Mark Geyer

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Assessment of murine startle reactivity, prepulse inhibition, and habituation
    Mark A Geyer
    University of California at San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2003
  2. pmc From antipsychotic to anti-schizophrenia drugs: role of animal models
    Mark A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, San Diego, CA, USA
    Trends Pharmacol Sci 33:515-21. 2012
  3. pmc GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
    Jared W Young
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 208:443-54. 2010
  4. pmc LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor
    Adam L Halberstadt
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 208:179-89. 2010
  5. pmc Factor analysis of attentional set-shifting performance in young and aged mice
    Shoji Tanaka
    Department of Information and Communication Sciences, Sophia University, Tokyo, Japan
    Behav Brain Funct 7:33. 2011
  6. ncbi request reprint Effects of LU-111995 in three models of disrupted prepulse inhibition in rats
    M A Geyer
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Pharmacol Exp Ther 290:716-24. 1999
  7. pmc Developing translational animal models for symptoms of schizophrenia or bipolar mania
    M A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Neurotox Res 14:71-8. 2008
  8. ncbi request reprint Animal behavior models of the mechanisms underlying antipsychotic atypicality
    Mark A Geyer
    Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093 0804, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1071-9. 2003
  9. pmc Wayne Fenton's impact on academic neuroscience
    Mark A Geyer
    Schizophr Bull 33:1156-9. 2007
  10. pmc The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps?
    Mark A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Neurotox Res 10:211-20. 2006

Detail Information

Publications112 found, 100 shown here

  1. doi request reprint Assessment of murine startle reactivity, prepulse inhibition, and habituation
    Mark A Geyer
    University of California at San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2003
    ....
  2. pmc From antipsychotic to anti-schizophrenia drugs: role of animal models
    Mark A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, San Diego, CA, USA
    Trends Pharmacol Sci 33:515-21. 2012
    ..Lessons to be learned from those models and recent genetic and cognitive insights in schizophrenia can be utilized to develop better animal and human models and, potentially, novel treatment strategies...
  3. pmc GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
    Jared W Young
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 208:443-54. 2010
    ....
  4. pmc LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor
    Adam L Halberstadt
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 208:179-89. 2010
    ..LSD and other hallucinogens have been shown to disrupt prepulse inhibition (PPI), an operational measure of sensorimotor gating, by activating 5-HT(2A) receptors in rats...
  5. pmc Factor analysis of attentional set-shifting performance in young and aged mice
    Shoji Tanaka
    Department of Information and Communication Sciences, Sophia University, Tokyo, Japan
    Behav Brain Funct 7:33. 2011
    ..We hypothesized that the latent structure of cognitive performance would reflect functional localization in the brain and would be altered by aging...
  6. ncbi request reprint Effects of LU-111995 in three models of disrupted prepulse inhibition in rats
    M A Geyer
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Pharmacol Exp Ther 290:716-24. 1999
    ..It remains to be elucidated whether its effects on PPI can be attributed to a blockade of single dopamine and 5-hydroxytryptamine receptor subtypes, especially D(4) and 5-hydroxytryptamine(2A), or a combination of both...
  7. pmc Developing translational animal models for symptoms of schizophrenia or bipolar mania
    M A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Neurotox Res 14:71-8. 2008
    ..Another focus includes efforts to develop new human models of psychiatric symptoms that are designed to parallel existing tests used in rodents...
  8. ncbi request reprint Animal behavior models of the mechanisms underlying antipsychotic atypicality
    Mark A Geyer
    Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093 0804, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1071-9. 2003
    ..Moreover, there is an urgent need for animal models focusing more on the negative and the cognitive symptoms. Hence, improved animal models are crucial for developing better treatments for schizophrenia...
  9. pmc Wayne Fenton's impact on academic neuroscience
    Mark A Geyer
    Schizophr Bull 33:1156-9. 2007
    ....
  10. pmc The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps?
    Mark A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Neurotox Res 10:211-20. 2006
    ....
