Roberto Gherzi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Mol Cell 20:891-903. 2005
  2. ncbi request reprint KSRP promotes the maturation of a group of miRNA precursors
    Michele Trabucchi
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Adv Exp Med Biol 700:36-42. 2010
  3. doi request reprint The role of KSRP in mRNA decay and microRNA precursor maturation
    Roberto Gherzi
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Wiley Interdiscip Rev RNA 1:230-9. 2010
  4. pmc KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cell Biol 10:70. 2009
  5. pmc The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling
    Roberto Gherzi
    Nazionale per la Ricerca sul Cancro, Genova, Italy
    PLoS Biol 5:e5. 2006
  6. doi request reprint Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation
    R Gherzi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Cell Death Differ 17:975-83. 2010
  7. pmc Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
    Tina Ruggiero
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    BMC Mol Biol 8:28. 2007
  8. doi request reprint KSRP silencing favors neural differentiation of P19 teratocarcinoma cells
    Matteo Giovarelli
    University of Genova, Genova, Italy
    Biochim Biophys Acta 1829:469-79. 2013
  9. ncbi request reprint A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
    Roberto Gherzi
    Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genoa, Italy
    Mol Cell 14:571-83. 2004
  10. ncbi request reprint The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Mol Cell 12:1201-11. 2003

Collaborators

  • Tina Ruggiero
  • Giorgio Corte
  • Michael Karin
  • Pier Lorenzo Puri
  • P Briata
  • Georg Stoecklin
  • Tally Naveh-Many
  • Khalid Sa Khabar
  • Michele Trabucchi
  • Morris Nechama
  • Matteo Giovarelli
  • Michela Pasero
  • David Hollingworth
  • Annamaria Bevilacqua
  • Chu Fang Chou
  • Gabriele Bucci
  • Andres Ramos
  • María Flor García-Mayoral
  • Ching Yi Chen
  • Sergio Capaccioli
  • Angelo Nicolin
  • Gianfranco Canti
  • Martin Schmidlin
  • Giuseppe Nicastro
  • Adela M Candel
  • Stephen R Martin
  • Daniel R Schoenberg
  • Yong Peng
  • Osnat Bell
  • Iddo Z Ben-Dov
  • Irene Díaz-Moreno
  • Sara Franzi
  • Geoff Kelly
  • Giovanna Maresca
  • Laura Ghisolfi
  • Laura Masino
  • Sushmit Maitra
  • Wei Jye Lin
  • Alok Mulky
  • John Kappes
  • Brigitte Gross
  • Christoph Moroni
  • Sabrina A Leuenberger
  • Brian A Hemmings
  • Min Lu
  • Michel Mallaun
  • Daniel Hess
  • Maria Cristina Ceriani
  • Laura Asnaghi
  • Nicola Schiavone
  • Laura Papucci
  • Gary Brewer

