Nandini Ghosh-Choudhury

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis
    Nandini Ghosh-Choudhury
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Biol Chem 288:24503-17. 2013
  2. pmc Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning
    Michael Xavier Doss
    Institute of Neurophysiology, University of Cologne, Robert Koch Str 39, 50931 Cologne, Germany
    Genome Biol 8:R184. 2007
  3. ncbi Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
    J Biol Chem 277:33361-8. 2002
  4. ncbi BMP-2 regulates cardiomyocyte contractility in a phosphatidylinositol 3 kinase-dependent manner
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229, USA
    FEBS Lett 544:181-4. 2003
  5. ncbi Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element
    N Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Biochem Biophys Res Commun 286:101-8. 2001
  6. ncbi Concerted action of Smad and CREB-binding protein regulates bone morphogenetic protein-2-stimulated osteoblastic colony-stimulating factor-1 expression
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Biol Chem 281:20160-70. 2006
  7. ncbi Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation
    Nandini Ghosh-Choudhury
    Department of Pathology, The University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Biol Chem 282:4983-93. 2007
  8. ncbi Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation
    N Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio 78284 7750, USA
    Biochem Biophys Res Commun 272:705-11. 2000
  9. ncbi Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biol Chem 278:21998-2005. 2003
  10. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012

Research Grants

  1. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2005
  2. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2006
  3. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2007
  4. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009