  11. doi request reprint Serotonin research: contributions to understanding psychoses
    Mark A Geyer
    Department of Psychiatry, University of California San Diego, Room B 418 Clinical Teaching Facility, 212 W Dickinson Street, San Diego, CA 92103, USA
    Trends Pharmacol Sci 29:445-53. 2008
    ..This review summarizes experimental assessments of the serotonergic hallucinogen model psychosis in relation to the serotonin hypothesis of schizophrenia...
  12. ncbi request reprint Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review
    M A Geyer
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Psychopharmacology (Berl) 156:117-54. 2001
    ..In addition, some developmental manipulations, such as isolation rearing, have provided non-pharmacological animal models of the PPI deficits seen in schizophrenia...
  13. pmc Are cross-species measures of sensorimotor gating useful for the discovery of procognitive cotreatments for schizophrenia?
    Mark A Geyer
    Department of Psychiatry, University of California, San Diego, La Jolla, Calif 92093 0804, USA
    Dialogues Clin Neurosci 8:9-16. 2006
    ..Hence, treatment-induced reversals of glutamate antagonist effects on PPI may provide animal and human models to identify treatments of cognitive deficits in patients already treated with existing antipsychotics...
  14. ncbi request reprint New approaches to measurement and treatment research to improve cognition in schizophrenia
    Mark A Geyer
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Schizophr Bull 31:806-9. 2005
    ..Specific priorities for a research agenda involving collaborations among academic, industrial, and governmental participants are addressed...
  15. ncbi request reprint Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats
    S B Powell
    Department of Psychiatry, 9500 Gilman Drive, 0804, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroscience 119:233-40. 2003
    ....
  16. pmc Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders
    Cameron S Carter
    Department of Psychiatry, University of California at Davis, Sacramento, California, USA
    Biol Psychiatry 70:7-12. 2011
    ..This overview article describes the background and goals of the meeting together with a summary of the major issues discussed in more detail in the accompanying articles appearing in this issue of Biological Psychiatry...
  17. ncbi request reprint Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists
    R J Ralph
    Departments of Neuroscience and Psychiatry, University of California San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 21:305-13. 2001
    ..Furthermore, D1 receptor activation appears to be the critical substrate for the expression of preservative patterns of motor behavior, whereas both D1 and D2 receptors appear to regulate the amount of motor activity...
  18. ncbi request reprint The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice
    R J Ralph
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 19:4627-33. 1999
    ..Uncovering the neural mechanisms involved in PPI will further our understanding of the substrates of sensorimotor gating and could lead to better therapeutics to treat gating disorders, such as schizophrenia...
  19. ncbi request reprint Disruption of prepulse inhibition in mice lacking mGluR1
    S A Brody
    Department of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Eur J Neurosci 18:3361-6. 2003
    ..Thus, both group I metabotropic glutamate receptors are involved in the regulation of PPI in mice...
  20. ncbi request reprint Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice
    R J Ralph
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, USA
    J Pharmacol Exp Ther 298:148-55. 2001
    ..These findings highlight the importance of selecting appropriate strains of mice for behavioral, pharmacological, and genetic studies...
  21. pmc Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative
    Cameron S Carter
    Department of Psychiatry, University of California, Davis, CA 95817, USA
    Biol Psychiatry 64:4-10. 2008
    ..The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts...
  22. ncbi request reprint Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
    D L Braff
    Department of Psychiatry, UCSD, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:234-58. 2001
    ..In humans, PPI occurs in a robust, predictable manner when the prepulse and startling stimuli occur in either the same or different modalities (acoustic, visual, or cutaneous)...
  23. ncbi request reprint Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges
    N R Swerdlow
    Department of Psychiatry, UCSD Schools of Medicine, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:194-215. 2001
    ....
  24. ncbi request reprint Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors
    S A Brody
    Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Psychiatry 9:35-41. 2004
    ..The present findings further support the glutamate hypothesis of schizophrenia and identify a functional role for mGluR5 in sensorimotor gating...
