Elodie Ghedin

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Viral genome sequencing by random priming methods
    Appolinaire Djikeng
    Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Genomics 9:5. 2008
  2. pmc Draft genome of the filarial nematode parasite Brugia malayi
    Elodie Ghedin
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Science 317:1756-60. 2007
  3. pmc Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS Negl Trop Dis 3:e525. 2009
  4. pmc Mixed infection and the genesis of influenza virus diversity
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:8832-41. 2009
  5. pmc Sequences necessary for trans-splicing in transiently transfected Brugia malayi
    Canhui Liu
    Gorgas Center for Geographic Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 156:62-73. 2007
  6. pmc The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus
    Rachel Brower-Sinning
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA
    Genome Biol 10:R18. 2009
  7. pmc Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemic
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 84:5715-8. 2010
  8. ncbi request reprint Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi
    Katherine A Smith
    Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA
    Invert Neurosci 7:227-44. 2007
  9. pmc Mining predicted essential genes of Brugia malayi for nematode drug targets
    Sanjay Kumar
    Division of Parasitology, New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
    PLoS ONE 2:e1189. 2007
  10. pmc The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode
    Jeremy Foster
    Molecular Parasitology Division, New England Biolabs, Beverly, Massachusetts, USA
    PLoS Biol 3:e121. 2005

Research Grants

  1. Brugia Malayi Genome Project
    Elodie Ghedin; Fiscal Year: 2002
  2. High-throughput Analysis of Brugia malayi mRNA 5' ends
    Elodie Ghedin; Fiscal Year: 2005

Collaborators

Detail Information

Publications12

  1. pmc Viral genome sequencing by random priming methods
    Appolinaire Djikeng
    Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
    BMC Genomics 9:5. 2008
    ..Of increasing importance therefore is a better understanding of global viral diversity to enable better surveillance and prediction of pandemic threats; this will require rapid and flexible methods for complete viral genome sequencing...
  2. pmc Draft genome of the filarial nematode parasite Brugia malayi
    Elodie Ghedin
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Science 317:1756-60. 2007
    ..malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design...
  3. pmc Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS Negl Trop Dis 3:e525. 2009
    ..Elimination of the endosymbiont leads to sterilization of the adult female. Previous biochemical and genetic studies have established that communication with its endobacterium is essential for survival of the worm...
  4. pmc Mixed infection and the genesis of influenza virus diversity
    Elodie Ghedin
    University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 83:8832-41. 2009
    ..These results reveal that individuals can harbor influenza viruses that differ in major phenotypic properties, including those that are antigenically distinct and those that differ in their sensitivity to antiviral agents...
  5. pmc Sequences necessary for trans-splicing in transiently transfected Brugia malayi
    Canhui Liu
    Gorgas Center for Geographic Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 156:62-73. 2007
    ..malayi genes found homologues for the BmHSP70 TSM in roughly 25%. Thus, while the BmHSP70 TSM is necessary and sufficient to direct trans-splicing in some genomic contexts, independent trans-splicing signals are employed by other genes...
  6. pmc The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virus
    Rachel Brower-Sinning
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA
    Genome Biol 10:R18. 2009
    ..Current efforts to understand the host-specificity of the virus have largely focused on the amino acid differences between avian and human isolates...
  7. pmc Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemic
    Elodie Ghedin
    Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Virol 84:5715-8. 2010
    ..These results suggest that the unseasonal transmission of influenza A viruses may be more widespread than is usually supposed...
  8. ncbi request reprint Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayi
    Katherine A Smith
    Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA
    Invert Neurosci 7:227-44. 2007
    ..Our results provide a framework for how G-protein coupled receptors may be targeted for drug development in medically important parasitic nematodes...
  9. pmc Mining predicted essential genes of Brugia malayi for nematode drug targets
    Sanjay Kumar
    Division of Parasitology, New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
    PLoS ONE 2:e1189. 2007
    ..By virtue of the selection procedure, the potential B. malayi drug targets highlight components of key processes in nematode biology such as central metabolism, molting and regulation of gene expression...
  10. pmc The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode
    Jeremy Foster
    Molecular Parasitology Division, New England Biolabs, Beverly, Massachusetts, USA
    PLoS Biol 3:e121. 2005
    ..Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease...
  11. ncbi request reprint A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling
    David B Guiliano
    Department of Biological Sciences, Imperial College of Science and Technology, London SW7 2AY, UK
    Mol Biochem Parasitol 136:227-42. 2004
    ....
  12. ncbi request reprint First sequenced genome of a parasitic nematode
    Elodie Ghedin
    Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 20:151-3. 2004

Research Grants2

  1. Brugia Malayi Genome Project
    Elodie Ghedin; Fiscal Year: 2002
    ..malayi. ..
  2. High-throughput Analysis of Brugia malayi mRNA 5' ends
    Elodie Ghedin; Fiscal Year: 2005
    ..This could potentially lead to the discovery of previously undiscovered operons in 8. malayi. Moreover, the collection of trans-spliced genes will serve as a comparative marker for evolutionary studies in nematodes. ..