Affiliation: University of Pittsburgh
- Viral genome sequencing by random priming methodsAppolinaire Djikeng
Viral Genomics Group, J, Craig Venter Institute, Rockville, MD 20850, USA
BMC Genomics 9:5. 2008..Of increasing importance therefore is a better understanding of global viral diversity to enable better surveillance and prediction of pandemic threats; this will require rapid and flexible methods for complete viral genome sequencing...
- Draft genome of the filarial nematode parasite Brugia malayiElodie Ghedin
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Science 317:1756-60. 2007..malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design...
- Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatmentElodie Ghedin
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
PLoS Negl Trop Dis 3:e525. 2009..Elimination of the endosymbiont leads to sterilization of the adult female. Previous biochemical and genetic studies have established that communication with its endobacterium is essential for survival of the worm...
- Mixed infection and the genesis of influenza virus diversityElodie Ghedin
University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Virol 83:8832-41. 2009..These results reveal that individuals can harbor influenza viruses that differ in major phenotypic properties, including those that are antigenically distinct and those that differ in their sensitivity to antiviral agents...
- Sequences necessary for trans-splicing in transiently transfected Brugia malayiCanhui Liu
Gorgas Center for Geographic Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mol Biochem Parasitol 156:62-73. 2007..malayi genes found homologues for the BmHSP70 TSM in roughly 25%. Thus, while the BmHSP70 TSM is necessary and sufficient to direct trans-splicing in some genomic contexts, independent trans-splicing signals are employed by other genes...
- The role of RNA folding free energy in the evolution of the polymerase genes of the influenza A virusRachel Brower-Sinning
Department of Computational Biology, School of Medicine, University of Pittsburgh, Fifth Avenue, Pittsburgh, PA 15260, USA
Genome Biol 10:R18. 2009..Current efforts to understand the host-specificity of the virus have largely focused on the amino acid differences between avian and human isolates...
- Unseasonal transmission of H3N2 influenza A virus during the swine-origin H1N1 pandemicElodie Ghedin
Center for Vaccine Research, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Virol 84:5715-8. 2010..These results suggest that the unseasonal transmission of influenza A viruses may be more widespread than is usually supposed...
- Genes encoding putative biogenic amine receptors in the parasitic nematode Brugia malayiKatherine A Smith
Department of Biological Sciences, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA
Invert Neurosci 7:227-44. 2007..Our results provide a framework for how G-protein coupled receptors may be targeted for drug development in medically important parasitic nematodes...
- Mining predicted essential genes of Brugia malayi for nematode drug targetsSanjay Kumar
Division of Parasitology, New England Biolabs, Inc, Ipswich, Massachusetts, United States of America
PLoS ONE 2:e1189. 2007..By virtue of the selection procedure, the potential B. malayi drug targets highlight components of key processes in nematode biology such as central metabolism, molting and regulation of gene expression...
- The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematodeJeremy Foster
Molecular Parasitology Division, New England Biolabs, Beverly, Massachusetts, USA
PLoS Biol 3:e121. 2005..Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease...
- A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodelingDavid B Guiliano
Department of Biological Sciences, Imperial College of Science and Technology, London SW7 2AY, UK
Mol Biochem Parasitol 136:227-42. 2004....
- First sequenced genome of a parasitic nematodeElodie Ghedin
Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Trends Parasitol 20:151-3. 2004
- Brugia Malayi Genome ProjectElodie Ghedin; Fiscal Year: 2002..malayi. ..
- High-throughput Analysis of Brugia malayi mRNA 5' endsElodie Ghedin; Fiscal Year: 2005..This could potentially lead to the discovery of previously undiscovered operons in 8. malayi. Moreover, the collection of trans-spliced genes will serve as a comparative marker for evolutionary studies in nematodes. ..