  25. ncbi request reprint Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice
    X Zhou
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 6:269-76. 2007
    ..The abnormality of the molecular layer was indicated by a reduced level of synaptophysin expression in the mutant mice. The Sp4 transcription factor therefore appears to predominantly regulate the development of dentate granule cells...
  26. ncbi request reprint Cross-species studies of sensorimotor gating of the startle reflex
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Ann N Y Acad Sci 877:202-16. 1999
    ..In this manner, PPI can be used to probe the sensitivity of DAergic systems, and perhaps other CSPP elements, across normal and neuropsychiatric-disordered populations...
  27. ncbi request reprint Symptom correlates of prepulse inhibition deficits in male schizophrenic patients
    D L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Am J Psychiatry 156:596-602. 1999
    ..Prepulse inhibition deficits in schizophrenic patients correlate with core cognitive symptoms, such as thought disorder and distractibility, but their relationship to positive and negative symptoms of schizophrenia is less clear...
  28. ncbi request reprint Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients
    W Perry
    Department of Psychiatry, University of California, San Diego, USA
    Arch Gen Psychiatry 56:277-81. 1999
    ..To address this issue, sensorimotor gating and thought disturbance were measured in close temporal proximity, thus strengthening the evidence for the association of these 2 abnormalities in schizophrenic patients...
  29. ncbi request reprint Differential movement patterns but not amount of activity in unconditioned motor behavior of Fischer, Lewis, and Sprague-Dawley rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 65:601-6. 1998
    ..Differences in movement patterns across strains may provide an important behavioral variable to further explore the genetic and developmental aspects of behavior...
  30. ncbi request reprint Poor P50 suppression among schizophrenia patients and their first-degree biological relatives
    B A Clementz
    Department of Psychology, University of California, San Diego, La Jolla 92093 0109, USA
    Am J Psychiatry 155:1691-4. 1998
    ..This study's goal was to replicate the finding that family members of schizophrenia patients show poor P50 suppression during a paired-click auditory evoked response paradigm...
  31. ncbi request reprint Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects
    B A Clementz
    Department of Psychology, University of California, La Jolla, San Diego 92093 0109, USA
    Schizophr Res 30:71-80. 1998
    ..Further work investigating the neuropathological correlates of poor P50 suppression among schizophrenia patients by recording from multiple electrode locations, however, could be helpful...
  32. ncbi request reprint Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla 92093 0804, USA
    Behav Pharmacol 9:389-96. 1998
    ....
  33. ncbi request reprint Aging effects on the startle response and startle plasticity in Fischer F344 rats
    G B Varty
    Department of Psychiatry, University of California San Diego, La Jolla 92093 0804, USA
    Neurobiol Aging 19:243-51. 1998
    ..Finally, there were no effects of age on FPS. In summary, these studies suggest that in Fischer F344 rats, there are age-associated differences in startle reactivity, startle habituation, and PPI, but no aging effect on FPS...
  34. ncbi request reprint Latent inhibition in schizophrenia
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 20:91-103. 1996
    ....
  35. ncbi request reprint Sex differences in sensorimotor gating of the human startle reflex: all smoke?
    N R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 146:228-32. 1999
    ..A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers...
  36. ncbi request reprint Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 19:9550-6. 1999
    ..Hence, D4R-/- mice exhibit reductions in behavioral responses to novelty, reflecting a decrease in novelty-related exploration...
  37. ncbi request reprint Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 20:4325-36. 2000
    ..These findings demonstrate robust, innate, neurochemically specific, and apparently heritable phenotypic differences in an animal model of sensorimotor gating deficits in human neuropsychiatric disorders...
  38. ncbi request reprint Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia
    D L Braff
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 49:171-8. 2001
    ....
  39. ncbi request reprint Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..Although schizotypal subjects have been shown to have deficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 sensory gating in schizotypal personality disorder has yet to be reported...
  40. ncbi request reprint Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 22:650-9. 2000
    ..Findings suggest that 5-HT(1B) receptor activation decreases PPI and habituation, and 5-HT(1A) receptor activation increases PPI in mice...
