Research Topics
| R Mark GhobrialSummaryAffiliation: University of California Country: USA Publications
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Publications
Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experienceRonald W Busuttil
Dumont UCLA Liver Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Ann Surg 241:905-16; discussion 916-8. 2005..This work analyzes the experience of nearly 2 decades by the same team in a single center. Outcomes of OLT and factors affecting survival were analyzed...- Donor and recipient outcomes in right lobe adult living donor liver transplantationRafik M Ghobrial
Department of Surgery, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Liver Transpl 8:901-9. 2002..Continuous standardized reporting of ALDLT outcomes is required to allow successful and safe implementation of the procedure... - Retransplantation for recurrent hepatitis CRafik M Ghobrial
Department of Surgery, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
Liver Transpl 8:S38-43. 2002..5. Good outcomes are obtained in selected patients when re-OLT is performed early in the course of recurrent disease before transplant recipients become critically ill... - Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicatorsMichael A Zimmerman
Dumont University of California, Los Angeles, Transplant Center, 77 120 CHS, Box 957054, 10833 Le Conte Ave, Los Angeles, CA 90095 7054, USA
Arch Surg 143:182-8; discussion 188. 2008..To review the preoperative and postoperative variables that predict hepatocellular carcinoma (HCC) recurrence following orthotopic liver transplantation (OLT)... - Longterm outcomes for whole and segmental liver grafts in adult and pediatric liver transplant recipients: a 10-year comparative analysis of 2,988 casesJohnny C Hong
Department of Surgery, Dumont UCLA Transplant Center, Pfleger Liver Institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095 7054, USA
J Am Coll Surg 208:682-9; discusion 689-91. 2009..We compared 10-year outcomes for liver transplant patients who received whole grafts (WLT), split grafts from deceased donors (SLT), and partial grafts from living donors (LDLT)... - Anemia in liver transplant recipients undergoing antiviral treatment for recurrent hepatitis CSammy Saab
Department of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Liver Transpl 13:1032-8. 2007..01) and age (P = 0.02) were found to be independent predictors of anemia. Anemia is common in liver transplant recipients treated for recurrent HCV. Special vigilance is required for older patients and patients with a low BMI... - Mortality predictors in liver transplant recipients with recurrent hepatitis C cirrhosisSammy Saab
Division of Digestive Diseases, Department of Medicine, UCLA Medical Center, University of California Los Angeles, 200 Medical Plaza, Los Angeles, CA 90095, USA
Liver Int 25:940-5. 2005..The aim of this study was to identify predictors of survival in liver transplant recipients who develop cirrhosis from recurrent HCV... - Pretransplant variables associated with quality of life in liver transplant recipientsSammy Saab
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Liver Int 28:1087-94. 2008..Our goal is to identify pretransplant variables associated with post-transplant quality of life in liver transplant recipients... - MELD score predicts 1-year patient survival post-orthotopic liver transplantationSammy Saab
Division of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA
Liver Transpl 9:473-6. 2003..99; 95% CI 1.07, 3.7). The MELD stratum is better associated with 1-year patient survival in liver transplant recipients than UNOS statuses. Patient survival was worse with higher MELD scores... - Outcomes of hepatitis C- and hepatitis B core antibody-positive grafts in orthotopic liver transplantationSammy Saab
Department of Medicine, Division of Digestive Diseases, Dumont UCLA Liver Transplant Center, University of California Los Angeles, 90095, USA
Liver Transpl 9:1053-61. 2003..Furthermore, the use of combined HBcAb+/HCV+ grafts did not impact patient or graft survival. This provides a potential new pool of donor livers that can be used for transplantation in select patients... - Outcome of liver transplantation in septuagenarians: a single-center experienceGerald S Lipshutz
Center for Surgical Outcomes and Quality, Department of Surgery, David Geffen School of Medicine at UCLA, Room 77 120 CHS, Los Angeles, CA 90095, USA
Arch Surg 142:775-81; discussion 781-4. 2007..This work compares post-liver transplant survival in septuagenarians with that of patients aged 50 to 59 years... - Outcomes of acute rejection after interferon therapy in liver transplant recipientsSammy Saab
Department of Medicine, Dumont UCLA Liver Transplant Center, Los Angeles, CA, USA
