Othman Ghribi

Summary

Affiliation: University of North Dakota
Country: USA

Publications

  1. ncbi request reprint Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis
    Xuesong Chen
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 N Columbia Road, Grand Forks, North Dakota 58203, USA
    Am J Physiol Regul Integr Comp Physiol 294:R829-35. 2008
  2. ncbi request reprint Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 0214, USA
    J Neurochem 82:137-45. 2002
  3. ncbi request reprint Is amyloid beta-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
    John Savory
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 168, Charlottesville 22908, USA
    Neurobiol Aging 23:1089-92. 2002
  4. ncbi request reprint GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Neurobiol Dis 16:417-27. 2004
  5. ncbi request reprint High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, 58202, USA
    Exp Neurol 200:460-7. 2006
  6. ncbi request reprint The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in Alzheimer's disease
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, 58202, USA
    Curr Mol Med 6:119-33. 2006
  7. ncbi request reprint Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA
    J Alzheimers Dis 10:407-8. 2006
  8. pmc Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, ND 58202, USA
    J Alzheimers Dis 15:673-84. 2008
  9. pmc Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
    Jaya Rp Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Mol Neurodegener 4:1. 2009
  10. pmc The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells
    Bhanu Dasari
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, North Dakota 58202, USA
    BMC Ophthalmol 10:22. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Rabbits fed cholesterol-enriched diets exhibit pathological features of inclusion body myositis
    Xuesong Chen
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 N Columbia Road, Grand Forks, North Dakota 58203, USA
    Am J Physiol Regul Integr Comp Physiol 294:R829-35. 2008
    ....
  2. ncbi request reprint Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 0214, USA
    J Neurochem 82:137-45. 2002
    ..We propose that the neuroprotective effect of lithium involves the modulation of apoptosis-regulatory proteins present in the subcellular organelles of rabbit brain...
  3. ncbi request reprint Is amyloid beta-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
    John Savory
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 168, Charlottesville 22908, USA
    Neurobiol Aging 23:1089-92. 2002
  4. ncbi request reprint GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Neurobiol Dis 16:417-27. 2004
    ....
  5. ncbi request reprint High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, 58202, USA
    Exp Neurol 200:460-7. 2006
    ..Increased Abeta levels may in turn trigger the phosphorylation of tau by activating ERK...
  6. ncbi request reprint The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in Alzheimer's disease
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, 58202, USA
    Curr Mol Med 6:119-33. 2006
    ..Finally, I will summarize data that show the endoplasmic reticulum stress as a mechanism underlying exogenous Abeta neurotoxicity...
  7. ncbi request reprint Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA
    J Alzheimers Dis 10:407-8. 2006
  8. pmc Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, ND 58202, USA
    J Alzheimers Dis 15:673-84. 2008
    ..We also have found pathological hallmarks in the skeletal muscle of cholesterol-fed rabbits that are suggestive of inclusion body myositis, a disease that shares some pathological similarities with AD...
  9. pmc Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
    Jaya Rp Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Mol Neurodegener 4:1. 2009
    ..abstract:..
  10. pmc The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells
    Bhanu Dasari
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, North Dakota 58202, USA
    BMC Ophthalmol 10:22. 2010
    ..In this study, the effects of 27-OHC on AMD-related pathology were determined in ARPE-19 cells. These cells have structural and functional properties relevant to retinal pigmented epithelial cells, a target in the course of AMD...
  11. ncbi request reprint Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, 58202, USA
    J Neurochem 99:438-49. 2006
    ..Our results suggest that BBB damage and disturbances in iron metabolism may render the cortex more vulnerable than the hippocampus to the cholesterol-induced cellular stress...
  12. pmc Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling
    Sunita Sharma
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Neurobiol Dis 32:426-32. 2008
    ..We suggest that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 signaling...
  13. pmc Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
    J Alzheimers Dis 19:1007-19. 2010
    ..We propose that leptin administration may prevent the progression of sporadic forms of AD that are related to increased cholesterol and oxidized cholesterol metabolite levels...
  14. pmc Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet
    Jaya R P Prasanthi
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Free Radic Biol Med 49:1212-20. 2010
    ..Our results suggest that even very low doses of caffeine might protect against sporadic AD-like pathology...
  15. pmc Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet
    Jaya R P Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    J Alzheimers Dis 30:167-82. 2012
    ..We propose that adding an antioxidant therapy to deferiprone may be necessary to fully protect against cholesterol-enriched diet-induced AD-like pathology...
  16. pmc β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    J Neurochem 115:373-84. 2010
    ..Our results demonstrate for the first time that Aβ regulates leptin expression and tau phosphorylation through mTORC1...
  17. pmc Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease
    R P Jaya Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, United States
    Mech Ageing Dev 129:649-55. 2008
    ..These results suggest that reducing Abeta accumulation in the brain may require strategies that combine reduction of generation and transport of Abeta in addition to acceleration of degradation and clearance of this peptide...
  18. pmc Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Cell Signal 24:484-92. 2012
    ..Our study implicates ER stress as the mechanistic link in the 27-OHC-induced negative regulation of leptin, a hormone that has potential therapeutic effects in AD by reducing Aβ and phosphorylated tau accumulation...
  19. pmc Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
    Xuesong Chen
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 N, Columbia Rd, Grand Forks, ND 58203, USA
    J Neuroinflammation 5:12. 2008
    ..Chronic ingestion of caffeine protects against high cholesterol diet-induced increases in disruptions of the BBB, and caffeine and drugs similar to caffeine might be useful in the treatment of Alzheimer's disease...