  41. ncbi request reprint The genetic liability to stress and postweaning isolation have a competitive influence on behavioral organization in rats
    M P Paulus
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Physiol Behav 68:389-94. 2000
    ....
  42. ncbi request reprint Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Behav Pharmacol 11:185-204. 2000
    ..Some of these issues--ranging from the cross-species methods for quantifying specific variables to the relevance of genetic drift to animal and human studies of PPI--and their implications for future studies are the focus of this review...
  43. ncbi request reprint Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice
    S A Brody
    Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, CA 92093 0804, La Jolla, USA
    Psychopharmacology (Berl) 172:187-95. 2004
    ..Metabotropic glutamate receptor 5 (mGluR5) has been implicated in schizophrenia, in part because mGluR5 knockout (KO) mice exhibit PPI deficits...
  44. ncbi request reprint Tactile prepuff inhibition of startle in children with Tourette's syndrome: in search of an "fMRI-friendly" startle paradigm
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, California 92093-0804, USA
    Biol Psychiatry 50:578-85. 2001
    ..CONCLUSIONS: Sensorimotor gating can be assessed in an "fMRI-friendly" paradigm that detects inhibitory deficits in TS...
  45. ncbi request reprint Psychopharmacology of prepulse inhibition in mice
    S C Dulawa
    Department of Neuroscience, University of California at San Diego, La Jolla 92093 0804, USA
    Chin J Physiol 39:139-46. 1996
    ..0 mg/kg d-amphetamine produced a large reduction of PPI that approached significance. Our findings suggest that the mouse may provide another model system for the study of sensorimotor gating mechanisms...
  46. ncbi request reprint Measurement of startle response, prepulse inhibition, and habituation
    M A Geyer
    University of California, San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2001
    ....
  47. ncbi request reprint 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics
    D M Weiner
    ACADIA Pharmaceuticals Inc, San Diego, California 92121, USA
    J Pharmacol Exp Ther 299:268-76. 2001
    ..The behavioral pharmacology of AC-90179 is characteristic of an atypical antipsychotic agent...
  48. ncbi request reprint Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release
    C W Callaway
    Department of Psychiatry, UCSD School of Medicine, La Jolla 92093 0804
    Psychopharmacology (Berl) 111:169-78. 1993
    ..These data suggest that the decrease in activity induced by fenfluramine, norfenfluramine and the related drug MMAI is not related to 5-HT release...
  49. ncbi request reprint The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    S A Henry
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 43:1199-209. 2002
    ..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors...
  50. ncbi request reprint 5HT-2 mediation of acute behavioral effects of hallucinogens in rats
    L L Wing
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093
    Psychopharmacology (Berl) 100:417-25. 1990
    ..In contrast, ketanserin had no significant effect on the suppression of activity produced by the 5HT-1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8OHDPAT).(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. ncbi request reprint Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093
    Psychopharmacology (Berl) 101:414-20. 1990
    ....
  52. ncbi request reprint Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach
    C A Ogden
    Laboratory of Neurophenomics, University of California, San Diego, CA, USA
    Mol Psychiatry 9:1007-29. 2004
    ....
  53. pmc CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice
    Jodi Gresack
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropeptides 44:349-53. 2010
    ..As such, loss of CRF(2) activity via genetic variance may increase sensitivity to the long-term effects of developmental stress...
  54. pmc Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  55. ncbi request reprint Mouse genetic models for prepulse inhibition: an early review
    M A Geyer
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Mol Psychiatry 7:1039-53. 2002
    ..The use of mice to study PPI is increasing at a dramatic rate and is helping to increase our understanding of the biological basis for sensorimotor gating...
  56. ncbi request reprint Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization
    X Zhou
    Department of Medicine, Institute of Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Psychiatry 10:393-406. 2005
    ..Our studies thus reveal a novel Sp4 pathway that is essential for hippocampal integrity and modulates behavioral processes relevant to psychiatric disorders...