Liver Transpl 10:859-67. 2004..Interferon-based therapy may lead to acute rejection and subsequent graft loss and should therefore be used with caution. Treated recipients may also develop progressive cirrhosis despite achieving a sustained virological response... - Preoperative imaging in adult-to-adult living related liver transplant donors: what surgeons want to knowPiyaporn Limanond
Department of Radiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1721, USA
J Comput Assist Tomogr 28:149-57. 2004..The roles of high-field magnetic resonance (MR) imaging, MR angiography, MR cholangiopancreatography, multidetector-row computed tomography (CT) angiography, and CT cholangiography in the workup are discussed... - Efficacy of CT angiography for preoperative vascular mapping in adult to adult living related liver transplant donorsPiyaporn Apisarnthanarak
Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Med Assoc Thai 94:98-105. 2011..To assess the utility of CT angiography (CTA) in preoperative mapping of hepatic vascular anatomy in adult-to-adult living related liver transplant (LRLT) donors... - Portocaval hemitransposition in pediatric liver transplant recipients: a single-center experienceGerald S Lipshutz
Dumont-UCLA Liver Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Liver Transpl 12:1097-103. 2006..Appropriate selection of recipient and type of donor graft are essential for good outcomes. Portocaval hemitransposition should be used cautiously and as a last resort to establish portovenous inflow... - Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplantsAndrew M Cameron
Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Ann Surg 243:748-53; discussion 753-5. 2006..This work aimed to identify factors that impact survival outcomes for extended criteria donors (ECD) and developed an ECD scoring system to facilitate graft-recipient matching and optimize utilization of ECDs... - Employment and quality of life in liver transplant recipientsSammy Saab
Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Liver Transpl 13:1330-8. 2007.... - Analysis of liver transplant outcomes for United Network for Organ Sharing recipients 60 years old or older identifies multiple model for end-stage liver disease-independent prognostic factorsThomas A Aloia
Division of Transplantation, Department of Surgery, Weill Cornell Medical College, Methodist Hospital, Houston, TX 77030, USA
Liver Transpl 16:950-9. 2010..By optimization of donor selection for recipients over the age of 60 years, clinical utilization of the ORPS model may enhance organ utilization for all patients awaiting OLT... - Changing faces of liver transplantation: partial-liver grafts for adultsJohn F Renz
Dumont-UCLA Transplantation Center, Room 77-120 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
J Hepatobiliary Pancreat Surg 10:31-44. 2003..This manuscript details current technical considerations for the performance of adult-to-adult living-donor and split-liver transplantation, summarizes current outcomes, and explores the ethical dilemma of living-donation... - MELD fails to measure quality of life in liver transplant candidatesSammy Saab
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
Liver Transpl 11:218-23. 2005..The presence of ascites and/or encephalopathy was significantly associated with poor quality of life. CTP correlates better to QOL, probably because it contains ascites and encephalopathy... - Does race influence outcomes after primary liver transplantation? A 23-year experience with 2,700 patientsJohnny C Hong
Dumont UCLA Transplant Center, Pfleger Liver Institute, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA 90095 7054, USA
J Am Coll Surg 206:1009-16; discussion 1016-8. 2008..This study was undertaken to evaluate longterm outcomes for LT in African-American (AA) recipients compared with recipients of other races and to determine factors responsible for any observed differences... - A model to predict the development of mental status changes of unclear cause after liver transplantationFasiha Kanwal
Division of Digestive Diseases, David Geffen School of Medicine at University of California at Los Angeles, CA, USA
Liver Transpl 9:1312-9. 2003..A simple model can be used to calculate the risk for developing altered mental status post-LT... - Acquired hemophilia A after liver transplantation: a case reportGarrett M Hisatake
The Dumont-UCLA Transplant Center, Los Angeles, CA 90095-7054, USA
Liver Transpl 9:523-6. 2003..High levels of factor VIII inhibitor represents an absolute contraindication to liver donation... - The utility of MRCP in preoperative mapping of biliary anatomy in adult-to-adult living related liver transplant donorsPiyaporn Limanond
Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90005-1721, USA