Collaborators

Detail Information

Publications45

  1. pmc c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis
    Nandini Ghosh-Choudhury
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Biol Chem 288:24503-17. 2013
    ..We propose that activation of c-Abl is an important step, which induces into two signaling pathways involving noncanonical PI 3-kinase and canonical Smads to integrate BMP-2-induced osteogenesis. ..
  2. pmc Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning
    Michael Xavier Doss
    Institute of Neurophysiology, University of Cologne, Robert Koch Str 39, 50931 Cologne, Germany
    Genome Biol 8:R184. 2007
    ..The nature of the BMP2-expressing cells during the early stages of embryonic development, their transcriptome and cell phenotypes developed from these cells have not yet been characterized...
  3. ncbi Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
    J Biol Chem 277:33361-8. 2002
    ....
  4. ncbi BMP-2 regulates cardiomyocyte contractility in a phosphatidylinositol 3 kinase-dependent manner
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229, USA
    FEBS Lett 544:181-4. 2003
    ..Also we provide the first evidence that BMP-2-induced PI 3 kinase activity regulates this cardiomyocyte function...
  5. ncbi Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element
    N Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    Biochem Biophys Res Commun 286:101-8. 2001
    ..Furthermore, we demonstrate for the first time that BMP-2 autoregulates its expression in osteoblasts through the proximal promoter-dependent transcriptional mechanism...
  6. ncbi Concerted action of Smad and CREB-binding protein regulates bone morphogenetic protein-2-stimulated osteoblastic colony-stimulating factor-1 expression
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Biol Chem 281:20160-70. 2006
    ..These data represent the first evidence that BMP-2 increases the osteoclastogenic CSF-1 expression by a transcriptional mechanism using the canonical Smad pathway and provide a mechanism for BMP-2-induced osteoclast differentiation...
  7. ncbi Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation
    Nandini Ghosh-Choudhury
    Department of Pathology, The University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Biol Chem 282:4983-93. 2007
    ....
  8. ncbi Bone morphogenetic protein-2 blocks MDA MB 231 human breast cancer cell proliferation by inhibiting cyclin-dependent kinase-mediated retinoblastoma protein phosphorylation
    N Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio 78284 7750, USA
    Biochem Biophys Res Commun 272:705-11. 2000
    ..Our data provide a mechanism for the antiproliferative effect of BMP-2 in the breast cancer cells...
  9. ncbi Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Biol Chem 278:21998-2005. 2003
    ..Together these data provide the first evidence that BMP-2-induced PI 3-kinase signaling regulates MEF-2A expression and define a mechanism of MEF-2A-dependent BMP-2 transcription...
  10. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
    ..Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion...
  11. pmc Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase
    Falguni Das
    Veterans Affairs Research, South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 287:3808-22. 2012
    ..These results unravel a previously unrecognized cell-autonomous function of TORC1 and TORC2 in the up-regulation of PTEN, which prevents phosphorylation of Akt and may shield against the development of malignancy in TSC patients...
  12. pmc High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy
    Falguni Das
    Department of Medicine, University of Texas Health Science Center at San Antonio, TX, 78229 3900, USA
    Cell Signal 23:1311-9. 2011
    ..Furthermore, DJ-1 increased protein synthesis and hypertrophy of mesangial cells. Our results provide evidence for a unique mechanism whereby DJ-1 induces Akt/PRAS40/TORC1-mediated hypertrophy in response to high glucose...
  13. pmc TGFβ-induced PI 3 kinase-dependent Mnk-1 activation is necessary for Ser-209 phosphorylation of eIF4E and mesangial cell hypertrophy
    Falguni Das
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Cell Physiol 228:1617-26. 2013
    ..Moreover, we conclude that TGFβ-induced noncanonical signaling circuit involving PI 3 kinase-dependent Mnk-1-mediated phosphorylation of eIF4E at Ser-209 is required to facilitate mesangial cell hypertrophy...
  14. pmc TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e42316. 2012
    ..Our results uncover an essential role of TGFβ-induced expression of miR-21, which targets PTEN to initiate a non-canonical signaling circuit involving Akt/mTORC1 axis for mesangial cell hypertrophy and matrix protein synthesis...
  15. ncbi Akt kinase targets association of CBP with SMAD 3 to regulate TGFbeta-induced expression of plasminogen activator inhibitor-1
    Falguni Das
    Department of Medicine, University of Texas Health Science Center at San Antonio, Texas, USA
    J Cell Physiol 214:513-27. 2008
    ..Together our findings identify TGFbeta-induced PI 3 kinase/Akt signaling as a critical regulator of Smad 3-CBP interaction and Smad 3 acetylation, which cause increased PAI-1 expression...
  16. pmc Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy
    Falguni Das
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Biol Chem 288:7756-68. 2013
    ..Our results support that TGFβ-stimulated Smad 3 acts as a key node to instill a feedback loop between deptor down-regulation and TORC1/2 activation in driving mesangial cell hypertrophy...
  17. pmc Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth
    Triparna Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Breast Cancer Res Treat 118:213-28. 2009
    ..Taken together, our data reveals a novel signaling pathway linking the fish oil diet to increased PTEN expression that attenuates the growth promoting signals and augments the apoptotic signals, resulting in breast tumor regression...
  18. pmc PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Cell Physiol 225:27-41. 2010
    ..Thus, our data identify high glucose-induced phosphorylation and inactivation of PRAS40 as a central node for mesangial cell hypertrophy in diabetic nephropathy...
  19. pmc Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B
    Balachandar Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    FASEB J 22:3469-82. 2008
    ..PTP1B significantly inhibited PDGF-induced DNA synthesis without inducing apoptosis. These results for the first time provide evidence that the stilbene resveratrol targets PTP1B to inhibit PDGFR mitogenic signaling...
  20. ncbi Activation of renal signaling pathways in db/db mice with type 2 diabetes
    D Feliers
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Kidney Int 60:495-504. 2001
    ..Altered regulation of signaling pathways may contribute to the pathogenesis of renal disease. We examined renal cortical signaling pathways in type 2 diabetes...
  21. ncbi Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells
    Balachandar Venkatesan
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Cell Physiol 211:457-67. 2007
    ..These results demonstrate that ROS downregulate the expression of catalase in mesangial cells by PI 3 kinase/Akt signaling via FoxO1 as a target...
  22. ncbi TGFbeta intercepts nuclear glycogen synthase kinase 3beta to inhibit PDGF-induced DNA synthesis in mesangial cells
    Falguni Das
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    FEBS Lett 581:5259-67. 2007
    ..These results provide the first evidence that TGFbeta intercepts Akt kinase activity in the nucleus to block inactivation of GSK3beta, leading to attenuation of PDGF-induced CDK2 activity and DNA synthesis...
  23. ncbi Raptor-rictor axis in TGFbeta-induced protein synthesis
    Falguni Das
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Cell Signal 20:409-23. 2008
    ..Our data also provide novel evidence that rictor negatively regulates TORC1 activity to control basal protein synthesis, thus conferring tight control on cellular hypertrophy...
  24. ncbi Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