  57. pmc A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia
    Holly Moore
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 60:253-64. 2006
    ..Specifically, we tested whether this manipulation leads to disruptions of frontal and limbic corticostriatal circuit function, while producing schizophrenia-like, region-dependent reductions in gray matter in cortex and thalamus...
  58. ncbi request reprint Isolation rearing of mice induces deficits in prepulse inhibition of the startle response
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Behav Brain Res 169:162-7. 2006
    ..Isolation rearing induced locomotor hyperactivity and PPI deficits in mice and may be an effective developmental manipulation to use in combination with studies of genetically altered mice...
  59. ncbi request reprint The indirect serotonergic agonist d-fenfluramine and prepulse inhibition in healthy men
    Kathryn M Abel
    Academic Department of Psychiatry and Behavioural Sciences, 7th Floor, Williamson Building, Manchester University, Oxford Road, Manchester M13 9LR, UK
    Neuropharmacology 52:1088-94. 2007
    ..There were no significant associations between PPI effects and behaviour...
  60. pmc Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:506-15. 2006
    ..Despite similarities in drug sensitivity, these results suggest that distinct neurobiological mechanisms underlie drug-induced deficits in PPI and N40 gating...
  61. pmc An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition
    Jacob C Ong
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    J Pharmacol Exp Ther 315:1163-71. 2005
    ..Hence, further studies using these dopaminergic and glutamatergic models of deficient PPI may provide valuable insights into the mechanisms underlying the differential therapeutic effects of antimanic and mood-stabilizing treatments...
  62. ncbi request reprint The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval
    Franz X Vollenweider
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Neuropsychopharmacology 32:1876-87. 2007
    ....
  63. ncbi request reprint Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice
    Victoria B Risbrough
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:2349-58. 2006
    ..More specifically, D1 receptor activation appears to modify the type of activity (linear vs circumscribed), whereas D2 receptor activation appears to contribute to the repetitive circling behavior produced by MDMA...
  64. pmc Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating
    Christiaan H Vinkers
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pharmacol Biochem Behav 86:550-8. 2007
    ..These results indicate that neither D(1)- nor D(2)-receptor activation is necessary for CRF to exert its effects on acoustic startle and PPI in mice...
  65. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  66. ncbi request reprint Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels
    Philipp A Csomor
    University Hospital of Psychiatry Zurich, Experimental Psychopathology and Brain Imaging, Zurich, Switzerland
    Neuropsychopharmacology 33:497-512. 2008
    ..Furthermore, the results suggest a relation between sensorimotor gating and working memory performance...
  67. ncbi request reprint A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics
    Veena Kumari
    Department of Psychology, Institute of Psychiatry, King s College London, London, UK
    Int J Neuropsychopharmacol 10:463-77. 2007
    ..Imaging data buttress the validity of PPI as a useful animal model of schizophrenia...
  68. pmc A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor
    Jared W Young
    University of California San Diego, Department of Psychiatry, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Neurosci Biobehav Rev 31:882-96. 2007
    ..This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents...
  69. ncbi request reprint Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
    Alasdair M Barr
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 51:457-65. 2006
    ..The absence of effect in isolation-reared rats may be due to the relatively small effect size of isolation rearing on PPI or dose of iloperidone...
  70. pmc Spontaneous nicotine withdrawal potentiates the effects of stress in rats
    Sietse Jonkman
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 33:2131-8. 2008
    ..These findings support the hypothesis that nicotine withdrawal exacerbates stress responding, and indicate LES may be a useful model to examine withdrawal effects on anxiety...
  71. ncbi request reprint Prepulse inhibition and P50 suppression: commonalities and dissociations
    Bob Oranje
    Center for Neuropsychiatric Schizophrenia Research, Department of Psychiatry, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen NV, Denmark
    Psychiatry Res 143:147-58. 2006
    ..They are not intrinsically auditory phenomena, and both appear to involve frontal cortical activity. In contrast, N100 suppression is most likely based on refractory mechanisms intrinsic to the auditory system...