J Magn Reson Imaging 19:209-15. 2004..4%). Overall, MRCP had an accuracy 84.6% (22/26). CONCLUSIONS: MRCP has potential in the preoperative assessment of nondilated bile ducts in LRLT donors, however further improvements are desired to increase its quality and accuracy... - Gastric radiation enteritis after intra-arterial yttrium-90 microsphere therapy for early stage hepatocellular carcinomaThomas A Aloia
Department of Surgery, Division of Transplantation, The Methodist Hospital, Houston, Texas 77030, USA
Exp Clin Transplant 7:141-4. 2009..To demonstrate the potential risks associated with this treatment, in the following case report, we describe a patient with early stage hepatocellular carcinoma who experienced severe toxicity from intra-arterial radiotherapy... - Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findingsPiyaporn Limanond
Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095-1721, USA
Radiology 230:276-80. 2004..Core liver biopsy is still necessary in the majority of donors with normal LAI to identify those with both fatty liver and coexistent hemosiderin deposition or radiologically occult diffuse liver diseases... - Liver transplantation for fulminant hepatic failure: experience with more than 200 patients over a 17-year periodDouglas G Farmer
Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Ann Surg 237:666-75; discussion 675-6. 2003..To analyze outcomes after liver transplantation (LT) in patients with fulminant hepatic failure (FHF) with emphasis on pretransplant variables that can potentially help predict posttransplant outcome... - New era of liver transplantation for hepatitis B: a 17-year single-center experienceDean M Anselmo
Department of Surgery, Dumont-UCLA Liver Transplant Center, UCLA School of Medicine, Los Angeles, California 90095-7054, USA
Ann Surg 235:611-9; discussion 619-20. 2002..Viral prophylactic therapy has effectively reduced HBV recurrence and prolonged survival outcomes. The combination of HBIg and lamivudine is the prophylactic regimen of choice... - Liver transplantation for HELLP syndromeAli Zarrinpar
Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Am Surg 73:1013-6. 2007..This is the largest single-center report of LT for HELLP. Early recognition and transfer to a transplant center will yield best results with this challenging complication of pregnancy... - Operative parameters that predict the outcomes of hepatic transplantationJames F Markmann
Department of Surgery, School of Medicine, Hospital of the University of Pennsylvania, 4th Floor Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Am Coll Surg 196:566-72. 2003..Early identification of grafts likely to have poor function might also provide an opportunity for therapeutic intervention to salvage graft function... - Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL ConsortiumKim M Olthoff
Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
Ann Surg 242:314-23, discussion 323-5. 2005.... - Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLAJohn P Duffy
Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Surg 246:502-9; discussion 509-11. 2007..To assess the efficacy of orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) and the impact of current staging criteria on long term survival... - Preoperative characteristics and intraoperative transfusion and vasopressor requirements in patients with low vs. high MELD scoresVictor W Xia
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
Liver Transpl 12:614-20. 2006..In conclusion, these data suggest that pretransplant MELD scores provide important information for perioperative management of patients undergoing liver transplantation... - When shouldn't we retransplant?Michael A Zimmerman
Department of Surgery, Division of Liver and Pancreas Transplantation, The Pfleger Liver Institute, The Dumont UCLA Transplant Center, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095 7054, USA
Liver Transpl . 2005..5. Accurate definitions of acceptable outcomes after retransplantation and "futile re-OLT" are desperately needed... - Is it cost-effective to treat recurrent hepatitis C infection in orthotopic liver transplantation patients?Sammy Saab
Department of Medicine, University of California Los Angeles, USA
Liver Transpl 8:449-57. 2002..Our model was sensitive to antiviral drug costs, cirrhosis rate, and sustained viral response. Patients with a progressive course of recurrent HCV are likely to have the greatest gain from antiviral therapy... - The MELD score in advanced liver disease: association with clinical portal hypertension and mortalitySammy Saab
Department of Medicine, University of California at Los Angeles 90095, and Department of Medicine at Olive View Medical Center, Pasadena, USA
