antiretroviral therapy
    Sara Gianella
    aUniversity of California, San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego, California, USA
    AIDS 29:2093-7. 2015
    ..Median time to HIV-RNA rebound after ART interruption was 0.9 months (range: 0.2-6.4 months). ..
  23. pmc Minority variants of drug-resistant HIV
    Sara Gianella
    Departments of Pathology and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Infect Dis 202:657-66. 2010
    ..In this review, we summarize the attributes and limitations of the currently available detection assays and review the existing information about both acquired and transmitted drug-resistant minority variants...
  24. doi request reprint Cell-free mitochondrial DNA in CSF is associated with early viral rebound, inflammation, and severity of neurocognitive deficits in HIV infection
    Josué Pérez-Santiago
    University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    J Neurovirol 22:191-200. 2016
    ..Our findings suggest that within a subset of subjects cell-free CSF mtDNA is associated with inflammation and degree of NCI. ..
  25. doi request reprint Comparative Analysis of Cell-Associated HIV DNA Levels in Cerebrospinal Fluid and Peripheral Blood by Droplet Digital PCR
    Michelli Faria de Oliveira
    University of California, San Diego, La Jolla, California, United States of America
    PLoS ONE 10:e0139510. 2015
    ..Measurement of HIV DNA-bearing cells in cerebrospinal fluid (CSF) is challenging because few cells are present. We present a novel application of the sensitive droplet digital (dd)PCR in this context...
  26. pmc The Sordid Affair Between Human Herpesvirus and HIV
    Sara Gianella
    University of California San Diego, La Jolla
    J Infect Dis 212:845-52. 2015
    ..In this review, we discuss how HHVs, and cytomegalovirus in particular, interact with concurrent HIV infection, and we describe the next steps necessary to understand and address these connections. ..
  27. pmc Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Infect Dis 202:1553-61. 2010
    ..The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments within the gut may support varying levels of HIV...
  28. doi request reprint (1→3)-β-D-Glucan Levels Correlate With Neurocognitive Functioning in HIV-Infected Persons on Suppressive Antiretroviral Therapy: A Cohort Study
    Martin Hoenigl
    From the Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA MH, MFDO, JP S, SM, SG, Department of Internal Medicine, Section of Infectious Diseases and Tropical Medicine MH, Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria MH, Research Laboratory, Associates of Cape Cod, Inc, Falmouth, MA YZ, MF, Department of Psychiatry AJM, TDM, and Department of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, CA RJE
    Medicine (Baltimore) 95:e3162. 2016
    ..BDG may be a promising independent biomarker associated with neurocognitive functioning in virologically suppressed HIV-infected individuals. ..
  29. pmc Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy
    Antoine Chaillon
    1 University of California, San Diego, La Jolla, California
    AIDS Res Hum Retroviruses 30:165-9. 2014
    ..We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach...
  30. pmc Estimating the timing of mother-to-child transmission of the human immunodeficiency virus type 1 using a viral molecular evolution model
    Antoine Chaillon
    Universite Francois Rabelais, Institut National de la Santé et de la Recherche Médicale Unité 966 et Laboratoire de Virologie, Centre Hopsitalier Universitaire Bretonneau, Tours, France University of California San Diego, Department of Pathology, San Diego, California, United States of America
    PLoS ONE 9:e90421. 2014
    ..Taking advantage of the constant accumulation of HIV genetic variation over time and using longitudinally sampled viral sequences, we used a coalescent approach to investigate the timing of MTCT...