  72. ncbi request reprint The effects of sex and neonatal maternal separation on fear-potentiated and light-enhanced startle
    Reinoud de Jongh
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Behav Brain Res 161:190-6. 2005
    ..In contrast, the effects of MS on startle potentiation argue against the idea that MS provides a robust model for the predicted influences of early adverse effects on these startle potentiation measures of fear and anxiety...
  73. ncbi request reprint A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle
    Suzanne A Brody
    Department of Neuroscience, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 57:1147-52. 2005
    ..NR3A reduces NMDA current in native neurons expressing NR1 and NR2 subunits and forms glycine receptors when expressed with NR1 in the absence of NR2 in both oocyte and mammalian expression systems...
  74. ncbi request reprint Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors
    Susan B Powell
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 180:491-500. 2005
    ..The noradrenergic system appears to play a role in PPI as the alpha1 agonist cirazoline disrupts PPI and the alpha1 antagonist prazosin blocks the disruptions in PPI produced by phencyclidine...
  75. ncbi request reprint Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects
    Veena Kumari
    Section of Cognitive Psychopharmacology, Institute of Psychiatry, King s College, De Crespigny Park, London SE5 8AF, UK
    Psychiatry Res 122:99-113. 2003
    ..The findings demonstrate involvement of the striatum, hippocampus, thalamus, and frontal and parietal cortical regions in PPI. Dysfunctions in any of these regions may underlie observations of reduced PPI in schizophrenia...
  76. ncbi request reprint Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice
    Suzanne A Brody
    Department of Psychiatry and Neurosciences, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0804, USA
    Psychopharmacology (Berl) 169:240-6. 2003
    ..Acutely manic bipolar patients, like persons with schizophrenia, Tourette's, and obsessive compulsive disorder, exhibit decreases in sensorimotor gating, as measured by prepulse inhibition of the startle response (PPI)...
  77. ncbi request reprint Low dose ketamine increases prepulse inhibition in healthy men
    Kathryn M Abel
    7th Floor Williamson Building, University of Manchester, Manchester M13 9PL, UK
    Neuropharmacology 44:729-37. 2003
    ..These findings suggest that the cognitive and PPI changes of NMDA antagonists are not consistently linked at a phenomenological or neurochemical level...
  78. ncbi request reprint GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice
    Victoria B Risbrough
    Department of Neurosciences, University of California, San Diego, La Jolla 92093 0804, USA
    Neuropsychopharmacology 28:654-63. 2003
    ..These data demonstrate a novel method of studying acquisition of FPS, and support the predictive validity of the FPS model of anxiolytic drug action in mice...
  79. ncbi request reprint RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice
    Susan B Powell
    Dept of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 44:473-81. 2003
    ..These results support the hypothesis that stimulation of D4R can enhance novelty seeking in mice and that this effect may be dependent on subtle genetic differences...
  80. ncbi request reprint The relationship of age to prepulse inhibition and habituation of the acoustic startle response
    Joel Ellwanger
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychol 62:175-95. 2003
    ..The results do not support the theory that aging is associated with a general decline in inhibitory function and contrast with previous studies that have compared only extreme age groups and have found no effects of age on PPI...
  81. ncbi request reprint Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice
    Rebecca J Ralph-Williams
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA, USA
    Neuropsychopharmacology 28:108-18. 2003
    ..Nevertheless, due to the limited selectivity of DA receptor agonists, further studies using specific receptor knockout mice are warranted to clarify the respective roles of specific DA receptor subtypes in modulating PPI in mice...
  82. ncbi request reprint Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice
    Rebecca J Ralph-Williams
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 22:9604-11. 2002
    ..These findings emphasize that further cross-species comparisons of the pharmacology of PPI are essential to understand the relevance of rodent PPI studies to the deficits in PPI observed in patients with schizophrenia...
  83. ncbi request reprint Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation
    Susan B Powell
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive 0804, La Jolla, CA 92093, USA
    Physiol Behav 77:55-64. 2002
    ..Isolation rearing significantly disrupts PPI and locomotor habituation independent of any effects of water deprivation...
  84. ncbi request reprint Prestimulus effects on startle magnitude: sensory or motor?
