M Ghoneum

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Phagocytosis of candida albicans by lymphatic tumour cells in vitro
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Acta Histochem 105:127-33. 2003
  2. ncbi request reprint Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Anticancer Res 25:4187-96. 2005
  3. ncbi request reprint In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice
    Nariman K Badr El-Din
    Department of Zoology, Faculty of Science, University of Mansoura, Mansoura, Egypt
    Nutr Cancer 60:235-44. 2008
  4. ncbi request reprint Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma
    Eman Noaman
    Department of Radiation Biology, National Center for Radiation Research and Technology, Cairo, Egypt
    Cancer Lett 268:348-59. 2008
  5. ncbi request reprint Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:1603-9. 2008
  6. pmc Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 44:830-7. 2014
  7. pmc Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in γ-radiated Nile tilapia, Oreochromis niloticus
    Mamdooh Ghoneum
    Departments of Otolaryngology, Charles Drew University of Medicine and Science, 1621 East, 120th Street, Los Angeles, California 90059
    J Radiat Res 54:852-62. 2013
  8. pmc MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120 Street, Los Angeles, CA 90059, USA
    Evid Based Complement Alternat Med 7:427-32. 2010
  9. ncbi request reprint Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA, U S A
    Anticancer Res 34:81-7. 2014
  10. pmc Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of hematopoietic tissues
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Radiat Res 54:419-29. 2013

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Phagocytosis of candida albicans by lymphatic tumour cells in vitro
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Acta Histochem 105:127-33. 2003
    ..This phenomenon may represent one mechanism by which tumour cells downregulate immune surveillance...
  2. ncbi request reprint Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Anticancer Res 25:4187-96. 2005
    ..5% after 1 h to 21.7% after 4 h, and was enhanced in the presence of MGN-3. These data may have implications in the treatment of breast cancer...
  3. ncbi request reprint In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice
    Nariman K Badr El-Din
    Department of Zoology, Faculty of Science, University of Mansoura, Mansoura, Egypt
    Nutr Cancer 60:235-44. 2008
    ..No adverse side effects due to MGN-3 treatment were observed; all animals displayed normal feeding/drinking and life activity patterns. These data may have clinical implications for the treatment of solid cancers...
  4. ncbi request reprint Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma
    Eman Noaman
    Department of Radiation Biology, National Center for Radiation Research and Technology, Cairo, Egypt
    Cancer Lett 268:348-59. 2008
    ..In conclusion, MGN-3-induced oncostatic activity by modulating lipid peroxidation, augmenting the antioxidant defense system and protecting against oxidative stress...
  5. ncbi request reprint Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:1603-9. 2008
    ..These results suggest that Thymax exerts its effects via the mitochondrial pathway of apoptosis and may represent a new class of adjuvants for the treatment of breast cancer...
  6. pmc Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 44:830-7. 2014
    ..This hole induction may be responsible for the apoptotic effect on cancer cells. These results suggest that PFT may act as a potential therapy for the treatment of MDR leukemia. ..
  7. pmc Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in γ-radiated Nile tilapia, Oreochromis niloticus
    Mamdooh Ghoneum
    Departments of Otolaryngology, Charles Drew University of Medicine and Science, 1621 East, 120th Street, Los Angeles, California 90059
    J Radiat Res 54:852-62. 2013
    ..We conclude that MRN-100 is a radioprotective agent in fish and may be useful as an adjuvant treatment to counteract the adverse side effects associated with radiation exposure. ..
  8. pmc MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120 Street, Los Angeles, CA 90059, USA
    Evid Based Complement Alternat Med 7:427-32. 2010
    ..We concluded that MRN-100 possesses anti-HIV activity in vitro and without an increase in lymphocyte proliferation, MRN-100 may be a useful agent for treating patients with acquired immunodeficiency syndrome...
  9. ncbi request reprint Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA, U S A
    Anticancer Res 34:81-7. 2014
    ..In the present study, we further evaluated the ability of MGN-3 to sensitize cells to another chemotherapy agent, paclitaxel...
  10. pmc Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body γ-irradiation in mice via restoration of hematopoietic tissues
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Radiat Res 54:419-29. 2013
    ....
  11. ncbi request reprint Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran)
    M Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
    Int J Immunopathol Pharmacol 24:941-8. 2011
    ..Results suggest that MGN-3 functions as a natural adjuvant for DC activation and thus may be used in DC-based vaccine strategies against infections and cancer...
  12. pmc An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro
    Mamdooh Ghoneum
    Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, California 90059, USA
    Nutr J 8:18. 2009
    ..MRN-100, or HydroFerrate fluid, is an iron-based beverage composed of bivalent and trivalent ferrates...
  13. ncbi request reprint S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 33:533-9. 2008
    ..However, yeast had no effect on NO levels. In conclusion, yeast induces apoptosis of human MBC cells in vitro by a mechanism involving intracellular Ca2+ and Bax:Bcl-2...
  14. ncbi request reprint Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Oncol Rep 22:155-9. 2009
    ..We conclude that MCM has an apoptotic effect toward human prostate cancer cells, which may suggest its broader potential as an innovative, non-toxic anti-cancer agent...
  15. ncbi request reprint Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extract
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    In Vivo 23:895-902. 2009
    ..In this study, the role of Thymax in phenotypic correction of age-associated functional decline in immune cells in mice was evaluated...