Exp Clin Transplant 4:395-9. 2006..However, clinical factors that affect the MELD score are unknown. We sought to identify predictors of mortality for potential transplant patients and examine factors that might predict changes in MELD score... - Conversion from intravenous to intramuscular hepatitis B immune globulin in combination with lamivudine is safe and cost-effective in patients receiving long-term prophylaxis to prevent hepatitis B recurrence after liver transplantationSteven Huy Han
Division of Digestive Diseases, UCLA School of Medicine, Los Angeles, CA, USA
Liver Transpl 9:182-7. 2003.... - Donor morbidity after living donation for liver transplantationRafik M Ghobrial
Department of Surgery, University of California Los Angeles, Los Angeles, California, USA
Gastroenterology 135:468-76. 2008..The rate and severity of complications in living donors were investigated in the 9-center Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL)... - Discordance between ALT values and fibrosis in liver transplant recipients treated with ribavirin for recurrent hepatitis CSammy Saab
Department of Medicine, Dumont UCLA Liver Transplant Center, University of California Los Angeles, USA
Am J Transplant 3:328-33. 2003..Our results suggest that HCV disease can progress despite a significant decrease in ALT values. ALT values are inadequate markers of the ribavirin monotherapy and can lead to erroneous conclusions of efficacy... - Hepatocellular carcinoma screening in patients waiting for liver transplantation: a decision analytic modelSammy Saab
Department of Medicine, Dumont UCLA Liver Transplant Center, University of California Los Angeles, USA
Liver Transpl 9:672-81. 2003..U/S screening strategy is the preferred screening strategy based on the lowest ICER. Ultimately, costs of the screening modalities determine the most cost-effective strategy... - Hepatitis C positive grafts may be used in orthotopic liver transplantation: a matched analysisSammy Saab
Division of Digestive Diseases, Dumont UCLA Liver Transplant Center, University of California, Los Angeles, CA 90095, USA
Am J Transplant 3:1167-72. 2003..Our results suggest that HCV-positive grafts can be used in a HCV liver transplant recipient... - Predictors of hyperkalemia in the prereperfusion, early postreperfusion, and late postreperfusion periods during adult liver transplantationVictor W Xia
Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1778, USA
Anesth Analg 105:780-5. 2007..Hyperkalemia poses serious hazards to patients undergoing orthotopic liver transplantation (OLT), and its predictors have not been thoroughly examined... - Predictors of survival after liver transplantation for hepatocellular carcinoma associated with Hepatitis CMitsugi Shimoda
Dumont-UCLA Liver Transplant Center, Department of Surgery, UCLA School of Medicine, 90095, USA
Liver Transpl 10:1478-86. 2004..Early pTNM stage, adjuvant chemotherapy, and preoperative chemoembolization were associated with positive outcomes for patients who underwent OLT for concomitant HCV and HCC... - Budd-Chiari syndromeMichael A Zimmerman
Division of Liver and Pancreas Transplantation, Department of Surgery, The Pfleger Liver Institute, The Dumont-UCLA Transplant Center, The David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
Clin Liver Dis 10:259-73, viii. 2006.... - Technical and logistical considerations of in situ split-liver transplantation for two adults: Part II. Creation of left segment I-IV and right segment V-VIII graftsHasan Yersiz
Dumont-UCLA Transplant Center, Department of Surgery, University of California, Los Angeles, CA, USA
Liver Transpl 8:78-81. 2002 - Future of adult living donor liver transplantationR Mark Ghobrial
Department of Surgery, Division of Liver and Pancreas Transplantation, The Dumont-UCLA Transplant Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095-7054, USA
Liver Transpl 9:S73-9. 2003 - Predictors of outcomes after pediatric liver transplantation: an analysis of more than 800 cases performed at a single institutionDouglas G Farmer
Department of Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 7054, USA
J Am Coll Surg 204:904-14; discussion 914-6. 2007..Unfortunately, there are few studies with substantial numbers of patients that identify outcomes predictors. The goal of this study was to determine factors that influence outcomes in a large, single-center cohort of PLTx... - Pretransplant model to predict posttransplant survival in liver transplant patientsRafik M Ghobrial
Dumont-UCLA Transplant Center, Department of Surgery, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Ann Surg 236:315-22; discussion 322-3. 2002.... - Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinomaValeria R Mas
Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, Virginia, USA