    Neal R Swerdlow
    Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093 0804, USA
    Behav Neurosci 116:672-81. 2002
    ..Despite apparent differences in the inhibitory processes mediating PPI and paired pulse inhibition, both are independent of the motoric response to the prestimulus...
  85. ncbi request reprint Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
    Am J Psychiatry 159:869-71. 2002
    ....
  86. ncbi request reprint Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 161:189-201. 2002
    ..25, 2.5 mg; pergolide: 0.025, 0.1 mg) and indirect DA agonists (amphetamine: 20 mg; amantadine: 200 mg) ( n=6-10/dose)...
  87. ncbi request reprint "Typical" but not "atypical" antipsychotic effects on startle gating deficits in prepubertal rats
    Zoe A Martinez
    Department of Psychology, University of California, Los Angeles, USA
    Psychopharmacology (Berl) 161:38-46. 2002
    ..We previously reported that the PPI disruptive effects of both APO and PCP are evident in 16- to 18-day-old rat pups, suggesting that the brain substrates for these effects are functional very early in development...
  88. ncbi request reprint Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia
    Katja Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, P O Box, CH 5201 Brugg, Switzerland
    Schizophr Res 55:129-37. 2002
    ..This PPI deficit was evident in all three sessions. These results indicate that PPI is a stable neurobehavioral measure in chronic schizophrenic patients in the absence of changes in clinical state...
  89. ncbi request reprint Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone
    Anneloes Dirks
    Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Biol Psychiatry 51:583-90. 2002
    ..In the present study, we investigated if sensory information processing of startling auditory stimuli was affected in CRH-OE(2122) mice...
  90. ncbi request reprint Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats
    Diana L Martinez-Price
    Graduate Program in Neuroscience and Department of Psychiatry 0804, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 71:569-80. 2002
    ....
  91. ncbi request reprint Reversal of startle gating deficits in transgenic mice overexpressing corticotropin-releasing factor by antipsychotic drugs
    Anneloes Dirks
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Neuropsychopharmacology 28:1790-8. 2003
    ..Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing...
  92. ncbi request reprint Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia
    Katja Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, Brugg, Switzerland
    Biol Psychiatry 54:121-8. 2003
    ..The aim of this study was to examine whether first-episode schizophrenia patients also exhibit deficits in PPI and habituation...
  93. ncbi request reprint The balance between approach and avoidance behaviors in a novel object exploration paradigm in mice
    Susan B Powell
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093, USA
    Behav Brain Res 152:341-9. 2004
    ..In combination, these results show that the approach and avoidance dimensions of novelty seeking can be manipulated experimentally and may be used in subsequent studies to examine the effects of drugs of abuse...
  94. ncbi request reprint Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation
    Michael K Harte
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    Biol Psychiatry 56:296-9. 2004
    ..Magnetic resonance spectroscopy studies have shown reductions of cortical and hippocampal NAA in schizophrenia, and a recent postmortem study has demonstrated a regionally selective temporal cortex deficit...
  95. ncbi request reprint Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice
    Suzanne A Brody
    Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Neurotox Res 6:79-90. 2004
    ....
  96. ncbi request reprint Sensitization and habituation of the acoustic startle reflex in patients with schizophrenia
    Ulrich Meincke
    Department of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Psychiatry Res 126:51-61. 2004
    ..In addition, the present data have important implications for designing startle studies to assess sensitization, habituation and prepulse inhibition in one session...
  97. ncbi request reprint Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis--a longitudinal study
    Ulrich Meincke
    Dept of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Arch Psychiatry Clin Neurosci 254:415-21. 2004
    ....
  98. ncbi request reprint Anxiogenic treatments do not increase fear-potentiated startle in mice
    Victoria B Risbrough
    Departments of Psychiatry and Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Biol Psychiatry 57:33-43. 2005
    ..The predictive validity of the model for anxiogenic drugs, however, remains unclear. Therefore, we evaluated the bi-directionality of the FPS model for anxiety-modulating compounds in mice...