    B K Bhandari
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78299-3900, USA
    Kidney Int 59:866-75. 2001
    ..The requirement for Erk-1/-2 MAP kinase activation for 4E-BP1 phosphorylation by insulin suggests a cross-talk between PI 3-kinase and Erk-1/-2-type MAP kinase pathways...
  25. pmc miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression
    Chandi Charan Mandal
    Department of Pathology University of Texas Health Science Center, San Antonio, TX, USA
    Carcinogenesis 33:1897-908. 2012
    ..Our results reveal a novel mechanism for the therapeutic function of fish oil diet that blocks miR-21, thereby increasing PTEN levels to prevent expression of CSF-1 in breast cancer...
  26. pmc Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation
    Chandi C Mandal
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Endocrinology 150:4989-98. 2009
    ..Together, these data for the first time demonstrate that PI3K-dependent Akt activation regulates BMP-2-induced CSF-1 expression and provides a mechanism for osteoblastic cell-assisted osteoclast differentiation...
  27. ncbi EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: involvement of c-fos and p27Kip1
    Lenin Mahimainathan
    Dept of Medicine, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 289:F72-82. 2005
    ..These data provide the evidence that a linear signal transduction pathway involving PI3-kinase-dependent MAPK regulates EGF-induced DNA synthesis in mesangial cells by regulating c-fos and p27(Kip1) expression...
  28. pmc Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44
    Chandi Charan Mandal
    Department of Pathology, University of Texas Health Science Center, San Antonio, San Antonio, Texas 78229, USA
    J Biol Chem 286:11314-27. 2011
    ..Our results reveal a unique function of statins, which foster enhanced expression of mutant p53R280K to prevent breast cancer cell metastasis to bone...
  29. doi Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation
    Chandi C Mandal
    Department of Pathology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    Biochem J 433:393-402. 2011
    ..Our results provide the first evidence for a new signalling pathway linking BMP-2-stimulated Nox4-derived physiological ROS to BMP-2 expression and osteoblast differentiation...
  30. pmc Association and direct activation of signal transducer and activator of transcription1alpha by platelet-derived growth factor receptor
    G G Choudhury
    Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, San Antonio, Texas 78284, USA
    J Clin Invest 101:2751-60. 1998
    ..Incubation of pure STAT1alpha with autophosphorylated PDGFR resulted in physical association of the two proteins. These data indicate that activated PDGFR may be sufficient to tyrosine phosphorylate and thus directly activate STAT1alpha...
  31. pmc Fish oil prevents breast cancer cell metastasis to bone
    Chandi Charan Mandal
    Department of Pathology, University of Texas Health Science Center at San Antonio, Texas, USA
    Biochem Biophys Res Commun 402:602-7. 2010
    ..Our results identify a novel function of the fish oil active components, DHA and EPA, which target the cell-intrinsic pro-metastatic molecule CD44 to inhibit migration/invasion...
  32. pmc A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF
    Amit Bera
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas and
    Am J Physiol Cell Physiol 306:C1089-100. 2014
    ..Thus our data unfold the presence of a positive feedback microcircuit between Erk5 and Akt downstream of PI3-kinase nodal point for PDGF-induced mesangial cell proliferation. ..
  33. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
    ..These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency...
  34. pmc MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes
    Nirmalya Dey
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas, USA
    J Biol Chem 286:25586-603. 2011
    ..Thus, our results identify a previously unrecognized function of miR-21 that is the reciprocal regulation of PTEN levels and Akt/TORC1 activity that mediate critical pathologic features of diabetic kidney disease...
  35. ncbi c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells
    Goutam Ghosh Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Cell Signal 18:1854-64. 2006
    ..Furthermore our results demonstrate that c-Src integrates signals into the nucleus to activate CDK2, which is required for DNA synthesis...
  36. pmc Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth
    Nayana Ghosh-Choudhury
    Department of Pathology, University of Texas Health Science Center, San Antonio, USA
    Cell Signal 22:749-58. 2010
    ....
  37. pmc Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E-binding protein-1 in proximal tubular epithelial cells
    D Senthil
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
    Biochem J 360:87-95. 2001
    ..Our data provide a mechanistic basis for insulin insensitivity induced by angiotensin II...
  38. pmc TGFβ enforces activation of eukaryotic elongation factor-2 (eEF2) via inactivation of eEF2 kinase by p90 ribosomal S6 kinase (p90Rsk) to induce mesangial cell hypertrophy
    Falguni Das
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    FEBS Lett 584:4268-72. 2010
    ..These results present the first evidence that TGFβ utilizes the two layered kinase module Erk/p90Rsk to activate eEF2 for increased protein synthesis during cellular hypertrophy...
  39. ncbi PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression
    Balachandar A Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78220 3900, USA
    Cell Signal 18:508-18. 2006
    ..These data provide the first evidence that PI 3 kinase-dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1...
  40. ncbi Analysis of the mouse CSF-1 gene promoter in a transgenic mouse model
    Sherry L Abboud
    South Texas Veterans Health Care System, Audie L Murphy Division, and the Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
    J Histochem Cytochem 51:941-9. 2003
    ..CSF-1 promoter/lacZ mice may be useful for studying the transcriptional mechanisms involved in regulating CSF-1 gene expression in tissues throughout development...
  41. ncbi Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Kidney Int 57:908-17. 2000
    ....
  42. ncbi Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase
    Y Gorin
    Department of Medicine, Division of Nephrology, The University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA
    FASEB J 15:1909-20. 2001
    ..These data provide the first evidence that Ang II induces protein synthesis and hypertrophy in MCs through AA/redox-dependent pathway and Akt/PKB activation independent of PI3-K...
  43. ncbi Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression
    G G Choudhury
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Biol Chem 276:35636-43. 2001
    ....
  44. pmc Integration of phosphatidylinositol 3-kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression
    Chandi Charan Mandal
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Calcif Tissue Int 87:533-40. 2010
    ..Finally, both DN PI 3-kinase and DN Akt significantly attenuated Smad 5-dependent transcription of Osx, demonstrating the first evidence for a concerted action of PI 3-kinase/Akt signaling with BMP-specific Smads for expression of Osx...
  45. ncbi Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells
    M Arar
    Department of Pediatrics, South Texas Department of Veterans Affairs Health Care System, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:9527-33. 2000
    ..PDGF B-chain also likely stimulates proliferation of mesangial cell precursors in an autocrine fashion once these cells migrate to the glomerular tuft...

Research Grants5

  1. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2005
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  2. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2006
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  3. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2007
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  4. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..