Research Topics
| M GhoneumSummaryAffiliation: University of California Country: USA Publications
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Publications
Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinomaEman Noaman
Department of Radiation Biology, National Center for Radiation Research and Technology, Cairo, Egypt
Cancer Lett 268:348-59. 2008..In conclusion, MGN-3-induced oncostatic activity by modulating lipid peroxidation, augmenting the antioxidant defense system and protecting against oxidative stress...
Phagocytosis of candida albicans by lymphatic tumour cells in vitroMamdooh Ghoneum
Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Acta Histochem 105:127-33. 2003..This phenomenon may represent one mechanism by which tumour cells downregulate immune surveillance...- Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cellsMamdooh Ghoneum
Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Anticancer Res 25:4187-96. 2005..5% after 1 h to 21.7% after 4 h, and was enhanced in the presence of MGN-3. These data may have implications in the treatment of breast cancer... - In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing miceNariman K Badr El-Din
Department of Zoology, Faculty of Science, University of Mansoura, Mansoura, Egypt
Nutr Cancer 60:235-44. 2008..No adverse side effects due to MGN-3 treatment were observed; all animals displayed normal feeding/drinking and life activity patterns. These data may have clinical implications for the treatment of solid cancers... - Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathwayMamdooh Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Anticancer Res 28:1603-9. 2008..These results suggest that Thymax exerts its effects via the mitochondrial pathway of apoptosis and may represent a new class of adjuvants for the treatment of breast cancer... - Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran)M Ghoneum
Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA
Int J Immunopathol Pharmacol 24:941-8. 2011..Results suggest that MGN-3 functions as a natural adjuvant for DC activation and thus may be used in DC-based vaccine strategies against infections and cancer... - Modified arabinoxylan rice bran (MGN3/Biobran) enhances intracellular killing of microbes by human phagocytic cells in vitroM Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Int J Immunopathol Pharmacol 21:87-95. 2008..These findings may have applications in the treatment of infections in the elderly and in immunocompromised patients... - S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2Mamdooh Ghoneum
Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Int J Oncol 33:533-9. 2008..However, yeast had no effect on NO levels. In conclusion, yeast induces apoptosis of human MBC cells in vitro by a mechanism involving intracellular Ca2+ and Bax:Bcl-2... 
An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitroMamdooh Ghoneum
Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, California 90059, USA
Nutr J 8:18. 2009..MRN-100, or HydroFerrate fluid, is an iron-based beverage composed of bivalent and trivalent ferrates...- Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitroMamdooh Ghoneum
Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Oncol Rep 22:155-9. 2009..We conclude that MCM has an apoptotic effect toward human prostate cancer cells, which may suggest its broader potential as an innovative, non-toxic anti-cancer agent... - Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extractMamdooh Ghoneum
Department of Otolaryngology, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
In Vivo 23:895-902. 2009..In this study, the role of Thymax in phenotypic correction of age-associated functional decline in immune cells in mice was evaluated... - Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extractMamdooh Ghoneum
Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Anticancer Res 29:4367-71. 2009..In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mononuclear cells... - Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated materialMamdooh Ghoneum
Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
In Vivo 24:141-6. 2010..Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined... - Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitroMamdooh Ghoneum
Charles Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, California 90059, USA
Anticancer Res 30:4075-9. 2010..This study examined the role of a dispersed aqueous mixture of ND/NP (DPV576) in activating human dendritic cells (DCs) in vitro... - Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitroM Ghoneum
Department of Otalaryngology, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Neoplasma 58:118-23. 2011..We conclude that MGN-3 and curcumin synergize in the induction of U266 cell apoptosis. This data may establish the foundation for in vivo studies that could have therapeutic implications... - Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing miceMamdooh Ghoneum
Department of Otolaryngology, Charles R Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
Cancer Immunol Immunother 57:581-92. 2008..5%, P < 0.01) at day 35. These data may have clinical implications for the treatment of solid cancer with yeast, which is known to be safe for human consumption... - Yeast therapy for the treatment of breast cancer: a nude mice model studyMamdooh Ghoneum
Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA, USA
In Vivo 21:251-8. 2007..Studies have demonstrated that phagocytosis of yeast induces apoptosis in human breast cancer (BC) cells in vitro. Here, the in vivo apoptotic activity of the S. cerevisiae against human BC (MCF-7) bearing nude mice was investigated... - Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal myceliaMamdooh Ghoneum
Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Anticancer Res 26:2013-22. 2006..albicans > C. glabrata > Y. lipolytica, as examined by flow cytometry. In contrast, MCF-7 did not phagocytize or undergo apoptosis post-culture with conidia. This data may have clinical implications for the treatment of breast cancer... - Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosisMamdooh Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
Cancer Lett 201:41-9. 2003..These results suggest that MGN-3 increases the susceptibility of cancer cells to undergo apoptosis mediated by death ligands, which may be relevant for anti-cancer activities... - Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitroMamdooh Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
Cancer Detect Prev 28:17-26. 2004..Phagocytosis was not associated with oxidative burst in any cell lines used. In conclusion, metastatic breast cancer cells possess phagocytic activity which may explain their invasive property... - Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivoMamdooh Ghoneum
Department of Otolaryngology, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Acta Otolaryngol 124:621-7. 2004..To examine the immune suppressive effect of Actinobacillus actinomycetemcomitans (Aa) on rat natural killer (NK) cell activity in vivo... - Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitroMamdooh Ghoneum
Charles R Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Anticancer Res 24:1455-63. 2004..This data may have clinical implications... - Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)Mamdooh Ghoneum
Charles R Drew University of Medicine and Science, Department of Otolaryngology, 1621 E 120th Street, Los Angeles, CA 90059, USA
J Pharm Pharmacol 56:1581-8. 2004..Data showed that peritoneal macrophages inhibit NK activity. In conclusion, MGN-3 enhances murine NK activity of aged mice and may be useful for enhancing NK function in aged humans... - Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitroMamdooh Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, 1621 E 120th Street, Los Angeles, CA 90059, USA
Anticancer Res 25:859-70. 2005..This data demonstrates that MGN-3 accelerates phagocytosis-induced apoptosis of cancer cells, which may represent a novel therapeutic strategy for the treatment of breast cancer... - Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitroMamdooh Ghoneum
Drew University of Medicine and Science, Department of Otolaryngology, 1621 E 120th Street, Los Angeles, CA 90059, USA
Anticancer Res 25:981-9. 2005..Apoptosis in cancer cells was inhibited by caspase inhibitor, Z-VAD-FMK; this suggests that caspases may be involved in apoptosis of the GI cancers. This data may have clinical implications for the treatment of solid tumors... - The effects of carcinogenic methylcholanthrene on carbohydrate residues of NK cellsM Ghoneum
Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA 90059, USA
Toxicol Ind Health 13:727-41. 1997..Identification of the relationship between receptor level, induction of second messenger and cytotoxic activity may resolve the molecular basis of suppression of NK cytotoxicity by MCA and other PAH compounds... - Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran)M Ghoneum
Department of Otolaryngology, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Int J Immunopathol Pharmacol 17:283-92. 2004..This data demonstrates that MGN-3 is a potent inducer of phagocytic function by macrophage, and suggests that MGN-3 is a useful agent for fighting microbial infection... - MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicinSastry Gollapudi
University of California at Irvine, Division of Basic and Clinical Immunology, Irvine, CA 92697, USA
Cancer Detect Prev 32:1-6. 2008..MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett 2003;201:41-9]. In this study, we evaluated the chemo-sensitizing activity of MGN-3 against human breast cancer cells (BCCs) in vitro...