Anatole Ghazalpour

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Integrating genetic and network analysis to characterize genes related to mouse weight
    Anatole Ghazalpour
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e130. 2006
  2. pmc Variations in DNA elucidate molecular networks that cause disease
    Yanqing Chen
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Nature 452:429-35. 2008
  3. pmc High-resolution mapping of gene expression using association in an outbred mouse stock
    Anatole Ghazalpour
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 4:e1000149. 2008
  4. pmc Genomic analysis of metabolic pathway gene expression in mice
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
    Genome Biol 6:R59. 2005
  5. pmc Comparative analysis of proteome and transcriptome variation in mouse
    Anatole Ghazalpour
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1001393. 2011
  6. pmc Copy number variation influences gene expression and metabolic traits in mice
    Luz D Orozco
    Department of Human Genetics, UCLA, Los Angeles, CA, USA
    Hum Mol Genet 18:4118-29. 2009
  7. pmc An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association
    Charles R Farber
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    J Bone Miner Res 24:105-16. 2009
  8. pmc Weighted gene coexpression network analysis strategies applied to mouse weight
    Tova F Fuller
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Mamm Genome 18:463-72. 2007
  9. pmc Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
    Luz D Orozco
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 151:658-70. 2012
  10. pmc Gene networks associated with conditional fear in mice identified using a systems genetics approach
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    BMC Syst Biol 5:43. 2011

Detail Information

Publications19

  1. pmc Integrating genetic and network analysis to characterize genes related to mouse weight
    Anatole Ghazalpour
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e130. 2006
    ..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
  2. pmc Variations in DNA elucidate molecular networks that cause disease
    Yanqing Chen
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, 401 Terry Avenue North, Seattle, Washington 98109, USA
    Nature 452:429-35. 2008
    ..Our analysis provides direct experimental support that complex traits such as obesity are emergent properties of molecular networks that are modulated by complex genetic loci and environmental factors...
  3. pmc High-resolution mapping of gene expression using association in an outbred mouse stock
    Anatole Ghazalpour
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 4:e1000149. 2008
    ..Our results also highlight the importance of correcting for population structure in whole-genome association studies in the outbred stock...
  4. pmc Genomic analysis of metabolic pathway gene expression in mice
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
    Genome Biol 6:R59. 2005
    ..Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice...
  5. pmc Comparative analysis of proteome and transcriptome variation in mouse
    Anatole Ghazalpour
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1001393. 2011
    ..In light of the widespread use of high-throughput technologies in both clinical and basic research, the results presented have practical as well as basic implications...
  6. pmc Copy number variation influences gene expression and metabolic traits in mice
    Luz D Orozco
    Department of Human Genetics, UCLA, Los Angeles, CA, USA
    Hum Mol Genet 18:4118-29. 2009
    ..Our results suggest that CNVs have a significant impact on gene expression and that CNVs may be playing a role in the mechanisms underlying metabolic traits in mice...
  7. pmc An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association
    Charles R Farber
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    J Bone Miner Res 24:105-16. 2009
    ..Integration of multiple genetic and genomic data sets can substantially improve the efficiency of QTL fine-mapping and candidate gene identification...
  8. pmc Weighted gene coexpression network analysis strategies applied to mouse weight
    Tova F Fuller
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Mamm Genome 18:463-72. 2007
    ..These examples provide evidence that integration of network properties may well help chart the path across the gene-trait chasm...
  9. pmc Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
    Luz D Orozco
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 151:658-70. 2012
    ..We have created a public database where the data presented here can be used as a resource for understanding many common inflammatory traits that are modeled in the mouse and for the dissection of regulatory relationships between genes...
  10. pmc Gene networks associated with conditional fear in mice identified using a systems genetics approach
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    BMC Syst Biol 5:43. 2011
    ..To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution...
  11. ncbi request reprint Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1679, USA
    J Lipid Res 45:1793-805. 2004
    ..In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks...
  12. pmc A high-resolution association mapping panel for the dissection of complex traits in mice
    Brian J Bennett
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 20:281-90. 2010
    ..This resource, termed the Hybrid Mouse Diversity Panel, makes possible the integration of multiple data sets and should prove useful for systems-based approaches to complex traits and studies of gene-by-environment interactions...
  13. pmc Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
    Xia Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Nat Genet 41:415-23. 2009
    ..Integration of gene expression in the design and analysis of traditional F(2) intercross studies allows high-confidence prediction of causal genes and identification of pathways and networks involved...
  14. ncbi request reprint Genetic regulation of mouse liver metabolite levels
    Anatole Ghazalpour
    Division of Cardiology, Department of Medicine, UCLA, Los Angeles, CA, USA
    Mol Syst Biol 10:730. 2014
    ..We also integrated the metabolomic data with transcriptomic and clinical phenotypic data to evaluate the extent of co-variation across various biological scales. ..
  15. pmc The systems genetics resource: a web application to mine global data for complex disease traits
    Atila Van Nas
    Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Front Genet 4:84. 2013
    ..The web site includes detailed protocols for all of the studies. Data from published studies are freely available; unpublished studies have restricted access during their embargo period...
  16. pmc Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits
    Anatole Ghazalpour
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Mamm Genome 23:680-92. 2012
    ..In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches...
  17. pmc Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice
    Anatole Ghazalpour
    Department of Microbiology Immunology and Molecular Genetics, University of California, Los Angeles, California 90095 1679, USA
    Genetics 173:943-51. 2006
    ..This complexity should be considered when interpreting results of knockout studies...
  18. ncbi request reprint Genetic loci contributing to age-related hippocampal lesions in mice
    Kelly L Krass
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Neurobiol Dis 13:102-8. 2003
    ..The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus...
  19. ncbi request reprint Using mice to dissect genetic factors in atherosclerosis
    Hooman Allayee
    Department of Human Genetics, David Geffen School of Medicine at UCLA, USA
    Arterioscler Thromb Vasc Biol 23:1501-9. 2003
    ....