Amin S Ghabrial

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, 1214 BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 14:386-93. 2012
  2. pmc A sweet spot in the FGFR signal transduction pathway
    Amin S Ghabrial
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Signal 5:pe1. 2012
  3. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
  4. ncbi request reprint Social interactions among epithelial cells during tracheal branching morphogenesis
    Amin S Ghabrial
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 441:746-9. 2006
  5. ncbi request reprint Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization
    Boaz P Levi
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Development 133:2383-93. 2006
  6. pmc Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2
    Yanjun Song
    Department of Cell and Developmental Biology, Perelman School of Medicine, BRBII III Room 1214, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 25:507-19. 2013
  7. pmc Tube continued: morphogenesis of the Drosophila tracheal system
    Jodi Schottenfeld
    Department of Cell and Developmental Biology, 1214 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 22:633-9. 2010
  8. pmc Seamless tube shape is constrained by endocytosis-dependent regulation of active moesin
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 24:1756-64. 2014
  9. doi request reprint Osmotic regulation of seamless tube growth
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Nat Cell Biol 15:137-9. 2013

Collaborators

  • Jodi Schottenfeld-Roames
  • Yanjun Song
  • Jodi Schottenfeld
  • Boaz P Levi
  • Jeffrey B Rosa
  • Melissa Eng
  • Mark A Krasnow

Detail Information

Publications9

  1. pmc Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 421 Curie Boulevard, 1214 BRB II III, Philadelphia, Pennsylvania 19104, USA
    Nat Cell Biol 14:386-93. 2012
    ..Thus, vesicle trafficking has key roles in making and shaping seamless tubes...
  2. pmc A sweet spot in the FGFR signal transduction pathway
    Amin S Ghabrial
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Signal 5:pe1. 2012
    ..Embryos lacking maternal and zygotic nst gene products show defective O-GlcNAcylation of a fibroblast growth factor receptor (FGFR)-specific adaptor protein, which impairs FGFR-dependent migration of mesodermal and tracheal cells...
  3. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
    ....
  4. ncbi request reprint Social interactions among epithelial cells during tracheal branching morphogenesis
    Amin S Ghabrial
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    Nature 441:746-9. 2006
    ..There may also be cooperation between budding cells, because in a mosaic epithelium, cells that cannot respond to the chemoattractant, or respond only poorly, allow other cells in the epithelium to move ahead of them...
  5. ncbi request reprint Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization
    Boaz P Levi
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Development 133:2383-93. 2006
    ..Similar complexes may stabilize other tubular networks and may be targeted for inactivation during network remodeling events...
  6. pmc Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2
    Yanjun Song
    Department of Cell and Developmental Biology, Perelman School of Medicine, BRBII III Room 1214, 421 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 25:507-19. 2013
    ..Ectopic junctional and apical proteins are present in wheezy terminal cells, and we show that tube dilation is suppressed by reduction of NSF2, of the apical determinant Crumbs, or of septate junction protein Varicose...
  7. pmc Tube continued: morphogenesis of the Drosophila tracheal system
    Jodi Schottenfeld
    Department of Cell and Developmental Biology, 1214 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Curr Opin Cell Biol 22:633-9. 2010
    ....
  8. pmc Seamless tube shape is constrained by endocytosis-dependent regulation of active moesin
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 24:1756-64. 2014
    ..We propose that early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moe, which in turn regulates seamless tube shape through modulation of cortical actin filaments. ..
  9. doi request reprint Osmotic regulation of seamless tube growth
    Jodi Schottenfeld-Roames
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Nat Cell Biol 15:137-9. 2013
    ....

Research Grants1

  1. Competition and morphogenesis in tip cell-mediated branching of tubular networks
    Amin S Ghabrial; Fiscal Year: 2010
    ..This proposal aims to use Drosophila tracheal branching as a model to uncover the genetic and molecular mechanisms by which tip cells are selected and by which they lead outgrowth of new tubes. ..