Mol Med 15:85-94. 2009..Characteristic gene signatures were identified at different stages of HCV-HCC progression. A set of genes were identified to predict whether the cirrhotic tissue was associated with HCC... - Long-term analysis of combined liver and kidney transplantation at a single centerRichard Ruiz
Department of Surgery, Dumont-UCLA Transplant Center, University of California, Los Angeles, USA
Arch Surg 141:735-41; discussion 741-2. 2006..Second, CLKT for hepatorenal syndrome is indicated in patients receiving hemodialysis for longer than 8 weeks and confers advantages in patient survival and use of hospital resources. Third, the liver is immunoprotective for the kidney... - Vascular complications of orthotopic liver transplantation: experience in more than 4,200 patientsJohn P Duffy
Department of Surgery, Dumont UCLA Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Am Coll Surg 208:896-903; discussion 903-5. 2009..This study was undertaken to evaluate the incidence of major vascular complications after OLT, determine efficacy of therapies, and identify factors influencing longterm outcomes... - Effect of nonviral factors on hepatitis C recurrence after liver transplantationAndrew M Cameron
Department of Surgery, Dumont-UCLA Liver Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Ann Surg 244:563-71. 2006..A change in the current national liver allocation system would be needed to realize the full value of this benefit... - Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strainsNatalya V Semiletova
The Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 77 120 CHS, Los Angeles, CA 90095 7054, USA
Cell Immunol 248:48-58. 2007.... - Timing of referral impacts surgical outcomes in patients undergoing repair of bile duct injuriesCraig P Fischer
Department of Surgery, Weill Cornell Medical College, The Methodist Hospital Department of Surgery Houston, TX, USA
HPB (Oxford) 11:32-7. 2009..Additionally, we examined the impact of delayed referral to our centre on short- and long-term outcomes after surgical repair of BDI... - Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation toleranceNatalya Semiltova
The Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-7054, USA
Transplantation 75:550-3. 2003..CONCLUSION: Allochimeric MHC class-I therapy is a unique and novel clinically applicable approach for induction of "true" transplantation tolerance where chronic rejection is concomitantly abrogated... - Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndromeEric A Collisson
David Geffen School of Medicine, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095, USA
Liver Transpl 8:925-31. 2002..This supports the newly implemented United Network for Organ Sharing (UNOS) criteria, that LT for HPS may be extended to include patients with Pa(O2) < 60 mm Hg... - Giant cavernous liver hemangiomas: effect of operative approach on outcomeSusan M Lerner
Department of Surgery, Pennsylvania State Milton S. Hershey Medical Center, Hershey, USA
Arch Surg 139:818-21; discussion 821-3. 2004..Although lobectomy and enucleation are curative, enucleation offers greater preservation of normal hepatic parenchyma and fewer complications and is the preferred technique for suitable lesions... - Incisional hernia after liver transplantationAndrew J Vardanian
Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont-UCLA Transplant Center, David Geffen School of Medicine at UCLA, 650 C.E. Young Drive South, Los Angeles, CA 90095, USA
J Am Coll Surg 203:421-5. 2006..Repair is safe when undertaken after acute problems have resolved and is best accomplished using mesh reinforcement of autologous tissue... - Inhibition of chronic rejection by antibody induced vascular accommodation in fully allogeneic heart allograftsNatalya V Semiletova
The Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-7054, USA
Transplantation 80:1535-40. 2005..CONCLUSION: Alteration of humoral immunity induces vascular accommodation in allogeneic transplantation. Vascular accommodation is the underlying mechanism for inhibition allograft vasculopathy following allochimeric MHC class I therapy... - Postresection hepatic failure: successful treatment with liver transplantationYuichiro Otsuka
Department of Surgery, Toho University School of Medicine, Tokyo, Japan
Liver Transpl 13:672-9. 2007..In conclusion, patients with low platelets, biopsy-proven cirrhosis, or those undergoing extended resection are at increased risk for PLF. OLT for PLF has significant morbidity but allows salvage of an otherwise fatal condition...
Research Grants
- ADLDT: An Opportunity to Expand the National Donor PoolRonald Busuttil; Fiscal Year: 2007..Additionally, health utility index assessments and evaluation of health care resource utilization will be conducted. ..