  16. ncbi request reprint Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract
    Mamdooh Ghoneum
    Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Anticancer Res 29:4367-71. 2009
    ..In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mononuclear cells...
  17. ncbi request reprint Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material
    Mamdooh Ghoneum
    Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    In Vivo 24:141-6. 2010
    ..Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined...
  18. ncbi request reprint Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitro
    Mamdooh Ghoneum
    Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, California 90059, USA
    Anticancer Res 30:4075-9. 2010
    ..This study examined the role of a dispersed aqueous mixture of ND/NP (DPV576) in activating human dendritic cells (DCs) in vitro...
  19. ncbi request reprint Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro
    M Ghoneum
    Department of Otalaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Neoplasma 58:118-23. 2011
    ..We conclude that MGN-3 and curcumin synergize in the induction of U266 cell apoptosis. This data may establish the foundation for in vivo studies that could have therapeutic implications...
  20. ncbi request reprint The effects of carcinogenic methylcholanthrene on carbohydrate residues of NK cells
    M Ghoneum
    Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Toxicol Ind Health 13:727-41. 1997
    ..Identification of the relationship between receptor level, induction of second messenger and cytotoxic activity may resolve the molecular basis of suppression of NK cytotoxicity by MCA and other PAH compounds...
  21. ncbi request reprint Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
    Anticancer Res 25:859-70. 2005
    ..This data demonstrates that MGN-3 accelerates phagocytosis-induced apoptosis of cancer cells, which may represent a novel therapeutic strategy for the treatment of breast cancer...
  22. ncbi request reprint Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivo
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Acta Otolaryngol 124:621-7. 2004
    ..To examine the immune suppressive effect of Actinobacillus actinomycetemcomitans (Aa) on rat natural killer (NK) cell activity in vivo...
  23. ncbi request reprint Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Anticancer Res 24:1455-63. 2004
    ..This data may have clinical implications...
  24. ncbi request reprint Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, 1621 E 120th Street, Los Angeles, CA 90059, USA
    J Pharm Pharmacol 56:1581-8. 2004
    ..Data showed that peritoneal macrophages inhibit NK activity. In conclusion, MGN-3 enhances murine NK activity of aged mice and may be useful for enhancing NK function in aged humans...
  25. ncbi request reprint Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
    Cancer Lett 201:41-9. 2003
    ..These results suggest that MGN-3 increases the susceptibility of cancer cells to undergo apoptosis mediated by death ligands, which may be relevant for anti-cancer activities...
  26. ncbi request reprint Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro
    Mamdooh Ghoneum
    Drew University of Medicine and Science, Department of Otolaryngology, 1621 E 120th Street, Los Angeles, CA 90059, USA
    Anticancer Res 25:981-9. 2005
    ..Apoptosis in cancer cells was inhibited by caspase inhibitor, Z-VAD-FMK; this suggests that caspases may be involved in apoptosis of the GI cancers. This data may have clinical implications for the treatment of solid tumors...
  27. ncbi request reprint Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal mycelia
    Mamdooh Ghoneum
    Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
    Anticancer Res 26:2013-22. 2006
    ..glabrata > Y. lipolytica, as examined by flow cytometry. In contrast, MCF-7 did not phagocytize or undergo apoptosis post-culture with conidia. This data may have clinical implications for the treatment of breast cancer...
  28. ncbi request reprint Yeast therapy for the treatment of breast cancer: a nude mice model study
    Mamdooh Ghoneum
    Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA, USA
    In Vivo 21:251-8. 2007
    ..Studies have demonstrated that phagocytosis of yeast induces apoptosis in human breast cancer (BC) cells in vitro. Here, the in vivo apoptotic activity of the S. cerevisiae against human BC (MCF-7) bearing nude mice was investigated...
  29. ncbi request reprint Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice
    Mamdooh Ghoneum
    Department of Otolaryngology, Charles R Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
    Cancer Immunol Immunother 57:581-92. 2008
    ..5%, P < 0.01) at day 35. These data may have clinical implications for the treatment of solid cancer with yeast, which is known to be safe for human consumption...
  30. ncbi request reprint Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitro
    M Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Immunopathol Pharmacol 21:87-95. 2008
    ..These findings may have applications in the treatment of infections in the elderly and in immunocompromised patients...
  31. ncbi request reprint Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro
    Mamdooh Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
    Cancer Detect Prev 28:17-26. 2004
    ..Phagocytosis was not associated with oxidative burst in any cell lines used. In conclusion, metastatic breast cancer cells possess phagocytic activity which may explain their invasive property...
  32. ncbi request reprint Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran)
    M Ghoneum
    Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Immunopathol Pharmacol 17:283-92. 2004
    ..This data demonstrates that MGN-3 is a potent inducer of phagocytic function by macrophage, and suggests that MGN-3 is a useful agent for fighting microbial infection...
  33. ncbi request reprint MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin
    Sastry Gollapudi
    University of California at Irvine, Division of Basic and Clinical Immunology, Irvine, CA 92697, USA
    Cancer Detect Prev 32:1-6. 2008
    ..MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett 2003;201:41-9]. In this study, we evaluated the chemo-sensitizing activity of MGN-3 against human breast cancer cells (BCCs) in vitro...