Elodie Ghedin

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission
    Elodie Ghedin
    Department of Computational and Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Infect Dis 206:1504-11. 2012
  2. pmc Deep sequencing reveals mixed infection with 2009 pandemic influenza A (H1N1) virus strains and the emergence of oseltamivir resistance
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Infect Dis 203:168-74. 2011
  3. pmc Mixed infection and the genesis of influenza virus diversity
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:8832-41. 2009
  4. pmc Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS Negl Trop Dis 3:e525. 2009
  5. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
  6. pmc Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemic
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 84:5715-8. 2010
  7. pmc Whole genome analysis of sierra nevada virus, a novel mononegavirus in the family nyamiviridae
    Matthew B Rogers
    Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Tsinghua University School of Medicine, Beijing, China Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas
    Am J Trop Med Hyg 91:159-64. 2014
  8. pmc Kolente virus, a rhabdovirus species isolated from ticks and bats in the Republic of Guinea
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Gen Virol 94:2609-15. 2013
  9. pmc Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS Biol 3:e300. 2005
  10. pmc The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus
    Rachel Brower-Sinning
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA
    Genome Biol 10:R18. 2009

Detail Information

Publications12

  1. pmc Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission
    Elodie Ghedin
    Department of Computational and Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Infect Dis 206:1504-11. 2012
    ..These observations provide important information on the relative fitness of the Y275 mutation in the absence of oseltamivir treatment...
  2. pmc Deep sequencing reveals mixed infection with 2009 pandemic influenza A (H1N1) virus strains and the emergence of oseltamivir resistance
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Infect Dis 203:168-74. 2011
    ..Immunocompromised individuals may, therefore, constitute an important source of genetic and phenotypic diversity, both through mixed infection and de novo mutation...
  3. pmc Mixed infection and the genesis of influenza virus diversity
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:8832-41. 2009
    ..These results reveal that individuals can harbor influenza viruses that differ in major phenotypic properties, including those that are antigenically distinct and those that differ in their sensitivity to antiviral agents...
  4. pmc Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS Negl Trop Dis 3:e525. 2009
    ..Elimination of the endosymbiont leads to sterilization of the adult female. Previous biochemical and genetic studies have established that communication with its endobacterium is essential for survival of the worm...
  5. pmc Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3
    Ben Wen Li
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Genomics 10:267. 2009
    ..Radiation effects are especially interesting because irradiated L3 induce partial immunity to filarial infections. The underlying molecular mechanisms responsible for the efficacy of such vaccines are unkown...
  6. pmc Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemic
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 84:5715-8. 2010
    ..These results suggest that the unseasonal transmission of influenza A viruses may be more widespread than is usually supposed...
  7. pmc Whole genome analysis of sierra nevada virus, a novel mononegavirus in the family nyamiviridae
    Matthew B Rogers
    Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Tsinghua University School of Medicine, Beijing, China Center for Biodefense and Emerging Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas
    Am J Trop Med Hyg 91:159-64. 2014
    ..Although NYMV was found to infect land birds, and MIDWV seabirds, it is presently unknown whether SNVV naturally infects birds or mammals. ..
  8. pmc Kolente virus, a rhabdovirus species isolated from ticks and bats in the Republic of Guinea
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Gen Virol 94:2609-15. 2013
    ..In summary, KOLEV represents a novel species in the family Rhabdoviridae. ..
  9. pmc Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS Biol 3:e300. 2005
    ....
  10. pmc The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus
    Rachel Brower-Sinning
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA
    Genome Biol 10:R18. 2009
    ..Current efforts to understand the host-specificity of the virus have largely focused on the amino acid differences between avian and human isolates...
  11. pmc Sequence analysis of in vivo defective interfering-like RNA of influenza A H1N1 pandemic virus
    Kazima Saira
    Department of Computational and Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Virol 87:8064-74. 2013
    ..The presence of identical DI-like RNAs in patients linked by direct contact is compatible with transmission between them. The functional role of DI-like RNAs in natural infections remains to be established. ..
  12. pmc Draft genome of the filarial nematode parasite Brugia malayi
    Elodie Ghedin
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Science 317:1756-60. 2007
    ..malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design...