Anuja Ghorpade

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi Development of a rapid autopsy program for studies of brain immunity
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:135-44. 2005
  2. ncbi HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway
    A Ghorpade
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 141:141-9. 2003
  3. ncbi Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:145-56. 2005
  4. ncbi Potential mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases
    Jessica Gardner
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 83:1281-92. 2006
  5. pmc Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
  6. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
  7. pmc Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of human immunodeficiency virus-1 encephalitis
    Raghava Potula
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Am J Pathol 168:1335-44. 2006
  8. pmc Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation
    Alok Dhar
    Laboratory of Cellular Neuroimmunology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 83:1271-80. 2006
  9. pmc Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: implications for HIV-1-induced neurodegeneration
    Tao Jing
    Laboratory of Neurophysiology, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Biochem Biophys Res Commun 402:241-6. 2010
  10. ncbi Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia
    David Erichsen
    Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 138:144-55. 2003

Collaborators

Detail Information

Publications20

  1. ncbi Development of a rapid autopsy program for studies of brain immunity
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:135-44. 2005
    ..The challenges in developing this initiative, reflecting experiences from 69 autopsies over 4 years, are presented...
  2. ncbi HIV-1 and IL-1 beta regulate Fas ligand expression in human astrocytes through the NF-kappa B pathway
    A Ghorpade
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 141:141-9. 2003
    ..001) and seronegative individuals (p<0.01). We propose that astrocyte expression of FasL may participate in neuronal injury in HAD...
  3. ncbi Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects
    Anuja Ghorpade
    Laboratory of Cellular Neuroimmunology, 985215 Nebraska Medical Center, Omaha, NE, 68198 5215, USA
    J Neuroimmunol 163:145-56. 2005
    ..Monocytes from seronegative donors paralleled these diminished immune responses following repeated LPS-activation. These results demonstrate changes in innate microglial function following viral infection or chronic immune activation...
  4. ncbi Potential mechanisms for astrocyte-TIMP-1 downregulation in chronic inflammatory diseases
    Jessica Gardner
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 83:1281-92. 2006
    ..These data are important for unraveling the mechanisms underlying astrocyte responses during chronic neuroinflammation and have broader implications in other inflammatory diseases that involve MMP/TIMP imbalance...
  5. pmc Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia
    Radhika Suryadevara
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Glia 44:47-56. 2003
    ..Our studies reveal new opportunities for repair-based therapeutic strategies in HAD...
  6. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
    ....
  7. pmc Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of human immunodeficiency virus-1 encephalitis
    Raghava Potula
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Am J Pathol 168:1335-44. 2006
    ..Thus, alcohol abuse could be a co-factor in progression of HIV-1 infection of the brain...
  8. pmc Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation
    Alok Dhar
    Laboratory of Cellular Neuroimmunology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 83:1271-80. 2006
    ..We propose that one of the mechanisms involved in TIMP-1 downregulation may be through TGF-signaling in chronic immune activation. These studies show a novel extracellular regulatory loop in astrocyte-TIMP-1 regulation...
  9. pmc Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: implications for HIV-1-induced neurodegeneration
    Tao Jing
    Laboratory of Neurophysiology, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Biochem Biophys Res Commun 402:241-6. 2010
    ..These results suggest that IL-1β stimulated astrocytes activate NR1a/NR2B receptors which may have implications in HIV-1-associated neurodegeneration...
  10. ncbi Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia
    David Erichsen
    Laboratory of Neurotoxicology, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 138:144-55. 2003
    ..0345). These results demonstrate a possible role of FKN in HAD pathogenesis...
  11. ncbi CD38/cyclic ADP-ribose regulates astrocyte calcium signaling: implications for neuroinflammation and HIV-1-associated dementia
    Sugato Banerjee
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    J Neuroimmune Pharmacol 3:154-64. 2008
    ..These data are important for unraveling the mechanisms underlying the role of astrocyte-CD38 in HAD and have broader implications in other inflammatory diseases involving astrocyte activation and CD38 dysregulation...
  12. ncbi Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise
    James Haorah
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Alcohol Clin Exp Res 29:999-1009. 2005
    ..BBB dysfunction is associated with disruption of tight junctions (TJ) in the brain endothelium. We propose that alcohol abuse may impair BBB permeability through TJ modification...
  13. ncbi Isolation and HIV-1 infection of primary human microglia from fetal and adult tissue
    Kathleen Borgmann
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 304:49-70. 2005
    ....
  14. ncbi Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity
    Tsuneya Ikezu
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neurochem 85:925-34. 2003
    ..These results demonstrate that neuronal APP-processing products can induce oxidative neurotoxicity through microglial activation...
  15. ncbi Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease
    James Haorah
    Liver Study Unit, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Cell Immunol 229:139-48. 2004
    ..The latter was restored by anti-oxidant. The data support the notion that HIV-1 infection and EtOH may work in concert to affect immune function including antigen presentation and thereby affect disease progression...
  16. ncbi Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia
    Huangui Xiong
    The Laboratory of Neurophysiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 71:600-7. 2003
    ..The induction of IL-8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD...
  17. pmc Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system
    Jessica Gardner
    Laboratory of Cellular Neuroimmunology, Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 74:801-6. 2003
    ..Astrocyte TIMP-1 expression is differentially regulated in inflammatory neurodegenerative diseases and may have significant therapeutic relevance...
  18. ncbi Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis
    Adeline Nukuna
    Center for Neurovirology and Neurodegenerative Disorders, Omahan NE 68195 5215, USA
    J Neurovirol 10:82-90. 2004
    ..Virus infection, per se, may affect the ability of macrophages to respond to immune stimuli by overproduction of proinflammatory factors and neurotoxins, leading to neuronal dysfunction...
  19. ncbi Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120
    Zhuying Wang
    Molecular Virology Division, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10019, USA
    Virology 312:60-73. 2003
    ..Reduction of the ability of HIV-1-infected astrocytes to take up glutamate may contribute to the development of neurological disease...
  20. ncbi A functional transsulfuration pathway in the brain links to glutathione homeostasis
    Victor Vitvitsky
    Redox Biology Center, University of Nebraska Lincoln, Lincoln, Nebraska 68588, USA
    J Biol Chem 281:35785-93. 2006
    ..This study establishes the presence of an intact transsulfuration pathway and demonstrates its contribution to glutathione-dependent redox-buffering capacity under ex vivo conditions in brain cells and slices...