  99. ncbi request reprint Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system
    Rebecca J Ralph-Williams
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 53:352-9. 2003
    ..We hypothesized that the DAT KD mice would also display deficits in prepulse inhibition (PPI) and would be perseverative in their locomotor behavior...
  100. ncbi request reprint Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior
    Victoria B Risbrough
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 24:6545-52. 2004
    ..We hypothesize that excessive CRF1 activation combined with reduced CRF2 signaling may contribute to information processing deficits seen in panic and posttraumatic stress disorder patients and support CRF1-specific pharmacotherapy...
  101. pmc Information-processing deficits and cognitive dysfunction in panic disorder
    Stephan Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, Brugg, Switzerland
    J Psychiatry Neurosci 30:37-43. 2005
    ..Moreover, we tested whether there was a relation between startle reflex measures and dysfunctional cognition...

Research Grants53

  1. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark Geyer; Fiscal Year: 2009
    ..Hence, Aim 3 studies will test the hypothesized differential roles of specific CRF receptors in mediating isolation rearing-induced deficits in PPI in mice, using CRF-R1 and CRF-R2 null mutant mice. ..
  2. Serotonin Club IUPHAR Satellite Meeting
    Mark Geyer; Fiscal Year: 2006
    ..Hence, helping neuroscientists-in-training attend the meeting will have a positive influence on trainees and a lasting impact on the field. ..
  3. STARTLE GATING AND LOCOMOTION IN D2-FAMILY KNOCKOUT MICE
    Mark Geyer; Fiscal Year: 2004
    ..This information will have important implications for the further development of therapeutic approaches to the treatment of both schizophrenia and drug abuse. ..
  4. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark Geyer; Fiscal Year: 2004
    ....
  5. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark Geyer; Fiscal Year: 2003
    ..These studies should further our basic understanding of the behavioral functions of serotonergic systems and the mechanisms of action of drugs of abuse such as hallucinogens and serotonin releasers. ..
  6. Sp4 pathway in hippocampus modulates sensorimotor gating
    Mark Geyer; Fiscal Year: 2007
    ..These experiments will yield novel insights into genetic pathways within the hippocampus that underlie behavioral abnormalities relevant to several psychiatric disorders. ..
  7. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark A Geyer; Fiscal Year: 2010
    ..Hence, Aim 3 studies will test the hypothesized differential roles of specific CRF receptors in mediating isolation rearing-induced deficits in PPI in mice, using CRF-R1 and CRF-R2 null mutant mice. ..
  8. MONOAMINE AND HALLUCINOGEN EFFECTS ON RODENT BEHAVIOR
    Mark Geyer; Fiscal Year: 2009
    ..This research is designed to elucidate the neurobiological mechanisms responsible for the acute effects of hallucinogens, which presumably lead to the recreational use of these drugs of abuse. ..
  9. Sp4 pathway in hippocampus modulates sensorimotor gating
    Mark Geyer; Fiscal Year: 2009
    ..These experiments will yield novel insights into genetic pathways within the hippocampus that underlie behavioral abnormalities relevant to several psychiatric disorders. ..
  10. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark Geyer; Fiscal Year: 2007
    ..Hence, Aim 3 studies will test the hypothesized differential roles of specific CRF receptors in mediating isolation rearing-induced deficits in PPI in mice, using CRF-R1 and CRF-R2 null mutant mice. ..
  11. Stress and CRF System Effects on Information Processing
    Mark Geyer; Fiscal Year: 2007
    ....
  12. MONOAMINE AND HALLUCINOGEN EFFECTS ON RAT BEHAVIOR
    Mark Geyer; Fiscal Year: 1993
    ..The work should further our understanding of the' basic neural mechanisms mediating the behavioral effects of these drugs of abuse and facilitate the_development of antagonists for their effects...
  13. MONOAMINES & HALLUCINOGENS' EFFECTS ON RAT BEHAVIOR
    Mark Geyer; Fiscal Year: 1992
    ..facilitate the development of antagonists for their effects, and begin to clarify the long-term functional consequences of their use...