  20. pmc Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina
    Bhanu Dasari
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    BMC Ophthalmol 11:22. 2011
    ..High intake of cholesterol and saturated fat were also long been suspected to increase the risk for AMD. However, the extent to which cholesterol-enriched diet may also cause AMD-like features in rabbit retinas is not well known...
  21. pmc Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet
    Xuesong Chen
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    J Alzheimers Dis 22:1289-303. 2010
    ....
  22. pmc Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus
    Jaya R P Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, United States of America
    PLoS ONE 6:e26420. 2011
    ....
  23. pmc Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits
    Min Wu
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203, USA
    J Neurochem 111:1011-21. 2009
    ..Together, our studies suggest that critical DNA repair proteins are associated with development of AD, and may serve as potential targets for the treatment of AD...
  24. pmc Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    PLoS ONE 8:e70773. 2013
    ..Agents that inhibit gadd153 activation and subsequent interaction with NF-κB might be promising targets to reduce BACE1 and Aβ overproduction and may ultimately serve as disease-modifying treatments for AD. ..
  25. pmc Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases
    Xuesong Chen
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA
    J Alzheimers Dis 20:S127-41. 2010
    ..The present review focuses on the role of BBB dysfunction in the pathogenesis of AD and PD, caffeine's protective effects against AD and PD, and potential mechanisms whereby caffeine protects against BBB leakage...
  26. ncbi request reprint Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels
    Matthew Schrag
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58202, USA
    Hippocampus 18:239-44. 2008
    ....
  27. pmc The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease
    Gurdeep Marwarha
    Department of Pharmacology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA
    J Neurochem 119:1119-36. 2011
    ..Concomitant activation of ERβ and inhibition of LXRβ prevent 27-OHC effects and may therefore reduce the progression of Parkinson's disease by precluding TH reduction and α-synuclein accumulation...
  28. pmc Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells
    Jaya Prasanthi Rantham Prabhakara
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    J Neurochem 107:1722-9. 2008
    ..As steady state levels of 24-OHC and 27-OHC are tightly regulated in the brain, disturbances in these levels may contribute to the pathogenesis of PD...
  29. pmc Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58202, USA
    Mol Neurodegener 6:41. 2011
    ..As IGF-1 can activate mTORC1 and leptin can modulate JAK/STAT pathway, we determined the extent to which IGF-1 and leptin can upregulate the expression of one another and protect against Aβ-induced downregulation...
  30. pmc Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease
    Rugao Liu
    Department of Anatomy and Cell Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA
    Neurobiol Dis 45:902-12. 2012
    ..Together, our data raise the possibility that alteration of EID1 expression, particularly the increase of EID1 nuclear localization that inhibits CBP/p300 activity in neuronal cells, may play an important role in AD pathogenesis...
  31. pmc Leptin signaling and Alzheimer's disease
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences Grand Forks, North Dakota, 58202
    Am J Neurodegener Dis 1:245-65. 2012
    ..All this work points to leptin as a possible target for developing supplementation therapies for reducing the progression of Alzheimer's disease...
  32. ncbi request reprint Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Inorg Biochem 97:151-4. 2003
    ..This animal model system involving neurotoxicity induced by an aluminum compound provides new information on mechanisms of neurodegeneration and neuroprotection...
  33. ncbi request reprint Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis
    David A DeWitt
    Department of Biology, Liberty University, Lynchburg, VA 24502, USA
    J Alzheimers Dis 9:195-205. 2006
    ....
  34. ncbi request reprint Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 10:135-44. 2006
    ..Finally, we will examine data on the possible cellular mechanisms underlying aluminum neurotoxicity, and potential neuroprotective strategies against aluminum toxicity...
  35. ncbi request reprint The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus
    Othman Ghribi
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Neurosci Lett 324:217-21. 2002
    ..Inhibition of the latter enzyme by directly targeting its main site of activation could represent a strategy to prevent this adverse event...
  36. ncbi request reprint Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    J Neurosci Res 71:853-62. 2003
    ....
  37. ncbi request reprint Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 800214, Charlottesville, VA 22908, USA
    Brain Res Mol Brain Res 119:201-6. 2003
    ..Our results demonstrate that lithium, at this dose, effectively inhibits the Abeta-induced apoptosis but has no effect on tau phosphorylation, and that MAP kinases are not involved in the phosphorylation of tau...
  38. ncbi request reprint MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neuropathol Exp Neurol 62:1144-53. 2003
    ..We propose that pharmacological agents that inhibit the perturbation of endoplasmic reticulum function or the activation of JNK may represent a potential therapeutic approach for the prevention of neurotoxin-induced Parkinson disease...
  39. ncbi request reprint Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease?
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 11:429-30; discussion 431-2. 2007
  40. ncbi request reprint Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release
    Kathleen J S Griffioen
    Department of Biology and Chemistry, Liberty University, 1971 University Blvd, Lynchburg, VA 24502, USA
    Neurotoxicology 25:859-67. 2004
    ..The release of cytochrome c was demonstrated with Western blot analysis. This in vitro model using human cells adds to our understanding of Al neurotoxicity and could provide insight into the neurodegenerative processes in human disease...
  41. ncbi request reprint Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons
    Michael S Forbes
    Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Ann Clin Lab Sci 32:75-86. 2002
    ..This suggests that protein subunits that are already present in the neurons under normal circumstances are recruited, in the presence of aluminum, to form NFAs through the directed assembly of masses of oriented filaments...
  42. ncbi request reprint Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer's disease?
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 10:25-7. 2006