Detail Information

Publications21

  1. ncbi request reprint p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Mol Cell 20:891-903. 2005
    ..Our results uncover an unanticipated role for KSRP in establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs...
  2. ncbi request reprint KSRP promotes the maturation of a group of miRNA precursors
    Michele Trabucchi
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093 0648, USA
    Adv Exp Med Biol 700:36-42. 2010
    ..This uncovers a new level of complexity of miRNA mechanisms for gene expression regulation...
  3. doi request reprint The role of KSRP in mRNA decay and microRNA precursor maturation
    Roberto Gherzi
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Wiley Interdiscip Rev RNA 1:230-9. 2010
    ..We also discuss how its peculiar modular structure allows KSRP to specifically interact with a wide spectrum of RNA sequences and how post-translational modifications influence KSRP functions in cell proliferation and differentiation...
  4. pmc KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    BMC Cell Biol 10:70. 2009
    ..AUF1 and Unr stabilize PTH mRNA while KSRP, recruiting the exoribonucleolytic complex exosome, promotes PTH mRNA decay...
  5. pmc The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling
    Roberto Gherzi
    Nazionale per la Ricerca sul Cancro, Genova, Italy
    PLoS Biol 5:e5. 2006
    ..We propose KSRP phosphorylation as a link between phosphatidylinositol 3-kinase-AKT signaling and beta-catenin accumulation...
  6. doi request reprint Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation
    R Gherzi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Cell Death Differ 17:975-83. 2010
    ..Upon Akt2-phosphorylation, the complex Pitx2/HuR/Ccnd1 mRNA dissociates and Ccnd1 mRNA is destabilized. These events contribute to the switch of C2C12 cells from a proliferating to a differentiating phenotype...
  7. pmc Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
    Tina Ruggiero
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    BMC Mol Biol 8:28. 2007
    ..We have recently described that phosphatidylinositol 3-kinase/AKT (PI3K-AKT) activation induces stabilization and accumulation of the labile beta-catenin mRNA through an impairment of KSRP function...
  8. doi request reprint KSRP silencing favors neural differentiation of P19 teratocarcinoma cells
    Matteo Giovarelli
    University of Genova, Genova, Italy
    Biochim Biophys Acta 1829:469-79. 2013
    ..Our data suggests that KSRP function is required to maintain P19 cells in a multipotent undifferentiated state and that its inactivation can orient cells towards neural differentiation...
  9. ncbi request reprint A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
    Roberto Gherzi
    Gene Transfer Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genoa, Italy
    Mol Cell 14:571-83. 2004
    ..The ability of KHs to promote mRNA decay correlates with their ability to bind the ARE and associate with RNA-degrading enzymes. Thus, KHs promote rapid mRNA decay by recruiting degradation machinery to ARE-containing mRNAs...
  10. ncbi request reprint The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Mol Cell 12:1201-11. 2003
    ..Our previous and present data support the hypothesis that a single pathway can coordinately regulate sequential transcriptional and posttranscriptional events leading to an integrated functional gene regulatory network...
  11. doi request reprint Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation
    Michela Pasero
    University of Genova, IRCCS Azienda Universitaria Ospedaliera San Martino IST, 16132 Genova, Italy
    Cell Rep 2:1159-68. 2012
    ..Thus, SMAD-induced blockade of KSRP-dependent myomiR maturation is critical for orienting C2C12 cell differentiation toward osteoblastic lineage...
  12. doi request reprint Functional and molecular insights into KSRP function in mRNA decay
    Paola Briata
    IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Biochim Biophys Acta 1829:689-94. 2013
    ..We discuss also some aspects of KSRP-dependent microRNA maturation from precursors that are related to its mRNA destabilizing function. This article is part of a Special Issue entitled: RNA Decay mechanisms...
  13. ncbi request reprint KSRP, many functions for a single protein
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Front Biosci (Landmark Ed) 16:1787-96. 2011
    ..In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors...
  14. doi request reprint KSRP Promotes the Maturation of a Group of miRNA Precuresors
    Michele Trabucchi
    Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California, USA
    Adv Exp Med Biol 700:36-42. 2011
    ..This uncovers a new level of complexity of miRNA mechanisms for gene expression regulation...
  15. pmc KH domains with impaired nucleic acid binding as a tool for functional analysis
    David Hollingworth
    Molecular Structure Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nucleic Acids Res 40:6873-86. 2012
    ..This work defines a general molecular biology tool for the investigation of the function of individual KH domains in nucleic acid binding proteins...
  16. doi request reprint The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
    Morris Nechama
    Minerva Center for Calcium and Bone Metabolism, Hadassah Hebrew University Medical Center, PO Box 12000, Jerusalem, Israel 91120
    FASEB J 22:3458-68. 2008
    ..Therefore, calcium or phosphorus depletion, as well as chronic kidney failure, regulate the interaction of KSRP and AUF1 with PTH mRNA and its half-life. Our data indicate a novel role for KSRP in PTH gene expression...
  17. pmc Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay
    Chu Fang Chou
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Cell Biol 26:3695-706. 2006
    ..These results provide a foundation for the development of novel therapeutic strategies to inhibit specific gene expression in patients with acquired or hereditary diseases...
  18. pmc The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
    Martin Schmidlin
    Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    EMBO J 23:4760-9. 2004
    ..In vivo and in vitro data support a model where PKB causes ARE-mRNA stabilization by inactivating BRF1 through binding to 14-3-3...
  19. ncbi request reprint The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation
    María Flor García-Mayoral
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Structure 15:485-98. 2007
    ..Surprisingly, we find that KH4 binds to its target AREs with lower affinity than KH3 and that KSRP's mRNA binding, and mRNA degradation activities are closely associated with a conserved structural element of KH4...
  20. ncbi request reprint Stabilization of cellular mRNAs and up-regulation of proteins by oligoribonucleotides homologous to the Bcl2 adenine-uridine rich element motif
    Annamaria Bevilacqua
    Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Mol Pharmacol 71:531-8. 2007
    ....
  21. ncbi request reprint Bcl-2 protein is required for the adenine/uridine-rich element (ARE)-dependent degradation of its own messenger
    Annamaria Bevilacqua
    Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Biol Chem 278:23451-9. 2003
    ..We conclude that Bcl-2 is necessary to activate the degradation complex on the relevant RNA target...